Publications du Neurocentre Magendie

Publications







IF du Neurocentre
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1123 publications

* equal contribution
The indicated IF have been collected by the Web of Sciences in June 2019



12/2019 | Diabetes Care   IF 15.3
Prospective Study of Neuropathic Symptoms Preceding Clinically Diagnosed Diabetic Polyneuropathy: ADDITION-Denmark.
Maatta LL, Charles M, Witte DR, Bjerg L, Jorgensen ME, Jensen TS, Andersen ST

Abstract:
OBJECTIVE: To evaluate whether diabetic polyneuropathy (DPN) follows the hypothesis for the course of nerve fiber damage reflected by symptoms progressing from pure small through mixed to large nerve fiber symptoms with or without symptoms of loss of function of small nerve fibers. RESEARCH DESIGN AND METHODS: Repeated assessments of nerve fiber-specific symptoms were obtained in 518 participants of the ADDITION-Denmark study from the time of a screening-based diagnosis of type 2 diabetes using specific items of the Michigan Neuropathy Screening Instrument questionnaire. DPN was clinically assessed 13 years after inclusion. The course of symptoms reflecting dysfunction of specific nerve fibers was evaluated, and the association between symptoms and DPN was estimated using logistic regression models. RESULTS: An overall stable, yet heterogeneous course of symptoms was seen. According to the hypothesis of symptom progression, 205 (40%) participants remained free of symptoms and 56 (11%) had stable, 114 (23%) progressing, and 132 (26%) improving symptoms. Cross-sectional estimates showed a higher risk of DPN (odds ratios between 2.1 and 4.1) for participants with mixed or large nerve fiber symptoms with or without symptoms of loss of function of small nerve fibers compared with participants without symptoms. CONCLUSIONS: There was no evidence for a progressive development of nerve fiber damage in DPN reflected by symptoms going from pure small through mixed to large nerve fiber symptoms with or without symptoms of loss of function of small nerve fibers. Yet overall, neuropathic symptoms were prospectively associated with a higher risk of DPN.





12/2019 | diagn microbiol infect dis
FilmArray respiratory panel assay: An effective method for detecting viral and atypical bacterial pathogens in bronchoscopy specimens.
Locher K, Roscoe D, Jassem A, Wong T, Hoang LMN, Charles M, Bryce E, Grant J, Stefanovic A

Abstract:
The BioFire FilmArray Respiratory Panel (FA RP) is a rapid multiplexed molecular assay approved for detection of viral and atypical bacterial pathogens in nasopharyngeal specimens. This study aimed to evaluate the performance of the BioFire FilmArray Respiratory Panel v1.7 on bronchoscopy specimens. We tested 133 bronchial specimens (87 archived and 46 prospectively collected) with the FA RP and compared the results to the Luminex NxTAG Respiratory Pathogen Panel (NxTAG RPP). After discordant analysis, 123 specimens gave concordant results using the FA RP and the NxTAG RPP for an overall agreement of 93.9% (kappa=0.88 [95% CI 0.80-0.96]), a positive percent agreement of 93.7% (95% CI 83.7-97.7) and a negative percent agreement of 94.1% (95% CI 84.9-98.1). In conclusion, the BioFire FilmArray RP performed reliably to detect a broad range of respiratory pathogens in bronchoscopy specimens.





12/11/2019 | bmj open
Protocol for a mixed-methods feasibility study for the surviving opioid overdose with naloxone education and resuscitation (SOONER) randomised control trial.
Orkin A, Campbell D, Handford C, Hopkins S, Klaiman M, Leece P, Parsons JA, Shahin R, Strike C, Thorpe K, Sellen K, Milos G, Wright A, Charles M, Sniderman R, Morrison L

Abstract:
INTRODUCTION: The surviving opioid overdose with naloxone education and resuscitation (SOONER) project uses co-design and trial methods to develop and evaluate a point-of-care overdose education and naloxone distribution (OEND) tool. We plan to conduct a randomised controlled trial to assess the effectiveness of our OEND tool in comparison with best available standard of care by observing participants' performance as a responder to a simulated overdose. Recruiting and retaining people at risk of or likely to witness opioid overdose raises scientific, logistical and bioethical challenges. A feasibility study is needed to establish the effectiveness of recruitment and retention strategies and acceptability of study procedures prior to launching the full trial. METHODS AND ANALYSIS: Strategies to enhance recruitment include candidate-driven recruitment, verbal informed consent, and attractive, destigmatising materials. Adults at risk of or likely to witness opioid overdose will be recruited through an urban emergency department, inpatient and ambulatory addiction medicine service, and outpatient family practice settings. Participants randomised to the intervention arm will receive our OEND intervention; those in the control arm will be referred to existing OEND programme. Retention procedures include participant reminders, flexible scheduling, cash and comfort compensation, and strategies to maintain a consistent relationship between individual study staff and participants. Within 2 weeks following recruitment, participants will engage as a responder to a manikin-simulated overdose, and complete overdose knowledge and attitudes questionnaires. The primary outcome is recruitment and retention feasibility, defined as the recruitment of 28 participants within 28 days of recruitment and <50% attrition at the overdose simulation. Staff and participant feedback will also be collected and considered. ETHICS AND DISSEMINATION: The study has been reviewed by ethics boards at St. Michael's Hospital, Toronto Public Health and the University of Toronto. Dissemination will occur through peer-reviewed publication and presentations. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov registry (NCT03821649).





02/11/2019 | Neuroscience   IF 3.2
POMC Neurons Dysfunction in Diet-induced Metabolic Disease: Hallmark or Mechanism of Disease?
Quarta C, Fioramonti X, Cota D

Abstract:
One important lesson from the last decade of studies in the field of systemic energy metabolism is that obesity is first and foremost a brain disease. Hypothalamic neurons dysfunction observed in response to chronic metabolic stress is a key pathogenic node linking consumption of hypercaloric diets with body weight gain and associated metabolic sequelae. A key hypothalamic neuronal population expressing the neuropeptide Pro-opio-melanocortin (POMC) displays altered electrical activity and dysregulated neuropeptides production capacity after long-term feeding with hypercaloric diets. However, whether such neuronal dysfunction represents a consequence or a mechanism of disease, remains a subject of debate. Here, we will review and highlight emerging pathogenic mechanisms that explain why POMC neurons undergo dysfunctional activity in response to caloric overload, and critically address whether these mechanisms may be causally implicated in the physiopathology of obesity and of its associated co-morbidities.





Abstract:
This study aimed at assessing the pathogenicity of two Vibrio splendidus-related species and evaluating the influence of the origin and annual life cycle of mussels on their sensitivity during a bacterial challenge. Thus, in vivo infection assays were made with Vibrio crassostreae 7T4_12 and Vibrio splendidus 3G1_6, over, respectively, thirteen and 9 months, on adult blue mussels from five recruitment areas in France. Two bacterial concentrations were tested: one consistent with the loads of Vibrio spp. in environment and mussel tissues (~10(5) CFU/ml) and another one much higher (~10(8) CFU/ml). The tested environmental concentration has no pathogenic effect whatever the time of year, the strain used and the origin of mussels. However, at the highest concentration, a pathogenic effect was observed only at specific moments, and one of the origins appeared to be more resistant. The physiological state of mussels-depending on the time of year-seemed significant in mussels' sensitivity, as their recruitment origin. This study is the first to test the pathogenicity of V. splendidus-related strains at concentrations close to what is found in the wild, over the annual cycle of mussels, and considering their origin.





24/10/2019 | Psychoneuroendocrinology   IF 4
The ergogenic impact of the glucocorticoid prednisolone does not translate into increased running motivation in mice.
Redon B, Violleau C, Georges F, Marsicano G, Chaouloff F

Abstract:
Glucocorticoids, such as prednisolone, are considered sport doping agents owing to their ergogenic properties. These are accounted for by peripheral mechanisms associated with energetic and anti-inflammatory processes. However, because glucocorticoids target brain tissues, it is likely that these ergogenic impacts are associated with central effects. One of these might be reward motivation, which relies on glucocorticoid receptor-expressing mesocorticolimbic dopaminergic neurons. In keeping with this possibility, this study has explored in mice whether repeated prednisolone administration (5 or 15mug/ml of drinking water for 10 days) affected intrinsic motivation for running, a strong reinforcer in rodents. Running motivation was assessed by means of a cued-reward motivated instrumental task wherein wheel-running was conditioned by prior nose poke responses under fixed (FR), and then progressive (PR), ratio reinforcement schedules. Sub-chronic ingestion of prednisolone decreased the running distance covered during each rewarded sequence under FR schedules. This finding did not extend to wheel-running performances in mice provided free (i.e. unconditioned) wheel-running opportunities. Running motivation, as estimated under a PR reinforcement schedule, was found to be decreased (lowest concentration) or to remain unaffected (highest concentration) by prednisolone concentration. Lastly, an inter-individual analysis of the respective effects of prednisolone on muscular endurance (as assessed in the wire grid-hanging test) and on running motivation indicated that the former was not predictive of the latter. This observation suggests that prednisolone ergogenic impacts might occur without any concomitant increase in intrinsic exercise motivation.





18/10/2019 | gynecol obstet fertil senol
[Contribution of array CGH in the management of fetal nuchal translucency].
Julien B, Guillaume J, Anne-Helene S, Henri C, Fabrice S, Jean G, Philippe M, Charles M

Abstract:
INTRODUCTION: Increased nuchal translucency and cystic hygroma have a neonatal prognosis, when the karyotype is normal, which depends on the findings during the medical follow-up. Array comparative genomic hybridization (aCGH) has been systematically included in this follow-up by prenatal diagnosis teams. There are no guidelines and little information on the advantages of carrying out this test systematically. The aim of our study is to evaluate the contribution of the aCGH in the medical follow-up. MATERIAL AND METHODS: 51 patients were included during 18 months and followed till the end of their pregnancy in prenatal diagnosis centers in Brest and Amiens. Inclusion criterion was a nuchal translucency above 3,5mm on the first trimester ultrasound. A fetal DNA ChromoQuant and aCGH analysis on chorionic villi sampling, and an ultrasound at 18 weeks of gestation were performed during the follow-up. RESULTS: The aCGH was decisive in only 2 cases. The ultrasound at 18 weeks gestation seemed to be more sensible in the detection of an abnormality. When the aCGH relieved an abnormality, the ultrasound permitted already to detect the presence of a deformity. In 10 cases, the aCGH could not be interpreted on the chorionic villi sampling. In 9 cases, an amniocentesis was performed in order to obtain this result. CONCLUSION: Given the results of this study, the aCGH was rarely determinant or decisive on the realization of a therapeutic abortion. These elements make us reflect on the necessity of maintaining this test before 14 weeks of gestation or propose it as a second-line test after the ultrasound shows signs at 18 weeks of gestation.





17/10/2019 | j invertebr pathol
Implementation of various approaches to study the prevalence, incidence and progression of disseminated neoplasia in mussel stocks.
Burioli EAV, Trancart S, Simon A, Bernard I, Charles M, Oden E, Bierne N, Houssin M

Abstract:
Marine mussel production is of substantial economic interest in numerous coastal areas worldwide, making crucial the study of pathologies that affect them. Disseminated neoplasia (DN) has recently been suggested to be linked to blue mussel, Mytilus edulis, mortality outbreaks observed in France since 2014, although the evidence remains indirect. In order to improve DN detection and monitoring, we compared the sensitivity of four diagnostic tools, namely haemocytology, histology, flow cytometry, and genetics. Haemocytological examination gave the best results in sensitivity and had the advantage of being non-invasive, allowing disease progression to be followed in affected mussels. Using this approach, we showed that DN progression is usually slow, and we provide evidence of remission events. We observed a high diversity of forms and mitotic features of neoplastic cells located in the vesicular connective tissue but rarely in the haemolymph. Circulating cells occur as four main types but are homogenous in morphology and DNA content within a single individual. Polyploidy proved very high, from 8N to 18N. Genetic analysis of haemolymph DNA showed that a Mytilus trossulus genetic signal was associated with almost all the DN cases here diagnosed by haemocytological examination, regardless of the DN type. This result corroborates DN is a transmissible cancer that first originated in a M. trossulus host and subsequently crossed into M. edulis. No pre-neoplastic conditions were detectable. The prevalence of the disease was quite low, which, together with the low morbidity observed in the lab, suggest DN is unlikely to be the direct cause of mortality outbreaks in France.





11/10/2019 | phys rev lett
Observation of New Resonances in the Lambda_{b}^{0}pi^{+}pi^{-} System.
Aaij R, Abellan Beteta C, Ackernley T, Adeva B, Adinolfi M, Afsharnia H, Aidala CA, Aiola S, Ajaltouni Z, Akar S, Albicocco P, Albrecht J, Alessio F, Alexander M, Alfonso Albero A, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Archilli F, Arnau Romeu J, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Back JJ, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barsuk S, Barter W, Bartolini M, Baryshnikov F, Bassi G, Batozskaya V, Batsukh B, Battig A, Battista V, Bay A, Becker M, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Belavin V, Belin S, Beliy N, Bellee V, Belous K, Belyaev I, Bencivenni G, Ben-Haim E, Benson S, Beranek S, Berezhnoy A, Bernet R, Berninghoff D, Bertholet E, Bertolin A, Betancourt C, Betti F, Bettler MO, Bezshyiko I, Bhasin S, Bhom J, Bieker MS, Bifani S, Billoir P, Birnkraut A, Bizzeti A, Bjorn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Bocci V, Boente Garcia O, Boettcher T, Boldyrev A, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Borsuk JT, Boubdir M, Bowcock TJV, Bozzi C, Braun S, Brea Rodriguez A, Brodski M, Brodzicka J, Brossa Gonzalo A, Brundu D, Buchanan E, Buonaura A, Burr C, Bursche A, Butter JS, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Cali S, Calladine R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carvalho Akiba K, Casais Vidal A, Casse G, Cattaneo M, Cavallero G, Cenci R, Cerasoli J, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chekalina V, Chen C, Chen S, Chernov A, Chitic SG, Chobanova V, Chrzaszcz M, Chubykin A, Ciambrone P, Cicala MF, Cid Vidal X, Ciezarek G, Cindolo F, Clarke PEL, Clemencic M, Cliff HV, Closier J, Cobbledick JL, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Comerma-Montells A, Contu A, Cooke N, Coombs G, Coquereau S, Corti G, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Currie R, Da Silva CL, Dall'Occo E, Dalseno J, D'Ambrosio C, Danilina A, d'Argent P, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, de Vries JA, Dean CT, Dean W, Decamp D, Del Buono L, Delaney B, Dembinski HP, Demmer M, Dendek A, Denysenko V, Derkach D, Deschamps O, Desse F, Dettori F, Dey B, Di Canto A, Di Nezza P, Didenko S, Dijkstra H, Dordei F, Dorigo M, Dos Reis AC, Dosil Suarez A, Douglas L, Dovbnya A, Dreimanis K, Dudek MW, Dufour L, Dujany G, Durante P, Durham JM, Dutta D, Dzhelyadin R, Dziewiecki M, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Ekelhof R, Ek-In S, Eklund L, Ely S, Ene A, Escher S, Esen S, Evans T, Falabella A, Fan J, Farley N, Farry S, Fazzini D, Feo M, Fernandez Declara P, Fernandez Prieto A, Ferrari F, Ferreira Lopes L, Ferreira Rodrigues F, Ferreres Sole S, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fischer KM, Fitzpatrick C, Fiutowski T, Fleuret F, Fontana M, Fontanelli F, Forty R, Franco Lima V, Franco Sevilla M, Frank M, Frei C, Friday DA, Fu J, Funk W, Gabriel E, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gan Y, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garcia Plana B, Garcia Rosales FA, Garra Tico J, Garrido L, Gascon D, Gaspar C, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Gerstel D, Ghez P, Gibson V, Gioventu A, Girard OG, Gironella Gironell P, Giubega L, Giugliano C, Gizdov K, Gligorov VV, Gobel C, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Grabowski JP, Graciani Diaz R, Grammatico T, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruber L, Gruberg Cazon BR, Gu C, Gushchin E, Guth A, Guz Y, Gys T, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton PM, Han Q, Han X, Hancock TH, Hansmann-Menzemer S, Harnew N, Harrison T, Hart R, Hasse C, Hatch M, He J, Hecker M, Heijhoff K, Heinicke K, Heister A, Hennequin AM, Hennessy K, Henry L, Hess M, Heuel J, Hicheur A, Hidalgo Charman R, Hill D, Hilton M, Hopchev PH, Hu J, Hu W, Huang W, Huard ZC, Hulsbergen W, Humair T, Hunter RJ, Hushchyn M, Hutchcroft D, Hynds D, Ibis P, Idzik M, Ilten P, Inglessi A, Inyakin A, Ivshin K, Jacobsson R, Jakobsen S, Jalocha J, Jans E, Jashal BK, Jawahery A, Jevtic V, Jiang F, John M, Johnson D, Jones CR, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kazeev N, Kecke M, Keizer F, Kelsey M, Kenzie M, Ketel T, Khanji B, Kharisova A, Khurewathanakul C, Kim KE, Kirn T, Kirsebom VS, Klaver S, Klimaszewski K, Koliiev S, Kondybayeva A, Konoplyannikov A, Kopciewicz P, Kopecna R, Koppenburg P, Kostiuk I, Kot O, Kotriakhova S, Kozeiha M, Kravchuk L, Krawczyk RD, Kreps M, Kress F, Kretzschmar S, Krokovny P, Krupa W, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuindersma HS, Kunde GJ, Kuonen AK, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lancierini D, Lane JJ, Lanfranchi G, Langenbruch C, Latham T, Lazzari F, Lazzeroni C, Le Gac R, Lefevre R, Leflat A, Lemaitre F, Leroy O, Lesiak T, Leverington B, Li H, Li PR, Li X, Li Y, Li Z, Liang X, Lindner R, Lionetto F, Lisovskyi V, Liu G, Liu X, Loh D, Loi A, Lomba Castro J, Longstaff I, Lopes JH, Loustau G, Lovell GH, Lucchesi D, Lucio Martinez M, Luo Y, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Maccolini S, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Madhan Mohan LR, Maev O, Maevskiy A, Maguire K, Maisuzenko D, Majewski MW, Malde S, Malecki B, Malinin A, Maltsev T, Malygina H, Manca G, Mancinelli G, Manera Escalero R, Manuzzi D, Marangotto D, Maratas J, Marchand JF, Marconi U, Mariani S, Marin Benito C, Marinangeli M, Marino P, Marks J, Marshall PJ, Martellotti G, Martinazzoli L, Martinelli M, Martinez Santos D, Martinez Vidal F, Massafferri A, Materok M, Matev R, Mathad A, Mathe Z, Matiunin V, Matteuzzi C, Mattioli KR, Mauri A, Maurice E, McCann M, Mcconnell L, McNab A, McNulty R, Mead JV, Meadows B, Meaux C, Meinert N, Melnychuk D, Meloni S, Merk M, Merli A, Michielin E, Milanes DA, Millard E, Minard MN, Mineev O, Minzoni L, Mitchell SE, Mitreska B, Mitzel DS, Modden A, Mogini A, Moise RD, Mombacher T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Moron J, Morris AB, Morris AG, Mountain R, Mu H, Muheim F, Mukherjee M, Mulder M, Muller D, Muller J, Muller K, Muller V, Murphy CH, Murray D, Muzzetto P, Naik P, Nakada T, Nandakumar R, Nandi A, Nanut T, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Newcombe R, Nguyen TD, Nguyen-Mau C, Niel EM, Nieswand S, Nikitin N, Nolte NS, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, O'Hanlon DP, Oldeman R, Onderwater CJG, Osborn JD, Ossowska A, Otalora Goicochea JM, Ovsiannikova T, Owen P, Oyanguren A, Pais PR, Pajero T, Palano A, Palutan M, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Pereima D, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pietrzyk B, Pietrzyk G, Pikies M, Pili M, Pinci D, Pinzino J, Pisani F, Piucci A, Placinta V, Playfer S, Plews J, Plo Casasus M, Polci F, Poli Lener M, Poliakova M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Poslavskii S, Prasanth K, Promberger L, Prouve C, Pugatch V, Puig Navarro A, Pullen H, Punzi G, Qian W, Qin J, Quagliani R, Quintana B, Raab NV, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Ratnikov F, Raven G, Ravonel Salzgeber M, Reboud M, Redi F, Reichert S, Reiss F, Remon Alepuz C, Ren Z, Renaudin V, Ricciardi S, Richards S, Rinnert K, Robbe P, Robert A, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Roehrken M, Roiser S, Rollings A, Romanovskiy V, Romero Lamas M, Romero Vidal A, Roth JD, Rotondo M, Rudolph MS, Ruf T, Ruiz Vidal J, Ryzka J, Saborido Silva JJ, Sagidova N, Saitta B, Sanchez Gras C, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santangelo P, Santimaria M, Santovetti E, Sarpis G, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Scantlebury Smead LG, Schael S, Schellenberg M, Schiller M, Schindler H, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubiger M, Schulte S, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Sellam S, Semennikov A, Sergi A, Serra N, Serrano J, Sestini L, Seuthe A, Seyfert P, Shangase DM, Shapkin M, Shears T, Shekhtman L, Shevchenko V, Shmanin E, Shupperd JD, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Skiba I, Skidmore N, Skwarnicki T, Slater MW, Smeaton JG, Smith E, Smith IT, Smith M, Soares M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spadaro Norella E, Spradlin P, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stepanova M, Stevens H, Stocchi A, Stone S, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Strokov S, Sun J, Sun L, Sun Y, Svihra P, Swientek K, Szabelski A, Szumlak T, Szymanski M, Taneja S, Tang Z, Tekampe T, Tellarini G, Teubert F, Thomas E, Thomson KA, Tilley MJ, Tisserand V, T'Jampens S, Tobin M, Tolk S, Tomassetti L, Tonelli D, Tou DY, Tournefier E, Traill M, Tran MT, Trisovic A, Tsaregorodtsev A, Tuci G, Tully A, Tuning N, Ukleja A, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valat S, Valenti G, van Beuzekom M, Van Hecke H, van Herwijnen E, Van Hulse CB, van Tilburg J, van Veghel M, Vazquez Gomez R, Vazquez Regueiro P, Vazquez Sierra C, Vecchi S, Velthuis JJ, Veltri M, Venkateswaran A, Vernet M, Veronesi M, Vesterinen M, Viana Barbosa JV, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitkovskiy A, Volkov V, Vollhardt A, Vom Bruch D, Voneki B, Vorobyev A, Vorobyev V, Voropaev N, Waldi R, Walsh J, Wang J, Wang J, Wang M, Wang Y, Wang Z, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Weisser C, Westhenry BDC, White DJ, Whitehead M, Wiedner D, Wilkinson G, Wilkinson M, Williams I, Williams M, Williams MRJ, Williams T, Wilson FF, Winn M, Wislicki W, Witek M, Wormser G, Wotton SA, Wu H, Wyllie K, Xiang Z, Xiao D, Xie Y, Xing H, Xu A, Xu L, Xu M, Xu Q, Xu Z, Xu Z, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zdybal M, Zeng M, Zhang D, Zhang L, Zhang S, Zhang WC, Zhang Y, Zhelezov A, Zheng Y, Zhou X, Zhou Y, Zhu X, Zhukov V, Zonneveld JB, Zucchelli S

Abstract:
We report the observation of a new structure in the Lambda_{b}^{0}pi^{+}pi^{-} spectrum using the full LHCb data set of pp collisions, corresponding to an integrated luminosity of 9 fb^{-1}, collected at sqrt[s]=7, 8, and 13 TeV. A study of the structure suggests its interpretation as a superposition of two almost degenerate narrow states. The masses and widths of these states are measured to be m_{Lambda_{b}(6146)^{0}}=6146.17+/-0.33+/-0.22+/-0.16 MeV,m_{Lambda_{b}(6152)^{0}}=6152.51+/-0.26+/-0.22+/-0.16 MeV,Gamma_{Lambda_{b}(6146)^{0}}=2.9+/-1.3+/-0.3 MeV,Gamma_{Lambda_{b}(6152)^{0}}=2.1+/-0.8+/-0.3 MeV,with a mass splitting of Deltam=6.34+/-0.32+/-0.02 MeV, where the first uncertainty is statistical, the second systematic. The third uncertainty for the mass measurements derives from the knowledge of the mass of the Lambda_{b}^{0} baryon. The measured masses and widths of these new excited states suggest their possible interpretation as a doublet of Lambda_{b}(1D)^{0} states.





