Our group is investigating neuron-glia interactions with a particular interest for the tripartite synapse that considers astrocytes as active partners of chemical synapses.
The ability of astrocytes to ensure neurotransmitter uptake and to release gliotransmitters and their impact on synaptic transmission and synaptic plasticity has raised a lot of attention, identifying astroglial cells as possible targets to generate new and effective therapeutic strategies for brain diseases.
The general objective of our current research projects is to enhance our understanding of glial functions in healthy and diseased nervous system. We aim at characterize the impact of astrocytes on synaptic functions in physiological conditions as well as in the context of different pathologies like Alzheimer disease, multiple sclerosis, amyotrophic lateral sclerosis and addiction. To investigate glia-neurons interactions, we are using different physiological and pathological models in combination with the multidisciplinary approach available in our team like in vitro electrophysiology, morphological analysis, biochemical assays, state-of-the-art cell imaging and MRI.
More specifically, we are interested in deciphering the cellular mechanisms underlying gliotrasmission from detecting synaptic activity, identifying intracellular 2nd messenger pathways and defining independent domains of activity within individual astrocytes. We are also interested in analyzing fine anatomical morphological changes as well as monitoring membrane trafficking of key proteins. All these different glial-dependent process are investigated in regards of their impact onto synaptic transmission, synaptic plasticity, neuronal excitability, network activity and behaviour.
Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in excitatory circui
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Astrocytic Ca(2+) signals can be fast and local, supporting the idea that astrocytes have the ability to regulate single synapses. However, the anatomical basis of such specific signaling remains uncl
Alteration of brain aerobic glycolysis is often observed early in the course of Alzheimer's disease (AD). Whether and how such metabolic dysregulation contributes to both synaptic plasticity and behav
Astrocytes constantly adapt their ramified morphology in order to support brain cell assemblies. Such plasticity is partly mediated by ion and water fluxes, which rely on the water channel aquaporin-4