Publications du Neurocentre Magendie

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IF du Neurocentre
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1124 publications

* equal contribution
Les IF indiqués ont été collectés par le Web of Sciences en Juin 2019



23/06/2017 | phys rev lett
Search for the Decays B_{s}^{0}-->tau^{+}tau^{-} and B^{0}-->tau^{+}tau^{-}.
Aaij R, Adeva B, Adinolfi M, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Ali S, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Aslanides E, Auriemma G, Baalouch M, Babuschkin I, Bachmann S, Back JJ, Badalov A, Baesso C, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barschel C, Barsuk S, Barter W, Baryshnikov F, Baszczyk M, Batozskaya V, Batsukh B, Battista V, Bay A, Beaucourt L, Beddow J, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Beranek S, Berezhnoy A, Bernet R, Bertolin A, Betancourt C, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bifani S, Billoir P, Birnkraut A, Bitadze A, Bizzeti A, Blake T, Blanc F, Blouw J, Blusk S, Bocci V, Boettcher T, Bondar A, Bondar N, Bonivento W, Bordyuzhin I, Borgheresi A, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJV, Bowen E, Bozzi C, Braun S, Britton T, Brodzicka J, Buchanan E, Burr C, Bursche A, Buytaert J, Cadeddu S, Calabrese R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Castillo Garcia L, Cattaneo M, Cavallero G, Cenci R, Chamont D, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chen S, Cheung SF, Chobanova V, Chrzaszcz M, Chubykin A, Cid Vidal X, Ciezarek G, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Cogan J, Cogneras E, Cogoni V, Cojocariu L, Collins P, Comerma-Montells A, Contu A, Cook A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Cunliffe S, Currie R, D'Ambrosio C, Da Cunha Marinho F, Dall'Occo E, Dalseno J, David PNY, Davis A, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Deckenhoff M, Del Buono L, Dembinski HP, Demmer M, Dendek A, Derkach D, Deschamps O, Dettori F, Dey B, Di Canto A, Di Nezza P, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Dungs K, Durante P, Dzhelyadin R, Dziewiecki M, Dziurda A, Dzyuba A, Deleage N, Easo S, Ebert M, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Esen S, Evans HM, Evans T, Falabella A, Farley N, Farry S, Fay R, Fazzini D, Ferguson D, Fernandez G, Fernandez Prieto A, Ferrari F, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiore M, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fohl K, Fontana M, Fontanelli F, Forshaw DC, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Furfaro E, Farber C, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garra Tico J, Garrido L, Garsed PJ, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Ghez P, Giani S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruberg Cazon BR, Grunberg O, Gushchin E, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han X, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison J, Hatch M, He J, Head T, Heister A, Hennessy K, Henrard P, Henry L, van Herwijnen E, Hess M, Hicheur A, Hill D, Hombach C, Hopchev H, Huard ZC, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Idzik M, Ilten P, Jacobsson R, Jalocha J, Jans E, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kecke M, Kelsey M, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kirn T, Klaver S, Klimaszewski K, Klimkovich T, Koliiev S, Kolpin M, Komarov I, Kopecna R, Koppenburg P, Kosmyntseva A, Kotriakhova S, Kozachuk A, Kozeiha M, Kravchuk L, Kreps M, Krokovny P, Kruse F, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kurek K, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, van Leerdam J, Leflat A, Lefrancois J, Lefevre R, Lemaitre F, Lemos Cid E, Leroy O, Lesiak T, Leverington