03/10/2019 | prim care diabetes
Factors associated with attendance at clinical follow-up of a cohort with screen-detected type 2 diabetes: ADDITION-Denmark.
Jensen AD, Andersen ST, Charles M, Bjerg L, Witte DR, Gram B, Jorgensen ME, Sandbaek A, Dalsgaard EM

Abstract:
AIMS: To determine the association between concurrent overall burden of disease, cardiovascular disease, cancer, self-rated health, HbA1c levels, and attendance at clinical follow-up of the Danish arm of the ADDITION-study. METHODS: Logistic regression models were used to study factors proposed being associated with attendance in clinical follow-up. We used data from clinical examinations, questionnaires and national registers at a time-point near the follow-up examination. RESULTS: A total of 1119 participants were eligible for the follow-up conducted a median of 12.8 years (IQR 11.6; 13.4) after type 2 diabetes diagnosis by screening. Concurrent high burden of disease was associated with lower attendance (OR 0.6 (95% CI: 0.4; 0.9) for high-versus no burden of disease). Concurrent cardiovascular disease and cancer showed no statistically significant association with attendance (OR 1.0 (95% CI: 0.7; 1.4)) and (OR 0.8 (95% CI: 0.6; 1.1) for (disease versus no disease). Similarly, self-rated health (OR 0.7 (95% CI: 0.5; 1.0) poor-versus good self-rated health) and HbA1c levels (OR 1.0 (95% CI: 0.9; 1.2 unit=10mmol/mol)) were not statistically significant associated with attendance. CONCLUSIONS: This study showed a lower attendance in clinical follow-up after nearly 13years among individuals with concurrent high burden of disease. No associations were found between concurrent CVD, cancer, self-rated health and Hba1c levels and attendance.





10/2019 | acta diabetol
TRActional DIabetic reTInal detachment surgery with co-adjuvant intravitreal dexamethasONe implant: the TRADITION STUDY.
Iglicki M, Zur D, Fung A, Gabrielle PH, Lupidi M, Santos R, Busch C, Rehak M, Cebeci Z, Charles M, Masarwa D, Schwarz S, Barak A, Loewenstein A

Abstract:
AIM: Main failure of diabetic tractional retinal detachment (TRD) surgery is the development of proliferative vitreoretinopathy (PVR), causing higher re-detachment rates. We investigated whether the use of dexamethasone (DEX) implant at the end of pars plana vitrectomy (PPV) with silicone oil tamponade might have an impact on these outcomes. DESIGN: Comparative, nonrandomized, retrospective study. PARTICIPANTS: A total of 148 eyes from 148 patients that underwent PPV with silicone oil tamponade for diabetic TRD (with DEX implant, n = 52; without DEX implant, n = 96). METHODS: Consecutive patients' records were reviewed for time between TRD diagnosis and surgery; lens status before surgery and after 6, 12, and 24 months; retina attachment rate after primary PPV; change in postoperative PVR severity; rate of re-detachment at 6, 12, and 24 months; use of IOP lowering treatment after 6, 12, and 24 months; surgery details; intra- and postoperative complications. Correlations between outcome measures, postoperative PVR severity, and re-detachment rates were analyzed. MAIN OUTCOME MEASURES: Change in postoperative PVR severity and retinal re-detachment rates with and without the adjuvant use of DEX implant. RESULTS: Retinal re-detachment rates were significantly higher in the group of patients that did not receive DEX implant [11/96 (11.5%) vs. 0/52 (0%), p = 0.049; 11/84 (12.9%) vs. 4/52 (7.7%), p = 0.007; 14/71 (19.7%) vs. 5/52 (10%) p < 0.001 at 6, 12, and 24 months, respectively]. PVR severity correlated with retinal status at 12 and 24 months (p = 0.018 and p = 0.027, respectively). The difference in PVR severity between the two groups was statistically significant at 6, 12, and 24 months (p < 0.001). CONCLUSIONS: DEX implant at the end of PPV in patients with diabetic TRD improves PVR severity and decreases re-detachment rates. This should be considered as an option in the customized treatment of TRD.





21/09/2019 | Nutrients   IF 4.2
Effects of a High-Protein/Moderate-Carbohydrate Diet on Appetite, Gut Peptides, and Endocannabinoids-A Preview Study.
Tischmann L, Drummen M, Gatta-Cherifi B, Raben A, Fogelholm M, Hartmann B, Holst JJ, Matias I, Cota D, Mensink RP, Joris PJ, Westerterp-Plantenga MS, Adam TC

Abstract:
Favorable effects of a high-protein/moderate-carbohydrate (HP/MCHO) diet after weight loss on body weight management have been shown. To extend these findings, associations between perception of hunger and satiety with endocannabinoids, and with glucagon-like peptide-1 (GLP-1) and polypeptide YY (PYY) were assessed. At approximately 34 months after weight loss, 22 female and 16 male participants (mean age 64.5 +/- 5.9 years; body mass index (BMI) 28.9 +/- 3.9 kg/m(2)) completed a 48 h respiration chamber study. Participants were fed in energy balance with a HP/MCHO diet with 25%:45%:30% or a moderate-protein/high-carbohydrate (MP/HCHO) diet with 15%:55%:30% of energy from protein:carbohydrate:fat. Endocannabinoids and related compounds, relevant postprandial hormones (GLP-1, PYY), hunger, satiety, and ad libitum food intake were assessed. HP/MCHO versus MP/HCHO reduced hunger perception. The lower decremental area under the curve (dAUC) for hunger in the HP/MCHO diet (-56.6% compared to MP, p < 0.05) was associated with the higher AUC for 2-arachidonoylglycerol (2-AG) concentrations (p < 0.05). Hunger was inversely associated with PYY in the HP/MCHO group (r = -0.7, p < 0.01). Ad libitum food intake, homeostatic model assessment for insulin resistance (HOMA-IR) and incremental AUCs for gut peptides were not different between conditions. HP/MCHO versus MP/HCHO diet-induced reduction in hunger was present after 34 months weight maintenance in the post-obese state. HP/MCHO diet-induced decrease of hunger is suggested to interact with increased 2-AG and PYY concentrations.





18/09/2019 | bmc genomics
Alpha de novo 3.8-Mb inversion affecting the EDA and XIST genes in a heterozygous female calf with generalized hypohidrotic ectodermal dysplasia.
Escouflaire C, Rebours E, Charles M, Orellana S, Cano M, Riviere J, Grohs C, Hayes H, Capitan A

Abstract:
BACKGROUND: In mammals, hypohidrotic ectodermal dysplasia (HED) is a genetic disorder that is characterized by sparse hair, tooth abnormalities, and defects in cutaneous glands. Only four genes, EDA, EDAR, EDARADD and WNT10A account for more than 90% of HED cases, and EDA, on chromosome X, is involved in 50% of the cases. In this study, we explored an isolated case of a female Holstein calf with symptoms similar to HED. RESULTS: Clinical examination confirmed the diagnosis. The affected female showed homogeneous hypotrichosis and oligodontia as previously observed in bovine EDAR homozygous and EDA hemizygous mutants. Under light microscopy, the hair follicles were thinner and located higher in the dermis of the frontal skin in the affected animal than in the control. Moreover, the affected animal showed a five-fold increase in the number of hair follicles and a four-fold decrease in the diameter of the pilary canals. Pedigree analysis revealed that the coefficient of inbreeding of the affected calf (4.58%) was not higher than the average population inbreeding coefficient (4.59%). This animal had ten ancestors in its paternal and maternal lineages. By estimating the number of affected cases that would be expected if any of these common ancestors carried a recessive mutation, we concluded that, if they existed, other cases of HED should have been reported in France, which is not the case. Therefore, we assumed that the causal mutation was dominant and de novo. By analyzing whole-genome sequencing data, we identified a large chromosomal inversion with breakpoints located in the first introns of the EDA and XIST genes. Genotyping by PCR-electrophoresis the case and its parents allowed us to demonstrate the de novo origin of this inversion. Finally, using various sources of information we present a body of evidence that supports the hypothesis that this mutation is responsible for a skewed inactivation of X, and that only the normal X can be inactivated. CONCLUSIONS: In this article, we report a unique case of X-linked HED affected Holstein female calf with an assumed full inactivation of the normal X-chromosome, thus leading to a severe phenotype similar to that of hemizygous males.





23/08/2019 | phys rev lett
Measurement of CP-Violating and Mixing-Induced Observables in B_{s}^{0}-->varphigamma Decays.
Aaij R, Abellan Beteta C, Adeva B, Adinolfi M, Aidala CA, Ajaltouni Z, Akar S, Albicocco P, Albrecht J, Alessio F, Alexander M, Alfonso Albero A, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Archilli F, Arnau Romeu J, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Back JJ, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barsuk S, Barter W, Bartolini M, Baryshnikov F, Batozskaya V, Batsukh B, Battig A, Battista V, Bay A, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Belavin V, Belin S, Beliy N, Bellee V, Belloli N, Belous K, Belyaev I, Bencivenni G, Ben-Haim E, Benson S, Beranek S, Berezhnoy A, Bernet R, Berninghoff D, Bertholet E, Bertolin A, Betancourt C, Betti F, Bettler MO, Bezshyiko I, Bhasin S, Bhom J, Bieker MS, Bifani S, Billoir P, Birnkraut A, Bizzeti A, Bjorn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Bocci V, Boente Garcia O, Boettcher T, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Boubdir M, Bowcock TJV, Bozzi C, Braun S, Brea Rodriguez A, Brodski M, Brodzicka J, Brossa Gonzalo A, Brundu D, Buchanan E, Buonaura A, Burr C, Bursche A, Butter JS, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Cali S, Calladine R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carvalho Akiba K, Casais Vidal A, Casse G, Cattaneo M, Cavallero G, Cenci R, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chekalina V, Chen C, Chen S, Chitic SG, Chobanova V, Chrzaszcz M, Chubykin A, Ciambrone P, Cid Vidal X, Ciezarek G, Cindolo F, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Comerma-Montells A, Contu A, Coombs G, Coquereau S, Corti G, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Currie R, Da Silva CL, Dall'Occo E, Dalseno J, D'Ambrosio C, Danilina A, d'Argent P, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, de Vries JA, Dean CT, Dean W, Decamp D, Del Buono L, Delaney B, Dembinski HP, Demmer M, Dendek A, Derkach D, Deschamps O, Desse F, Dettori F, Dey B, Di Canto A, Di Nezza P, Didenko S, Dijkstra H, Dordei F, Dorigo M, Dos Reis AC, Dosil Suarez A, Douglas L, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Durante P, Durham JM, Dutta D, Dzhelyadin R, Dziewiecki M, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Ek-In S, Eklund L, Ely S, Ene A, Escher S, Esen S, Evans T, Falabella A, Farber C, Farley N, Farry S, Fazzini D, Feo M, Fernandez Declara P, Fernandez Prieto A, Ferrari F, Ferreira Lopes L, Ferreira Rodrigues F, Ferreres Sole S, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fontana M, Fontanelli F, Forty R, Franco Lima V, Franco Sevilla M, Frank M, Frei C, Fu J, Funk W, Gabriel E, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gan Y, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garcia Plana B, Garra Tico J, Garrido L, Gascon D, Gaspar C, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Gerstel D, Ghez P, Gibson V, Girard OG, Gironella Gironell P, Giubega L, Gizdov K, Gligorov VV, Gobel C, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Grabowski JP, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruber L, Gruberg Cazon BR, Gu C, Gushchin E, Guth A, Guz Y, Gys T, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han Q, Han X, Hancock TH, Hansmann-Menzemer S, Harnew N, Harrison T, Hasse C, Hatch M, He J, Hecker M, Heinicke K, Heister A, Hennessy K, Henry L, Hess M, Heuel J, Hicheur A, Hidalgo Charman R, Hill D, Hilton M, Hopchev PH, Hu J, Hu W, Huang W, Huard ZC, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Hynds D, Ibis P, Idzik M, Ilten P, Inglessi A, Inyakin A, Ivshin K, Jacobsson R, Jakobsen S, Jalocha J, Jans E, Jashal BK, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kazeev N, Kecke M, Keizer F, Kelsey M, Kenzie M, Ketel T, Khanji B, Kharisova A, Khurewathanakul C, Kim KE, Kirn T, Kirsebom VS, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Kondybayeva A, Konoplyannikov A, Kopecna R, Koppenburg P, Kostiuk I, Kot O, Kotriakhova S, Kozeiha M, Kravchuk L, Kreps M, Kress F, Kretzschmar S, Krokovny P, Krupa W, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kunde GJ, Kuonen AK, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lancierini D, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, Lefevre R, Leflat A, Lemaitre F, Leroy O, Lesiak T, Leverington B, Li H, Li PR, Li X, Li Y, Li Z, Liang X, Likhomanenko T, Lindner R, Lionetto F, Lisovskyi V, Liu G, Liu X, Loh D, Loi A, Lomba Castro J, Longstaff I, Lopes JH, Loustau G, Lovell GH, Lucchesi D, Lucio Martinez M, Luo Y, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Maev O, Maguire K, Maisuzenko D, Majewski MW, Malde S, Malecki B, Malinin A, Maltsev T, Malygina H, Manca G, Mancinelli G, Marangotto D, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Marshall PJ, Martellotti G, Martinazzoli L, Martinelli M, Martinez Santos D, Martinez Vidal F, Massafferri A, Materok M, Matev R, Mathad A, Mathe Z, Matiunin V, Matteuzzi C, Mattioli KR, Mauri A, Maurice E, Maurin B, McCann M, McNab A, McNulty R, Mead JV, Meadows B, Meaux C, Meinert N, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Millard E, Minard MN, Mineev O, Minzoni L, Mitzel DS, Modden A, Mogini A, Moise RD, Mombacher T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Moron J, Morris AB, Mountain R, Mu H, Muheim F, Mukherjee M, Mulder M, Muller D, Muller J, Muller K, Muller V, Murphy CH, Murray D, Naik P, Nakada T, Nandakumar R, Nandi A, Nanut T, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Newcombe R, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nolte NS, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, O'Hanlon DP, Oldeman R, Onderwater CJG, Osborn JD, Ossowska A, Otalora Goicochea JM, Ovsiannikova T, Owen P, Oyanguren A, Pais PR, Pajero T, Palano A, Palutan M, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Pereima D, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pietrzyk B, Pietrzyk G, Pikies M, Pili M, Pinci D, Pinzino J, Pisani F, Piucci A, Placinta V, Playfer S, Plews J, Plo Casasus M, Polci F, Poli Lener M, Poliakova M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Poslavskii S, Price E, Prouve C, Pugatch V, Puig Navarro A, Pullen H, Punzi G, Qian W, Qin J, Quagliani R, Quintana B, Raab NV, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Ratnikov F, Raven G, Ravonel Salzgeber M, Reboud M, Redi F, Reichert S, Reiss F, Remon Alepuz C, Ren Z, Renaudin V, Ricciardi S, Richards S, Rinnert K, Robbe P, Robert A, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Roehrken M, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Roth JD, Rotondo M, Rudolph MS, Ruf T, Ruiz Vidal J, Saborido Silva JJ, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Gras C, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarpis G, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubiger M, Schulte S, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sepulveda ES, Sergi A, Serra N, Serrano J, Sestini L, Seuthe A, Seyfert P, Shapkin M, Shears T, Shekhtman L, Shevchenko V, Shmanin E, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Skiba I, Skidmore N, Skwarnicki T, Slater MW, Smeaton JG, Smith E, Smith IT, Smith M, Soares M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spadaro Norella E, Spradlin P, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stepanova M, Stevens H, Stocchi A, Stone S, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Strokov S, Sun J, Sun L, Sun Y, Swientek K, Szabelski A, Szumlak T, Szymanski M, Tang Z, Tekampe T, Tellarini G, Teubert F, Thomas E, Tilley MJ, Tisserand V, T'Jampens S, Tobin M, Tolk S, Tomassetti L, Tonelli D, Tou DY, Tournefier E, Traill M, Tran MT, Trisovic A, Tsaregorodtsev A, Tuci G, Tully A, Tuning N, Ukleja A, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valat S, Valenti G, van Beuzekom M, Van Hecke H, van Herwijnen E, Van Hulse CB, van Tilburg J, van Veghel M, Vazquez Gomez R, Vazquez Regueiro P, Vazquez Sierra C, Vecchi S, Velthuis JJ, Veltri M, Venkateswaran A, Vernet M, Veronesi M, Vesterinen M, Viana Barbosa JV, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitkovskiy A, Vitti M, Volkov V, Vollhardt A, Vom Bruch D, Voneki B, Vorobyev A, Vorobyev V, Voropaev N, Waldi R, Walsh J, Wang J, Wang J, Wang M, Wang Y, Wang Z, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Weisser C, Whitehead M, Wilkinson G, Wilkinson M, Williams I, Williams M, Williams MRJ, Williams T, Wilson FF, Winn M, Wislicki W, Witek M, Wormser G, Wotton SA, Wyllie K, Xiao D, Xie Y, Xing H, Xu A, Xu L, Xu M, Xu Q, Xu Z, Xu Z, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zeng M, Zhang D, Zhang L, Zhang S, Zhang WC, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zonneveld JB, Zucchelli S

Abstract:
A time-dependent analysis of the B_{s}^{0}-->varphigamma decay rate is performed to determine the CP -violating observables S_{varphigamma} and C_{varphigamma} and the mixing-induced observable A_{varphigamma}^{Delta}. The measurement is based on a sample of pp collision data recorded with the LHCb detector, corresponding to an integrated luminosity of 3 fb^{-1} at center-of-mass energies of 7 and 8 TeV. The measured values are S_{varphigamma}=0.43+/-0.30+/-0.11, C_{varphigamma}=0.11+/-0.29+/-0.11, and A_{varphigamma}^{Delta}=-0.67_{-0.41}^{+0.37}+/-0.17, where the first uncertainty is statistical and the second systematic. This is the first measurement of the observables S and C in radiative B_{s}^{0} decays. The results are consistent with the standard model predictions.





13/08/2019 | Biochem Biophys Res Commun   IF 2.7
DNAJC2 is required for mouse early embryonic development.
Helary L, Castille J, Passet B, Vaiman A, Beauvallet C, Jaffrezic F, Charles M, Tamzini M, Baraige F, Letheule M, Laubier J, Moazami-Goudarzi K, Vilotte JL, Blanquet V, Duchesne A

Abstract:
DNAJC2 protein, also known as ZRF1 or MPP11, acts both as chaperone and as chromatin regulator. It is involved in stem cell differentiation and its expression is associated with various cancer malignancies. However, the role of Dnajc2 gene during mouse embryogenesis has not been assessed so far. To this aim, we invalidated Dnajc2 gene in FVB/Nj mice using the CrispR/Cas9 approach. We showed that this invalidation leads to the early post-implantation lethality of the nullizygous embryos. Furthermore, using siRNAs against Dnajc2 in mouse 1-cell embryos, we showed that maternal Dnajc2 mRNAs may allow for the early preimplantation development of these embryos. Altogether, these data demonstrate for the first time the requirement of DNAJC2 for early mouse embryogenesis.





