| AJNR Am J Neuroradiol IF 3.3 Multinodular and Vacuolating Posterior Fossa Lesions of Unknown Significance.
Lecler A, Bailleux J, Carsin B, Adle-Biassette H, Baloglu S, Bogey C, Bonneville F, Calvier E, Comby PO, Cottier JP, Cotton F, Deschamps R, Diard-Detoeuf C, Ducray F, Duron L, Drissi C, Elmaleh M, Farras J, Garcia JA, Gerardin E, Grand S, Jianu DC, Kremer S, Magne N, Mejdoubi M, Moulignier A, Ollivier M, Nagi S, Rodallec M, Sadik JC, Shor N, Tourdias T, Vandendries C, Broquet V, Savatovsky J
Multinodular and vacuolating neuronal tumor of the cerebrum is a rare supratentorial brain tumor described for the first time in 2013. Here, we report 11 cases of infratentorial lesions showing similar striking imaging features consisting of a cluster of low T1-weighted imaging and high T2-FLAIR signal intensity nodules, which we referred to as multinodular and vacuolating posterior fossa lesions of unknown significance. No relationship was found between the location of the lesion and clinical symptoms. A T2-FLAIR hypointense central dot sign was present in images of 9/11 (82%) patients. Cortical involvement was present in 2/11 (18%) of patients. Only 1 nodule of 1 multinodular and vacuolating posterior fossa lesion of unknown significance showed enhancement on postcontrast T1WI. DWI, SWI, MRS, and PWI showed no malignant pattern. Lesions did not change in size or signal during a median follow-up of 3 years, suggesting that multinodular and vacuolating posterior fossa lesions of unknown significance are benign malformative lesions that do not require surgical intervention or removal.