Neurocentre Magendie

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Hottopic
24/06/2020 10h00
Pierre Louis Raux from Revest's lab will give a presentation entitled "Physiological regulation of the cannabinoid type-1 receptor by the neurosteroid pregnenolone: study in mutant CB1-E134G mice"


Le concours de l’école doctorale SVS de l’Université de Bordeaux a rendu son verdict : le Neurocentre glane 4 des 16 contrats doctoraux. Bravo à Mohamed-Lyès KACI (Éq. Abrous, Dir de thèse Muriel Koehl) qui se classe 5ème, Emma MESGUICH (Éq. Marsicano, Dir de thèse France Chaouloff) qui se classe 7ème, Pierre-Louis RAUX (Éq. Revest, Dir de thèse Monique Vallée) qui se classe 11ème et Yifan WU (Éq. Beyeler) qui se classe 17ème. Ils intégreront les équipes du centre dès la rentrée prochaine.




Hottopic
30/01/2019 10h30
Nadia DI FRANCO from Revest's lab will give a presentation entitled "CB1 in Down Syndrome: a new potential target"

Hottopic
28/03/2018 10h30
Giovanni TOMASELLI from Revest's lab will give a presentation entitled "Role of PREG and its derivates on the regulation of CB1 signalling in mediating THC-induced behavioural effects"

Info Générale
08/03/2018
Deroche-Gamonet, Revest et al. in Molecular Psychiatry:

First causal evidence of a role of neurogenesis in a drug-related behavior.

The hippocampus is the main locus for adult dentate gyrus (DG) neurogenesis. A number of studies have shown that aberrant DG neurogenesis correlates with many neuropsychiatric disorders, including drug addiction. Although clear causal relationships have been established between DG neurogenesis and memory dysfunction or mood-related disorders, evidence of the causal role of DG neurogenesis in drug-seeking behaviors has not been established. Here we assessed the role of new DG neurons in cocaine self-administration using an inducible transgenic approach that selectively depletes adult DG neurogenesis. Our results show that transgenic mice with decreased adult DG neurogenesis exhibit increased motivation to self-administer cocaine and a higher seeking response to cocaine-related cues. These results identify adult hippocampal neurogenesis as a key factor in vulnerability to cocaine addiction.

Deroche-Gamonet V*, Revest JM*, Fiancette JF, Balado E, Koehl M, Grosjean N, Abrous DN*, Piazza PV*. Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior. Mol Psychiatry. 2018 Mar 5. doi: 10.1038/s41380-018-0038-0.





Pregnenolone can protect the brain from cannabis intoxication.
Vallée M, Vitiello S, Bellocchio L, Hébert-Chatelain E, Monlezun S, Martin-Garcia E, Kasanetz F, Baillie GL, Panin F, Cathala A, Roullot-Lacarrière V, Fabre S, Hurst DP, Lynch DL, Shore DM, Deroche-Gamonet V, Spampinato U, Revest JM, Maldonado R, Reggio PH, Ross RA, Marsicano G, Piazza PV.
Science. 2014 Jan 3;343(6166):94-8. doi: 10.1126/science.1243985





Jean Michel Revest et l'équipe de P-V Piazza

Bases moléculaires de la mémoire de peur contextuelle induite par les glucocorticoïdes
- Voir plus: http://www.neuroscience.univ-bordeauxsegalen.fr/fr/publications/toutes-les-interview/mol-psychiatry-jm-revest.html#sthash.rtEvzc8x.dpuf





Kasanetz F, Lafourcade M, Deroche-Gamonet V, Revest JM, Berson N, Balado E, Fiancette JF, Renault P, Piazza PV, Manzoni OJ.
Prefrontal synaptic markers of cocaine addiction-like behavior in rats.
Mol Psychiatry. 2012 May 15. 2012





Yves Deris a rencontré Marlène Maître et Jean Michel Revest à l'occasion de leur publication dans le Journal of Neuroscience Methods.




Hottopic
16/04/2010 16h00
Jean-Michel REVEST Hottopics: Jean-Michel REVEST from Piazza's lab will present his project entitled 'identification of GR target genes mediating the behavioral effects of glucocorticoids on stress-related memory'