Abstract:
OBJECTIVE: The hypothalamic paraventricular nucleus (PVN) is a key target of the melanocortin system, which orchestrates behavioral and metabolic responses depending on energy availability. The mechanistic target of rapamycin complex 1 (mTORC1) and the endocannabinoid type 1 receptor (CB1R) pathways are two key signaling systems involved in the regulation of energy balance whose activity closely depends upon energy availability. Here we tested the hypothesis that modulation of mTORC1 and CB1R signaling regulates excitatory glutamatergic inputs onto the PVN. METHODS: Patch-clamp recordings in C57BL/6J mice, in mice lacking the mTORC1 component Rptor or CB1R in pro-opio-melanocortin (POMC) neurons, combined with pharmacology targeting mTORC1, the melanocortin receptor type 4 (MC4R), or the endocannabinoid system under chow or a hypercaloric diet. RESULTS: Acute pharmacological inhibition of mTORC1 in C57BL/6J mice decreased glutamatergic inputs onto the PVN via a mechanism requiring modulation of MC4R, endocannabinoid 2-AG mobilization by PVN parvocellular neurons, and retrograde activation of presynaptic CB1R. Further electrophysiology studies using mice lacking mTORC1 activity or CB1R in POMC neurons indicated that the observed effects involved mTORC1 and CB1R-dependent regulation of glutamate release from POMC neurons. Finally, energy surfeit caused by hypercaloric high-fat diet feeding, rapidly and time-dependently altered the glutamatergic inputs onto parvocellular neurons and the ability of mTORC1 and CB1R signaling to modulate such excitatory activity. CONCLUSIONS: These findings pinpoint the relationship between mTORC1 and endocannabinoid-CB1R signaling in the regulation of the POMC-mediated glutamatergic inputs onto PVN parvocellular neurons and its rapid alteration in conditions favoring the development of obesity.





08/2019 | Neurobiology of Stress
Neurobiological links between stress and anxiety
Nuria Daviu, Michael Bruchas, Bita Moghaddam, Carmen Sandi, Beyeler A

Abstract:
Stress and anxiety have intertwined behavioral and neural underpinnings. These commonalities are critical for understanding each state, as well as their mutual interactions. Grasping the mechanisms underlying this bidirectional relationship will have major clinical implications for managing a wide range of psychopathologies. After briefly defining key concepts for the study of stress and anxiety in pre-clinical models, we present circuit, as well as cellular and molecular mechanisms involved in either or both stress and anxiety. First, we review studies on divergent circuits of the basolateral amygdala (BLA) underlying emotional valence processing and anxiety-like behaviors, and how norepinephrine inputs from the locus coeruleus (LC) to the BLA are responsible for acute-stress induced anxiety. We then describe recent studies revealing a new role for mitochondrial function within the nucleus accumbens (NAc), defining individual trait anxiety in rodents, and participating in the link between stress and anxiety. Next, we report findings on the impact of anxiety on reward encoding through alteration of circuit dynamic synchronicity. Finally, we present work unravelling a new role for hypothalamic corticotropin-releasing hormone (CRH) neurons in controlling anxiety-like and stress-induce behaviors. Altogether, the research reviewed here reveals circuits sharing subcortical nodes and underlying the processing of both stress and anxiety. Understanding the neural overlap between these two psychobiological states, might provide alternative strategies to manage disorders such as post-traumatic stress disorder (PTSD).





25/07/2019 | J Med Chem   IF 6.1
Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models.
Finlay MRV, Anderton M, Bailey A, Boyd S, Brookfield J, Cairnduff C, Charles M, Cheasty A, Critchlow SE, Culshaw J, Ekwuru T, Hollingsworth I, Jones N, Leroux F, Littleson M, McCarron H, McKelvie J, Mooney L, Nissink JWM, Perkins D, Powell S, Quesada MJ, Raubo P, Sabin V, Smith J, Smith PD, Stark A, Ting A, Wang P, Wilson Z, Winter-Holt JJ, Wood JM, Wrigley GL, Yu G, Zhang P

Abstract:
Tumors have evolved a variety of methods to reprogram conventional metabolic pathways to favor their own nutritional needs, including glutaminolysis, the first step of which is the hydrolysis of glutamine to glutamate by the amidohydrolase glutaminase 1 (GLS1). A GLS1 inhibitor could potentially target certain cancers by blocking the tumor cell's ability to produce glutamine-derived nutrients. Starting from the known GLS1 inhibitor bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide, we describe the medicinal chemistry evolution of a series from lipophilic inhibitors with suboptimal physicochemical and pharmacokinetic properties to cell potent examples with reduced molecular weight and lipophilicity, leading to compounds with greatly improved oral exposure that demonstrate in vivo target engagement accompanied by activity in relevant disease models.





19/07/2019 | phys rev lett
First Observation of the Radiative Decay Lambda_{b}^{0}-->Lambdagamma.
Aaij R, Abellan Beteta C, Adeva B, Adinolfi M, Aidala CA, Ajaltouni Z, Akar S, Albicocco P, Albrecht J, Alessio F, Alexander M, Alfonso Albero A, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Archilli F, Arnau Romeu J, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Back JJ, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barsuk S, Barter W, Bartolini M, Baryshnikov F, Batozskaya V, Batsukh B, Battig A, Battista V, Bay A, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Belin S, Beliy N, Bellee V, Belloli N, Belous K, Belyaev I, Bencivenni G, Ben-Haim E, Benson S, Beranek S, Berezhnoy A, Bernet R, Berninghoff D, Bertholet E, Bertolin A, Betancourt C, Betti F, Bettler MO, Bezshyiko I, Bhasin S, Bhom J, Bieker MS, Bifani S, Billoir P, Birnkraut A, Bizzeti A, Bjorn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Bocci V, Boente Garcia O, Boettcher T, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Boubdir M, Bowcock TJV, Bozzi C, Braun S, Brodski M, Brodzicka J, Brossa Gonzalo A, Brundu D, Buchanan E, Buonaura A, Burr C, Bursche A, Butter JS, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Cali S, Calladine R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carvalho Akiba K, Casse G, Cattaneo M, Cavallero G, Cenci R, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chekalina V, Chen C, Chen S, Chitic SG, Chobanova V, Chrzaszcz M, Chubykin A, Ciambrone P, Cid Vidal X, Ciezarek G, Cindolo F, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Comerma-Montells A, Contu A, Coombs G, Coquereau S, Corti G, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Currie R, Da Silva CL, Dall'Occo E, Dalseno J, D'Ambrosio C, Danilina A, d'Argent P, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, de Vries JA, Dean CT, Dean W, Decamp D, Del Buono L, Delaney B, Dembinski HP, Demmer M, Dendek A, Derkach D, Deschamps O, Desse F, Dettori F, Dey B, Di Canto A, Di Nezza P, Didenko S, Dijkstra H, Dordei F, Dorigo M, Dos Reis AC, Dosil Suarez A, Douglas L, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Durante P, Durham JM, Dutta D, Dzhelyadin R, Dziewiecki M, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Ene A, Escher S, Esen S, Evans T, Falabella A, Farber C, Farley N, Farry S, Fazzini D, Feo M, Fernandez Declara P, Fernandez Prieto A, Ferrari F, Ferreira Lopes L, Ferreira Rodrigues F, Ferreres Sole S, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fontana M, Fontanelli F, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Gabriel E, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gan Y, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garcia Plana B, Garra Tico J, Garrido L, Gascon D, Gaspar C, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Gerstel D, Ghez P, Gibson V, Girard OG, Gironella Gironell P, Giubega L, Gizdov K, Gligorov VV, Gobel C, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Grabowski JP, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruber L, Gruberg Cazon BR, Gu C, Gushchin E, Guth A, Guz Y, Gys T, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han Q, Han X, Hancock TH, Hansmann-Menzemer S, Harnew N, Harrison T, Hasse C, Hatch M, He J, Hecker M, Heinicke K, Heister A, Hennessy K, Henry L, Hess M, Heuel J, Hicheur A, Hidalgo Charman R, Hill D, Hilton M, Hopchev PH, Hu J, Hu W, Huang W, Huard ZC, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Hynds D, Ibis P, Idzik M, Ilten P, Inglessi A, Inyakin A, Ivshin K, Jacobsson R, Jakobsen S, Jalocha J, Jans E, Jashal BK, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kazeev N, Kecke M, Keizer F, Kelsey M, Kenzie M, Ketel T, Khanji B, Kharisova A, Khurewathanakul C, Kim KE, Kirn T, Kirsebom VS, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Kopecna R, Koppenburg P, Kostiuk I, Kot O, Kotriakhova S, Kozeiha M, Kravchuk L, Kreps M, Kress F, Kretzschmar S, Krokovny P, Krupa W, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kunde GJ, Kuonen AK, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lancierini D, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, Lefevre R, Leflat A, Lemaitre F, Leroy O, Lesiak T, Leverington B, Li H, Li PR, Li X, Li Y, Li Z, Liang X, Likhomanenko T, Lindner R, Lionetto F, Lisovskyi V, Liu G, Liu X, Loh D, Loi A, Longstaff I, Lopes JH, Loustau G, Lovell GH, Lucchesi D, Lucio Martinez M, Luo Y, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Maev O, Maguire K, Maisuzenko D, Majewski MW, Malde S, Malecki B, Malinin A, Maltsev T, Malygina H, Manca G, Mancinelli G, Marangotto D, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Marshall PJ, Martellotti G, Martinelli M, Martinez Santos D, Martinez Vidal F, Massafferri A, Materok M, Matev R, Mathad A, Mathe Z, Matiunin V, Matteuzzi C, Mattioli KR, Mauri A, Maurice E, Maurin B, McCann M, McNab A, McNulty R, Mead JV, Meadows B, Meaux C, Meinert N, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Millard E, Minard MN, Minzoni L, Mitzel DS, Modden A, Mogini A, Moise RD, Mombacher T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Moron J, Morris AB, Mountain R, Muheim F, Mukherjee M, Mulder M, Muller D, Muller J, Muller K, Muller V, Murphy CH, Murray D, Naik P, Nakada T, Nandakumar R, Nandi A, Nanut T, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Newcombe R, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nolte NS, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, O'Hanlon DP, Oldeman R, Onderwater CJG, Osborn JD, Ossowska A, Otalora Goicochea JM, Ovsiannikova T, Owen P, Oyanguren A, Pais PR, Pajero T, Palano A, Palutan M, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Pereima D, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pietrzyk B, Pietrzyk G, Pikies M, Pili M, Pinci D, Pinzino J, Pisani F, Piucci A, Placinta V, Playfer S, Plews J, Plo Casasus M, Polci F, Poli Lener M, Poliakova M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Poslavskii S, Price E, Prouve C, Pugatch V, Puig Navarro A, Pullen H, Punzi G, Qian W, Qin J, Quagliani R, Quintana B, Raab NV, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Ratnikov F, Raven G, Ravonel Salzgeber M, Reboud M, Redi F, Reichert S, Reiss F, Remon Alepuz C, Ren Z, Renaudin V, Ricciardi S, Richards S, Rinnert K, Robbe P, Robert A, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Roehrken M, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Roth JD, Rotondo M, Rudolph MS, Ruf T, Ruiz Vidal J, Saborido Silva JJ, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Gras C, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarpis G, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubiger M, Schulte S, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sepulveda ES, Sergi A, Serra N, Serrano J, Sestini L, Seuthe A, Seyfert P, Shapkin M, Shears T, Shekhtman L, Shevchenko V, Shmanin E, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Skiba I, Skidmore N, Skwarnicki T, Slater MW, Smeaton JG, Smith E, Smith IT, Smith M, Soares M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spadaro Norella E, Spradlin P, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stepanova M, Stevens H, Stocchi A, Stone S, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Strokov S, Sun J, Sun L, Sun Y, Swientek K, Szabelski A, Szumlak T, Szymanski M, Tang Z, Tekampe T, Tellarini G, Teubert F, Thomas E, Tilley MJ, Tisserand V, T'Jampens S, Tobin M, Tolk S, Tomassetti L, Tonelli D, Tou DY, Tourinho Jadallah Aoude R, Tournefier E, Traill M, Tran MT, Trisovic A, Tsaregorodtsev A, Tuci G, Tully A, Tuning N, Ukleja A, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valat S, Valenti G, van Beuzekom M, Van Hecke H, van Herwijnen E, Van Hulse CB, van Tilburg J, van Veghel M, Vasiliev A, Vazquez Gomez R, Vazquez Regueiro P, Vazquez Sierra C, Vecchi S, Velthuis JJ, Veltri M, Venkateswaran A, Vernet M, Veronesi M, Vesterinen M, Viana Barbosa JV, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitkovskiy A, Vitti M, Volkov V, Vollhardt A, Vom Bruch D, Voneki B, Vorobyev A, Vorobyev V, Voropaev N, Waldi R, Walsh J, Wang J, Wang M, Wang Y, Wang Z, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Weisser C, Whitehead M, Wilkinson G, Wilkinson M, Williams I, Williams M, Williams MRJ, Williams T, Wilson FF, Winn M, Wislicki W, Witek M, Wormser G, Wotton SA, Wyllie K, Xiao D, Xie Y, Xing H, Xu A, Xu M, Xu Q, Xu Z, Xu Z, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zeng M, Zhang D, Zhang L, Zhang WC, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zonneveld JB, Zucchelli S

Abstract:
The radiative decay Lambda_{b}^{0}-->Lambdagamma is observed for the first time using a data sample of proton-proton collisions corresponding to an integrated luminosity of 1.7 fb^{-1} collected by the LHCb experiment at a center-of-mass energy of 13 TeV. Its branching fraction is measured exploiting the B^{0}-->K^{*0}gamma decay as a normalization mode and is found to be B(Lambda_{b}^{0}-->Lambdagamma)=(7.1+/-1.5+/-0.6+/-0.7)x10^{-6}, where the quoted uncertainties are statistical, systematic, and systematic from external inputs, respectively. This is the first observation of a radiative decay of a beauty baryon.





02/07/2019 | Curr Biol   IF 9.2
CB1 Receptors in the Anterior Piriform Cortex Control Odor Preference Memory.
Terral G, Busquets-Garcia A, Varilh M, Achicallende S, Cannich A, Bellocchio L, Bonilla-Del Rio I, Massa F, Puente N, Soria-Gomez E, Grandes P, Ferreira G, Marsicano G

Abstract:
The retrieval of odor-related memories shapes animal behavior. The anterior piriform cortex (aPC) is the largest part of the olfactory cortex, and it plays important roles in olfactory processing and memory. However, it is still unclear whether specific cellular mechanisms in the aPC control olfactory memory, depending on the appetitive or aversive nature of the stimuli involved. Cannabinoid-type 1 (CB1) receptors are present in the aPC (aPC-CB1), but their potential impact on olfactory memory was never explored. Here, we used a combination of behavioral, genetic, anatomical, and electrophysiological approaches to characterize the functions of aPC-CB1 receptors in the regulation of appetitive and aversive olfactory memory. Pharmacological blockade or genetic deletion of aPC-CB1 receptors specifically impaired the retrieval of conditioned odor preference (COP). Interestingly, expression of conditioned odor aversion (COA) was unaffected by local CB1 receptor blockade, indicating that the role of aPC endocannabinoid signaling is selective for retrieval of appetitive memory. Anatomical investigations revealed that CB1 receptors are highly expressed on aPC GABAergic interneurons, and ex vivo electrophysiological recordings showed that their pharmacological activation reduces miniature inhibitory post-synaptic currents (mIPSCs) onto aPC semilunar (SL), but not pyramidal principal neurons. COP retrieval, but not COA, was associated with a specific CB1-receptor-dependent decrease of mIPSCs in SL cells. Altogether, these data indicate that aPC-CB1 receptor-dependent mechanisms physiologically control the retrieval of olfactory memory, depending on odor valence and engaging modulation of local inhibitory transmission.





25/06/2019 | Cell Rep   IF 7.8
Aquaporin-4 Surface Trafficking Regulates Astrocytic Process Motility and Synaptic Activity in Health and Autoimmune Disease.
Ciappelloni S, Bouchet D, Dubourdieu N, Boue-Grabot E, Kellermayer B, Manso C, Marignier R, Oliet SHR, Tourdias T, Groc L

Abstract:
Astrocytes constantly adapt their ramified morphology in order to support brain cell assemblies. Such plasticity is partly mediated by ion and water fluxes, which rely on the water channel aquaporin-4 (AQP4). The mechanism by which this channel locally contributes to process dynamics has remained elusive. Using a combination of single-molecule and calcium imaging approaches, we here investigated in hippocampal astrocytes the dynamic distribution of the AQP4 isoforms M1 and M23. Surface AQP4-M1 formed small aggregates that contrast with the large AQP4-M23 clusters that are enriched near glutamatergic synapses. Strikingly, stabilizing surface AQP4-M23 tuned the motility of astrocyte processes and favors glutamate synapse activity. Furthermore, human autoantibodies directed against AQP4 from neuromyelitis optica (NMO) patients impaired AQP4-M23 dynamic distribution and, consequently, astrocyte process and synaptic activity. Collectively, it emerges that the membrane dynamics of AQP4 isoform regulate brain cell assemblies in health and autoimmune brain disease targeting AQP4.





14/06/2019 | phys rev lett
Measurement of the Mass Difference Between Neutral Charm-Meson Eigenstates.
Aaij R, Abellan Beteta C, Adeva B, Adinolfi M, Aidala CA, Ajaltouni Z, Akar S, Albicocco P, Albrecht J, Alessio F, Alexander M, Alfonso Albero A, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Archilli F, Arnau Romeu J, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Back JJ, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barrand GC, Barsuk S, Barter W, Bartolini M, Baryshnikov F, Batozskaya V, Batsukh B, Battig A, Battista V, Bay A, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Belin S, Beliy N, Bellee V, Belloli N, Belous K, Belyaev I, Bencivenni G, Ben-Haim E, Benson S, Beranek S, Berezhnoy A, Bernet R, Berninghoff D, Bertholet E, Bertolin A, Betancourt C, Betti F, Bettler MO, Bezshyiko I, Bhasin S, Bhom J, Bieker MS, Bifani S, Billoir P, Birnkraut A, Bizzeti A, Bjorn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Bocci V, Boente Garcia O, Boettcher T, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Boubdir M, Bowcock TJV, Bozzi C, Braun S, Brodski M, Brodzicka J, Brossa Gonzalo A, Brundu D, Buchanan E, Buonaura A, Burr C, Bursche A, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Calladine R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carvalho Akiba K, Casse G, Cattaneo M, Cavallero G, Cenci R, Chamont D, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chekalina V, Chen C, Chen S, Chitic SG, Chobanova V, Chrzaszcz M, Chubykin A, Ciambrone P, Cid Vidal X, Ciezarek G, Cindolo F, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Comerma-Montells A, Contu A, Coombs G, Coquereau S, Corti G, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Currie R, Da Silva CL, Dall'Occo E, Dalseno J, D'Ambrosio C, Danilina A, d'Argent P, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, de Vries JA, Dean CT, Dean W, Decamp D, Del Buono L, Delaney B, Dembinski HP, Demmer M, Dendek A, Derkach D, Deschamps O, Desse F, Dettori F, Dey B, Di Canto A, Di Nezza P, Didenko S, Dijkstra H, Dordei F, Dorigo M, Dos Reis AC, Dosil Suarez A, Douglas L, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Durante P, Durham JM, Dutta D, Dzhelyadin R, Dziewiecki M, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Ene A, Escher S, Esen S, Evans T, Falabella A, Farber C, Farley N, Farry S, Fazzini D, Feo M, Fernandez Declara P, Fernandez Prieto A, Ferrari F, Ferreira Lopes L, Ferreira Rodrigues F, Ferreres Sole S, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fontana M, Fontanelli F, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Gabriel E, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gan Y, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garcia Plana B, Garra Tico J, Garrido L, Gascon D, Gaspar C, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Gerstel D, Ghez P, Gibson V, Girard OG, Gironella Gironell P, Giubega L, Gizdov K, Gligorov VV, Gobel C, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Grabowski JP, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruber L, Gruberg Cazon BR, Gu C, Gushchin E, Guth A, Guz Y, Gys T, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han X, Hancock TH, Hansmann-Menzemer S, Harnew N, Harrison T, Hasse C, Hatch M, He J, Hecker M, Heinicke K, Heister A, Hennessy K, Henry L, Hess M, Heuel J, Hicheur A, Hidalgo Charman R, Hill D, Hilton M, Hopchev PH, Hu J, Hu W, Huang W, Huard ZC, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Hynds D, Ibis P, Idzik M, Ilten P, Inglessi A, Inyakin A, Ivshin K, Jacobsson R, Jakobsen S, Jalocha J, Jans E, Jashal BK, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kazeev N, Kecke M, Keizer F, Kelsey M, Kenzie M, Ketel T, Khanji B, Kharisova A, Khurewathanakul C, Kim KE, Kirn T, Kirsebom VS, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Kopecna R, Koppenburg P, Kostiuk I, Kotriakhova S, Kozeiha M, Kravchuk L, Kreps M, Kress F, Kretzschmar S, Krokovny P, Krupa W, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lancierini D, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, Lefevre R, Leflat A, Lemaitre F, Leroy O, Lesiak T, Leverington B, Li H, Li PR, Li Y, Li Z, Liang X, Likhomanenko T, Lindner R, Lionetto F, Lisovskyi V, Liu G, Liu X, Loh D, Loi A, Longstaff I, Lopes JH, Loustau G, Lovell GH, Lucchesi D, Lucio Martinez M, Luo Y, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Maev O, Maguire K, Maisuzenko D, Majewski MW, Malde S, Malecki B, Malinin A, Maltsev T, Malygina H, Manca G, Mancinelli G, Marangotto D, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Marshall PJ, Martellotti G, Martinelli M, Martinez Santos D, Martinez Vidal F, Massafferri A, Materok M, Matev R, Mathad A, Mathe Z, Matiunin V, Matteuzzi C, Mattioli KR, Mauri A, Maurice E, Maurin B, McCann M, McNab A, McNulty R, Mead JV, Meadows B, Meaux C, Meinert N, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Millard E, Minard MN, Minzoni L, Mitzel DS, Modden A, Mogini A, Moise RD, Mombacher T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Moron J, Morris AB, Mountain R, Muheim F, Mukherjee M, Mulder M, Muller D, Muller J, Muller K, Muller V, Murphy CH, Murray D, Naik P, Nakada T, Nandakumar R, Nandi A, Nanut T, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Newcombe R, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nolte NS, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, O'Hanlon DP, Oldeman R, Onderwater CJG, Osborn JD, Ossowska A, Otalora Goicochea JM, Ovsiannikova T, Owen P, Oyanguren A, Pais PR, Pajero T, Palano A, Palutan M, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Pereima D, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pietrzyk B, Pietrzyk G, Pikies M, Pili M, Pinci D, Pinzino J, Pisani F, Piucci A, Placinta V, Playfer S, Plews J, Plo Casasus M, Polci F, Poli Lener M, Poliakova M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Poslavskii S, Price E, Prouve C, Pugatch V, Puig Navarro A, Pullen H, Punzi G, Qian W, Qin J, Quagliani R, Quintana B, Raab NV, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Ratnikov F, Raven G, Ravonel Salzgeber M, Reboud M, Redi F, Reichert S, Reiss F, Remon Alepuz C, Ren Z, Renaudin V, Ricciardi S, Richards S, Rinnert K, Robbe P, Robert A, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Roehrken M, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Roth JD, Rotondo M, Rudolph MS, Ruf T, Ruiz Vidal J, Saborido Silva JJ, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Gras C, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarpis G, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubiger M, Schulte S, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sepulveda ES, Sergi A, Serra N, Serrano J, Sestini L, Seuthe A, Seyfert P, Shapkin M, Shears T, Shekhtman L, Shevchenko V, Shmanin E, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Skiba I, Skidmore N, Skwarnicki T, Slater MW, Smeaton JG, Smith E, Smith IT, Smith M, Soares M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spadaro Norella E, Spradlin P, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stepanova M, Stevens H, Stocchi A, Stone S, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Strokov S, Sun J, Sun L, Sun Y, Swientek K, Szabelski A, Szumlak T, Szymanski M, Tang Z, Tekampe T, Tellarini G, Teubert F, Thomas E, Tilley MJ, Tisserand V, T'Jampens S, Tobin M, Tolk S, Tomassetti L, Tonelli D, Tou DY, Tourinho Jadallah Aoude R, Tournefier E, Traill M, Tran MT, Trisovic A, Tsaregorodtsev A, Tuci G, Tully A, Tuning N, Ukleja A, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valat S, Valenti G, van Beuzekom M, van Herwijnen E, Van Hulse CB, van Tilburg J, van Veghel M, Vazquez Gomez R, Vazquez Regueiro P, Vazquez Sierra C, Vecchi S, Velthuis JJ, Veltri M, Venkateswaran A, Vernet M, Veronesi M, Vesterinen M, Viana Barbosa JV, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitkovskiy A, Vitti M, Volkov V, Vollhardt A, Vom Bruch D, Voneki B, Vorobyev A, Vorobyev V, Voropaev N, Waldi R, Walsh J, Wang J, Wang M, Wang Y, Wang Z, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Weisser C, Whitehead M, Wilkinson G, Wilkinson M, Williams I, Williams M, Williams MRJ, Williams T, Wilson FF, Winn M, Wislicki W, Witek M, Wormser G, Wotton SA, Wyllie K, Xiao D, Xie Y, Xing H, Xu A, Xu M, Xu Q, Xu Z, Xu Z, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zeng M, Zhang D, Zhang L, Zhang WC, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zonneveld JB, Zucchelli S

