Neurocentre Magendie

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Séminaire
21/09/2018 11h30
Jason Shepherd, University of Utah - Host Anna Beyeler

Meeting room: Amphithéâtre du Centre Broca Nouvelle-Aquitaine

Inter-cellular RNA transfer: a novel role of the neuronal gene Arc which encodes a repurposed retrotransposon protein

The neuronal gene Arc is essential for long-lasting information storage in the mammalian brain. We recently found that Arc self-assembles into virus-like capsids that encapsulate RNA. Endogenous Arc protein is released from neurons in extracellular vesicles that mediate the transfer of Arc mRNA into new target cells. These results show that Arc exhibits similar molecular properties to retroviral Gag proteins. Evolutionary analysis indicates that Arc is derived from a vertebrate lineage of Ty3/gypsy retrotransposons, which are also ancestors to retroviruses. These findings suggest that Gag retroelements have been repurposed during evolution to mediate intercellular communication in the nervous system. Our working model posits that Arc protein is locally translated in dendrites, where it forms a capsid that binds local mRNAs that are transported out of the cell.




Séminaire
15/06/2018 11h30
François Amaury

Meeting room: Amphi Broca Nouvelle-Aquitaine

from Institut de génomique fonctionnelle de Montpellier, Department of Neuroscience's lab will give a presentation entitled 'RVM GABAergic neurons command enkephalinergic spinal neurons to act as gatekeepers of mechanical pain.'

Invitant : Pascal Fossat , Assistant Professor, Team: Central Mechanisms of Pain Sensitization and Anna Beyeler: Teamleader 'Neural Circuits of Anxiety', IINS et Neurocentre Magendie







Séminaire
17/05/2018 09h00
Neurocampus day

Meeting room: Université, Agora du Haut Carré, Talenc

Point fort de l’année ! le « Neurocampus Day » avec ses 6 instituts de recherche, ses rencontres, ses échanges prometteurs , une journée riche en sciences du cerveau... Domaine du Haut Carré , Talence le Jeudi 17 Mai 2018

Du Neurocentre Magendie:
14h40-15h05 Anna Beyeler / Anatomical and functional organization of neural populations in the amygdala and insula

17h15-17h40 Luigi Bellochio (Equipe Marsicano) / Striatonigral mitochondrial CB1 receptors mediate cannabinoid-induced catalepsy



Séminaire
10/04/2018 10h00
Davide Amato

Meeting room: Neurocentre Magendie Seminar room

Davide Amato will present his latest work on the role of D1 and D2 neurons of the nucleus accumbens in cocaine sensitization and cross-sensitization with antipsychotics. The study he will share was performed with single-cell calcium imaging in freely moving mice.

Invited by Anna Beyeler.




The team of Ian Wickersham at MIT developped a new generation of non toxic rabies vectors. Anna Beyeler was part of the team showing that neurons were still functioning normally up to four months after infection. In this new construct the gene coding for the polymerase necessary for transcribing viral genes was deleted. Without this gene, the virus becomes less harmful and infected cells can survive much longer.




Hottopic
31/01/2018 11h00
Anna BEYELER from BEYELER's lab will give a presentation entitled "Anatomical and Functional Organization of Neural Populations in the Amygdala and the Insula."

Info Générale
01/06/2017
Une 1Oième équipe à Magendie

Le Neurocentre est très fier d'accueillir Anna Beyeler qui prend la tête de la dixième équipe du centre. Bienvenue !