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Interview de Nora Abrous, Directeur de recherche à l'Inserm au Neurocentre Magendie à Bordeaux. Elle est notamment spécialiste en neurobiologie du développement, mémoire et système de mémoire, vieillissement cérébral, apprentissage, vulnérabilité et addictions. Elle dirige l'équipe "Neurogenèse et physiopathologie".
Émission autour du cerveau, de la mémoire et du vieillissement sur France Bleu





Le prochain congrès « Aging 2018 » se tiendra au domaine du Haut Carré à Talence du 26 au 28 septembre 2018. Il réunira les membres de la communauté neuroscientifique internationale autour d’un thème central : le vieillissement cognitif en absence de MA et l’existence de différences inter-individuelles dans l’atteinte mnésique au cours de l’âge.

Invitant : Bordeaux Neurocampus, Gwenaelle Catheline, Aline Marighetto, Nora Abrous
L’inscription est obligatoire pour toute personne participant ou assistant au Congrès. La soumission d’un abstract ne peut se faire qu’après inscription. Le colloque accueillera un maximum de 280 personnes. Les participants sont tenus d'être présents durant les 3 jours.






Beau succès pour le congrès Aging co-organisé par Nora Abrous, Aline Marighetto et Gwenaelle Catherine pour faire le point sur les dernières découvertes concernant le vieillissement cognitif.




Seminars
25/09/2018 14h00
Sophie TRONEL

Meeting room: Neurocentre Magendie Seminar room

Soutenance HDR: Sophie Tronel from Abrous's lab will give a presentation entitled 'Etude de la stabilisation de la mémoire'





Team “Neurogenesis and pathophysiology”. Neurocentre Magendie / Bordeaux Neurocampus:

The dentate gyrus (DG) of the hippocampus is one of the few mammalian brain structures where neurogenesis is maintained throughout the lifetime of individuals. Indeed the dentate granule cells (GCs), the main neuronal cell type in the DG, are generated via several distinct phases occurring during late embryogenesis, the early postnatal life, the juvenile period and throughout adulthood. Because of this continuous addition of new cells, the DG appears as a heterogeneous structure composed of different populations of granule neurons. Whether these different populations have similar or distinct structural and functional properties is still a matter of debate. Surprisingly, although most dentate GCs are generated during development, little was known about their properties compared to adult-born neurons. Nevertheless, it was generally admitted that these populations are morphologically indistinguishable once mature. However a detailed and extensive analysis of developmentally-born neurons was lacking for proper comparison.


In this study, we used in vivo electroporation to label dentate GCs generated in mouse embryos (E14.5) or in neonates (P0) and followed their morphological development up to 6 months after birth. Importantly, we highlight for the first time major morphological differences with GCs born during the juvenile period (P21) or during adulthood (P84). Importantly, we also identified different morphological parameters that can be used to predict the birthdate of granule neurons in adult brain sections. In addition, our data indicate that two other poorly studied populations of GCs in the DG, the semilunar and hilar granule cells are generated during the embryonic and the neonatal periods respectively. Thus, our findings provide new insights into the development of the different populations of granule neurons in the DG and open new questions regarding their function in the brain. Indeed, the dendritic tree determines the amount and specificity of inputs a neuron receives and is involved in sophisticated signal processing and neural computation. Consequently, mature dentate GCs born at embryonic, neonatal or adult stages might contribute differently to hippocampal function. Future analyses of the inputs and functional properties of the different populations of GCs using in vivo electroporation might help to address this controversial question.(Pictures : Thomas Kerloch, Nora Abrous, Emilie Pacary)

Dentate Granule Neurons Generated During Perinatal Life Display Distinct Morphological Features Compared With Later-Born Neurons in the Mouse Hippocampus. Thomas Kerloch, Solène Clavreul, Adeline Goron, Djoher Nora Abrous, Emilie Pacary. Cereb Cortex. 2018 Sep 12. doi: 10.1093/cercor/bhy224.




Hottopic
27/06/2018 10h30
Marie Lods from Abrous's lab will give a presentation entitled “Rôle of hippocampal adult neurogenesis on spatial memory reconsolidation”

Seminars
22/06/2018 11h30
Martin Giurfa

Meeting room: Neurocentre Magendie Seminar room

from Research Center on Animal Cognition's lab will give a presentation entitled 'Searching for the neural bases of non-elemental learning in a miniature brain'

DR CNRS / Centre de Recherches sur la Cognition Animale - UMR 5169 Team leader: Plasticité dépendante de l’expérience chez l’insecte (EXPLAIN) Research Center on Animal Cognition, CNRS - Université de Toulouse

Invitant : Nora Abrous / Team leader : 'Neurogénèse et physiopathologie' , DR Inserm / Neurocentre Magendie



General informations
08/03/2018
Deroche-Gamonet, Revest et al. in Molecular Psychiatry:

First causal evidence of a role of neurogenesis in a drug-related behavior.

The hippocampus is the main locus for adult dentate gyrus (DG) neurogenesis. A number of studies have shown that aberrant DG neurogenesis correlates with many neuropsychiatric disorders, including drug addiction. Although clear causal relationships have been established between DG neurogenesis and memory dysfunction or mood-related disorders, evidence of the causal role of DG neurogenesis in drug-seeking behaviors has not been established. Here we assessed the role of new DG neurons in cocaine self-administration using an inducible transgenic approach that selectively depletes adult DG neurogenesis. Our results show that transgenic mice with decreased adult DG neurogenesis exhibit increased motivation to self-administer cocaine and a higher seeking response to cocaine-related cues. These results identify adult hippocampal neurogenesis as a key factor in vulnerability to cocaine addiction.

Deroche-Gamonet V*, Revest JM*, Fiancette JF, Balado E, Koehl M, Grosjean N, Abrous DN*, Piazza PV*. Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior. Mol Psychiatry. 2018 Mar 5. doi: 10.1038/s41380-018-0038-0.





La plasticité synaptique, c'est fantastique: une nouvelle stratégie contre la dépression:

L'un des principaux défis de la neuropsychopharmacologie moderne réside dans le traitement de la dépression. En effet, les antidépresseurs (AD) couramment utilisés en clinique, dont le Prozac constitue toujours le chef de file, sont loin de présenter un profil optimal, un tiers seulement des patients répondant de manière satisfaisante au traitement. Un autre tiers ne répond que partiellement, alors que chez le dernier tiers de patients, les symptômes de la dépression sont malheureusement résistants au médicament.

Inducing a long-term potentiation in the dentate gyrus is sufficient to produce rapid antidepressant-like effects.
Kanzari A, Bourcier-Lucas C, Freyssin A, Abrous DN, Haddjeri N, Lucas G. Mol Psychiatry. 2017 May 9.





Le Concours du Prix de Thèse SCILIGHT est un concours organisé par la société SCILIGHT avec le soutien de l’Ecole Doctorale des Sciences de la Vie et de la Santé de l’Université de Bordeaux. Il a pour objectif de promouvoir la diffusion de l’information scientifique par le biais des nouveaux médias de communication et de valoriser les résultats scientifiques et l’importance de leur représentation. Chaque année, il récompense un futur docteur qui a montré au cours de sa thèse des qualités remarquables de communication dans la transmission du savoir scientifique. En 2017, le prix est allé à Marie Lods, doctorante dans l'équipe Abrous. Voyez sa production sur la chaîne YouTUbe du centre : https://youtu.be/qPy3DQZLU9k.