Abstract:
We report a measurement of the mass difference between neutral charm-meson eigenstates using a novel approach that enhances sensitivity to this parameter. We use 2.3x10^{6} D^{0}-->K_{S}^{0}pi^{+}pi^{-} decays reconstructed in proton-proton collisions collected by the LHCb experiment in 2011 and 2012. Allowing for CP violation in mixing and in the interference between mixing and decay, we measure the CP-averaged normalized mass difference x_{CP}=[2.7+/-1.6(stat)+/-0.4(syst)]x10^{-3} and the CP-violating parameter Deltax=[-0.53+/-0.70(stat)+/-0.22(syst)]x10^{-3}. The results are consistent with CP symmetry. These determinations are the most precise from a single experiment and, combined with current world-average results, yield the first evidence that the masses of the neutral charm-meson eigenstates differ.





14/06/2019 | phys rev lett
Observation of an Excited B_{c}^{+} State.
Aaij R, Abellan Beteta C, Adeva B, Adinolfi M, Aidala CA, Ajaltouni Z, Akar S, Albicocco P, Albrecht J, Alessio F, Alexander M, Alfonso Albero A, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Back JJ, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barsuk S, Barter W, Bartolini M, Baryshnikov F, Batozskaya V, Batsukh B, Battig A, Battista V, Bay A, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Belin S, Beliy N, Bellee V, Belloli N, Belous K, Ben-Haim E, Bencivenni G, Benson S, Beranek S, Berezhnoy A, Bernet R, Berninghoff D, Bertholet E, Bertolin A, Betancourt C, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bhasin S, Bhom J, Bieker MS, Bifani S, Billoir P, Birnkraut A, Bizzeti A, Bjorn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Bocci V, Boente Garcia O, Boettcher T, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Boubdir M, Bowcock TJV, Bozzi C, Braun S, Brodski M, Brodzicka J, Brossa Gonzalo A, Brundu D, Buchanan E, Buonaura A, Burr C, Bursche A, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Cali S, Calladine R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carvalho Akiba K, Casse G, Cattaneo M, Cavallero G, Cenci R, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chekalina V, Chen C, Chen S, Chitic SG, Chobanova V, Chrzaszcz M, Chubykin A, Ciambrone P, Cid Vidal X, Ciezarek G, Cindolo F, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Comerma-Montells A, Contu A, Coombs G, Coquereau S, Corti G, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Currie R, D'Ambrosio C, Da Silva CL, Dall'Occo E, Dalseno J, Danilina A, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Dean W, Decamp D, Del Buono L, Delaney B, Dembinski HP, Demmer M, Dendek A, Derkach D, Deschamps O, Desse F, Dettori F, Dey B, Di Canto A, Di Nezza P, Didenko S, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Douglas L, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Durante P, Durham JM, Dutta D, Dzhelyadin R, Dziewiecki M, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Ene A, Escher S, Esen S, Evans T, Falabella A, Farley N, Farry S, Fazzini D, Fernandez Declara P, Fernandez Prieto A, Ferrari F, Ferreira Lopes L, Ferreira Rodrigues F, Ferreres Sole S, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fontana M, Fontanelli F, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Farber C, Feo M, Gabriel E, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gan Y, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Plana B, Garcia Pardinas J, Garra Tico J, Garrido L, Gascon D, Gaspar C, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Gerstel D, Ghez P, Gibson V, Girard OG, Gironella Gironell P, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Grabowski JP, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruber L, Gruberg Cazon BR, Gu C, Guo X, Gushchin E, Guth A, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han Q, Han X, Hancock TH, Hansmann-Menzemer S, Harnew N, Harrison T, Hasse C, Hatch M, He J, Hecker M, Heinicke K, Heister A, Hennessy K, Henry L, van Herwijnen E, Heuel J, Hess M, Hicheur A, Hidalgo Charman R, Hill D, Hilton M, Hopchev PH, Hu J, Hu W, Huang W, Huard ZC, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Hynds D, Ibis P, Idzik M, Ilten P, Inglessi A, Inyakin A, Ivshin K, Jacobsson R, Jakobsen S, Jalocha J, Jans E, Jashal BK, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kazeev N, Kecke M, Keizer F, Kelsey M, Kenzie M, Ketel T, Khanji B, Kharisova A, Khurewathanakul C, Kim KE, Kirn T, Kirsebom VS, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Kopecna R, Koppenburg P, Kostiuk I, Kotriakhova S, Kozeiha M, Kravchuk L, Kreps M, Kress F, Kretzschmar S, Krokovny P, Krupa W, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kunde GJ, Kuonen AK, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lancierini D, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, Leflat A, Lefevre R, Lemaitre F, Leroy O, Lesiak T, Leverington B, Li H, Li PR, Li X, Li Y, Li Z, Liang X, Likhomanenko T, Lindner R, Ling P, Lionetto F, Lisovskyi V, Liu G, Liu X, Loh D, Loi A, Longstaff I, Lopes JH, Loustau G, Lovell GH, Lucchesi D, Lucio Martinez M, Luo Y, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Ma R, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Maev O, Maguire K, Maisuzenko D, Majewski MW, Malde S, Malecki B, Malinin A, Maltsev T, Malygina H, Manca G, Mancinelli G, Marangotto D, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Marshall PJ, Martellotti G, Martinelli M, Martinez Santos D, Martinez Vidal F, Massafferri A, Materok M, Matev R, Mathad A, Mathe Z, Matiunin V, Matteuzzi C, Mattioli KR, Mauri A, Maurice E, Maurin B, McCann M, McNab A, McNulty R, Mead JV, Meadows B, Meaux C, Meinert N, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Millard E, Minard MN, Minzoni L, Mitzel DS, Mogini A, Moise RD, Mombacher T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Moron J, Morris AB, Mountain R, Muheim F, Mukherjee M, Mulder M, Murphy CH, Murray D, Modden A, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nanut T, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Newcombe R, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nolte NS, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJG, Osborn JD, Ossowska A, Otalora Goicochea JM, Ovsiannikova T, Owen P, Oyanguren A, Pais PR, Pajero T, Palano A, Palutan M, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Pereima D, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pietrzyk B, Pietrzyk G, Pikies M, Pili M, Pinci D, Pinzino J, Pisani F, Piucci A, Placinta V, Playfer S, Plews J, Plo Casasus M, Polci F, Poli Lener M, Poliakova M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Poslavskii S, Price E, Prouve C, Pugatch V, Puig Navarro A, Pullen H, Punzi G, Qian W, Qin J, Quagliani R, Quintana B, Raab NV, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Ratnikov F, Raven G, Ravonel Salzgeber M, Reboud M, Redi F, Reichert S, Dos Reis AC, Reiss F, Remon Alepuz C, Ren Z, Renaudin V, Ricciardi S, Richards S, Rinnert K, Robbe P, Robert A, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Roehrken M, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Roth JD, Rotondo M, Rudolph MS, Ruf T, Ruiz Vidal J, Saborido Silva JJ, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Gras C, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarpis G, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubiger M, Schulte S, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sepulveda ES, Sergi A, Serra N, Serrano J, Sestini L, Seuthe A, Seyfert P, Shapkin M, Shears T, Shekhtman L, Shevchenko V, Shmanin E, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Skiba I, Skidmore N, Skwarnicki T, Slater MW, Smeaton JG, Smith E, Smith IT, Smith M, Soares M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spadaro Norella E, Spradlin P, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stepanova M, Stevens H, Stocchi A, Stone S, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Strokov S, Sun J, Sun L, Sun Y, Swientek K, Szabelski A, Szumlak T, Szymanski M, T'Jampens S, Tang Z, Tekampe T, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Tou DY, Tourinho Jadallah Aoude R, Tournefier E, Traill M, Tran MT, Trisovic A, Tsaregorodtsev A, Tuci G, Tully A, Tuning N, Ukleja A, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valat S, Valenti G, Van Hecke H, Van Hulse CB, Vasiliev A, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Venkateswaran A, Vernet M, Veronesi M, Vesterinen M, Viana Barbosa JV, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitkovskiy A, Vitti M, Volkov V, Vollhardt A, Vom Bruch D, Voneki B, Vorobyev A, Vorobyev V, Voropaev N, de Vries JA, Vazquez Sierra C, Waldi R, Walsh J, Wang J, Wang M, Wang Y, Wang Z, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Weisser C, Whitehead M, Wilkinson G, Wilkinson M, Williams I, Williams MRJ, Williams M, Williams T, Wilson FF, Winn M, Wislicki W, Witek M, Wormser G, Wotton SA, Wyllie K, Xiao D, Xie Y, Xing H, Xu A, Xu M, Xu Q, Xu Z, Xu Z, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zeng M, Zhang D, Zhang L, Zhang WC, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zonneveld JB, Zucchelli S

Abstract:
Using pp collision data corresponding to an integrated luminosity of 8.5 fb^{-1} recorded by the LHCb experiment at center-of-mass energies of sqrt[s]=7, 8, and 13 TeV, the observation of an excited B_{c}^{+} state in the B_{c}^{+}pi^{+}pi^{-} invariant-mass spectrum is reported. The observed peak has a mass of 6841.2+/-0.6(stat)+/-0.1(syst)+/-0.8(B_{c}^{+}) MeV/c^{2}, where the last uncertainty is due to the limited knowledge of the B_{c}^{+} mass. It is consistent with expectations of the B_{c}^{*}(2^{3}S_{1})^{+} state reconstructed without the low-energy photon from the B_{c}^{*}(1^{3}S_{1})^{+}-->B_{c}^{+}gamma decay following B_{c}^{*}(2^{3}S_{1})^{+}-->B_{c}^{*}(1^{3}S_{1})^{+}pi^{+}pi^{-}. A second state is seen with a global (local) statistical significance of 2.2sigma (3.2sigma) and a mass of 6872.1+/-1.3(stat)+/-0.1(syst)+/-0.8(B_{c}^{+}) MeV/c^{2}, and is consistent with the B_{c}(2^{1}S_{0})^{+} state. These mass measurements are the most precise to date.





07/06/2019 | phys rev lett
Observation of a Narrow Pentaquark State, P_{c}(4312)^{+}, and of the Two-Peak Structure of the P_{c}(4450)^{+}.
Aaij R, Abellan Beteta C, Adeva B, Adinolfi M, Aidala CA, Ajaltouni Z, Akar S, Albicocco P, Albrecht J, Alessio F, Alexander M, Alfonso Albero A, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Back JJ, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barsuk S, Barter W, Bartolini M, Baryshnikov F, Batozskaya V, Batsukh B, Battig A, Battista V, Bay A, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Belavin V, Belin S, Beliy N, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Beranek S, Berezhnoy A, Bernet R, Berninghoff D, Bertholet E, Bertolin A, Betancourt C, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bhasin S, Bhom J, Bieker MS, Bifani S, Billoir P, Birnkraut A, Bizzeti A, Bjorn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Bocci V, Boente Garcia O, Boettcher T, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Boubdir M, Bowcock TJV, Bozzi C, Braun S, Brea Rodriguez A, Brodski M, Brodzicka J, Brossa Gonzalo A, Brundu D, Buchanan E, Buonaura A, Burr C, Bursche A, Butter JS, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Cali S, Calladine R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carvalho Akiba K, Casais Vidal A, Casse G, Cattaneo M, Cavallero G, Cenci R, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chekalina V, Chen C, Chen S, Chitic SG, Chobanova V, Chrzaszcz M, Chubykin A, Ciambrone P, Cid Vidal X, Ciezarek G, Cindolo F, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Comerma-Montells A, Contu A, Coombs G, Coquereau S, Corti G, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Currie R, D'Ambrosio C, Da Silva CL, Dall'Occo E, Dalseno J, Danilina A, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Dean W, Decamp D, Del Buono L, Delaney B, Dembinski HP, Demmer M, Dendek A, Derkach D, Deschamps O, Desse F, Dettori F, Dey B, Di Canto A, Di Nezza P, Didenko S, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Douglas L, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Durante P, Durham JM, Dutta D, Dzhelyadin R, Dziewiecki M, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ek-In S, Ekelhof R, Eklund L, Ely S, Ene A, Escher S, Esen S, Evans T, Falabella A, Farley N, Farry S, Fazzini D, Fernandez Declara P, Fernandez Prieto A, Fernandez-Ramirez C, Ferrari F, Ferreira Lopes L, Ferreira Rodrigues F, Ferreres Sole S, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fontana M, Fontanelli F, Forty R, Franco Lima V, 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G, Morello MJ, Moron J, Morris AB, Mountain R, Mu H, Muheim F, Mukherjee M, Mulder M, Murphy CH, Murray D, Modden A, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nanut T, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Newcombe R, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nolte NS, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJG, Osborn JD, Ossowska A, Otalora Goicochea JM, Ovsiannikova T, Owen P, Oyanguren A, Pais PR, Pajero T, Palano A, Palutan M, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Pereima D, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pietrzyk B, Pietrzyk G, Pikies M, Pili M, Pilloni A, Pinci D, Pinzino J, Pisani F, Piucci A, Placinta V, Playfer S, Plews J, Plo Casasus M, Polci F, Poli Lener M, Poliakova M, 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Y, Zhu X, Zhukov V, Zonneveld JB, Zucchelli S

Abstract:
A narrow pentaquark state, P_{c}(4312)^{+}, decaying to J/psip, is discovered with a statistical significance of 7.3sigma in a data sample of Lambda_{b}^{0}-->J/psipK^{-} decays, which is an order of magnitude larger than that previously analyzed by the LHCb Collaboration. The P_{c}(4450)^{+} pentaquark structure formerly reported by LHCb is confirmed and observed to consist of two narrow overlapping peaks, P_{c}(4440)^{+} and P_{c}(4457)^{+}, where the statistical significance of this two-peak interpretation is 5.4sigma. The proximity of the Sigma_{c}^{+}D[over ]^{0} and Sigma_{c}^{+}D[over ]^{*0} thresholds to the observed narrow peaks suggests that they play an important role in the dynamics of these states.





06/06/2019 | genet sel evol
Genome-wide estimates of genetic diversity, inbreeding and effective size of experimental and commercial rainbow trout lines undergoing selective breeding.
D'Ambrosio J, Phocas F, Haffray P, Bestin A, Brard-Fudulea S, Poncet C, Quillet E, Dechamp N, Fraslin C, Charles M, Dupont-Nivet M

Abstract:
BACKGROUND: Selective breeding is a relatively recent practice in aquaculture species compared to terrestrial livestock. Nevertheless, the genetic variability of farmed salmonid lines, which have been selected for several generations, should be assessed. Indeed, a significant decrease in genetic variability due to high selection intensity could have occurred, potentially jeopardizing the long-term genetic progress as well as the adaptive capacities of populations facing change(s) in the environment. Thus, it is important to evaluate the impact of selection practices on genetic diversity to limit future inbreeding. The current study presents an analysis of genetic diversity within and between six French rainbow trout (Oncorhynchus mykiss) experimental or commercial lines based on a medium-density single nucleotide polymorphism (SNP) chip and various molecular genetic indicators: fixation index (FST), linkage disequilibrium (LD), effective population size (Ne) and inbreeding coefficient derived from runs of homozygosity (ROH). RESULTS: Our results showed a moderate level of genetic differentiation between selected lines (FST ranging from 0.08 to 0.15). LD declined rapidly over the first 100 kb, but then remained quite high at long distances, leading to low estimates of Ne in the last generation ranging from 24 to 68 depending on the line and methodology considered. These results were consistent with inbreeding estimates that varied from 10.0% in an unselected experimental line to 19.5% in a commercial line, and which are clearly higher than corresponding estimates in ruminants or pigs. In addition, strong variations in LD and inbreeding were observed along the genome that may be due to differences in local rates of recombination or due to key genes that tended to have fixed favorable alleles for domestication or production. CONCLUSIONS: This is the first report on ROH for any aquaculture species. Inbreeding appeared to be moderate to high in the six French rainbow trout lines, due to founder effects at the start of the breeding programs, but also likely to sweepstakes reproductive success in addition to selection for the selected lines. Efficient management of inbreeding is a major goal in breeding programs to ensure that populations can adapt to future breeding objectives and SNP information can be used to manage the rate at which inbreeding builds up in the fish genome.





06/2019 |
Rainbow trout resistance to bacterial cold water disease: two new quantitative trait loci identified after a natural disease outbreak on a French farm.
Fraslin C, Brard-Fudulea S, D'Ambrosio J, Bestin A, Charles M, Haffray P, Quillet E, Phocas F

Abstract:
In rainbow trout farming, Flavobacterium psychrophilum, the causative agent of bacterial cold water disease, is responsible for important economic losses. Resistance to F. psychrophilum is heritable, and several quantitative trait loci (QTL) with moderate effects have been detected, opening up promising perspectives for the genetic improvement of resistance. In most studies however, resistance to F. psychrophilum was assessed in experimental infectious challenges using injection as the infection route, which is not representative of natural infection. Indeed, injection bypasses external barriers, such as mucus and skin, that likely play a protective role against the infection. In this study, we aimed at describing the genetic architecture of the resistance to F. psychrophilum after a natural disease outbreak. In a 2000-fish cohort, reared on a French farm, 720 fish were sampled and genotyped using the medium-throughput Axiom Trout Genotyping Array. Overall mortality at the end of the outbreak was 25%. Genome-wide association studies were performed under two different models for time to death measured on 706 fish with validated genotypes for 30 060 SNPs. This study confirms the polygenic inheritance of resistance to F. psychrophilum with a few QTL with moderate effects and a large polygenic background, the heritability of the trait being estimated at 0.34. Two new chromosome-wide significant QTL and three suggestive QTL were detected, each of them explaining between 1% and 4% of genetic variance.





06/2019 | diagn microbiol infect dis
Frequency of 16S ribosomal RNA methyltransferase detection among Escherichia coli and Klebsiella pneumoniae clinical isolates obtained from patients in Canadian hospitals (CANWARD, 2013-2017).
Walkty A, Karlowsky JA, Baxter MR, Adam HJ, Boyd D, Bharat A, Mulvey MR, Charles M, Bergevin M, Zhanel GG

Abstract:
Pan-aminoglycoside (amikacin, gentamicin, tobramycin, plazomicin)-resistant Escherichia coli and Klebsiella pneumoniae clinical isolates from patients in Canadian Hospitals (2013-2017) were evaluated by whole genome sequencing for 16S ribosomal RNA methyltransferase genes. The rmtB gene was detected in 2 isolates (1 of 3094 E. coli [0.03%], 1 of 1039K. pneumoniae [0.1%]).





