Obesity is a major health problem worldwide. However, despite the human and economic costs of this disease, efficient anti-obesity therapies are currently lacking.
One of the avenues that might lead to gain significant insights into the causes and potential treatments of obesity is the unravelling of the biological mechanisms regulating energy balance. Integrative systems and specific fuel sensing pathways are among the mechanisms known to control energy balance. Therefore, our past 4 years of research activity has been committed to studying in an integrated way both integrative systems and specific fuel sensing pathways. In particular, among the integrative systems, we have investigated the endogenous cannabinoid system (ECS) and, among the fuel sensing mechanisms, we have studied the mammalian Target Of Rapamycin complex 1 (mTORc1) cascade. Our studies on the ECS have helped to further detail the role of this system in energy balance by showing that while food intake and energy expenditure are controlled by cannabinoid receptors type 1 (CB1) located in the central nervous system, the equilibrium between energy storage and utilization is mediated by a direct action of CB1 on peripheral tissues. At the same time, our ground-breaking studies on the mTORc1 pathway have been the first to demonstrate that mTORc1 is a critical integrator of the effects of hormones and nutrients on food intake, and that the dysregulation of this pathway favours obesity.
Memory reconsolidation, the process by which memories are again stabilized after being reactivated, has strengthened the idea that memory stabilization is a highly plastic process. To date, the molecu
The mechanistic target of rapamycin (mTOR) is a ubiquitously expressed kinase that acts through two complexes, mTORC1 and mTORC2, to regulate protein homeostasis, as well as long lasting forms of syna
Hypothalamic AgRP and POMC neurons are conventionally viewed as the yin and yang of the body's energy status, since they act in an opposite manner to modulate appetite and systemic energy metabolism.
GLP-1 receptor (GLP-1R) agonists effectively improve glycemia and body weight in patients with type 2 diabetes and obesity, but have limited weight-lowering efficacy and minimal insulin sensitizing ac
Water intake is crucial for maintaining body fluid homeostasis and animals' survival [1-4]. In the brain, complex processes trigger thirst and drinking behavior [1-5]. The anterior wall of the third v