The general objective of our team is to identify the biological mechanisms underlying the transition from physiological to pathological behaviour, particularly for stress-related diseases, in order to develop therapeutic approaches. The first axis focuses on the study of the biological system involving glucocorticoid hormones and more specifically on the identification of cellular and molecular communication underlying the memory effects of these hormones. Indeed, understanding the cellular and molecular mechanisms through which stressful events induce a higher trace of memory than those with low emotional valence is at the heart of the pathophysiology of many psychiatric diseases where the subject's inability to forget certain events is a major impairment.
The second axis focuses on the study of the biological system involving neurosteroids and more specifically pregnenolone and the new class of pharmacological inhibitors derived from pregnenolone. These synthetic inhibitors specific for cannabinoid CB1 receptor signalling (sCB1-SSi) are capable of selectively antagonizing CB1 receptor-dependent behavioural effects. This axis focuses on the study of the functional role of pregenolone and aims to characterize the cellular and molecular mechanisms and therapeutic applications of sCB1-SSi in the field of the harmful effects of cannabis and the sphere of cognitive deficits.
BACKGROUND: Phosphorylation by protein kinases is a fundamental molecular process involved in the regulation of signaling activities in living organisms. Understanding this complex network of phosphor
Intellectual disability is the most limiting hallmark of Down syndrome, for which there is no gold-standard clinical treatment yet. The endocannabinoid system is a widespread neuromodulatory system in
The central serotonin2B receptor (5-HT2BR) is a well-established modulator of dopamine (DA) neuron activity in the rodent brain. Recent studies in rats have shown that the effect of 5-HT2BR antagonist
The hippocampus is the main locus for adult dentate gyrus (DG) neurogenesis. A number of studies have shown that aberrant DG neurogenesis correlates with many neuropsychiatric disorders, including dru
The serotonin2C receptor (5-HT2CR) is known to control dopamine (DA) neuron function by modulating DA neuronal firing and DA exocytosis at terminals. Recent studies assessing the influence of 5-HT2CRs