Abstract:
Psychoanalysis is a transformational process through which meanings become visible and foreclosed identity may be further constituted. Winnicott (1971) marks the crucial developmental function of the relationship that is good enough to tolerate the separateness of the other. The analyst's ability to 'take the transference' enables the patient to locate himself in relation to another mind and being in ways that did not happen sufficiently in childhood. This process requires the signification of personal meanings that can become consensual without subverting one's own becoming in the process. The dream provides idiosyncratic images that can demarcate conceptual space in ways that can enable the individual to move from the sign to the symbol; from what Kleinians term the symbolic equation, to the symbol proper, the domain of language and consensual meanings. I describe a case in which one young man used his dreams as a way of moving from a universe in which meanings could not be made into one in which he could build meanings in relation to his own experience and ideas.





31/05/2019 | phys rev lett
Observation of CP Violation in Charm Decays.
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Idzik M, Ilten P, Inglessi A, Inyakin A, Ivshin K, Jacobsson R, Jakobsen S, Jalocha J, Jans E, Jashal BK, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kazeev N, Kecke M, Keizer F, Kelsey M, Kenzie M, Ketel T, Khanji B, Kharisova A, Khurewathanakul C, Kim KE, Kirn T, Kirsebom VS, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Kopecna R, Koppenburg P, Kostiuk I, Kotriakhova S, Kozeiha M, Kravchuk L, Kreps M, Kress F, Kretzschmar S, Krokovny P, Krupa W, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kunde GJ, Kuonen AK, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lancierini D, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, Leflat A, Lefevre R, Lemaitre F, Leroy O, Lesiak T, Leverington B, Li H, Li PR, Li X, Li Y, Li Z, Liang X, Likhomanenko T, Lindner R, Ling P, Lionetto F, Lisovskyi V, Liu G, Liu X, Loh D, Loi A, Longstaff I, Lopes JH, Loustau G, Lovell GH, Lucchesi D, Lucio Martinez M, Luo Y, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Ma R, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Maev O, Maguire K, Maisuzenko D, Majewski MW, Malde S, Malecki B, Malinin A, Maltsev T, Malygina H, Manca G, Mancinelli G, Marangotto D, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Marshall PJ, Martellotti G, Martinelli M, Martinez Santos D, Martinez Vidal F, Massafferri A, Materok M, Matev R, Mathad A, Mathe Z, Matiunin V, Matteuzzi C, Mattioli KR, Mauri A, Maurice E, Maurin B, McCann M, McNab A, McNulty R, Mead JV, Meadows B, Meaux C, Meinert N, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Millard E, Minard MN, Minzoni L, Mitzel DS, Mogini A, Moise RD, Mombacher T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Moron J, Morris AB, Mountain R, Muheim F, Mukherjee M, Mulder M, Murphy CH, Murray D, Modden A, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nanut T, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Newcombe R, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nolte NS, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJG, Osborn JD, Ossowska A, Otalora Goicochea JM, Ovsiannikova T, Owen P, Oyanguren A, Pais PR, Pajero T, Palano A, Palutan M, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Pereima D, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pietrzyk B, Pietrzyk G, Pikies M, Pili M, Pinci D, Pinzino J, Pisani F, Piucci A, Placinta V, Playfer S, Plews J, Plo Casasus M, Polci F, Poli Lener M, Poliakova M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Poslavskii S, Price E, Prouve C, Pugatch V, Puig Navarro A, Pullen H, Punzi G, Qian W, Qin J, Quagliani R, Quintana B, Raab NV, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Ratnikov F, Raven G, Ravonel Salzgeber M, Reboud M, Redi F, Reichert S, Dos Reis AC, Reiss F, Remon Alepuz C, Ren Z, Renaudin V, Ricciardi S, Richards S, Rinnert K, Robbe P, Robert A, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Roehrken M, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Roth JD, Rotondo M, Rudolph MS, Ruf T, Ruiz Vidal J, Saborido Silva JJ, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Gras C, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarpis G, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubiger M, Schulte S, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sepulveda ES, Sergi A, Serra N, Serrano J, Sestini L, Seuthe A, Seyfert P, Shapkin M, Shears T, Shekhtman L, Shevchenko V, Shmanin E, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Skiba I, Skidmore N, Skwarnicki T, Slater MW, Smeaton JG, Smith E, Smith IT, Smith M, Soares M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spadaro Norella E, Spradlin P, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stepanova M, Stevens H, Stocchi A, Stone S, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Strokov S, Sun J, Sun L, Sun Y, Swientek K, Szabelski A, Szumlak T, Szymanski M, T'Jampens S, Tang Z, Tekampe T, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Tou DY, Tourinho Jadallah Aoude R, Tournefier E, Traill M, Tran MT, Trisovic A, Tsaregorodtsev A, Tuci G, Tully A, Tuning N, Ukleja A, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valat S, Valenti G, Van Hecke H, Van Hulse CB, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Venkateswaran A, Vernet M, Veronesi M, Vesterinen M, Viana Barbosa JV, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitkovskiy A, Vitti M, Volkov V, Vollhardt A, Vom Bruch D, Voneki B, Vorobyev A, Vorobyev V, Voropaev N, de Vries JA, Vazquez Sierra C, Waldi R, Walsh J, Wang J, Wang M, Wang Y, Wang Z, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Weisser C, Whitehead M, Wilkinson G, Wilkinson M, Williams I, Williams MRJ, Williams M, Williams T, Wilson FF, Winn M, Wislicki W, Witek M, Wormser G, Wotton SA, Wyllie K, Xiao D, Xie Y, Xing H, Xu A, Xu M, Xu Q, Xu Z, Xu Z, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zeng M, Zhang D, Zhang L, Zhang WC, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zonneveld JB, Zucchelli S

Abstract:
A search for charge-parity (CP) violation in D^{0}-->K^{-}K^{+} and D^{0}-->pi^{-}pi^{+} decays is reported, using pp collision data corresponding to an integrated luminosity of 5.9 fb^{-1} collected at a center-of-mass energy of 13 TeV with the LHCb detector. The flavor of the charm meson is inferred from the charge of the pion in D^{*}(2010)^{+}-->D^{0}pi^{+} decays or from the charge of the muon in B[over ]-->D^{0}mu^{-}nu[over ]_{mu}X decays. The difference between the CP asymmetries in D^{0}-->K^{-}K^{+} and D^{0}-->pi^{-}pi^{+} decays is measured to be DeltaA_{CP}=[-18.2+/-3.2(stat)+/-0.9(syst)]x10^{-4} for pi-tagged and DeltaA_{CP}=[-9+/-8(stat)+/-5(syst)]x10^{-4} for mu-tagged D^{0} mesons. Combining these with previous LHCb results leads to DeltaA_{CP}=(-15.4+/-2.9)x10^{-4}, where the uncertainty includes both statistical and systematic contributions. The measured value differs from zero by more than 5 standard deviations. This is the first observation of CP violation in the decay of charm hadrons.





17/05/2019 | phys rev lett
Observation of B_{(s)}^{0}-->J/psipp[over ] Decays and Precision Measurements of the B_{(s)}^{0} Masses.
Aaij R, Abellan Beteta C, Adeva B, Adinolfi M, Aidala CA, Ajaltouni Z, Akar S, Albicocco P, Albrecht J, Alessio F, Alexander M, Alfonso Albero A, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Archilli F, Arnau Romeu J, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Back JJ, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barrand GC, Barsuk S, Barter W, Bartolini M, Baryshnikov F, Batozskaya V, Batsukh B, Battig A, Battista V, Bay A, Beddow J, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Belin S, Beliy N, Bellee V, Belloli N, Belous K, Belyaev I, Bencivenni G, Ben-Haim E, Benson S, Beranek S, Berezhnoy A, Bernet R, Berninghoff D, Bertholet E, Bertolin A, Betancourt C, Betti F, Bettler MO, Bezshyiko I, Bhasin S, Bhom J, Bieker MS, Bifani S, Billoir P, Birnkraut A, Bizzeti A, Bjorn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Bocci V, Boente Garcia O, Boettcher T, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Boubdir M, Bowcock TJV, Bozzi C, Braun S, Brodski M, Brodzicka J, Brossa Gonzalo A, Brundu D, Buchanan E, Buonaura A, Burr C, Bursche A, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Calladine R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carvalho Akiba K, Casse G, Cattaneo M, Cavallero G, Cenci R, Chamont D, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chekalina V, Chen C, Chen S, Chitic SG, Chobanova V, Chrzaszcz M, Chubykin A, Ciambrone P, Cid Vidal X, Ciezarek G, Cindolo F, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Comerma-Montells A, Contu A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Currie R, Da Cunha Marinho F, Da Silva CL, Dall'Occo E, Dalseno J, D'Ambrosio C, Danilina A, d'Argent P, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, de Vries JA, Dean CT, Dean W, Decamp D, Del Buono L, Delaney B, Dembinski HP, Demmer M, Dendek A, Derkach D, Deschamps O, Desse F, Dettori F, Dey B, Di Canto A, Di Nezza P, Didenko S, Dijkstra H, Dordei F, Dorigo M, Dos Reis AC, Dosil Suarez A, Douglas L, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Durante P, Durham JM, Dutta D, Dzhelyadin R, Dziewiecki M, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Ene A, Escher S, Esen S, Evans T, Falabella A, Farber C, Farley N, Farry S, Fazzini D, Feo M, Fernandez Declara P, Fernandez Prieto A, Ferrari F, Ferreira Lopes L, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fontana M, Fontanelli F, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Gabriel E, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gan Y, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garcia Plana B, Garra Tico J, Garrido L, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Gerstel D, Ghez P, Gibson V, Girard OG, Gironella Gironell P, Giubega L, Gizdov K, Gligorov VV, Gobel C, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Grabowski JP, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruber L, Gruberg Cazon BR, Grunberg O, Gu C, Gushchin E, Guth A, Guz Y, Gys T, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han X, Hancock TH, Hansmann-Menzemer S, Harnew N, Harrison T, Hasse C, Hatch M, He J, Hecker M, Heinicke K, Heister A, Hennessy K, Henry L, Hess M, Heuel J, Hicheur A, Hidalgo Charman R, Hill D, Hilton M, Hopchev PH, Hu J, Hu W, Huang W, Huard ZC, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Hynds D, Ibis P, Idzik M, Ilten P, Inglessi A, Inyakin A, Ivshin K, Jacobsson R, Jalocha J, Jans E, Jashal BK, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kazeev N, Kecke M, Keizer F, Kelsey M, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kim KE, Kirn T, Kirsebom VS, Klaver S, Klimaszewski K, Klimkovich T, Koliiev S, Kolpin M, Kopecna R, Koppenburg P, Kostiuk I, Kotriakhova S, Kozeiha M, Kravchuk L, Kreps M, Kress F, Krokovny P, Krupa W, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lancierini D, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, Lefevre R, Leflat A, Lemaitre F, Leroy O, Lesiak T, Leverington B, Li PR, Li Y, Li Z, Liang X, Likhomanenko T, Lindner R, Lionetto F, Lisovskyi V, Liu G, Liu X, Loh D, Loi A, Longstaff I, Lopes JH, Lovell GH, Lucchesi D, Lucio Martinez M, Luo Y, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Maev O, Maguire K, Maisuzenko D, Majewski MW, Malde S, Malecki B, Malinin A, Maltsev T, Malygina H, Manca G, Mancinelli G, Marangotto D, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Marshall PJ, Martellotti G, Martinelli M, Martinez Santos D, Martinez Vidal F, Massafferri A, Materok M, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurice E, Maurin B, McCann M, McNab A, McNulty R, Mead JV, Meadows B, Meaux C, Meinert N, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Millard E, Minard MN, Minzoni L, Mitzel DS, Modden A, Mogini A, Moise RD, Mombacher T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Morgunova O, Moron J, Morris AB, Mountain R, Muheim F, Mukherjee M, Mulder M, Muller D, Muller J, Muller K, Muller V, Murphy CH, Murray D, Naik P, Nakada T, Nandakumar R, Nandi A, Nanut T, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Newcombe R, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nogay A, Nolte NS, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, O'Hanlon DP, Oldeman R, Onderwater CJG, Ossowska A, Otalora Goicochea JM, Ovsiannikova T, Owen P, Oyanguren A, Pais PR, Pajero T, Palano A, Palutan M, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Pereima D, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pietrzyk B, Pietrzyk G, Pikies M, Pili M, Pinci D, Pinzino J, Pisani F, Piucci A, Placinta V, Playfer S, Plews J, Plo Casasus M, Polci F, Poli Lener M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Poslavskii S, Price E, Prisciandaro J, Prouve C, Pugatch V, Puig Navarro A, Pullen H, Punzi G, Qian W, Qin J, Quagliani R, Quintana B, Raab NV, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Ratnikov F, Raven G, Ravonel Salzgeber M, Reboud M, Redi F, Reichert S, Reiss F, Remon Alepuz C, Ren Z, Renaudin V, Ricciardi S, Richards S, Rinnert K, Robbe P, Robert A, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Roehrken M, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Roth JD, Rotondo M, Rudolph MS, Ruf T, Ruiz Vidal J, Saborido Silva JJ, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Gras C, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarpis G, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubiger M, Schulte S, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sepulveda ES, Sergi A, Serra N, Serrano J, Sestini L, Seuthe A, Seyfert P, Shapkin M, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Shmanin E, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Skiba I, Skidmore N, Skwarnicki T, Slater MW, Smeaton JG, Smith E, Smith IT, Smith M, Soares M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spadaro Norella E, Spradlin P, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stepanova M, Stevens H, Stocchi A, Stone S, Storaci B, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Strokov S, Sun J, Sun L, Sun Y, Swientek K, Szabelski A, Szumlak T, Szymanski M, Tang Z, Tekampe T, Tellarini G, Teubert F, Thomas E, Tilley MJ, Tisserand V, T'Jampens S, Tobin M, Tolk S, Tomassetti L, Tonelli D, Tou DY, Tourinho Jadallah Aoude R, Tournefier E, Traill M, Tran MT, Trisovic A, Tsaregorodtsev A, Tuci G, Tully A, Tuning N, Ukleja A, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valat S, Valenti G, van Beuzekom M, van Herwijnen E, van Tilburg J, van Veghel M, Vazquez Gomez R, Vazquez Regueiro P, Vazquez Sierra C, Vecchi S, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Vernet M, Veronesi M, Vesterinen M, Viana Barbosa JV, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitkovskiy A, Vitti M, Volkov V, Vollhardt A, Vom Bruch D, Voneki B, Vorobyev A, Vorobyev V, Voropaev N, Waldi R, Walsh J, Wang J, Wang M, Wang Y, Wang Z, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Weisser C, Whitehead M, Wilkinson G, Wilkinson M, Williams I, Williams M, Williams MRJ, Williams T, Wilson FF, Winn M, Wislicki W, Witek M, Wormser G, Wotton SA, Wyllie K, Xiao D, Xie Y, Xu A, Xu M, Xu Q, Xu Z, Xu Z, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang D, Zhang L, Zhang WC, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zonneveld JB, Zucchelli S

Abstract:
The first observation of the decays B_{(s)}^{0}-->J/psipp[over ] is reported, using proton-proton collision data corresponding to an integrated luminosity of 5.2 fb^{-1}, collected with the LHCb detector. These decays are suppressed due to limited available phase space, as well as due to Okubo-Zweig-Iizuka or Cabibbo suppression. The measured branching fractions are B(B^{0}-->J/psipp[over ])=[4.51+/-0.40(stat)+/-0.44(syst)]x10^{-7}, B(B_{s}^{0}-->J/psipp[over ])=[3.58+/-0.19(stat)+/-0.39(syst)]x10^{-6}. For the B_{s}^{0} meson, the result is much higher than the expected value of O(10^{-9}). The small available phase space in these decays also allows for the most precise single measurement of both the B^{0} mass as 5279.74+/-0.30(stat)+/-0.10(syst) MeV and the B_{s}^{0} mass as 5366.85+/-0.19(stat)+/-0.13(syst) MeV.





17/05/2019 | phys rev lett
Search for Lepton-Universality Violation in B^{+}-->K^{+}l^{+}l^{-} Decays.
Aaij R, Abellan Beteta C, Adeva B, Adinolfi M, Aidala CA, Ajaltouni Z, Akar S, Albicocco P, Albrecht J, Alessio F, Alexander M, Alfonso Albero A, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Archilli F, Arnau Romeu J, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Back JJ, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barsuk S, Barter W, Bartolini M, Baryshnikov F, Batozskaya V, Batsukh B, Battig A, Battista V, Bay A, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Belin S, Beliy N, Bellee V, Belloli N, Belous K, Belyaev I, Bencivenni G, Ben-Haim E, Benson S, Beranek S, Berezhnoy A, Bernet R, Berninghoff D, Bertholet E, Bertolin A, Betancourt C, Betti F, Bettler MO, Bezshyiko I, Bhasin S, Bhom J, Bieker MS, Bifani S, Billoir P, Birnkraut A, Bizzeti A, Bjorn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Bocci V, Boente Garcia O, Boettcher T, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Boubdir M, Bowcock TJV, Bozzi C, Braun S, Brodski M, Brodzicka J, Brossa Gonzalo A, Brundu D, Buchanan E, Buonaura A, Burr C, Bursche A, Butter J, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Cali S, Calladine R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carvalho Akiba K, Casse G, Cattaneo M, Cavallero G, Cenci R, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chekalina V, Chen C, Chen S, Chitic SG, Chobanova V, Chrzaszcz M, Chubykin A, Ciambrone P, Cid Vidal X, Ciezarek G, Cindolo F, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Comerma-Montells A, Contu A, Coombs G, Coquereau S, Corti G, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Currie R, Da Silva CL, Dall'Occo E, Dalseno J, D'Ambrosio C, Danilina A, d'Argent P, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, de Vries JA, Dean CT, Dean W, Decamp D, Del Buono L, Delaney B, Dembinski HP, Demmer M, Dendek A, Derkach D, Deschamps O, Desse F, Dettori F, Dey B, Di Canto A, Di Nezza P, Didenko S, Dijkstra H, Dordei F, Dorigo M, Dos Reis AC, Dosil Suarez A, Douglas L, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Durante P, Durham JM, Dutta D, Dzhelyadin R, Dziewiecki M, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Ene A, Escher S, Esen S, Evans T, Falabella A, Farber C, Farley N, Farry S, Fazzini D, Feo M, Fernandez Declara P, Fernandez Prieto A, Ferrari F, Ferreira Lopes L, Ferreira Rodrigues F, Ferreres Sole S, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fontana M, Fontanelli F, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Gabriel E, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gan Y, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garcia Plana B, Garra Tico J, Garrido L, Gascon D, Gaspar C, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Gerstel D, Ghez P, Gibson V, Girard OG, Gironella Gironell P, Giubega L, Gizdov K, Gligorov VV, Gobel C, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Grabowski JP, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruber L, Gruberg Cazon BR, Gu C, Gushchin E, Guth A, Guz Y, Gys T, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han Q, Han X, Hancock TH, Hansmann-Menzemer S, Harnew N, Harrison T, Hasse C, Hatch M, He J, Hecker M, Heinicke K, Heister A, Hennessy K, Henry L, Hess M, Heuel J, Hicheur A, Hidalgo Charman R, Hill D, Hilton M, Hopchev PH, Hu J, Hu W, Huang W, Huard ZC, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Hynds D, Ibis P, Idzik M, Ilten P, Inglessi A, Inyakin A, Ivshin K, Jacobsson R, Jakobsen S, Jalocha J, Jans E, Jashal BK, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kazeev N, Kecke M, Keizer F, Kelsey M, Kenzie M, Ketel T, Khanji B, Kharisova A, Khurewathanakul C, Kim KE, Kirn T, Kirsebom VS, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Kopecna R, Koppenburg P, Kostiuk I, Kotriakhova S, Kozeiha M, Kravchuk L, Kreps M, Kress F, Kretzschmar S, Krokovny P, Krupa W, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kunde GJ, Kuonen AK, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lancierini D, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, Lefevre R, Leflat A, Lemaitre F, Leroy O, Lesiak T, Leverington B, Li H, Li PR, Li X, Li Y, Li Z, Liang X, Likhomanenko T, Lindner R, Lionetto F, Lisovskyi V, Liu G, Liu X, Loh D, Loi A, Longstaff I, Lopes JH, Loustau G, Lovell GH, Lucchesi D, Lucio Martinez M, Luo Y, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Maev O, Maguire K, Maisuzenko D, Majewski MW, Malde S, Malecki B, Malinin A, Maltsev T, Malygina H, Manca G, Mancinelli G, Marangotto D, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Marshall PJ, Martellotti G, Martinelli M, Martinez Santos D, Martinez Vidal F, Massafferri A, Materok M, Matev R, Mathad A, Mathe Z, Matiunin V, Matteuzzi C, Mattioli KR, Mauri A, Maurice E, Maurin B, McCann M, McNab A, McNulty R, Mead JV, Meadows B, Meaux C, Meinert N, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Millard E, Minard MN, Minzoni L, Mitzel DS, Modden A, Mogini A, Moise RD, Mombacher T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Moron J, Morris AB, Mountain R, Muheim F, Mukherjee M, Mulder M, Muller D, Muller J, Muller K, Muller V, Murphy CH, Murray D, Naik P, Nakada T, Nandakumar R, Nandi A, Nanut T, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Newcombe R, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nolte NS, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, O'Hanlon DP, Oldeman R, Onderwater CJG, Osborn JD, Ossowska A, Otalora Goicochea JM, Ovsiannikova T, Owen P, Oyanguren A, Pais PR, Pajero T, Palano A, Palutan M, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Pereima D, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pietrzyk B, Pietrzyk G, Pikies M, Pili M, Pinci D, Pinzino J, Pisani F, Piucci A, Placinta V, Playfer S, Plews J, Plo Casasus M, Polci F, Poli Lener M, Poliakova M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Poslavskii S, Price E, Prouve C, Pugatch V, Puig Navarro A, Pullen H, Punzi G, Qian W, Qin J, Quagliani R, Quintana B, Raab NV, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Ratnikov F, Raven G, Ravonel Salzgeber M, Reboud M, Redi F, Reichert S, Reiss F, Remon Alepuz C, Ren Z, Renaudin V, Ricciardi S, Richards S, Rinnert K, Robbe P, Robert A, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Roehrken M, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Roth JD, Rotondo M, Rudolph MS, Ruf T, Ruiz Vidal J, Saborido Silva JJ, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Gras C, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarpis G, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubiger M, Schulte S, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sepulveda ES, Sergi A, Serra N, Serrano J, Sestini L, Seuthe A, Seyfert P, Shapkin M, Shears T, Shekhtman L, Shevchenko V, Shmanin E, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Skiba I, Skidmore N, Skwarnicki T, Slater MW, Smeaton JG, Smith E, Smith IT, Smith M, Soares M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spadaro Norella E, Spradlin P, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stepanova M, Stevens H, Stocchi A, Stone S, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Strokov S, Sun J, Sun L, Sun Y, Swientek K, Szabelski A, Szumlak T, Szymanski M, Tang Z, Tekampe T, Tellarini G, Teubert F, Thomas E, Tilley MJ, Tisserand V, T'Jampens S, Tobin M, Tolk S, Tomassetti L, Tonelli D, Tou DY, Tourinho Jadallah Aoude R, Tournefier E, Traill M, Tran MT, Trisovic A, Tsaregorodtsev A, Tuci G, Tully A, Tuning N, Ukleja A, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valat S, Valenti G, van Beuzekom M, Van Hecke H, van Herwijnen E, Van Hulse CB, van Tilburg J, van Veghel M, Vazquez Gomez R, Vazquez Regueiro P, Vazquez Sierra C, Vecchi S, Velthuis JJ, Veltri M, Venkateswaran A, Vernet M, Veronesi M, Vesterinen M, Viana Barbosa JV, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitkovskiy A, Vitti M, Volkov V, Vollhardt A, Vom Bruch D, Voneki B, Vorobyev A, Vorobyev V, Voropaev N, Waldi R, Walsh J, Wang J, Wang M, Wang Y, Wang Z, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Weisser C, Whitehead M, Wilkinson G, Wilkinson M, Williams I, Williams M, Williams MRJ, Williams T, Wilson FF, Winn M, Wislicki W, Witek M, Wormser G, Wotton SA, Wyllie K, Xiao D, Xie Y, Xing H, Xu A, Xu M, Xu Q, Xu Z, Xu Z, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zeng M, Zhang D, Zhang L, Zhang WC, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zonneveld JB, Zucchelli S

