Neurocentre Magendie

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The origin of biological lanxit remains unclear, particularly pathological lanxit which nevertheless affects nearly 20% of the population. But thanks lquipe Atip Futures what was up and runs for two years, Anna Beyeler, researcher at Inserm Neurocenter Magendie Bordeaux, sest launches the challenge of some of the mechanisms rvler impliqus in this psychiatric disorder.

PhD/HDR defense
02/10/2020 14h00
Anna BEYELER Habilitation à diriger des recherches (HDR)

Habilitation à diriger des recherches (HDR)
Date de la soutenance: 02/10/2020 - 14h00
Lieu: Neurocentre Magendie Digital Meeting

30/09/2020 10h30
Céline NICOLAS from Beyeler's lab will give a presentation entitled "Role of insular cortex circuits in a model of alcohol use disorder"

The competition of the SVS doctoral school of the University of Bordeaux has given its verdict: the Neurocentre gleaned 4 of the 16 doctoral contracts. Congratulations to Mohamed-Lyès KACI (Eq. Abrous, Thesis Director Muriel Koehl) who ranks 5th, Emma MESGUICH (Eq. Marsicano, Thesis Director France Chaouloff) who ranks 7th, Pierre-Louis RAUX (Eq. Revest, Thesis Director Monique Vallée) who ranks 11th and Yifan WU (Eq. Beyeler) who ranks 17th. They will join the centre's teams from next school year.

29/05/2019 10h30
Anes JU from Beyeler's lab will give a presentation entitled "Serotonin receptor expression of the insular cortex involved in anxiety"

03/05/2019 14h00
Dr. Julia Lemos, Dissecting the actions of CRF in the NAc

Meeting room: Amphi Centre Broca

Dr. Julia Lemos is an Assistant Professor at the Department of Neuroscience of the University of Minnesota (USA) and will present the work of her lab dissecting the actions of corticotropin releasing factor (CRF) in the nucleus accumbens.
Host: Anna Beyeler

Outside of its well-characterized actions in the HPA axis, the stress-associated peptide corticotropin-releasing factor (CRF) regulates neuronal excitability and synaptic transmission in several extrahypothalamic brain regions. Previous research has shown that CRF in the nucleus accumbens (NAc) promotes appetitive behavior through mechanisms that remain poorly understood. We have recently showed that CRF potentiates both dopaminergic and cholinergic transmission in the NAc. However, it is unknown how CRF regulates the activity of medium spiny neurons (MSNs), the principle projection neurons of the NAc, to modulate behavioral output. MSNs are classified by their peptide expression and projection targets within the basal ganglia: dMSNs form the direct projection pathway and express dynorphin, whereas iMSNs form the indirect pathway and express enkephalin. RNAscope in situ hybridization was used to assess Crh1 mRNA expression in MSN subpopulations, identifying dMSNs and iMSNs with expression of dynorphin (pdyn) or enkephalin (pEnk), respectively. 20% of all cells were positive for Crh1 mRNA, with approximately 30% co-expressing pEnk mRNA (iMSNs), 30% co-expressing pDyn mRNA (dMSNs) and 30% co-expressing neither marker. Using whole-cell patch clamp electrophysiology recordings in brain slices, we examined the function of exogenously-applied CRF on the excitability of MSNs in the NAc core. Application of 100 nM CRF produced a leftward shift in the current-voltage relationship, demonstrating that CRF can enhance the firing rate of both dMSNs and iMSNs. Next steps will focus on identifying the role of CRF receptor subtypes in enhancing the spiking activity in MSNs and elucidate whether this effect is through direct actions on MSNs or through dopaminergic and cholinergic modulation of MSNs.

19/12/2018 10h30
Sebastien DELCASSO from Beyeler's lab will give a presentation entitled "Anatomical and functional organization of valence circuits in the insular cortex."