Neurocentre Magendie

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Venue: Bordeaux School of Neuroscience

The normal aging process is associated with reduced performance on cognitive tasks that require one to quickly process or transform information to make a decision, including measures of speed of processing, executive cognitive function, working and relational memories. Structural and functional alterations in the brain correlate with these age-related cognitive changes, such as loss of synapses, and dysfunction of neuronal networks. It is crucial to develop new approaches that consider the whole neuroanatomical, endocrine, immunological, vascular and cellular changes impacting on cognition.

This 3-week course will cover the fundamentals of cognitive aging -including inter-individual differences, cognitive and brain reserve and risk factors- and highlight the newest functional imaging methods to study human brain function. The Faculty will share the state-of-the-art molecular, optical, computational, electrophysiological, behavioural and epidemiological approaches available for studying the aging brain in diverse model systems. The Students will learn the potential and limitations of these methods, through practical experience in a combination of lectures addressing aging in both humans and animal models and hands-on-projects. They will acquire sufficient practical experience to model, design and interpret experiments and brainstorm on novel technologies and hypotheses to explore the aging of the brain using more integrative and creative approaches.

Keynote speakers:
Hélène Amieva - University of Bordeaux
Adam Antebi - MPI for Biology of Ageing
Carol Barnes - University of Arizona
LucBuée-Centrede Recherche Jean-Pierre Aubert
Gwenaëlle Catheline - University of Bordeaux
Maria Llorens-Martin - Centro de Biologia
Molecular Severo Ochoa
Aline Marighetto - University of Bordeaux
Lars Nyberg - Umeå University
Laure Rondi-Reig - Sorbonne University
Yaakov Stern - Columbia University
Tony Wyss-Coray - Stanford University

Course director: Luísa Lopes
Co-directors: Cheryl Grady and Nora Abrous

Application deadline: 25 May 2020
Stipends are available

Registration
Fee : 3.500 € (includes tuition fee, accommodation and meals)

The CAJAL programme offers 4 stipends per course (waived registration fee, not including travel expenses). Please apply through the course online application form. In order to identify candidates in real need of a stipend, any grant applicant is encouraged to first request funds from their lab, institution or government.

Kindly note that if you benefited from a Cajal stipend in the past, you are no longer eligible to receive this kind of funding. However other types of funding (such as partial travel grants from sponsors) might be made available after the participants selection process, depending on the course.

For enquiries, please contact: info@cajal-training.org




Séminaire
14/02/2020 11h30
Chantal Mathis

Meeting room: Neurocentre Magendie Seminar room

from DR2 CNRS, LNCA, Strasbourg's lab will give a presentation entitled 'Early memory deficits appearing during preclinical stages in mouse models of Alzheimer disease'

Invited by Nora Abrous (Neurocentre Magendie)

Abstract

Over the last decade, the main finding about Alzheimer’s disease (AD) is that initial signs have been detected 15 to 20 years before diagnosis (e.g., see Bateman et al, 2012 and Jack et al, 2009). Since then, a great deal of efforts concentrated on the identification of early events and biomarkers that might help us to understand AD pathogenesis. The nature and severity of recognition deficits evolve as AD pathology spreads through medial temporal lobe networks and connected brain structures playing a key role in recognition memories. Therefore, object recognition paradigms have been useful to determine early memory deficits in animal models of AD. The pertinence of behavioral data provided by these paradigms will be analyzed in regard to the neuropathological phenotype of genetically modified rodent models of AD. Our aim is to outline clear advantages and possible limitations in their translational value. We propose that future progress depends on understanding neural networks supporting each form of recognition memory in parallel with the improvement of animal models of AD.



Offre de poste
19/12/2019
Postdoc Position in calcium imaging (two-photon) and/or in vivo electrophysiology

The Cortical Plasticity group at the Neurocentre Magendie (Bordeaux, France) is seeking to recruit a postdoctoral researcher to join their group in 2020.

We are interested in the function of neocortical circuits and their pathophysiological modification in neurodevelopmental disorders. In particular, we study sensory information processing and perception. To address this, we will use in vivo calcium imaging (two-photon/miniscope) and electrophysiological approaches (multi-electrode/whole-cell) in behaving mice.

The project is funded for three years. We are looking for a highly motivated and proactive candidate with experience in in vivo electrophysiology and/or calcium imaging and analysis of this data. The successful candidate is expected to make significant contributions to the direction and conceptualization of the project. The appointee must have a PhD or equivalent qualification in either neuroscience, life sciences, medicine, or physics. The candidate should also have a good level of proficiency in English.

The team is based at the Neurocentre Magendie, an INSERM research institute, and member of the Bordeaux Neurocampus — a center of excellence for neuroscience research in France. The day-to-day language is English, but support would be provided for learning French if the candidate so wishes.

Interested applicants should send a cv, brief statement of research experience and interests, and names of 2-3 references to Dr. Andreas Frick: andreas.frick@inserm.fr

