Poste à pourvoir: AI (10 months), team « Pathophysiology of declarative memory”, Neurocentre Magendie, INSERM U1215.

Profil: contribuer à l’identification du réseau neuronal (cellules de l’engramme) sous-jacent à la transformation de la mémoire traumatique pathologique (i.e. associée au trouble de stress post-traumatique -TSPT) à la mémoire de peur normative (contextualisée) et vice versa. En utilisant des technologies parmi les plus avancées en neurosciences, e.g. souris transgéniques -FosTRAP2-, chémogénétique, optogénétique et imagerie cellulaire, l’assistant ingénieur étudiera la représentation et le devenir de « l’engramme mnésique » lors de la formation, prévention et normalisation de la représentation d’un trauma.

Compétences requises: approches comportementales chez la souris, chirurgie stéréotaxique, approches histologiques et immunohistochimiques. Ces travaux sont financés par une subvention d’excellence de la Brain & Behaviour Research Foundation (BBRF) (« Traiter ou prévenir la mémoire de type TSPT par la manipulation des cellules de l’engramme sous-jacentes ») débutant en avril 2026 et impliquera également l’utilisation des techniques d’optogénétique et de chémogénétique que le candidat pourra acquérir au sein de l’équipe.

Contact : Pr A Desmedt, aline.desmedt@inserm.fr

Location: Neurocentre Magendie, Bordeaux, France (https://neurocentre-magendie.fr/), Department Bordeaux Neurocampus (https://www.bordeaux-neurocampus.fr/en/)
Duration: 24 months
Expected Start Date: March 2026 (flexible)
Salary: Based on experience and institutional guidelines

We are seeking a highly motivated postdoctoral researcher to join a multidisciplinary team studying the neurobiological and behavioral mechanisms underlying vulnerability to cocaine addiction.

To identify the neuronal basis of behavioral transitions, this position is dedicated to combining the following approaches:
– Miniscope calcium imaging to record neuronal activity during cocaine self-administration
– AI-based behavioral phenotyping (e.g., DeepLabCut) and neural data analysis
Responsibilities

Implement and optimize miniscope recordings in cocaine self-administering rats
Apply machine learning tools to identify fine-grained behavioral motifs
Develop pipelines to link neural dynamics with behavior

Requirements

PhD in neuroscience, neurocomputation or related field
Experience with animal models and in vivo imaging
Programming skills (Python, MATLAB, etc.)
Familiarity with behavioral analysis or machine learning

Candidates should send their CV, letter of motivation, list of publications and 2 letters of reference (to be sent by references) to Dr Véronique Deroche-Gamonet (veronique.deroche@inserm.fr) and Dr Julien Courtin (julien.courtin@inserm.fr).

Vous souhaitez intégrer une plateforme en plein essor comme la Plateforme de Chimie Analytique ?

Découvrir des spectromètres de dernière génération ? Travailler en métabolomique et lipidomique ?

Si vous avez soif de challenges et que vous êtes passionné(e) par le développement de méthode cette opportunité est faite pour vous !

Envoyez vos CV à Isabelle Matias

isabelle.matias@inserm.fr

Location: Neurocentre Magendie, Bordeaux, France (https://neurocentre-magendie.fr/), Department Bordeaux Neurocampus (https://www.bordeaux-neurocampus.fr/en/)
Duration: 24 months
Expected Start Date: March 2026 (flexible)
Salary: Based on experience and institutional guidelines

We are seeking a highly motivated postdoctoral researcher to join a multidisciplinary team studying the neurobiological and behavioral mechanisms underlying vulnerability to cocaine addiction.

