Equipe Revest

Physiopathology and therapeutic approaches of stress-related diseases

Principal investigator: Jean-Michel Revest, PhD.


The general objective of our team is to identify the biological mechanisms underlying the transition from physiological to pathological behaviour, particularly for stress-related diseases, in order to develop therapeutic approaches. The first axis focuses on the study of the biological system involving glucocorticoid hormones and more specifically on the identification of cellular and molecular communication underlying the memory effects of these hormones. Indeed, understanding the cellular and molecular mechanisms through which stressful events induce a higher trace of memory than those with low emotional valence is at the heart of the pathophysiology of many psychiatric diseases where the subject's inability to forget certain events is a major impairment.

The second axis focuses on the study of the biological system involving neurosteroids and more specifically pregnenolone and the new class of pharmacological inhibitors derived from pregnenolone. These synthetic inhibitors specific for cannabinoid CB1 receptor signalling (sCB1-SSi) are capable of selectively antagonizing CB1 receptor-dependent behavioural effects. This axis focuses on the study of the functional role of pregenolone and aims to characterize the cellular and molecular mechanisms and therapeutic applications of sCB1-SSi in the field of the harmful effects of cannabis and the sphere of cognitive deficits.



Team members



Jean-Michel REVEST
Team leader
Guillaume DRUTEL
Teacher-Researcher
Umberto SPAMPINATO
Teacher-Researcher
Monique VALLEE
Researcher
Adeline CATHALA
ITA
Agnès GREL
ITA
Joelle HOANG-CHAUHONG
ITA (33%)
Valérie LACARRIERE
ITA
Valerie LALANNE
ITA
Marion PETITET
ITA
Lucile PRET
ITA
Nadia DI FRANCO
PhD
Giovanni TOMASELLI
PhD