Website: https://neurocentre-magendie.fr/recherche/Frick/descriptionTeam.php

A few project-relevant publications from our team:
- Aloisi, E., Le Corf, K., Dupuis, J., Zhang, P., Ginger, M., Labrousse, V., Spatuzza, M., Haberl, MG., Costa, LT., Shigemoto, R., Thappe Theoder, A., Drago, F., Piazza, PV., Mulle, C., Groc, L., Ciranna, L., Catania, MV., Frick, A. (2017) Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice. Nature Communications. 2017 Oct 24;8(1):1103. doi: 10.1038/s41467-017-01191-2.
- Frick, A., Ginger, M., El-Hassar, L., Kaczmarek, L.K. (2017) Ion channel dysfunction and FXS. Elsevier. "Fragile X syndrome: from genetics to targeted treatments”. Editors: R. Willemsen and F. Kooy. Chapter 16, pages 323-334.
- Haberl, M. G., Zerbi, V., Veltien, A., Ginger, M., Heerschap, A., and Frick A. (2015). Structural-functional connectivity deficits of neocortical circuits in the Fmr1-/y mouse model of autism. Science Advances, 1(10), e1500775–e1500775. doi:10.1126/sciadv.1500775.
- Zhang*, Y., Bonnan*, A., Bony*, G., Ferezou, I., Pietropaolo, S., Ginger, M., Sans, N., Rossier, J., Oostra, B., LeMasson, G., Frick, A. (2014) Dendritic Channelopathies Contribute to Neocortical Hyperexcitability and Sensory Hypersensitivity in the Fmr1-/y Mice. Nature Neuroscience, 17, 1701–1709 (2014) doi:10.1038/nn.3864.





Le concours de l’école doctorale SVS de l’Université de Bordeaux a rendu son verdict : le Neurocentre glane 4 des 16 contrats doctoraux. Bravo à Mohamed-Lyès KACI (Éq. Abrous, Dir de thèse Muriel Koehl) qui se classe 5ème, Emma MESGUICH (Éq. Marsicano, Dir de thèse France Chaouloff) qui se classe 7ème, Pierre-Louis RAUX (Éq. Revest, Dir de thèse Monique Vallée) qui se classe 11ème et Yifan WU (Éq. Beyeler) qui se classe 17ème. Ils intégreront les équipes du centre dès la rentrée prochaine.





Interview de Nora Abrous, Directeur de recherche à l'Inserm au Neurocentre Magendie à Bordeaux. Elle est notamment spécialiste en neurobiologie du développement, mémoire et système de mémoire, vieillissement cérébral, apprentissage, vulnérabilité et addictions. Elle dirige l'équipe "Neurogenèse et physiopathologie".
Émission autour du cerveau, de la mémoire et du vieillissement sur France Bleu





Le prochain congrès « Aging 2018 » se tiendra au domaine du Haut Carré à Talence du 26 au 28 septembre 2018. Il réunira les membres de la communauté neuroscientifique internationale autour d’un thème central : le vieillissement cognitif en absence de MA et l’existence de différences inter-individuelles dans l’atteinte mnésique au cours de l’âge.

Invitant : Bordeaux Neurocampus, Gwenaelle Catheline, Aline Marighetto, Nora Abrous
L’inscription est obligatoire pour toute personne participant ou assistant au Congrès. La soumission d’un abstract ne peut se faire qu’après inscription. Le colloque accueillera un maximum de 280 personnes. Les participants sont tenus d'être présents durant les 3 jours.






Beau succès pour le congrès Aging co-organisé par Nora Abrous, Aline Marighetto et Gwenaelle Catherine pour faire le point sur les dernières découvertes concernant le vieillissement cognitif.




Séminaire
25/09/2018 14h00
Sophie TRONEL

Meeting room: Neurocentre Magendie Seminar room

Soutenance HDR: Sophie Tronel from Abrous's lab will give a presentation entitled 'Etude de la stabilisation de la mémoire'





Team “Neurogenesis and pathophysiology”. Neurocentre Magendie / Bordeaux Neurocampus:

The dentate gyrus (DG) of the hippocampus is one of the few mammalian brain structures where neurogenesis is maintained throughout the lifetime of individuals. Indeed the dentate granule cells (GCs), the main neuronal cell type in the DG, are generated via several distinct phases occurring during late embryogenesis, the early postnatal life, the juvenile period and throughout adulthood. Because of this continuous addition of new cells, the DG appears as a heterogeneous structure composed of different populations of granule neurons. Whether these different populations have similar or distinct structural and functional properties is still a matter of debate. Surprisingly, although most dentate GCs are generated during development, little was known about their properties compared to adult-born neurons. Nevertheless, it was generally admitted that these populations are morphologically indistinguishable once mature. However a detailed and extensive analysis of developmentally-born neurons was lacking for proper comparison.


In this study, we used in vivo electroporation to label dentate GCs generated in mouse embryos (E14.5) or in neonates (P0) and followed their morphological development up to 6 months after birth. Importantly, we highlight for the first time major morphological differences with GCs born during the juvenile period (P21) or during adulthood (P84). Importantly, we also identified different morphological parameters that can be used to predict the birthdate of granule neurons in adult brain sections. In addition, our data indicate that two other poorly studied populations of GCs in the DG, the semilunar and hilar granule cells are generated during the embryonic and the neonatal periods respectively. Thus, our findings provide new insights into the development of the different populations of granule neurons in the DG and open new questions regarding their function in the brain. Indeed, the dendritic tree determines the amount and specificity of inputs a neuron receives and is involved in sophisticated signal processing and neural computation. Consequently, mature dentate GCs born at embryonic, neonatal or adult stages might contribute differently to hippocampal function. Future analyses of the inputs and functional properties of the different populations of GCs using in vivo electroporation might help to address this controversial question.(Pictures : Thomas Kerloch, Nora Abrous, Emilie Pacary)

Dentate Granule Neurons Generated During Perinatal Life Display Distinct Morphological Features Compared With Later-Born Neurons in the Mouse Hippocampus. Thomas Kerloch, Solène Clavreul, Adeline Goron, Djoher Nora Abrous, Emilie Pacary. Cereb Cortex. 2018 Sep 12. doi: 10.1093/cercor/bhy224.




Hottopic
27/06/2018 10h30
Marie Lods from Abrous's lab will give a presentation entitled “Rôle of hippocampal adult neurogenesis on spatial memory reconsolidation”