B, Li T, Li Y, Li Z, Likhomanenko T, Lindner R, Lionetto F, Liu X, Loh D, Longstaff I, Lopes JH, Lucchesi D, Lucio Martinez M, Luo H, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Maev O, Maguire K, Malde S, Malinin A, Maltsev T, Manca G, Mancinelli G, Manning P, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Martins Tostes D, Massacrier LM, Massafferri A, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurice E, Maurin B, Mazurov A, McCann M, McNab A, McNulty R, Meadows B, Meier F, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Minard MN, Mitzel DS, Mogini A, Molina Rodriguez J, Monroy IA, Monteil S, Morandin M, Morda A, Morello MJ, Morgunova O, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Mussini M, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nikodem T, Nogay A, Novoselov A, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJG, Ossowska A, Otalora Goicochea JM, Owen P, Oyanguren A, Pais PR, Palano A, Palutan M, Papanestis A, Pappagallo M, Pappalardo LL, Pappenheimer C, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petruzzo M, Picatoste Olloqui E, Pietrzyk B, Pikies M, Pinci D, Pistone A, Piucci A, Placinta V, Playfer S, Plo Casasus M, Poikela T, Polci F, Poli Lener M, Poluektov A, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Popovici B, Poslavskii S, Potterat C, Price E, Prisciandaro J, Prouve C, Pugatch V, Puig Navarro A, Punzi G, Qian C, Qian W, Quagliani R, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Raniuk I, Ratnikov F, Raven G, Redi F, Reichert S, Dos Reis AC, Remon Alepuz C, Renaudin V, Ricciardi S, Richards S, Rihl M, Rinnert K, Rives Molina V, Robbe P, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Rodriguez Perez P, Rogozhnikov A, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Ronayne JW, Rotondo M, Rudolph MS, Ruf T, Ruiz Valls P, Saborido Silva JJ, Sadykhov E, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Gonzalo D, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarti A, Satriano C, Satta A, Saunders DM, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schlupp M, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubert K, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sergi A, Serra N, Serrano J, Sestini L, Seyfert P, Shapkin M, Shapoval I, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Sirendi M, Skidmore N, Skwarnicki T, Smith E, Smith IT, Smith J, Smith M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spradlin P, Sridharan S, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stevens H, Stoica S, Stone S, Storaci B, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Sun L, Sutcliffe W, Swientek K, Syropoulos V, Szczekowski M, Szumlak T, T'Jampens S, Tayduganov A, Tekampe T, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Topp-Joergensen S, Toriello F, Tourinho Jadallah Aoude R, Tournefier E, Tourneur S, Trabelsi K, Traill M, Tran MT, Tresch M, Trisovic A, Tsaregorodtsev A, Tsopelas P, Tully A, Tuning N, Ukleja A, Ustyuzhanin A, Uwer U, Vacca C, Vagnoni V, Valassi A, Valat S, Valenti G, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Verlage TA, Vernet M, Vesterinen M, Viana Barbosa JV, Viaud B, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitti M, Volkov V, Vollhardt A, Voneki B, Vorobyev A, Vorobyev V, Voss C, de Vries JA, Vazquez Sierra C, Waldi R, Wallace C, Wallace R, Walsh J, Wang J, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams M, Williams MP, Williams M, Williams T, Wilson FF, Wimberley J, Winn MA, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wraight K, Wyllie K, Xie Y, Xing Z, Xu Z, Yang Z, Yang Z, Yao Y, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang L, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zucchelli S

