Anxiety disorders include four major classes of psychiatric diseases (DSM-5) and represent the most prevalent psychiatric conditions, with an estimated prevalence of 18% among adults, and more than 28% over a lifetime. Despite the high personal and societal costs of anxiety disorders, few therapeutic targets have been identified for the treatment of anxiety, and available treatments have limitations.
A leading hypothesis posits that anxiety disorders are caused by dysfunctions of the neural circuits controlling the level of anxiety or emotional valence in healthy conditions. However this hypothesis remains untested, and the brain circuit dysfunctions present in anxiety disorders remain unknown. Human imaging has identified that the activity of the insular cortex (insula) is altered in patients with anxiety disorders.
Our research program aims at identifying cellular, synaptic and molecular alterations of circuits of the insular cortex in animal models of anxiety disorders. We also envision to develop strategies to restore those dysfunctions, with the long term goal to translate our fundamental findings to clinical trials.More information
Our research is funded by the Région Nouvelle Aquitaine (Neurocampus Project), the Excellence initiative of the University of Bordeaux and the ATIP-Avenir Program of CNRS and INSERM.
The serotonin (5-HT) system is the target of multiple anxiolytics, including Buspirone, which is a partial agonist of the serotonin 1A receptor (5-HT1A). Similarly, ligands of the serotonin 2A recepto
The amygdala complex is a diverse group of more than thirteen nuclei, segregated in five major groups: the basolateral (BLA), central (CeA), medial (MeA), cortical (CoA) and basomedial (BMA) amygdala
Stress and anxiety have intertwined behavioral and neural underpinnings. These commonalities are critical for understanding each state, as well as their mutual interactions. Grasping the mechanisms un
The neural mechanisms underlying emotional valence are at the interface between perception and action, integrating inputs from the external environment with past experiences to guide the behavior of a