The proper functioning of neocortical circuits is central for sensory information processing, motor command, language, memory storage, cognition, and behavior. Neocortical circuits are composed of a great variety of neurons that receive information from hundreds-to-thousands other neurons belonging to many different brain regions, integrate (and perhaps store) this information, and then pass it on to numerous other connected neurons. Thus, the specific connections and the integrative properties of neurons are central to the operation of neocortical circuits. Both are malleable features that have been demonstrated to be altered by activity, during plasticity, or in physiopathological conditions. Consequently, their plastic modification or pathological alteration may change the operation of neocortical circuits and contribute to memory formation and neurological/psychiatric disorders.
Our research program aims at gaining a better understanding of the operation of neocortical circuits. To tackle this issue, we examine the connectivity of specific neocortical neuron types and their intrinsic excitability, and study the role of plastic modifications of these features for memory formation, as well as of their pathological alterations in autism spectrum disorders. Our ultimate goal is to find core mechanisms for the functioning or dysfunction of neocortical circuits and to provide a causal link between these mechanisms and cognitive abilities/behavior.
To address these questions we focus on the sensory and prefrontal cortex circuits of mice. To define neurons engaged in specific memory tasks, and to study the cellular and circuit mechanisms of autism spectrum disorders, we employ transgenic mice. In addition, we employ in vitro/in vivo single-cell and multi-electrode electrophysiological as well as calcium imaging approaches, opto-/chemogenetic approaches, viral tracing, whole-brain imaging and quantification of connectivity, and behavioral tasks.
Touch is essential for interacting with the world, and atypical tactile experience is a core feature of autism that profoundly affects daily life. However, we do not know the neural mechanisms of low-level […]
Neocortical memory engrams are thought to mature via strengthened interconnectivity, yet synaptic plasticity alone cannot explain the dynamic vividness of enduring memories. Neuronal intrinsic excitability […]
Excessive neural variability of sensory responses is a hallmark of atypical sensory processing in autistic individuals with cascading effects on other core autism symptoms but unknown neurobiological substrate. […]
Behavioral phenotyping devices have been successfully used to build ethograms, but many aspects of behavior remain out of reach of available phenotyping systems. We now report on a novel device, which […]
The hypothesis that reversed, excitatory GABA may be involved in various brain pathologies, including epileptogenesis, is appealing but controversial because of the technical difficulty of probing endogenous […]