Abstract:
A search for the rare decays B_{s}^{0}-->tau^{+}tau^{-} and B^{0}-->tau^{+}tau^{-} is performed using proton-proton collision data collected with the LHCb detector. The data sample corresponds to an integrated luminosity of 3 fb^{-1} collected in 2011 and 2012. The tau leptons are reconstructed through the decay tau^{-}-->pi^{-}pi^{+}pi^{-}nu_{tau}. Assuming no contribution from B^{0}-->tau^{+}tau^{-} decays, an upper limit is set on the branching fraction B(B_{s}^{0}-->tau^{+}tau^{-})<6.8x10^{-3} at the 95% confidence level. If instead no contribution from B_{s}^{0}-->tau^{+}tau^{-} decays is assumed, the limit is B(B^{0}-->tau^{+}tau^{-})<2.1x10^{-3} at the 95% confidence level. These results correspond to the first direct limit on B(B_{s}^{0}-->tau^{+}tau^{-}) and the world's best limit on B(B^{0}-->tau^{+}tau^{-}).





20/06/2017 | bio protoc
Representation-mediated Aversion as a Model to Study Psychotic-like States in Mice.
Busquets-Garcia A, Soria-Gomez E, Ferreira G, Marsicano G

Abstract:
Several paradigms for rodent models of the cognitive and negative endophenotypes found in schizophrenic patients have been proposed. However, significant efforts are needed in order to study the pathophysiology of schizophrenia-related positive symptoms. Recently, it has been shown that these positive symptoms can be studied in rats by using representation-mediated learning. This learning measure the accuracy of mental representations of reality, also called 'reality testing'. Alterations in 'reality testing' performance can be an indication of an impairment in perception which is a clear hallmark of positive psychotic-like states. Thus, we describe here a mouse task adapted from previous findings based on a sensory preconditioning task. With this task, associations made between different neutral stimuli (e.g., an odor and a taste) and subsequent selective devaluation of one of these stimuli have allowed us to study mental sensory representations. Thus, the interest of this task is that it can be used to model positive psychotic-like states in mice, as recently described.





12/06/2017 | Trends Neurosci   IF 12.3
Astroglial versus Neuronal D-Serine: Fact Checking.
Papouin T, Henneberger C, Rusakov DA, Oliet SHR

Abstract:
The activation of NMDA receptors (NMDARs) is conditioned by the binding of a co-agonist to a dedicated receptor binding site. It is now largely accepted that D-serine plays this role at many central synapses in the hippocampus, amygdala, hypothalamus, nucleus accumbens, and in prefrontal, visual, and somatosensory cortices. D-Serine has been found to be synthesized, stored, and released by astrocytes (Figure 1). However, several immunolabeling studies and experiments in genetically modified animals have recently led to a suggestion that neurons are primarily responsible for the synthesis and release of D-serine [1]. Here we argue that such conclusions could have resulted from the erroneous interpretation of experimental data and that they are at odds with a substantial amount of published work.





09/06/2017 | elife   IF 7.6
Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses.
Ferreira JS, Papouin T, Ladepeche L, Yao A, Langlais VC, Bouchet D, Dulong J, Mothet JP, Sacchi S, Pollegioni L, Paoletti P, Oliet SHR, Groc L

Abstract:
The subunit composition of synaptic NMDA receptors (NMDAR), such as the relative content of GluN2A- and GluN2B-containing receptors, greatly influences the glutamate synaptic transmission. Receptor co-agonists, glycine and D-serine, have intriguingly emerged as potential regulators of the receptor trafficking in addition to their requirement for its activation. Using a combination of single-molecule imaging, biochemistry and electrophysiology, we show that glycine and D-serine relative availability at rat hippocampal glutamatergic synapses regulate the trafficking and synaptic content of NMDAR subtypes. Acute manipulations of co-agonist levels, both ex vivo and in vitro, unveil that D-serine alter the membrane dynamics and content of GluN2B-NMDAR, but not GluN2A-NMDAR, at synapses through a process requiring PDZ binding scaffold partners. In addition, using FRET-based FLIM approach, we demonstrate that D-serine rapidly induces a conformational change of the GluN1 subunit intracellular C-terminus domain. Together our data fuels the view that the extracellular microenvironment regulates synaptic NMDAR signaling.





07/06/2017 | autism res   IF 3.7
Behavioral abnormalities in the Fmr1-KO2 mouse model of fragile X syndrome: The relevance of early life phases.
Gaudissard J*, Ginger M*, Premoli M, Memo M, Frick A*, Pietropaolo S*

Abstract:
Fragile X syndrome (FXS) is a developmental disorder caused by a mutation in the X-linked FMR1 gene, coding for the FMRP protein which is largely involved in synaptic function. FXS patients present several behavioral abnormalities, including hyperactivity, anxiety, sensory hyper-responsiveness, and cognitive deficits. Autistic symptoms, e.g., altered social interaction and communication, are also often observed: FXS is indeed the most common monogenic cause of autism. Mouse models of FXS are therefore of great interest for research on both FXS and autistic pathologies. The Fmr1-KO2 mouse line is the most recent FXS model, widely used for brain studies; surprisingly, little is known about the face validity of this model, i.e., its FXS-like behavioral phenotype. Furthermore, no data are available for the age-related expression of the pathological phenotypes in this mouse line, a critical issue for modelling neurodevelopmental disorders. Here we performed an extensive behavioral characterization of the KO2 model at infancy, adolescent and adult ages. Hyperactivity, altered emotionality, sensory hyper-responsiveness and memory deficits were already present in KO mice at adolescence and remained evident at adulthood. Alterations in social behaviors were instead observed only in young KO animals: during the first 2 weeks of life, KOs emitted longer ultrasonic vocalizations compared to their WT littermates and as adolescents they displayed more aggressive behaviors towards a conspecific. These results strongly support the face validity of the KO2 mouse as a model for FXS, at the same time demonstrating that its ability to recapitulate social autistic-relevant phenotypes depends on early testing ages. Autism Res 2017. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc.





