The team “Neurogenesis and Physiopathology”, led by Nora Abrous at the Neurocentre Magendie (Bordeaux, France), is seeking an independent postdoctoral scientist. The selected candidate will participate in a Franco-Canadian collaboration with Caroline Menard’s laboratory at Université Laval (Quebec City, Canada). The project’s objective is to investigate if neurovascular adaptations underlie age-related changes in neurogenesis and cognitive performances.
Normal, non-pathological aging –also called normative aging- is generally accompanied by a progressive cognitive decline particularly in hippocampal-dependent memory function. Intriguingly, age-related alterations are variable within a population. Hippocampal neurogenesis, defined as the formation of new neurons, has been associated with memory performances in rodents and in humans, blood-brain barrier (BBB) breakdown was identified as an early marker of cognitive impairment. During brain development, neurogenesis, and angiogenesis – growth of blood vessels – work in tandem, however, it is still unknown if these processes interact in the aging brain to favor maintenance of memory capacities vs cognitive decline. The aim of the project will be to study in the course of aging the relationship between BBB integrity, cognitive performance, and the morphological properties of neurons generated in young adult animals. Identification of signaling pathways involved in healthy cognitive aging could lead to the development of innovative therapies targeting conditions characterized by memory impairment.
Competences
We are seeking a highly motivated and competent individual, with a proven track record of success and expertise in either adult neurogenesis or the vascular field. Skills in in vivo experimentation, such as stereotaxic surgery in rodents, are required. Experience with brain immunohistology and imaging techniques (STED) would be advantageous. Candidates should be junior, if possible, immediately after their PhD, and in any case no more than three years after their PhD.
The applicant should possess strong team-working capabilities, the ability to independently conduct experimental research, and excellent communication skills in spoken and written English. Proficiency in French is not mandatory.
The project will be conducted in a stimulating and highly interdisciplinary and international environment in the Neurocentre Magendie, a part of the Bordeaux Neurocampus project.
You are interested?
Please send a cover letter with a brief description of research experiences, interests, and accomplishments, their CV, and the names of 2 to 3 references to:
Nora Abrous
nora.abrous@inserm.fr
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