Abstract:
A measurement of the ratio of branching fractions of the decays B^{+}-->K^{+}mu^{+}mu^{-} and B^{+}-->K^{+}e^{+}e^{-} is presented. The proton-proton collision data used correspond to an integrated luminosity of 5.0 fb^{-1} recorded with the LHCb experiment at center-of-mass energies of 7, 8, and 13 TeV. For the dilepton mass-squared range 1.1<q^{2}<6.0 GeV^{2}/c^{4} the ratio of branching fractions is measured to be R_{K}=0.846_{-0.054}^{+0.060}_{-0.014}^{+0.016}, where the first uncertainty is statistical and the second systematic. This is the most precise measurement of R_{K} to date and is compatible with the standard model at the level of 2.5 standard deviations.





17/05/2019 | phys rev lett
Search for CP Violation in D_{s}^{+}-->K_{S}^{0}pi^{+}, D^{+}-->K_{S}^{0}K^{+}, and D^{+}-->varphipi^{+} Decays.
Aaij R, Abellan Beteta C, Adeva B, Adinolfi M, Aidala CA, Ajaltouni Z, Akar S, Albicocco P, Albrecht J, Alessio F, Alexander M, Alfonso Albero A, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Back JJ, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barrand GC, Barsuk S, Barter W, Bartolini M, Baryshnikov F, Batozskaya V, Batsukh B, Battig A, Battista V, Bay A, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Belin S, Beliy N, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Beranek S, Berezhnoy A, Bernet R, Berninghoff D, Bertholet E, Bertolin A, Betancourt C, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bhasin S, Bhom J, Bieker MS, Bifani S, Billoir P, Birnkraut A, Bizzeti A, Bjorn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Bocci V, Boente Garcia O, Boettcher T, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Boubdir M, Bowcock TJV, Bozzi C, Braun S, Brodski M, Brodzicka J, Brossa Gonzalo A, Brundu D, Buchanan E, Buonaura A, Burr C, Bursche A, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Calladine R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carvalho Akiba K, Casse G, Cattaneo M, Cavallero G, Cenci R, Chamont D, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chekalina V, Chen C, Chen S, Chitic SG, Chobanova V, Chrzaszcz M, Chubykin A, Ciambrone P, Cid Vidal X, Ciezarek G, Cindolo F, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Comerma-Montells A, Contu A, Coombs G, Coquereau S, Corti G, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Currie R, D'Ambrosio C, Da Silva CL, Dall'Occo E, Dalseno J, Danilina A, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Dean W, Decamp D, Del Buono L, Delaney B, Dembinski HP, Demmer M, Dendek A, Derkach D, Deschamps O, Desse F, Dettori F, Dey B, Di Canto A, Di Nezza P, Didenko S, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Douglas L, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Durante P, Durham JM, Dutta D, Dzhelyadin R, Dziewiecki M, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Ene A, Escher S, Esen S, Evans T, Falabella A, Farley N, Farry S, Fazzini D, Fernandez Declara P, Fernandez Prieto A, Ferrari F, Ferreira Lopes L, Ferreira Rodrigues F, Ferreres Sole S, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fontana M, Fontanelli F, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Farber C, Feo M, Gabriel E, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gan Y, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Plana B, Garcia Pardinas J, Garra Tico J, Garrido L, Gascon D, Gaspar C, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Gerstel D, Ghez P, Gibson V, Girard OG, Gironella Gironell P, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Grabowski JP, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruber L, Gruberg Cazon BR, Gu C, Guo X, Gushchin E, Guth A, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han X, Hancock TH, Hansmann-Menzemer S, Harnew N, Harrison T, Hasse C, Hatch M, He J, Hecker M, Heinicke K, Heister A, Hennessy K, Henry L, van Herwijnen E, Heuel J, Hess M, Hicheur A, Hidalgo Charman R, Hill D, Hilton M, Hopchev PH, Hu J, Hu W, Huang W, Huard ZC, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Hynds D, Ibis P, Idzik M, Ilten P, Inglessi A, Inyakin A, Ivshin K, Jacobsson R, Jakobsen S, Jalocha J, Jans E, Jashal BK, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kazeev N, Kecke M, Keizer F, Kelsey M, Kenzie M, Ketel T, Khanji B, Kharisova A, Khurewathanakul C, Kim KE, Kirn T, Kirsebom VS, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Kopecna R, Koppenburg P, Kostiuk I, Kotriakhova S, Kozeiha M, Kravchuk L, Kreps M, Kress F, Kretzschmar S, Krokovny P, Krupa W, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kunde GJ, Kuonen AK, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lancierini D, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, Leflat A, Lefevre R, Lemaitre F, Leroy O, Lesiak T, Leverington B, Li H, Li PR, Li Y, Li Z, Liang X, Likhomanenko T, Lindner R, Ling P, Lionetto F, Lisovskyi V, Liu G, Liu X, Loh D, Loi A, Longstaff I, Lopes JH, Loustau G, Lovell GH, Lucchesi D, Lucio Martinez M, Luo Y, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Ma R, Maccolini S, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Maev O, Maguire K, Maisuzenko D, Majewski MW, Malde S, Malecki B, Malinin A, Maltsev T, Malygina H, Manca G, Mancinelli G, Marangotto D, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Marshall PJ, Martellotti G, Martinelli M, Martinez Santos D, Martinez Vidal F, Massafferri A, Materok M, Matev R, Mathad A, Mathe Z, Matiunin V, Matteuzzi C, Mattioli KR, Mauri A, Maurice E, Maurin B, McCann M, McNab A, McNulty R, Mead JV, Meadows B, Meaux C, Meinert N, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Millard E, Minard MN, Minzoni L, Mitzel DS, Mogini A, Moise RD, Mombacher T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Moron J, Morris AB, Mountain R, Muheim F, Mukherjee M, Mulder M, Murphy CH, Murray D, Modden A, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nanut T, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Newcombe R, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nolte NS, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJG, Osborn JD, Ossowska A, Otalora Goicochea JM, Ovsiannikova T, Owen P, Oyanguren A, Pais PR, Pajero T, Palano A, Palutan M, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Pereima D, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pietrzyk B, Pietrzyk G, Pikies M, Pili M, Pinci D, Pinzino J, Pisani F, Piucci A, Placinta V, Playfer S, Plews J, Plo Casasus M, Polci F, Poli Lener M, Poliakova M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Poslavskii S, Price E, Prouve C, Pugatch V, Puig Navarro A, Pullen H, Punzi G, Qian W, Qin J, Quagliani R, Quintana B, Raab NV, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Ratnikov F, Raven G, Ravonel Salzgeber M, Reboud M, Redi F, Reichert S, Dos Reis AC, Reiss F, Remon Alepuz C, Ren Z, Renaudin V, Ricciardi S, Richards S, Rinnert K, Robbe P, Robert A, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Roehrken M, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Roth JD, Rotondo M, Rudolph MS, Ruf T, Ruiz Vidal J, Saborido Silva JJ, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Gras C, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarpis G, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubiger M, Schulte S, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sepulveda ES, Sergi A, Serra N, Serrano J, Sestini L, Seuthe A, Seyfert P, Shapkin M, Shears T, Shekhtman L, Shevchenko V, Shmanin E, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Skiba I, Skidmore N, Skwarnicki T, Slater MW, Smeaton JG, Smith E, Smith IT, Smith M, Soares M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spadaro Norella E, Spradlin P, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stepanova M, Stevens H, Stocchi A, Stone S, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Strokov S, Sun J, Sun L, Sun Y, Swientek K, Szabelski A, Szumlak T, Szymanski M, T'Jampens S, Tang Z, Tekampe T, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Tou DY, Tourinho Jadallah Aoude R, Tournefier E, Traill M, Tran MT, Trisovic A, Tsaregorodtsev A, Tuci G, Tully A, Tuning N, Ukleja A, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valat S, Valenti G, Van Hecke H, Van Hulse CB, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Venkateswaran A, Vernet M, Veronesi M, Vesterinen M, Viana Barbosa JV, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitkovskiy A, Vitti M, Volkov V, Vollhardt A, Vom Bruch D, Voneki B, Vorobyev A, Vorobyev V, Voropaev N, de Vries JA, Vazquez Sierra C, Waldi R, Walsh J, Wang J, Wang M, Wang Y, Wang Z, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Weisser C, Whitehead M, Wilkinson G, Wilkinson M, Williams I, Williams MRJ, Williams M, Williams T, Wilson FF, Winn M, Wislicki W, Witek M, Wormser G, Wotton SA, Wyllie K, Xiao D, Xie Y, Xing H, Xu A, Xu M, Xu Q, Xu Z, Xu Z, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zeng M, Zhang D, Zhang L, Zhang WC, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zonneveld JB, Zucchelli S

Abstract:
A search for charge-parity (CP) violation in Cabibbo-suppressed D_{s}^{+}-->K_{S}^{0}pi^{+}, D^{+}-->K_{S}^{0}K^{+}, and D^{+}-->varphipi^{+} decays is reported using proton-proton collision data, corresponding to an integrated luminosity of 3.8 fb^{-1}, collected at a center-of-mass energy of 13 TeV with the LHCb detector. High-yield samples of kinematically and topologically similar Cabibbo-favored D_{(s)}^{+} decays are analyzed to subtract nuisance asymmetries due to production and detection effects, including those induced by CP violation in the neutral kaon system. The results areA_{CP}(D_{s}^{+}-->K_{S}^{0}pi^{+})=(1.3+/-1.9+/-0.5)x10^{-3},A_{CP}(D^{+}-->K _{S}^{0}K^{+})=(-0.09+/-0.65+/-0.48)x10^{-3},A_{CP}(D^{+}-->varphipi^{+})=(0.05+/ -0.42+/-0.29)x10^{-3},where the first uncertainties are statistical and the second systematic. They are the most precise measurements of these quantities to date, and are consistent with CP symmetry. A combination with previous LHCb measurements, based on data collected at 7 and 8 TeV, is also reported.





05/2019 | pediatr infect dis j
High Levels of HIV-1 Drug Resistance in Children Who Acquired HIV Infection Through Mother to Child Transmission in the Era of Option B+, Haiti, 2013 to 2014.
Louis FJ, Segaren N, Desinor O, Beard RS, Jean-Louis R, Chang J, Boisson S, Hulland EN, Wagar N, DeVos J, Francois K, Buteau J, Boncy J, Marston BJ, Domercant JW, Yang C, Charles M

Abstract:
BACKGROUND: The main objective of this study was to determine the frequency and patterns of HIV drug resistance-associated mutations among children under 18 months of age born to HIV-1-positive mothers enrolled in the prevention of mother-to-child transmission services in Haiti. METHODS: Between January 1, 2013 and December 31, 2014, HIV-positive remnant dried blood spots collected from children under 18 months of age for Early Infant Diagnosis at the National Public Health Laboratory were used for HIV-1 genotyping. HIV drug resistance mutations were analyzed using the Stanford Drug Resistance HIVdb program. RESULTS: Of the 3555 dried blood spots collected for Early Infant Diagnosis, 360 (10.1%) were HIV-positive and 355 were available for genotyping. Of these, 304 (85.6%) were successfully genotyped and 217 (71.4%) had >/=1 drug resistance mutation. Mutations conferring resistance to nucleoside reverse transcriptase inhibitor (NRTIs) and non-NRTIs were present in 40.5% (123) and 69.1% (210), respectively. The most frequent mutations were K103N/S (48.0%), M184V (37.5%), G190A/S (15.1%), and Y181C/G/V (14.1%). Predicted drug resistance analysis revealed that 68.8% of the children had high-level resistance to non-NRTIs and 11.5% had intermediate to high-level resistance to abacavir. CONCLUSIONS: This study showed high rates of resistance to NRTIs and non-NRTIs among newly HIV-diagnosed children in Haiti, suggesting that in the era of 'Option B+' (initiation of lifelong combination antiretroviral therapy to pregnant women with HIV), the majority of children who acquire HIV infection through mother-to-child transmission of HIV have resistant HIV. These results have led the National HIV Program to revise the pediatric guidelines to include protease inhibitors in first-line regimens for all HIV-positive newborns.





19/04/2019 | phys rev lett
Model-Independent Observation of Exotic Contributions to B^{0}-->J/psiK^{+}pi^{-} Decays.
Aaij R, Abellan Beteta C, Adeva B, Adinolfi M, Aidala CA, Ajaltouni Z, Akar S, Albicocco P, Albrecht J, Alessio F, Alexander M, Alfonso Albero A, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Archilli F, Arnau Romeu J, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Back JJ, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barsuk S, Barter W, Bartolini M, Baryshnikov F, Batozskaya V, Batsukh B, Battig A, Battista V, Bay A, Beddow J, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Belin S, Beliy N, Bellee V, Belloli N, Belous K, Belyaev I, Bencivenni G, Ben-Haim E, Benson S, Beranek S, Berezhnoy A, Bernet R, Berninghoff D, Bertholet E, Bertolin A, Betancourt C, Betti F, Bettler MO, Bezshyiko I, Bhasin S, Bhom J, Bifani S, Billoir P, Birnkraut A, Bizzeti A, Bjorn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Bocci V, Boente Garcia O, Boettcher T, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJV, Bozzi C, Braun S, Brodski M, Brodzicka J, Brossa Gonzalo A, Brundu D, Buchanan E, Buonaura A, Burr C, Bursche A, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Calladine R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carvalho Akiba K, Casse G, Cassina L, Cattaneo M, Cavallero G, Cenci R, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chekalina V, Chen C, Chen S, Chitic SG, Chobanova V, Chrzaszcz M, Chubykin A, Ciambrone P, Cid Vidal X, Ciezarek G, Cindolo F, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Comerma-Montells A, Contu A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Currie R, Da Cunha Marinho F, Da Silva CL, Dall'Occo E, Dalseno J, D'Ambrosio C, Danilina A, d'Argent P, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, de Vries JA, Dean CT, Decamp D, Del Buono L, Delaney B, Dembinski HP, Demmer M, Dendek A, Derkach D, Deschamps O, Desse F, Dettori F, Dey B, Di Canto A, Di Nezza P, Didenko S, Dijkstra H, Dordei F, Dorigo M, Dos Reis AC, Dosil Suarez A, Douglas L, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Durante P, Durham JM, Dutta D, Dzhelyadin R, Dziewiecki M, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Ene A, Escher S, Esen S, Evans T, Falabella A, Farber C, Farley N, Farry S, Fazzini D, Feo M, Fernandez Declara P, Fernandez Prieto A, Ferrari F, Ferreira Lopes L, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fontana M, Fontanelli F, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Gabriel E, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gan Y, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garcia Plana B, Garra Tico J, Garrido L, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Gerstel D, Ghez P, Gibson V, Girard OG, Gironella Gironell P, Giubega L, Gizdov K, Gligorov VV, Gobel C, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Grabowski JP, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruber L, Gruberg Cazon BR, Grunberg O, Gu C, Gushchin E, Guth A, Guz Y, Gys T, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han X, Hancock TH, Hansmann-Menzemer S, Harnew N, Harrison T, Hasse C, Hatch M, He J, Hecker M, Heinicke K, Heister A, Hennessy K, Henry L, Hess M, Heuel J, Hicheur A, Hidalgo Charman R, Hill D, Hilton M, Hopchev PH, Hu J, Hu W, Huang W, Huard ZC, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Hynds D, Ibis P, Idzik M, Ilten P, Inglessi A, Inyakin A, Ivshin K, Jacobsson R, Jalocha J, Jans E, Jashal BK, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kazeev N, Kecke M, Keizer F, Kelsey M, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kim KE, Kirn T, Kirsebom VS, Klaver S, Klimaszewski K, Klimkovich T, Koliiev S, Kolpin M, Kopecna R, Koppenburg P, Kostiuk I, Kotriakhova S, Kozeiha M, Kravchuk L, Kreps M, Kress F, Krokovny P, Krupa W, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lancierini D, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, Lefevre R, Leflat A, Lemaitre F, Leroy O, Lesiak T, Leverington B, Li PR, Li Y, Li Z, Liang X, Likhomanenko T, Lindner R, Lionetto F, Lisovskyi V, Liu G, Liu X, Loh D, Loi A, Longstaff I, Lopes JH, Lovell GH, Lucchesi D, Lucio Martinez M, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Maev O, Maguire K, Maisuzenko D, Majewski MW, Malde S, Malecki B, Malinin A, Maltsev T, Manca G, Mancinelli G, Marangotto D, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Marshall PJ, Martellotti G, Martinelli M, Martinez Santos D, Martinez Vidal F, Massafferri A, Materok M, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurice E, Maurin B, McCann M, McNab A, McNulty R, Mead JV, Meadows B, Meaux C, Meinert N, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Millard E, Minard MN, Minzoni L, Mitzel DS, Modden A, Mogini A, Moise RD, Mombacher T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Morgunova O, Moron J, Morris AB, Mountain R, Muheim F, Mukherjee M, Mulder M, Muller D, Muller J, Muller K, Muller V, Murphy CH, Murray D, Naik P, Nakada T, Nandakumar R, Nandi A, Nanut T, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Newcombe R, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nogay A, Nolte NS, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, O'Hanlon DP, Oldeman R, Onderwater CJG, Ossowska A, Otalora Goicochea JM, Ovsiannikova T, Owen P, Oyanguren A, Pais PR, Pajero T, Palano A, Palutan M, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Pereima D, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pietrzyk B, Pietrzyk G, Pikies M, Pili M, Pinci D, Pinzino J, Pisani F, Piucci A, Placinta V, Playfer S, Plews J, Plo Casasus M, Polci F, Poli Lener M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Poslavskii S, Price E, Prisciandaro J, Prouve C, Pugatch V, Puig Navarro A, Pullen H, Punzi G, Qian W, Qin J, Quagliani R, Quintana B, Raab NV, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Ratnikov F, Raven G, Ravonel Salzgeber M, Reboud M, Redi F, Reichert S, Reiss F, Remon Alepuz C, Ren Z, Renaudin V, Ricciardi S, Richards S, Rinnert K, Robbe P, Robert A, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Roehrken M, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Rotondo M, Rudolph MS, Ruf T, Ruiz Vidal J, Saborido Silva JJ, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Gras C, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarpis G, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubiger M, Schulte S, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sepulveda ES, Sergi A, Serra N, Serrano J, Sestini L, Seuthe A, Seyfert P, Shapkin M, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Shmanin E, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Skiba I, Skidmore N, Skwarnicki T, Slater MW, Smeaton JG, Smith E, Smith IT, Smith M, Soares M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spadaro Norella E, Spradlin P, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stepanova M, Stevens H, Stocchi A, Stone S, Storaci B, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Strokov S, Sun J, Sun L, Sun Y, Swientek K, Szabelski A, Szumlak T, Szymanski M, Tang Z, Tayduganov A, Tekampe T, Tellarini G, Teubert F, Thomas E, Tilley MJ, Tisserand V, T'Jampens S, Tobin M, Tolk S, Tomassetti L, Tonelli D, Tou DY, Tourinho Jadallah Aoude R, Tournefier E, Traill M, Tran MT, Trisovic A, Tsaregorodtsev A, Tuci G, Tully A, Tuning N, Ukleja A, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valat S, Valenti G, van Beuzekom M, van Herwijnen E, van Tilburg J, van Veghel M, Vasiliev A, Vazquez Gomez R, Vazquez Regueiro P, Vazquez Sierra C, Vecchi S, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Vernet M, Veronesi M, Vesterinen M, Viana Barbosa JV, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitkovskiy A, Vitti M, Volkov V, Vollhardt A, Vom Bruch D, Voneki B, Vorobyev A, Vorobyev V, Voropaev N, Waldi R, Walsh J, Wang J, Wang M, Wang Y, Wang Z, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Weisser C, Whitehead M, Wilkinson G, Wilkinson M, Williams I, Williams M, Williams MRJ, Williams T, Wilson FF, Winn M, Wislicki W, Witek M, Wormser G, Wotton SA, Wyllie K, Xiao D, Xie Y, Xu A, Xu M, Xu Q, Xu Z, Xu Z, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang D, Zhang L, Zhang WC, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zonneveld JB, Zucchelli S

Abstract:
An angular analysis of B^{0}-->J/psiK^{+}pi^{-} decays is performed, using proton-proton collision data corresponding to an integrated luminosity of 3 fb^{-1} collected with the LHCb detector. The m(K^{+}pi^{-}) spectrum is divided into fine bins. In each m(K^{+}pi^{-}) bin, the hypothesis that the three-dimensional angular distribution can be described by structures induced only by K^{*} resonances is examined, making minimal assumptions about the K^{+}pi^{-} system. The data reject the K^{*}-only hypothesis with a large significance, implying the observation of exotic contributions in a model-independent fashion. Inspection of the m(J/psipi^{-}) vs m(K^{+}pi^{-}) plane suggests structures near m(J/psipi^{-})=4200 and 4600 MeV.