To identify the neuronal basis of behavioral transitions, this position is dedicated to combining the following approaches:
– Miniscope calcium imaging to record neuronal activity during cocaine self-administration
– AI-based behavioral phenotyping (e.g., DeepLabCut) and neural data analysis
Responsibilities

Implement and optimize miniscope recordings in cocaine self-administering rats
Apply machine learning tools to identify fine-grained behavioral motifs
Develop pipelines to link neural dynamics with behavior

Requirements

PhD in neuroscience, neurocomputation or related field
Experience with animal models and in vivo imaging
Programming skills (Python, MATLAB, etc.)
Familiarity with behavioral analysis or machine learning

Candidates should send their CV, letter of motivation, list of publications and 2 letters of reference (to be sent by references) to Dr Véronique Deroche-Gamonet (veronique.deroche@inserm.fr) and Dr Julien Courtin (julien.courtin@inserm.fr).

Equipe Deroche:
Date de début souhaitée : Novembre 2025 à Janvier 2026
Les qualifications requises pour ce poste correspondent à celles d’un·e Assistant·e Ingénieur·e (AI) en Neurobiologie Comportementale. La mission consistera à contribuer à un projet de recherche portant sur les mécanismes neuronaux impliqués dans l’usage mal-adapté de cocaïne. En étroite collaboration avec un Ingénieur de Recherche, le ou la candidat·e participera à des tests comportementaux en lien avec l’usage de cocaïne et associés à des analyses en temps réel de l’activité neuronale, dans un modèle rongeur. Ses missions consisteront à l’appui et/ou la réalisation de chirurgies stéréotaxiques et vasculaires, ainsi qu’aux protocoles d’auto-administration intraveineuse couplés à la photométrie par fibre optique.
Diplôme requis : BUT, Licence Professionnelle ou Master
Durée du contrat : 12 mois, renouvelable
Contact: veronique.deroche@inserm.fr

The qualifications sought for this position correspond to those of an Engineer (IE) or Research Engineer (IR) in Behavioral Neurobiology, depending on titles (with/without PhD) and experience. The main mission of the engineer will be to participate in a project investigating the role of subpopulation of hypothalamic neurons in the regulation of whole body metabolic flexibility and impact on the vulnerability to obesity.

The engineer will join the energy balance and obesity laboratory at the neurocentre Magendie, whose work focuses on the neurobiology of obesity (http://www.neurocentre-magendie.fr/cota).

The candidate will be involved in all stages of the project and will conduct feeding behavioral testing in mice coupled with in vivo analyses of energy substrates use. Tasks will include stereotaxic surgeries and use of viral vectors, in vivo pharmacology, ELISA, western blot, immunohistochemistry, fluorescent in situ hybridization and RNAscope. The candidate will be in charge of data collection, analysis, and formatting.

Desired prerequisites: Animal experimentation certification as well as training in small animal surgery and practical experience in the field of behavioral neuroscience. Proficiency in immunohistochemistry techniques.

Contract duration: 12 months, renewable

Desired start date: September/October 2025.

Contact: daniela.cota@inserm.fr

The team “Neurogenesis and Physiopathology”, led by Nora Abrous at the Neurocentre Magendie (Bordeaux, France), is seeking an independent postdoctoral scientist. The selected candidate will participate in a Franco-Canadian collaboration with Caroline Menard’s laboratory at Université Laval (Quebec City, Canada). The project’s objective is to investigate if neurovascular adaptations underlie age-related changes in neurogenesis and cognitive performances.

Normal, non-pathological aging –also called normative aging- is generally accompanied by a progressive cognitive decline particularly in hippocampal-dependent memory function. Intriguingly, age-related alterations are variable within a population. Hippocampal neurogenesis, defined as the formation of new neurons, has been associated with memory performances in rodents and in humans, blood-brain barrier (BBB) breakdown was identified as an early marker of cognitive impairment. During brain development, neurogenesis, and angiogenesis – growth of blood vessels – work in tandem, however, it is still unknown if these processes interact in the aging brain to favor maintenance of memory capacities vs cognitive decline. The aim of the project will be to study in the course of aging the relationship between BBB integrity, cognitive performance, and the morphological properties of neurons generated in young adult animals. Identification of signaling pathways involved in healthy cognitive aging could lead to the development of innovative therapies targeting conditions characterized by memory impairment.