05/06/2017 | nat plants
Isotope evidence for agricultural extensification reveals how the world's first cities were fed.
Styring AK, Charles M, Fantone F, Hald MM, McMahon A, Meadow RH, Nicholls GK, Patel AK, Pitre MC, Smith A, Soltysiak A, Stein G, Weber JA, Weiss H, Bogaard A

Abstract:
This study sheds light on the agricultural economy that underpinned the emergence of the first urban centres in northern Mesopotamia. Using delta(13)C and delta(15)N values of crop remains from the sites of Tell Sabi Abyad, Tell Zeidan, Hamoukar, Tell Brak and Tell Leilan (6500-2000 cal bc), we reveal that labour-intensive practices such as manuring/middening and water management formed an integral part of the agricultural strategy from the seventh millennium bc. Increased agricultural production to support growing urban populations was achieved by cultivation of larger areas of land, entailing lower manure/midden inputs per unit area-extensification. Our findings paint a nuanced picture of the role of agricultural production in new forms of political centralization. The shift towards lower-input farming most plausibly developed gradually at a household level, but the increased importance of land-based wealth constituted a key potential source of political power, providing the possibility for greater bureaucratic control and contributing to the wider societal changes that accompanied urbanization.





03/06/2017 | Neuroscience   IF 3.2
The embryonic development of hindbrain respiratory networks is unaffected by mutation of the planar polarity protein Scribble.
Chevalier M, Cardoit L, Moreau M, Sans N, Montcouquiol M, Simmers J, Thoby-Brisson M

Abstract:
The central command for breathing arises mainly from two interconnected rhythmogenic hindbrain networks, the parafacial respiratory group (pFRG or epF at embryonic stages) and the preBotzinger complex (preBotC), which are comprised of a limited number of neurons located in confined regions of the ventral medulla. In rodents, both networks become active toward the end of gestation but little is known about the signaling pathways involved in their anatomical and functional establishment during embryogenesis. During embryonic development, epF and preBotC neurons migrate from their territories of origin to their final positions in ventral brainstem areas. Planar Cell Polarity (PCP) signaling, including the molecule Scrib, is known to control the developmental migration of several hindbrain neuronal groups. Accordingly, a homozygous mutation of Scrib leads to severe disruption of hindbrain anatomy and function. Here, we aimed to determine whether Scrib is also involved in the prenatal development of the hindbrain nuclei controlling breathing. We combined immunostaining, calcium imaging and electrophysiological recordings of neuronal activity in isolated in vitro preparations. In the Scrib mutant, despite severe neural tube defects, epF and preBotC neurons settled at their expected hindbrain positions. Furthermore, both networks remained capable of generating rhythmically organized, respiratory-related activities and exhibited normal sensitivity to pharmacological agents known to modify respiratory circuit function. Thus Scrib is not required for the proper migration of epF and preBotC neurons during mouse embryogenesis. Our findings thus further illustrate the robustness and specificity of the developmental processes involved in the establishment of hindbrain respiratory circuits.





01/06/2017 | Neuropharmacology   IF 4.4
Endocannabinoid modulation of homeostatic and non-homeostatic feeding circuits.
Lau BK, Cota D, Cristino L, Borgland SL