12/04/2019 | Science   IF 41
Perspective - Do antidepressants restore lost synapses?
Beyeler A



05/04/2019 | phys rev lett
First Measurement of Charm Production in its Fixed-Target Configuration at the LHC.
Aaij R, Adeva B, Adinolfi M, Aidala CA, Ajaltouni Z, Akar S, Albicocco P, Albrecht J, Alessio F, Alexander M, Alfonso Albero A, Ali S, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Back JJ, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barsuk S, Barter W, Baryshnikov F, Batozskaya V, Batsukh B, Battista V, Bay A, Beddow J, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Belin S, Beliy N, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Beranek S, Berezhnoy A, Bernet R, Berninghoff D, Bertholet E, Bertolin A, Betancourt C, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bhasin S, Bhom J, Bifani S, Billoir P, Birnkraut A, Bizzeti A, Bjorn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Bocci V, Boente Garcia O, Boettcher T, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJV, Bozzi C, Braun S, Brodski M, Brodzicka J, Brossa Gonzalo A, Brundu D, Buchanan E, Buonaura A, Burr C, Bursche A, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Calladine R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Cattaneo M, Cavallero G, Cenci R, Chamont D, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chekalina V, Chen C, Chen S, Chitic SG, Chobanova V, Chrzaszcz M, Chubykin A, Ciambrone P, Cid Vidal X, Ciezarek G, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Comerma-Montells A, Contu A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Currie R, D'Ambrosio C, Da Cunha Marinho F, Da Silva CL, Dall'Occo E, Dalseno J, Danilina A, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Del Buono L, Delaney B, Dembinski HP, Demmer M, Dendek A, Derkach D, Deschamps O, Desse F, Dettori F, Dey B, Di Canto A, Di Nezza P, Didenko S, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Douglas L, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Durante P, Durham JM, Dutta D, Dzhelyadin R, Dziewiecki M, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Ene A, Escher S, Esen S, Evans T, Falabella A, Farley N, Farry S, Fazzini D, Federici L, Fernandez Declara P, Fernandez Prieto A, Ferrari F, Ferreira Lopes L, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fontana M, Fontanelli F, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Farber C, Feo M, Gabriel E, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gan Y, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Plana B, Garcia Pardinas J, Garra Tico J, Garrido L, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Gerstel D, Ghez P, Giani S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Grabowski JP, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruber L, Gruberg Cazon BR, Grunberg O, Gu C, Gushchin E, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han X, Hancock TH, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison T, Hasse C, Hatch M, He J, Hecker M, Heinicke K, Heister A, Hennessy K, Henry L, van Herwijnen E, Hess M, Hicheur A, Hidalgo Charman R, Hill D, Hilton M, Hopchev PH, Hu W, Huang W, Huard ZC, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Hynds D, Ibis P, Idzik M, Ilten P, Ivshin K, Jacobsson R, Jalocha J, Jans E, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kazeev N, Kecke M, Keizer F, Kelsey M, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kim KE, Kirn T, Klaver S, Klimaszewski K, Klimkovich T, Koliiev S, Kolpin M, Kopecna R, Koppenburg P, Kostiuk I, Kotriakhova S, Kozeiha M, Kravchuk L, Kreps M, Kress F, Krokovny P, Krupa W, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lancierini D, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, Leflat A, Lefrancois J, Lefevre R, Lemaitre F, Leroy O, Lesiak T, Leverington B, Li PR, Li T, Li Z, Liang X, Likhomanenko T, Lindner R, Lionetto F, Lisovskyi V, Liu X, Loh D, Loi A, Longstaff I, Lopes JH, Lovell GH, Lucchesi D, Lucio Martinez M, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Maev O, Maguire K, Maisuzenko D, Majewski MW, Malde S, Malecki B, Malinin A, Maltsev T, Manca G, Mancinelli G, Marangotto D, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Marshall PJ, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Massafferri A, Materok M, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurice E, Maurin B, Mazurov A, McCann M, McNab A, McNulty R, Mead JV, Meadows B, Meaux C, Meier F, Meinert N, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Millard E, Minard MN, Minzoni L, Mitzel DS, Mogini A, Molina Rodriguez J, Mombacher T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Morgunova O, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Murphy CH, Murray D, Modden A, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nanut T, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nogay A, Nolte NS, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJG, Ossowska A, Otalora Goicochea JM, Owen P, Oyanguren A, Pais PR, Pajero T, Palano A, Palutan M, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Pereima D, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pietrzyk B, Pietrzyk G, Pikies M, Pili M, Pinci D, Pinzino J, Pisani F, Piucci A, Placinta V, Playfer S, Plews J, Plo Casasus M, Polci F, Poli Lener M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Poslavskii S, Potterat C, Price E, Prisciandaro J, Prouve C, Pugatch V, Puig Navarro A, Pullen H, Punzi G, Qian W, Qin J, Quagliani R, Quintana B, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Ratnikov F, Raven G, Ravonel Salzgeber M, Reboud M, Redi F, Reichert S, Dos Reis AC, Reiss F, Remon Alepuz C, Ren Z, Renaudin V, Ricciardi S, Richards S, Rinnert K, Robbe P, Robert A, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Roehrken M, Rogozhnikov A, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Rotondo M, Rudolph MS, Ruf T, Ruiz Vidal J, Saborido Silva JJ, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Gras C, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarpis G, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sepulveda ES, Sergi A, Serra N, Serrano J, Sestini L, Seuthe A, Seyfert P, Shapkin M, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Shmanin E, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Skidmore N, Skwarnicki T, Smeaton JG, Smith E, Smith IT, Smith M, Soares M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spradlin P, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stepanova M, Stevens H, Stocchi A, Stone S, Storaci B, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Strokov S, Sun J, Sun L, Swientek K, Syropoulos V, Szumlak T, Szymanski M, T'Jampens S, Tang Z, Tayduganov A, Tekampe T, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Tou DY, Tourinho Jadallah Aoude R, Tournefier E, Traill M, Tran MT, Trisovic A, Tsaregorodtsev A, Tuci G, Tully A, Tuning N, Ukleja A, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valat S, Valenti G, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Verlage TA, Vernet M, Veronesi M, Veronika NV, Vesterinen M, Viana Barbosa JV, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitkovskiy A, Vitti M, Volkov V, Vollhardt A, Voneki B, Vorobyev A, Vorobyev V, de Vries JA, Vazquez Sierra C, Waldi R, Walsh J, Wang J, Wang M, Wang Y, Wang Z, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Weisser C, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams I, Williams MRJ, Williams M, Williams T, Wilson FF, Wimberley J, Winn M, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wyllie K, Xiao D, Xie Y, Xu A, Xu M, Xu Q, Xu Z, Xu Z, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang D, Zhang L, Zhang WC, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zonneveld JB, Zucchelli S

Abstract:
The first measurement of heavy-flavor production by the LHCb experiment in its fixed-target mode is presented. The production of J/psi and D^{0} mesons is studied with beams of protons of different energies colliding with gaseous targets of helium and argon with nucleon-nucleon center-of-mass energies of sqrt[s_{NN}]=86.6 and 110.4 GeV, respectively. The J/psi and D^{0} production cross sections in pHe collisions in the rapidity range [2, 4.6] are found to be sigma_{J/psi}=652+/-33(stat)+/-42(syst) nb/nucleon and sigma_{D^{0}}=80.8+/-2.4(stat)+/-6.3(syst) mub/nucleon, where the first uncertainty is statistical and the second is systematic. No evidence for a substantial intrinsic charm content of the nucleon is observed in the large Bjorken-x region.





02/04/2019 | J Clin Invest   IF 12.3
The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system.
Bouyakdan K, Martin H, Lienard F, Budry L, Taib B, Rodaros D, Chretien C, Biron E, Husson Z, Cota D, Penicaud L, Fulton S, Fioramonti X, Alquier T

Abstract:
Glial cells have emerged as key players in the central control of energy balance and etiology of obesity. Astrocytes play a central role in neural communication via the release of gliotransmitters. Acyl-CoA binding protein (ACBP)-derived endozepines are secreted peptides that modulate the GABAA receptor. In the hypothalamus, ACBP is enriched in arcuate nucleus (ARC) astrocytes, ependymocytes and tanycytes. Central administration of the endozepine octadecaneuropeptide (ODN) reduces feeding and improves glucose tolerance, yet the contribution of endogenous ACBP in energy homeostasis is unknown. We demonstrated that ACBP deletion in GFAP+ astrocytes, but not in Nkx2.1-lineage neural cells, promoted diet-induced hyperphagia and obesity in both male and female mice, an effect prevented by viral rescue of ACBP in ARC astrocytes. ACBP-astrocytes were observed in apposition with proopiomelanocortin (POMC) neurons and ODN selectively activated POMC neurons through the ODN-GPCR but not GABAA, and supressed feeding while increasing carbohydrate utilization via the melanocortin system. Similarly, ACBP overexpression in ARC astrocytes reduced feeding and weight gain. Finally, the ODN-GPCR agonist decreased feeding and promoted weight loss in ob/ob mice. These findings uncover ACBP as an ARC gliopeptide playing a key role in energy balance control and exerting strong anorectic effects via the central melanocortin system.





04/2019 | cardiovasc diagn ther
Heart catheterization in adults in a sub-Saharan tertiary centre: 8 years' experience.
Ambassa JC, Charles M, Jacques Cabral TT

Abstract:
Background: The goal of the investigation was to analyze the results of heart catheterization in the Cardiac centre Shisong from December 2010 till December 2017. Methods: This retrospective study done in the Cardiac centre Shisong in adult patients that underwent a procedure in the catheterization laboratory from December 2010 till December 2017. Results: Three hundred and sixty-five adult underwent a cardiac catheterization procedure during the study period. Among the patients, 126 were female while 239 were male. The mean age at presentation was 52.6+/-12.9 years old. Patients were coming from neighboring countries: Nigeria n=5 (1.3%), Tchad n=3 (0.8%), Equatorial Guinea n=4 (1%), Democratic republic of Congo n=2 (0.5%). Patients were also coming from all the ten regions of Cameroon: Littoral n=122 (33.2%), Centre n=127 (34.8%), North west n=47 (12.9%), South west n=17 (4.5%), West n=26 (7.1%), North n=7 (1.8%), Adamaoua n=8 (2.1%), Far North n=5 (1.3%), South n=2 (0.5%), East n=4 (1%). Depending on the type of procedures diagnostic coronarography in case with suspicion of coronary artery disease and presurgical coronarography were the main procedures done in 171 patients (46.8%) and in 146 patients (40%) respectively. Diagnostic coronarography was positive in 31 cases (8.4%). In patients with ischemic heart disease (IHD), percutaneous intervention with dilatation of the coronary arteries and implantation of stents was done in 19 cases (5.2%). The remaining 12 cases (3.2%) were having many lesions that could be managed only by coronary artery grafting surgery, done with success in all the cases. In grown up congenital heart disease patients, diagnostic catheterization was done in 48 cases meanwhile interventional catheterization: pulmonary artery valvuloplasty, patent ductus arteriosus (PDA) closure, atrial septal defect closure and decoarctation of the aorta were done in n=11 (3.4%), n=9 (2.4%), n=12 (3.2%), n=6 (1.6%) cases respectively. Conclusions: Coronary heart disease was confirmed by angiography in 8.4% cases, and among grown up congenital heart disease 'patients, atrial septal defect was the pathology the most managed. Heart catheterization is done in the Cardiac centre Shisong with good results.





04/2019 | Diabetologia   IF 7.1
Effect of duration and burden of microvascular complications on mortality rate in type 1 diabetes: an observational clinical cohort study.
Bjerg L, Hulman A, Carstensen B, Charles M, Witte DR, Jorgensen ME

Abstract:
AIMS/HYPOTHESIS: The role of burden and duration of multiple microvascular complications on mortality rate has not been explored in detail in type 1 diabetes. Taking complication burden and time-updated duration into account we aimed to quantify mortality rate in individuals with and without microvascular complications. METHODS: This observational clinical cohort included 3828 individuals with type 1 diabetes attending the Steno Diabetes Center Copenhagen in 2001-2013. We used information on mortality and detailed clinical measures of microvascular complications from electronic patient records. Poisson models were used to model mortality rates according to complication burden. RESULTS: During 26,665 person-years of follow-up, 503 deaths occurred. Compared with individuals without microvascular complications, the mortality rate ratio was 2.20 (95% CI 1.79, 2.69) for individuals with diabetic kidney disease, 1.72 (95% CI 1.39, 2.12) for individuals with neuropathy and 1.02 (95% CI 0.77, 1.37) for individuals with retinopathy, all adjusted for calendar time (year/month/day), age, duration of diabetes, sex, HbA1c, LDL-cholesterol, BMI, smoking status, systolic blood pressure, use of antihypertensive and lipid-lowering medication, and cardiovascular disease status. In individuals with two complications or more, the risk of mortality did not exceed the combined risk from each individual complication. Mortality rate ratios increased immediately after diagnosis of neuropathy and diabetic kidney disease. Mortality rate ratios were independent of the duration of neuropathy and retinopathy, while the mortality rate associated with diabetic kidney disease reached a stable level after approximately 3 years. CONCLUSIONS/INTERPRETATION: Neuropathy and diabetic kidney disease are strong and independent risk markers of mortality in type 1 diabetes, whereas no evidence of higher mortality rate was found for retinopathy. We found no indication that the mortality risk with multiple complications exceeds the risk conferred by each complication separately. The duration spent with microvascular complications had only a marginal effect on mortality.





08/03/2019 | Nat Commun   IF 11.9
Deciphering the complex role of thrombospondin-1 in glioblastoma development.
Daubon T, Leon C, Clarke K, Andrique L, Salabert L, Darbo E, Pineau R, Guerit S, Maitre M, Dedieu S, Jeanne A, Bailly S, Feige JJ, Miletic H, Rossi M, Bello L, Falciani F, Bjerkvig R, Bikfalvi A

Abstract:
We undertook a systematic study focused on the matricellular protein Thrombospondin-1 (THBS1) to uncover molecular mechanisms underlying the role of THBS1 in glioblastoma (GBM) development. THBS1 was found to be increased with glioma grades. Mechanistically, we show that the TGFbeta canonical pathway transcriptionally regulates THBS1, through SMAD3 binding to the THBS1 gene promoter. THBS1 silencing inhibits tumour cell invasion and growth, alone and in combination with anti-angiogenic therapy. Specific inhibition of the THBS1/CD47 interaction using an antagonist peptide decreases cell invasion. This is confirmed by CD47 knock-down experiments. RNA sequencing of patient-derived xenograft tissue from laser capture micro-dissected peripheral and central tumour areas demonstrates that THBS1 is one of the gene with the highest connectivity at the tumour borders. All in all, these data show that TGFbeta1 induces THBS1 expression via Smad3 which contributes to the invasive behaviour during GBM expansion. Furthermore, tumour cell-bound CD47 is implicated in this process.





07/03/2019 | JCI Insight   IF 6
The motivation for exercise over palatable food is dictated by cannabinoid type-1 receptors.
Muguruza C, Redon B, Fois GR, Hurel I, Scocard A, Nguyen C, Stevens C, Soria-Gomez E, Varilh M, Cannich A, Daniault J, Busquets-Garcia A, Pelliccia T, Caille S, Georges F, Marsicano G, Chaouloff F

Abstract:
The lack of intrinsic motivation to engage in, and adhere to, physical exercise has major health consequences. However, the neurobiological bases of exercise motivation are still unknown. This study aimed at examining whether the endocannabinoid system (ECS) is involved in this process. To do so, we developed an operant conditioning paradigm wherein mice unlocked a running wheel with nose pokes. Using pharmacological tools and conditional mutants for cannabinoid type-1 (CB1) receptors, we provide evidence that CB1 receptors located on GABAergic neurons are both necessary and sufficient to positively control running motivation. Conversely, this receptor population proved dispensable for the modulation of running duration per rewarded sequence. Although the ECS mediated the motivation for another reward, namely palatable food, such a regulation was independent from CB1 receptors on GABAergic neurons. In addition, we report that the lack of CB1 receptors on GABAergic neurons decreases the preference for running over palatable food when mice were proposed an exclusive choice between the two rewards. Beyond providing a paradigm that enables motivation processes for exercise to be dissected either singly or in concurrence, this study is the first to our knowledge to identify a neurobiological mechanism that might contribute to sedentary behavior.





03/2019 | j appl res intellect disabil
The GO4KIDDS School Satisfaction Scale.
Perry A, Charles M, Ncube B, Weiss J

Abstract:
BACKGROUND: School experience is an important part of the life of children with developmental disabilities (DD) and their families. Research suggests that parents of children vary in their level of satisfaction with their child's school, but methodology and results have varied and no consistent reliable measure of school satisfaction exists. This paper presents a new brief measure of school satisfaction along with preliminary information on its psychometric properties. METHOD: Parents (n = 185) of children with moderate to severe DD completed a longer questionnaire that included the 9-item GO4KIDDS School Satisfaction Scale. RESULTS: The GO4KIDDS School Satisfaction Scale demonstrates high internal consistency reliability (alpha = 0.93), good item-total correlations, and strong correlations with a single-item rating of school satisfaction. CONCLUSIONS: Results support reliability and validity, making the proposed scale valuable for survey research investigating school satisfaction among parents of children with DD.





22/02/2019 | bmc public health
Validity of Danish register diagnoses of myocardial infarction and stroke against experts in people with screen-detected diabetes.
Dalsgaard EM, Witte DR, Charles M, Jorgensen ME, Lauritzen T, Sandbaek A

Abstract:
BACKGROUND: Administrative patient registers are often used to estimate morbidity in epidemiological studies. The validity of register data is thus important. This study aims to assess the positive predictive value of myocardial infarction and stroke registered in the Danish National Patient Register, and to examine the association between cardiovascular risk factors and cardiovascular disease based on register data or validated diagnoses in a well-defined diabetes population. METHODS: We included 1533 individuals found with screen-detected type 2 diabetes in the ADDITION-Denmark study in 2001-2006. All individuals were followed for cardiovascular outcomes until the end of 2014. Hospital discharge codes for myocardial infarction and stroke were identified in the Danish National Patient Register. Hospital medical records and other clinically relevant information were collected and an independent adjudication committee evaluated all possible events. The positive predictive value for myocardial infarction and stroke were calculated as the proportion of cases recorded in the Danish National Patient Register confirmed by the adjudication committee. RESULTS: The positive predictive value was 75% (95% CI: 64;84) for MI and 70% (95% CI: 54;80) for stroke. The association between cardiovascular risk factors and incident cardiovascular disease did not depend on using register-based or verified diagnoses. However, a tendency was seen towards stronger associations when using verified diagnoses. CONCLUSIONS: Our results show that studies using only register-based diagnoses are likely to misclassify cardiovascular outcomes. Moreover, the results suggest that the magnitude of associations between cardiovascular risk factors and cardiovascular outcomes may be underestimated when using register-based diagnoses.





02/2019 | Muscle Nerve   IF 2.4
The utility of a point-of-care sural nerve conduction device for detection of diabetic polyneuropathy: A cross-sectional study.
Kural MA, Andersen ST, Andersen NT, Andersen H, Charles M, Finnerup NB, Jensen TS, Tankisi H

Abstract:
INTRODUCTION: Rapid and accessible methods for diagnosing diabetic polyneuropathy (DPN) have been developed, but not validated, in large cohorts of people with diabetes. METHODS: The performance of a point-of-care device (POCD) was studied in 168 patients with type 2 diabetes, estimating the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) compared with conventional sural nerve conduction studies (NCS). RESULTS: A POCD amplitude limit of 6 microV increased the sensitivity (96%) and NPV (98%), but decreased the specificity (71%) and PPV (54%) compared with the 4-microV limit, which had values of 78%, 92%, 89%, and 71%, respectively. POCD on both legs showed better performance than on 1 leg. POCD amplitudes and conduction velocities correlated significantly with conventional sural NCS, but POCD values were underestimated compared with NCS. DISCUSSION: The POCD may be used as a suitable screening tool for detection of DPN. Patients with abnormal and borderline results should undergo conventional NCS. Muscle Nerve 59:187-193, 2019.