Competences

We are seeking a highly motivated and competent individual, with a proven track record of success and expertise in either adult neurogenesis or the vascular field. Skills in in vivo experimentation, such as stereotaxic surgery in rodents, are required. Experience with brain immunohistology and imaging techniques (STED) would be advantageous. Candidates should be junior, if possible, immediately after their PhD, and in any case no more than three years after their PhD.

The applicant should possess strong team-working capabilities, the ability to independently conduct experimental research, and excellent communication skills in spoken and written English. Proficiency in French is not mandatory.

The project will be conducted in a stimulating and highly interdisciplinary and international environment in the Neurocentre Magendie, a part of the Bordeaux Neurocampus project.

You are interested?

Please send a cover letter with a brief description of research experiences, interests, and accomplishments, their CV, and the names of 2 to 3 references to:
Nora Abrous
nora.abrous@inserm.fr

We seek a highly motivated and proactive team player to join our international group. In this collaborative project (collaborator: Brice Bathellier at Institut Pasteur), you will study the dysfunctional maturation of prefrontal cortex ensembles in a mouse model of Alzheimer’s disease using population activity measures (miniscope or mini-2-photon calcium imaging) together with innovative tools for labeling and computational approaches. Please see our recent paper on bioRxiv for some context of the project: https://www.biorxiv.org/content/10.1101/2024.09.13.612936v1


The postdoc position is fully funded for 3 years by the Foundation for Medical Research. The appointee must have a PhD or equivalent qualification in neuroscience, life sciences, medicine, bioinformatics, mathematics, or physics. The candidate should also be proficient in English. Interested applicants should send a cv, brief statement of research experience and interests, and names of 2-3 references to Dr. Andreas Frick: andreas.frick@inserm.fr

Nous recrutons un(e) ingénieur(e) très motivé(e) par la quantification en routine de biomolécules en spectrométrie de masse tandem couplée à toute forme de chromatographies et également par les projets de développement et de validation de méthodes en spectrométrie de masse tandem et en spectrométrie de masse haute résolution.

Le CDD est d’1 an renouvelable à partir du 1er janvier 2025 sur la plateforme de chimie analytique (PUMA).

2-year (renewable) position

We are looking for a highly motivated postdoc with a strong background in the field of behavioral neurophysiology. The successful candidate will be enthusiastic and passionate about understanding the brain and will hold a PhD and/or MD degree in neuroscience, biophysics, engineering, medicine, or related topics. A previous experience with in vivo recordings and data analysis is required. Programming skills will be a plus. The postdoctoral fellow will participate to an ongoing project on amygdalar interneurons, with room for the development a specific project.

The team
The Neural Circuits of Associative Learning team is led by Dr Cyril Herry. Our team is dynamic, international and inclusive, promoting team spirit while supporting individual achievements and career development. Each lab member is offered regular one-to-one meeting, and participates to weekly lab meetings and workshops.

The science
Our overarching goal is to dissect and neural circuit operations controlling emotions, motivation and behavior in health and disease. To achieve this, we integrate a range of cutting-edge expertise including high-density electrophysiological and miniscope recordings, optogenetic, chemogenetic and pharmacological manipulations in behaving animals, and advanced data analyses. Specific projects include the studies of mechanisms underlying anxiety, emotion generalization, as well as goal-directed and addictive behaviors.

The environment
the Institute, Neurocentre Magendie is part of the internationally renowned Bordeaux Neurocampus department at University of Bordeaux, gathering 700+ people of at least 35 nationalities, sharing the goal to understand brain functioning in normal and pathological conditions. The department offers many opportunities for collaborations, access to core facilities, as well as frequent seminars and workshops.
It is located in close proximity to the center of the vibrant city of Bordeaux.

Salary
Depending on previous experience, according to Inserm salary bands: 35-51k€ pa, before taxes. National health insurance is provided. France also offers financial support for childcare.

Contact:
thomas.bienvenu@u-bordeaux.fr