Abstract:
The endocannabinoid system has emerged as a key player in the control of eating. Endocannabinoids, including 2-arachidonoylglycerol (2-AG) and anandamide (AEA), modulate neuronal activity via cannabinoid 1 receptors (CB1Rs) in multiple nuclei of the hypothalamus to induce or inhibit food intake depending on nutritional and hormonal status, suggesting that endocannabinoids may act in the hypothalamus to integrate different types of signals informing about the animal's energy needs. In the mesocorticolimbic system, (endo)cannabinoids modulate synaptic transmission to promote dopamine release in response to palatable food. In addition, (endo)cannabinoids act within the nucleus accumbens to increase food's hedonic impact; although this effect depends on activation of CB1Rs at excitatory, but not inhibitory inputs in the nucleus accumbens. While hyperactivation of the endocannabinoid system is typically associated with overeating and obesity, much evidence has emerged in recent years suggesting a more complicated system than first thought - endocannabinoids promote or suppress feeding depending on cell and input type, or modulation by various neuronal or hormonal signals. This review presents our latest knowledge of the endocannabinoid system in non-homeostatic and homeostatic feeding circuits. In particular, we discuss the functional role and cellular mechanism of action by endocannabinoids within the hypothalamus and mesocorticolimbic system, and how these are modulated by neuropeptide signals related to feeding. In light of recent advances and complexity in the field, we review cannabinoid-based therapeutic strategies for the treatment of obesity and how peripheral restriction of CB1R antagonists may provide a different mechanism of weight loss without the central adverse effects.





06/2017 | Nat Neurosci   IF 21.1
Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment.
Burgos-Robles A, Kimchi EY, Izadmehr EM, Porzenheim MJ, Ramos-Guasp WA, Nieh EH, Felix-Ortiz AC, Namburi P, Leppla CA, Presbrey KN, Anandalingam KK, Pagan-Rivera PA, Anahtar M, Beyeler A, Tye KM

Abstract:
Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear-related responses, but how information flows between these reciprocally connected structures to coordinate behavior is unknown. We recorded neuronal activity from the BLA and PL while rats performed a task wherein competing shock- and sucrose-predictive cues were simultaneously presented. The correlated firing primarily displayed a BLA-->PL directionality during the shock-associated cue. Furthermore, BLA neurons optogenetically identified as projecting to PL more accurately predicted behavioral responses during competition than unidentified BLA neurons. Finally photostimulation of the BLA-->PL projection increased freezing, whereas both chemogenetic and optogenetic inhibition reduced freezing. Therefore, the BLA-->PL circuit is critical in governing the selection of behavioral responses in the face of competing signals.





06/2017 | evol lett
Unconscious selection drove seed enlargement in vegetable crops.
Kluyver TA, Jones G, Pujol B, Bennett C, Mockford EJ, Charles M, Rees M, Osborne CP

Abstract:
Domesticated grain crops evolved from wild plants under human cultivation, losing natural dispersal mechanisms to become dependent upon humans, and showing changes in a suite of other traits, including increasing seed size. There is tendency for seed enlargement during domestication to be viewed as the result of deliberate selection for large seeds by early farmers. However, like some other domestication traits, large seeds may have evolved through natural selection from the activities of people as they gathered plants from the wild, or brought them into cultivation in anthropogenic settings. Alternatively, larger seeds could have arisen via pleiotropic effects or genetic linkage, without foresight from early farmers, and driven by selection that acted on other organs or favored larger plants. We have separated these unconscious selection effects on seed enlargement from those of deliberate selection, by comparing the wild and domesticated forms of vegetable crops. Vegetables are propagated by planting seeds, cuttings, or tubers, but harvested for their edible leaves, stems, or roots, so that seed size is not a direct determinant of yield. We find that landrace varieties of seven vegetable crops have seeds that are 20% to 2.5-times larger than those of their closest wild relatives. These domestication effect sizes fall completely within the equivalent range of 14% to 15.2-times for grain crops, although domestication had a significantly larger overall effect in grain than vegetable crops. Seed enlargement in vegetable crops that are propagated vegetatively must arise from natural selection for larger seeds on the occasions when plants recruit from seed and are integrated into the crop gene pool, or via a genetic link to selection for larger plants or organs. If similar mechanisms operate across all species, then unconscious selection during domestication could have exerted stronger effects on the seed size of our staple crops than previously realized.





