Equipe Oliet - Relations glie-neurone

Glia-neuron interactions, Group leader: Stéphane Oliet, PhD.


Research Objectives


Our group is investigating neuron-glia interactions with a particular interest for the tripartite synapse that considers astrocytes as active partners of chemical synapses.

The ability of astrocytes to ensure neurotransmitter uptake and to release gliotransmitters and their impact on synaptic transmission and synaptic plasticity has raised a lot of attention, identifying astroglial cells as possible targets to generate new and effective therapeutic strategies for brain diseases.

The general objective of our current research projects is to enhance our understanding of glial functions in healthy and diseased nervous system. We aim at characterize the impact of astrocytes on synaptic functions in physiological conditions as well as in the context of different pathologies like Alzheimer disease, multiple sclerosis, amyotrophic lateral sclerosis and addiction. To investigate glia-neurons interactions, we are using different physiological and pathological models in combination with the multidisciplinary approach available in our team like in vitro electrophysiology, morphological analysis, biochemical assays, state-of-the-art cell imaging and MRI.

More specifically, we are interested in deciphering the cellular mechanisms underlying gliotrasmission from detecting synaptic activity, identifying intracellular 2nd messenger pathways and defining independent domains of activity within individual astrocytes. We are also interested in analyzing fine anatomical morphological changes as well as monitoring membrane trafficking of key proteins. All these different glial-dependent process are investigated in regards of their impact onto synaptic transmission, synaptic plasticity, neuronal excitability, network activity and behaviour.



Team members



Stéphane OLIET
Team leader
Stephanie CHEVALLIER
Teacher-Researcher
Delphine HAMEL
Teacher-Researcher
Thomas TOURDIAS
Teacher-Researcher
Daniel VOISIN
Teacher-Researcher
Bruno BROCHET
Researcher
Philippe CIOFI
Researcher
Vincent DOUSSET
Researcher
Gwendal LEMASSON
Researcher
Aude PANATIER
Researcher
Aurélie RUET
Researcher
Gosuke OKUBO
Guest researcher
Aurélie AMADIO
ITA
Nadège DUBOURDIEU
ITA
Claire LEGER
ITA
Aymeric OLIVEIRA
ITA
Misa ARIZONO
Post Doc
Anastassios KARAGIANNIS
Post Doc
Marco MATOS
Post Doc
Dorian ARNOUIL
PhD
Julien BOUREL
PhD
Ismail KOUBIYR
PhD
Dylan POMMIER
PhD
Yan LEFÈVRE
ph