The discovery that new neurons (neurogenesis) are generated in the adult mammalian brain, including humans, has generated a very strong interest in the scientific community. Indeed, adult neurogenesis takes place in the serrated gyrus of the hippocampal formation. This vast region, which allows the constitution of temporo-spatial memories and is involved in mood regulation, is affected by aging and exposure to stress. Our team is interested in the role of neurogenesis in different hippocampal functions (memory and mood) and in the physiopathology of the hippocampus that can be induced during development or during aging. We conduct longitudinal studies, from embryonic to senescent stages, taking into account individual differences to understand the role of these new neurons in hippocampal functions. We are also studying the effects of etiological factors such as prenatal stress that can induce pathological memories. In order to accomplish our projects we use multidisciplinary approaches ranging from cellular and molecular biology (viral production and development of transgenic models) to imaging and electrophysiological and behavioural studies.