We are proud to congratulate Monique VALLEE, Research Director in the Jean-Michel Revest's team at the Neurocentre Magendie, for her contribution to a new collaborative project funded through the IReSP - Institut pour la Recherche en Santé Publique 2026 Call for Proposals (Addictive Behaviors) and coordinated by Celine Nicolas (Institut de Neurosciences Cognitives et Intégratives d'Aquitaine - INCIA) in partnership with mario carta (Interdisciplinary Institute for Neuroscience (IINS)).

Post-traumatic stress disorder (PTSD) is a severe stress-related psychiatric condition triggered by traumatic life-threatening events, characterized notably by an altered memory profile. Although clinically well-documented, no specific biomarker exists. This translational study identifies plasminogen activator inhibitor-1 (PAI-1) as a brain risk factor for PTSD, thereby supporting its potential as a blood-derived biomarker. Mice with genetically ablated PAI-1 were protected from developing a PTSD-like memory profile. Conversely, mice exhibiting PTSD-like cognitive impairment showed increased blood PAI-1 levels, correlating with their profile severity. In the brain, PAI-1 levels were specifically increased in the dorsal hippocampus, a key region for cognitive functions and in the etiology of PTSD. Finally, a longitudinal study of soldiers revealed that those developing PTSD symptoms exhibit rising blood PAI-1 levels over a 12-month period. Its significant association with various indicators of PTSD-related psychological distress attests to PAI-1's potential as a blood biomarker and brain therapeutic target for PTSD.




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