24/01/2019 | Neurobiol Dis   IF 5.2
Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome.
Navarro-Romero A, Vazquez-Oliver A, Gomis-Gonzalez M, Garzon-Montesinos C, Falcon-Moya R, Pastor A, Martin-Garcia E, Pizarro N, Busquets-Garcia A, Revest JM, Piazza PV, Bosch F, Dierssen M, de la Torre R, Rodriguez-Moreno A, Maldonado R, Ozaita A

Abstract:
Intellectual disability is the most limiting hallmark of Down syndrome, for which there is no gold-standard clinical treatment yet. The endocannabinoid system is a widespread neuromodulatory system involved in multiple functions including learning and memory processes. Alterations of this system contribute to the pathogenesis of several neurological and neurodevelopmental disorders. However, the involvement of the endocannabinoid system in the pathogenesis of Down syndrome has not been explored before. We used the best-characterized preclinical model of Down syndrome, the segmentally trisomic Ts65Dn model. In male Ts65Dn mice, cannabinoid type-1 receptor (CB1R) expression was enhanced and its function increased in hippocampal excitatory terminals. Knockdown of CB1R in the hippocampus of male Ts65Dn mice restored hippocampal-dependent memory. Concomitant with this result, pharmacological inhibition of CB1R restored memory deficits, hippocampal synaptic plasticity and adult neurogenesis in the subgranular zone of the dentate gyrus. Notably, the blockade of CB1R also normalized hippocampal-dependent memory in female Ts65Dn mice. To further investigate the mechanisms involved, we used a second transgenic mouse model overexpressing a single gene candidate for Down syndrome cognitive phenotypes, the dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A). CB1R pharmacological blockade similarly improved cognitive performance, synaptic plasticity and neurogenesis in transgenic male Dyrk1A mice. Our results identify CB1R as a novel druggable target potentially relevant for the improvement of cognitive deficits associated with Down syndrome.





18/01/2019 | Int J Obes (Lond)   IF 4.5
Adenovirus 36 seropositivity is related to obesity risk, glycemic control, and leptin levels in Chilean subjects.
Sapunar J, Fonseca L, Molina V, Ortiz E, Barra MI, Reimer C, Charles M, Schneider C, Ortiz M, Brito R, Manriquez V, Pavez M, Cerda A

Abstract:
BACKGROUND: Adenovirus 36 (Ad-36) has been associated to adiposity in animal and in vitro studies. Ad-36 seropositivity has also been reported to contribute to obesity risk in children and adult populations. We investigated the relationship of Ad-36 serology with obesity and metabolic parameters in a Chilean population. SUBJECTS AND METHODS: Clinical and anthropometric data were obtained and blood samples were drawn from 99 lean (BMI: 18.5-24.9 kg/m(2)) and 151 obese (BMI > 30 kg/m(2)) subjects. Laboratory tests included lipid profile as well as glucose, insulin, leptin, and adiponectin levels. Ad-36 seropositivity was evaluated in serum samples by enzyme-linked immunosorbent assay. RESULTS: Seroprevalence of Ad-36 was higher in the obese group (58%) than in lean controls (34%) demonstrating that individuals previously infected with Ad-36 have higher risk of obesity in the study population (OR: 2.67, 95%CI: 1.58-4.51, p < 0.001). Interestingly, Ad-36 was related to lower concentrations of triglycerides and VLDL cholesterol in lean subjects (p = 0.049) and lower leptin in obese individuals (p = 0.014). Previous Ad-36 infection was also related to lower glycemia, insulinemia, and HOMA-IR (p < 0.05) in obese subjects who were not under antidiabetic drugs. CONCLUSIONS: Our results provide evidence of the contribution of previous Ad-36 infection to an increased risk of obesity in adult Chilean population. Ad-36 seropositivity was also associated to lipid profile, glycemic control, and leptin levels in adult Chilean population.





11/01/2019 | phys rev lett
Observation of Two Resonances in the Lambda_{b}^{0}pi^{+/-} Systems and Precise Measurement of Sigma_{b}^{+/-} and Sigma_{b}^{*+/-} Properties.
Aaij R, Abellan Beteta C, Adeva B, Adinolfi M, Aidala CA, Ajaltouni Z, Akar S, Albicocco P, Albrecht J, Alessio F, Alexander M, Alfonso Albero A, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Archilli F, Arnau Romeu J, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Back JJ, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barsuk S, Barter W, Baryshnikov F, Batozskaya V, Batsukh B, Battista V, Bay A, Beddow J, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Belin S, Beliy N, Bellee V, Belloli N, Belous K, Belyaev I, Bencivenni G, Ben-Haim E, Benson S, Beranek S, Berezhnoy A, Bernet R, Berninghoff D, Bertholet E, Bertolin A, Betancourt C, Betti F, Bettler MO, Bezshyiko I, Bhasin S, Bhom J, Bifani S, Billoir P, Birnkraut A, Bizzeti A, Bjorn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Bocci V, Boente Garcia O, Boettcher T, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJV, Bozzi C, Braun S, Brodski M, Brodzicka J, Brossa Gonzalo A, Brundu D, Buchanan E, Buonaura A, Burr C, Bursche A, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Calladine R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Cattaneo M, Cavallero G, Cenci R, Chamont D, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chekalina V, Chen C, Chen S, Chitic SG, Chobanova V, Chrzaszcz M, Chubykin A, Ciambrone P, Cid Vidal X, Ciezarek G, Cindolo F, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Comerma-Montells A, Contu A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Currie R, Da Cunha Marinho F, Da Silva CL, Dall'Occo E, Dalseno J, D'Ambrosio C, Danilina A, d'Argent P, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, de Vries JA, Dean CT, Decamp D, Del Buono L, Delaney B, Dembinski HP, Demmer M, Dendek A, Derkach D, Deschamps O, Desse F, Dettori F, Dey B, Di Canto A, Di Nezza P, Didenko S, Dijkstra H, Dordei F, Dorigo M, Dos Reis AC, Dosil Suarez A, Douglas L, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Durante P, Durham JM, Dutta D, Dzhelyadin R, Dziewiecki M, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Ene A, Escher S, Esen S, Evans T, Falabella A, Farber C, Farley N, Farry S, Fazzini D, Federici L, Feo M, Fernandez Declara P, Fernandez Prieto A, Ferrari F, Ferreira Lopes L, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fontana M, Fontanelli F, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Gabriel E, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gan Y, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garcia Plana B, Garra Tico J, Garrido L, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Gerstel D, Ghez P, Giani S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Gobel C, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Grabowski JP, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruber L, Gruberg Cazon BR, Grunberg O, Gu C, Gushchin E, Guz Y, Gys T, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han X, Hancock TH, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison T, Hasse C, Hatch M, He J, Hecker M, Heinicke K, Heister A, Hennessy K, Henry L, Hess M, Hicheur A, Hidalgo Charman R, Hill D, Hilton M, Hopchev PH, Hu W, Huang W, Huard ZC, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Hynds D, Ibis P, Idzik M, Ilten P, Inyakin A, Ivshin K, Jacobsson R, Jalocha J, Jans E, Jashal BK, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kazeev N, Kecke M, Keizer F, Kelsey M, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kim KE, Kirn T, Klaver S, Klimaszewski K, Klimkovich T, Koliiev S, Kolpin M, Kopecna R, Koppenburg P, Kostiuk I, Kotriakhova S, Kozeiha M, Kravchuk L, Kreps M, Kress F, Krokovny P, Krupa W, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lancierini D, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, Lefevre R, Leflat A, Lefrancois J, Lemaitre F, Leroy O, Lesiak T, Leverington B, Li PR, Li T, Li Z, Liang X, Likhomanenko T, Lindner R, Lionetto F, Lisovskyi V, Liu X, Loh D, Loi A, Longstaff I, Lopes JH, Lovell GH, Lucchesi D, Lucio Martinez M, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Maev O, Maguire K, Maisuzenko D, Majewski MW, Malde S, Malecki B, Malinin A, Maltsev T, Manca G, Mancinelli G, Marangotto D, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Marshall PJ, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Massafferri A, Materok M, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurice E, Maurin B, Mazurov A, McCann M, McNab A, McNulty R, Mead JV, Meadows B, Meaux C, Meier F, Meinert N, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Millard E, Minard MN, Minzoni L, Mitzel DS, Modden A, Mogini A, Molina Rodriguez J, Mombacher T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Morgunova O, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Muller D, Muller J, Muller K, Muller V, Murphy CH, Murray D, Naik P, Nakada T, Nandakumar R, Nandi A, Nanut T, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Newcombe R, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nogay A, Nolte NS, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, O'Hanlon DP, Oldeman R, Onderwater CJG, Ossowska A, Otalora Goicochea JM, Owen P, Oyanguren A, Pais PR, Pajero T, Palano A, Palutan M, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Pereima D, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pietrzyk B, Pietrzyk G, Pikies M, Pili M, Pinci D, Pinzino J, Pisani F, Piucci A, Placinta V, Playfer S, Plews J, Plo Casasus M, Polci F, Poli Lener M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Poslavskii S, Potterat C, Price E, Prisciandaro J, Prouve C, Pugatch V, Puig Navarro A, Pullen H, Punzi G, Qian W, Qin J, Quagliani R, Quintana B, Raab NV, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Ratnikov F, Raven G, Ravonel Salzgeber M, Reboud M, Redi F, Reichert S, Reiss F, Remon Alepuz C, Ren Z, Renaudin V, Ricciardi S, Richards S, Rinnert K, Robbe P, Robert A, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Roehrken M, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Rotondo M, Rudolph MS, Ruf T, Ruiz Vidal J, Saborido Silva JJ, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Gras C, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarpis G, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sepulveda ES, Sergi A, Serra N, Serrano J, Sestini L, Seuthe A, Seyfert P, Shapkin M, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Shmanin E, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Skiba I, Skidmore N, Skwarnicki T, Slater MW, Smeaton JG, Smith E, Smith IT, Smith M, Soares M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spadaro Norella E, Spradlin P, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stepanova M, Stevens H, Stocchi A, Stone S, Storaci B, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Strokov S, Sun J, Sun L, Swientek K, Szumlak T, Szymanski M, Tang Z, Tayduganov A, Tekampe T, Tellarini G, Teubert F, Thomas E, Tilley MJ, Tisserand V, T'Jampens S, Tobin M, Tolk S, Tomassetti L, Tonelli D, Tou DY, Tourinho Jadallah Aoude R, Tournefier E, Traill M, Tran MT, Trisovic A, Tsaregorodtsev A, Tuci G, Tully A, Tuning N, Ukleja A, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valat S, Valenti G, van Beuzekom M, van Herwijnen E, van Tilburg J, van Veghel M, Vazquez Gomez R, Vazquez Regueiro P, Vazquez Sierra C, Vecchi S, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Verlage TA, Vernet M, Veronesi M, Vesterinen M, Viana Barbosa JV, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitkovskiy A, Vitti M, Volkov V, Vollhardt A, Vom Bruch D, Voneki B, Vorobyev A, Vorobyev V, Voropaev N, Waldi R, Walsh J, Wang J, Wang M, Wang Y, Wang Z, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Weisser C, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams I, Williams M, Williams MRJ, Williams T, Wilson FF, Wimberley J, Winn M, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wyllie K, Xiao D, Xie Y, Xu A, Xu M, Xu Q, Xu Z, Xu Z, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang D, Zhang L, Zhang WC, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zonneveld JB, Zucchelli S

Abstract:
The first observation of two structures consistent with resonances in the final states Lambda_{b}^{0}pi^{-} and Lambda_{b}^{0}pi^{+} is reported using samples of pp collision data collected by the LHCb experiment at sqrt[s]=7 and 8 TeV, corresponding to an integrated luminosity of 3 fb^{-1}. The ground states Sigma_{b}^{+/-} and Sigma_{b}^{*+/-} are also confirmed and their masses and widths are precisely measured.





11/01/2019 | phys rev lett
Measurement of the Charm-Mixing Parameter y_{CP}.
Aaij R, Abellan Beteta C, Adeva B, Adinolfi M, Aidala CA, Ajaltouni Z, Akar S, Albicocco P, Albrecht J, Alessio F, Alexander M, Alfonso Albero A, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Arzymatov K, Aslanides E, Atzeni M, Audurier B, Bachmann S, Back JJ, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barrand GC, Barsuk S, Barter W, Bartolini M, Baryshnikov F, Batozskaya V, Batsukh B, Battig A, Battista V, Bay A, Beddow J, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Belin S, Beliy N, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Beranek S, Berezhnoy A, Bernet R, Berninghoff D, Bertholet E, Bertolin A, Betancourt C, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bhasin S, Bhom J, Bifani S, Billoir P, Birnkraut A, Bizzeti A, Bjorn M, Blago MP, Blake T, Blanc F, Blusk S, Bobulska D, Bocci V, Boente Garcia O, Boettcher T, Bondar A, Bondar N, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJV, Bozzi C, Braun S, Brodski M, Brodzicka J, Brossa Gonzalo A, Brundu D, Buchanan E, Buonaura A, Burr C, Bursche A, Buytaert J, Byczynski W, Cadeddu S, Cai H, Calabrese R, Calladine R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Cattaneo M, Cavallero G, Cenci R, Chamont D, Chapman MG, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chekalina V, Chen C, Chen S, Chitic SG, Chobanova V, Chrzaszcz M, Chubykin A, Ciambrone P, Cid Vidal X, Ciezarek G, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Coelho JAB, Cogan J, Cogneras E, Cojocariu L, Collins P, Colombo T, Comerma-Montells A, Contu A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Currie R, D'Ambrosio C, Da Cunha Marinho F, Da Silva CL, Dall'Occo E, Dalseno J, Danilina A, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Del Buono L, Delaney B, Dembinski HP, Demmer M, Dendek A, Derkach D, Deschamps O, Desse F, Dettori F, Dey B, Di Canto A, Di Nezza P, Didenko S, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Douglas L, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Durante P, Durham JM, Dutta D, Dzhelyadin R, Dziewiecki M, Dziurda A, Dzyuba A, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Ene A, Escher S, Esen S, Evans T, Falabella A, Farley N, Farry S, Fazzini D, Federici L, Fernandez Declara P, Fernandez Prieto A, Ferrari F, Ferreira Lopes L, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fontana M, Fontanelli F, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Farber C, Feo M, Gabriel E, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gan Y, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Plana B, Garcia Pardinas J, Garra Tico J, Garrido L, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Gerstel D, Ghez P, Gibson V, Girard OG, Gironella Gironell P, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Grabowski JP, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruber L, Gruberg Cazon BR, Grunberg O, Gu C, Gushchin E, Guth A, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han X, Hancock TH, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison T, Hasse C, Hatch M, He J, Hecker M, Heinicke K, Heister A, Hennessy K, Henry L, van Herwijnen E, Heuel J, Hess M, Hicheur A, Hidalgo Charman R, Hill D, Hilton M, Hopchev PH, Hu J, Hu W, Huang W, Huard ZC, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Hynds D, Ibis P, Idzik M, Ilten P, Ivshin K, Jacobsson R, Jalocha J, Jans E, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kazeev N, Kecke M, Keizer F, Kelsey M, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kim KE, Kirn T, Klaver S, Klimaszewski K, Klimkovich T, Koliiev S, Kolpin M, Kopecna R, Koppenburg P, Kostiuk I, Kotriakhova S, Kozeiha M, Kravchuk L, Kreps M, Kress F, Krokovny P, Krupa W, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lancierini D, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, Leflat A, Lefrancois J, Lefevre R, Lemaitre F, Leroy O, Lesiak T, Leverington B, Li PR, Li Y, Li Z, Liang X, Likhomanenko T, Lindner R, Lionetto F, Lisovskyi V, Liu G, Liu X, Loh D, Loi A, Longstaff I, Lopes JH, Lovell GH, Lucchesi D, Lucio Martinez M, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Macko V, Mackowiak P, Maddrell-Mander S, Maev O, Maguire K, Maisuzenko D, Majewski MW, Malde S, Malecki B, Malinin A, Maltsev T, Manca G, Mancinelli G, Marangotto D, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Marshall PJ, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Massafferri A, Materok M, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurice E, Maurin B, Mazurov A, McCann M, McNab A, McNulty R, Mead JV, Meadows B, Meaux C, Meinert N, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Millard E, Minard MN, Minzoni L, Mitzel DS, Mogini A, Moise RD, Mombacher T, Monroy IA, Monteil S, Morandin M, Morello G, Morello MJ, Morgunova O, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Murphy CH, Murray D, Modden A, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nanut T, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Newcombe R, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nogay A, Nolte NS, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJG, Ossowska A, Otalora Goicochea JM, Ovsiannikova T, Owen P, Oyanguren A, Pais PR, Pajero T, Palano A, Palutan M, Panshin G, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Pereima D, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petrucci S, Petruzzo M, Pietrzyk B, Pietrzyk G, Pikies M, Pili M, Pinci D, Pinzino J, Pisani F, Piucci A, Placinta V, Playfer S, Plews J, Plo Casasus M, Polci F, Poli Lener M, Poluektov A, Polukhina N, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Poslavskii S, Potterat C, Price E, Prisciandaro J, Prouve C, Pugatch V, Puig Navarro A, Pullen H, Punzi G, Qian W, Qin J, Quagliani R, Quintana B, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Ratnikov F, Raven G, Ravonel Salzgeber M, Reboud M, Redi F, Reichert S, Dos Reis AC, Reiss F, Remon Alepuz C, Ren Z, Renaudin V, Ricciardi S, Richards S, Rinnert K, Robbe P, Robert A, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Roehrken M, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Rotondo M, Rudolph MS, Ruf T, Ruiz Vidal J, Saborido Silva JJ, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Gras C, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarpis G, Sarti A, Satriano C, Satta A, Saur M, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sepulveda ES, Sergi A, Serra N, Serrano J, Sestini L, Seuthe A, Seyfert P, Shapkin M, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Shmanin E, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Skiba I, Skidmore N, Skwarnicki T, Slater MW, Smeaton JG, Smith E, Smith IT, Smith M, Soares M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spadaro Norella E, Spradlin P, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stepanova M, Stevens H, Stocchi A, Stone S, Storaci B, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Strokov S, Sun J, Sun L, Swientek K, Szabelski A, Szumlak T, Szymanski M, T'Jampens S, Tang Z, Tayduganov A, Tekampe T, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Tou DY, Tourinho Jadallah Aoude R, Tournefier E, Traill M, Tran MT, Trisovic A, Tsaregorodtsev A, Tuci G, Tully A, Tuning N, Ukleja A, Usachov A, Ustyuzhanin A, Uwer U, Vagner A, Vagnoni V, Valassi A, Valat S, Valenti G, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Vernet M, Veronesi M, Veronika NV, Vesterinen M, Viana Barbosa JV, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitkovskiy A, Vitti M, Volkov V, Vollhardt A, Vom Bruch D, Voneki B, Vorobyev A, Vorobyev V, de Vries JA, Vazquez Sierra C, Waldi R, Walsh J, Wang J, Wang M, Wang Y, Wang Z, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Weisser C, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams I, Williams MRJ, Williams M, Williams T, Wilson FF, Winn M, Wislicki W, Witek M, Wormser G, Wotton SA, Wyllie K, Xiao D, Xie Y, Xu A, Xu M, Xu Q, Xu Z, Xu Z, Yang Z, Yang Z, Yao Y, Yeomans LE, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang D, Zhang L, Zhang WC, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zonneveld JB, Zucchelli S

Abstract:
A measurement of the charm-mixing parameter y_{CP} using D^{0}-->K^{+}K^{-}, D^{0}-->pi^{+}pi^{-}, and D^{0}-->K^{-}pi^{+} decays is reported. The D^{0} mesons are required to originate from semimuonic decays of B^{-} and B[over ]^{0} mesons. These decays are partially reconstructed in a data set of proton-proton collisions at center-of-mass energies of 7 and 8 TeV collected with the LHCb experiment and corresponding to an integrated luminosity of 3 fb^{-1}. The y_{CP} parameter is measured to be (0.57+/-0.13(stat)+/-0.09(syst))%, in agreement with, and as precise as, the current world-average value.





07/01/2019 | Cold Spring Harb Perspect Med   IF 5.6
Development and Patterning of the Cochlea: From Convergent Extension to Planar Polarity.
Montcouquiol M, Kelley MW

Abstract:
Within the mammalian cochlea, sensory hair cells and supporting cells are aligned in curvilinear rows that extend along the length of the tonotopic axis. In addition, all of the cells within the epithelium are uniformly polarized across the orthogonal neural-abneural axis. Finally, each hair cell is intrinsically polarized as revealed by the presence of an asymmetrically shaped and apically localized stereociliary bundle. It has been known for some time that many of the developmental processes that regulate these patterning events are mediated, to some extent, by the core planar cell polarity (PCP) pathway. This article will review more recent work demonstrating how components of the PCP pathway interact with cytoskeletal motor proteins to regulate cochlear outgrowth. Finally, a signaling pathway originally identified for its role in asymmetric cell divisions has recently been shown to mediate several aspects of intrinsic hair cell polarity, including kinocilia migration, bundle shape, and elongation.





2019 | Current Opinion in Behavioral Sciences   IF 3.4
Valence Coding in Amygdala Circuits
Pignatelli M, Beyeler A

Abstract:
The neural mechanisms underlying emotional valence are at the interface between perception and action, integrating inputs from the external environment with past experiences to guide the behavior of an organism. Depending on the positive or negative valence assigned to an environmental stimulus, the organism will approach or avoid the source of the stimulus. Multiple convergent studies have demonstrated that the amygdala complex is a critical node of the circuits assigning valence. Here we examine the current progress in identifying valence coding properties of neural populations in different nuclei of the amygdala, based on their activity, connectivity, and gene expression profile.