12/05/2017 | phys rev lett
Measurement of the B_{s}^{0}-->mu^{+}mu^{-} Branching Fraction and Effective Lifetime and Search for B^{0}-->mu^{+}mu^{-} Decays.
Aaij R, Adeva B, Adinolfi M, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Ali S, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Aslanides E, Auriemma G, Baalouch M, Babuschkin I, Bachmann S, Back JJ, Badalov A, Baesso C, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barschel C, Barsuk S, Barter W, Baryshnikov F, Baszczyk M, Batozskaya V, Batsukh B, Battista V, Bay A, Beaucourt L, Beddow J, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Beranek S, Berezhnoy A, Bernet R, Bertolin A, Betancourt C, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bifani S, Billoir P, Birnkraut A, Bitadze A, Bizzeti A, Blake T, Blanc F, Blouw J, Blusk S, Bocci V, Boettcher T, Bondar A, Bondar N, Bonivento W, Bordyuzhin I, Borgheresi A, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJV, Bowen E, Bozzi C, Braun S, Britton T, Brodzicka J, Buchanan E, Burr C, Bursche A, Buytaert J, Cadeddu S, Calabrese R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Castillo Garcia L, Cattaneo M, Cavallero G, Cenci R, Chamont D, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chen S, Cheung SF, Chobanova V, Chrzaszcz M, Chubykin A, Cid Vidal X, Ciezarek G, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Cogan J, Cogneras E, Cogoni V, Cojocariu L, Collins P, Comerma-Montells A, Contu A, Cook A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Cunliffe S, Currie R, D'Ambrosio C, Da Cunha Marinho F, Dall'Occo E, Dalseno J, David PNY, Davis A, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Deckenhoff M, Del Buono L, Demmer M, Dendek A, Derkach D, Deschamps O, Dettori F, Dey B, Di Canto A, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Dungs K, Durante P, Dzhelyadin R, Dziurda A, Dzyuba A, Deleage N, Easo S, Ebert M, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Esen S, Evans HM, Evans T, Falabella A, Farley N, Farry S, Fay R, Fazzini D, Ferguson D, Fernandez G, Fernandez Prieto A, Ferrari F, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiore M, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fohl K, Fontana M, Fontanelli F, Forshaw DC, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Furfaro E, Farber C, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garra Tico J, Garrido L, Garsed PJ, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Ghez P, Giani S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruberg Cazon BR, Grunberg O, Gushchin E, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han X, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison J, Hatch M, He J, Head T, Heister A, Hennessy K, Henrard P, Henry L, van Herwijnen E, Hess M, Hicheur A, Hill D, Hombach C, Hopchev PH, Huard ZC, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Idzik M, Ilten P, Jacobsson R, Jalocha J, Jans E, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kecke M, Kelsey M, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kirn T, Klaver S, Klimaszewski K, Klimkovich T, Koliiev S, Kolpin M, Komarov I, Koppenburg P, Kosmyntseva A, Kotriakhova S, Kozeiha M, Kravchuk L, Kreplin K, Kreps M, Krokovny P, Kruse F, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kurek K, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, van Leerdam J, Leflat A, Lefrancois J, Lefevre R, Lemaitre F, Lemos Cid E, Leroy O, Lesiak T, Leverington B, Li T, Li Y, Li Z, Likhomanenko T, Lindner R, Lionetto F, Liu X, Loh D, Longstaff I, Lopes JH, Lucchesi D, Lucio Martinez M, Luo H, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Maev