Neurocentre Magendie

Les actualités de l'équipe

Afficher par type

28/03/2018 10h30
Giovanni TOMASELLI from Revest's lab will give a presentation entitled "Role of PREG and its derivates on the regulation of CB1 signalling in mediating THC-induced behavioural effects"

Info Générale
Deroche-Gamonet, Revest et al. in Molecular Psychiatry:

First causal evidence of a role of neurogenesis in a drug-related behavior.

The hippocampus is the main locus for adult dentate gyrus (DG) neurogenesis. A number of studies have shown that aberrant DG neurogenesis correlates with many neuropsychiatric disorders, including drug addiction. Although clear causal relationships have been established between DG neurogenesis and memory dysfunction or mood-related disorders, evidence of the causal role of DG neurogenesis in drug-seeking behaviors has not been established. Here we assessed the role of new DG neurons in cocaine self-administration using an inducible transgenic approach that selectively depletes adult DG neurogenesis. Our results show that transgenic mice with decreased adult DG neurogenesis exhibit increased motivation to self-administer cocaine and a higher seeking response to cocaine-related cues. These results identify adult hippocampal neurogenesis as a key factor in vulnerability to cocaine addiction.

Deroche-Gamonet V*, Revest JM*, Fiancette JF, Balado E, Koehl M, Grosjean N, Abrous DN*, Piazza PV*. Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior. Mol Psychiatry. 2018 Mar 5. doi: 10.1038/s41380-018-0038-0.

Pregnenolone can protect the brain from cannabis intoxication.
Vallée M, Vitiello S, Bellocchio L, Hébert-Chatelain E, Monlezun S, Martin-Garcia E, Kasanetz F, Baillie GL, Panin F, Cathala A, Roullot-Lacarrière V, Fabre S, Hurst DP, Lynch DL, Shore DM, Deroche-Gamonet V, Spampinato U, Revest JM, Maldonado R, Reggio PH, Ross RA, Marsicano G, Piazza PV.
Science. 2014 Jan 3;343(6166):94-8. doi: 10.1126/science.1243985

Jean Michel Revest et l'équipe de P-V Piazza

Bases moléculaires de la mémoire de peur contextuelle induite par les glucocorticoïdes
- Voir plus:

Kasanetz F, Lafourcade M, Deroche-Gamonet V, Revest JM, Berson N, Balado E, Fiancette JF, Renault P, Piazza PV, Manzoni OJ.
Prefrontal synaptic markers of cocaine addiction-like behavior in rats.
Mol Psychiatry. 2012 May 15. 2012

Yves Deris a rencontré Marlène Maître et Jean Michel Revest à l'occasion de leur publication dans le Journal of Neuroscience Methods.

16/04/2010 16h00
Jean-Michel REVEST Hottopics: Jean-Michel REVEST from Piazza's lab will present his project entitled 'identification of GR target genes mediating the behavioral effects of glucocorticoids on stress-related memory'

05/02/2009 10h00
Véronique Deroche, Fernando Kasanetz, Giovanni Marsicano, Jean-Michel Revest,Francis Chaouloff, Nora Abrous, Emiliana Borrelli Symposium : "stress, addiction and eating disorders". 10h00 : Véronique Deroche Psychobiological bases of transition to addiction: Strategies of investigation 10h40 : Fernando Kasanetz Synaptic plasticity and transition to addiction 11h20 : Giovanni Marsicano Differential involvement of GABAergic and glutamatergic neurons in the endocannabinoid control of food intake 14h00 : Jean-Michel Revest Molecular basis of stress related memories 14h40 : Francis Chaouloff Stress, corticosteroids and neuroplasticity 15h20 : Nora Abrous Neurogenesis and anxiety 16h30 : Emiliana Borrelli Getting specialized: presynaptic and postsynaptic D2 receptors