O, Maguire K, Malde S, Malinin A, Maltsev T, Manca G, Mancinelli G, Manning P, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Martins Tostes D, Massacrier LM, Massafferri A, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurice E, Maurin B, Mazurov A, McCann M, McNab A, McNulty R, Meadows B, Meier F, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Minard MN, Mitzel DS, Mogini A, Molina Rodriguez J, Monroy IA, Monteil S, Morandin M, Morawski P, Morello MJ, Morgunova O, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Mussini M, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nikodem T, Nogay A, Novoselov A, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJG, Otalora Goicochea JM, Otto A, Owen P, Oyanguren A, Pais PR, Palano A, Palutan M, Papanestis A, Pappagallo M, Pappalardo LL, Pappenheimer C, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Perret P, Perrin-Terrin M, Pescatore L, Petridis K, Petrolini A, Petrov A, Petruzzo M, Picatoste Olloqui E, Pietrzyk B, Pikies M, Pinci D, Pistone A, Piucci A, Placinta V, Playfer S, Plo Casasus M, Poikela T, Polci F, Poli Lener M, Poluektov A, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Popovici B, Poslavskii S, Potterat C, Price E, Prisciandaro J, Prouve C, Pugatch V, Puig Navarro A, Punzi G, Qian C, Qian W, Quagliani R, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Raniuk I, Ratnikov F, Raven G, Redi F, Reichert S, Dos Reis AC, Remon Alepuz C, Renaudin V, Ricciardi S, Richards S, Rihl M, Rinnert K, Rives Molina V, Robbe P, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Rodriguez Perez P, Rogozhnikov A, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Ronayne JW, Rotondo M, Rudolph MS, Ruf T, Ruiz Valls P, Saborido Silva JJ, Sadykhov E, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Gonzalo D, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarti A, Satriano C, Satta A, Saunders DM, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schlupp M, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubert K, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sergi A, Serra N, Serrano J, Sestini L, Seyfert P, Shapkin M, Shapoval I, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Sirendi M, Skidmore N, Skwarnicki T, Smith E, Smith IT, Smith J, Smith M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spradlin P, Sridharan S, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stevens H, Stoica S, Stone S, Storaci B, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Sun L, Sutcliffe W, Swientek K, Syropoulos V, Szczekowski M, Szumlak T, T'Jampens S, Tayduganov A, Tekampe T, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Topp-Joergensen S, Toriello F, Tourinho Jadallah Aoude R, Tournefier E, Tourneur S, Trabelsi K, Traill M, Tran MT, Tresch M, Trisovic A, Tsaregorodtsev A, Tsopelas P, Tully A, Tuning N, Ukleja A, Ustyuzhanin A, Uwer U, Vacca C, Vagnoni V, Valassi A, Valat S, Valenti G, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Verlage TA, Vernet M, Vesterinen M, Viana Barbosa JV, Viaud B, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitti M, Volkov V, Vollhardt A, Voneki B, Vorobyev A, Vorobyev V, Voss C, de Vries JA, Vazquez Sierra C, Waldi R, Wallace C, Wallace R, Walsh J, Wang J, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams M, Williams MP, Williams M, Williams T, Wilson FF, Wimberley J, Winn MA, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wraight K, Wyllie K, Xie Y, Xing Z, Xu Z, Yang Z, Yang Z, Yao Y, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang L, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zucchelli S

Abstract:
A search for the rare decays B_{s}^{0}-->mu^{+}mu^{-} and B^{0}-->mu^{+}mu^{-} is performed at the LHCb experiment using data collected in pp collisions corresponding to a total integrated luminosity of 4.4 fb^{-1}. An excess of B_{s}^{0}-->mu^{+}mu^{-} decays is observed with a significance of 7.8 standard deviations, representing the first observation of this decay in a single experiment. The branching fraction is measured to be B(B_{s}^{0}-->mu^{+}mu^{-})=(3.0+/-0.6_{-0.2}^{+0.3})x10^{-9}, where the first uncertainty is statistical and the second systematic. The first measurement of the B_{s}^{0}-->mu^{+}mu^{-} effective lifetime, tau(B_{s}^{0}-->mu^{+}mu^{-})=2.04+/-0.44+/-0.05 ps, is reported. No significant excess of B^{0}-->mu^{+}mu^{-} decays is found, and a 95% confidence level upper limit, B(B^{0}-->mu^{+}mu^{-})<3.4x10^{-10}, is determined. All results are in agreement with the standard model expectations.





12/05/2017 | phys rev lett
Study of J/psi Production in Jets.
Aaij R, Adeva B, Adinolfi M, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Ali S, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Aslanides E, Auriemma G, Baalouch M, Babuschkin I, Bachmann S, Back JJ, Badalov A, Baesso C, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barschel C, Barsuk S, Barter W, Baryshnikov F, Baszczyk M, Batozskaya V, Batsukh B, Battista V, Bay A, Beaucourt L, Beddow J, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Beranek S, Berezhnoy A, Bernet R, Bertolin A, Betancourt C, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bifani S, Billoir P, Bird T, Birnkraut A, Bitadze A, Bizzeti A, Blake T, Blanc F, Blouw J, Blusk S, Bocci V, Boettcher T, Bondar A, Bondar N, Bonivento W, Bordyuzhin I, Borgheresi A, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJV, Bowen E, Bozzi C, Braun S, Britsch M, Britton T, Brodzicka J, Buchanan E, Burr C, Bursche A, Buytaert J, Cadeddu S, Calabrese R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Castillo Garcia L, Cattaneo M, Cavallero G, Cenci R, Chamont D, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chen S, Cheung SF, Chobanova V, Chrzaszcz M, Cid Vidal X, Ciezarek G, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Cogan J, Cogneras E, Cogoni V, Cojocariu L, Collazuol G, Collins P, Comerma-Montells A, Contu A, Cook A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Cunliffe S, Currie R, D'Ambrosio C, Da Cunha Marinho F, Dall'Occo E, Dalseno J, David PNY, Davis A, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Deckenhoff M, Del Buono L, Demmer M, Dendek A, Derkach D, Deschamps O, Dettori F, Dey B, Di Canto A, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Dungs K, Durante P, Dzhelyadin R, Dziurda A, Dzyuba A, Deleage N, Easo S, Ebert M, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Esen S, Evans HM, Evans T, Falabella A, Farley N, Farry S, Fay R, Fazzini D, Ferguson D, Fernandez G, Fernandez Prieto A, Ferrari F, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiore M, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fohl K, Fontana M, Fontanelli F, Forshaw DC, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Furfaro E, Farber C, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garra Tico J, Garrido L, Garsed PJ, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Ghez P, Giani S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruberg Cazon BR, Grunberg O, Gushchin E, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han X, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison J, Hatch M, He J, Head T, Heister A, Hennessy K, Henrard P, Henry L, van Herwijnen E, Hess M, Hicheur A, Hill D, Hombach C, Hopchev H, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Idzik M, Ilten P, Jacobsson R, Jaeger A, Jalocha J, Jans E, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kecke M, Kelsey M, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kirn T, Klaver S, Klimaszewski K, Klimkovich T, Koliiev S, Kolpin M, Komarov I, Koppenburg P, Kosmyntseva A, Kozachuk A, Kozeiha M, Kravchuk L, Kreplin K, Kreps M, Krokovny P, Kruse F, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kurek K, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, van Leerdam J, Leflat A, Lefrancois J, Lefevre R, Lemaitre F, Lemos Cid E, Leroy O, Lesiak T, Leverington B, Li T, Li Y, Likhomanenko T, Lindner R, Linn C, Lionetto F, Liu X, Loh D, Longstaff I, Lopes JH, Lucchesi D, Lucio Martinez M, Luo H, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Maev O, Maguire K, Malde S, Malinin A, Maltsev T, Manca G, Mancinelli G, Manning P, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Martins Tostes D, Massacrier LM, Massafferri A, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurice E, Maurin B, Mazurov A, McCann M, McNab A, McNulty R, Meadows B, Meier F, Meissner M, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Minard MN, Mitzel DS, Mogini A, Molina Rodriguez J, Monroy IA, Monteil S, Morandin M, Morawski P, Morda A, Morello MJ, Morgunova O, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Mussini M, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nikodem T, Nogay A, Novoselov A, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Okhrimenko O, Oldeman R, Onderwater CJG, Otalora Goicochea JM, Otto A, Owen P, Oyanguren A, Pais PR, Palano A, Palutan M, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel GD, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petruzzo M, Picatoste Olloqui E, Pietrzyk B, Pikies M, Pinci D, Pistone A, Piucci A, Placinta V, Playfer S, Plo Casasus M, Poikela T, Polci F, Poluektov A, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Popovici B, Poslavskii S, Potterat C, Price E, Price JD, Prisciandaro J, Pritchard A, Prouve C, Pugatch V, Puig Navarro A, Punzi G, Qian W, Quagliani R, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Raniuk I, Ratnikov F, Raven G, Redi F, Reichert S, Dos Reis AC, Remon Alepuz C, Renaudin V, Ricciardi S, Richards S, Rihl M, Rinnert K, Rives Molina V, Robbe P, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Rodriguez Perez P, Rogozhnikov A, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Ronayne JW, Rotondo M, Rudolph MS, Ruf T, Ruiz Valls P, Saborido Silva JJ, Sadykhov E, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Gonzalo D, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarti A, Satriano C, Satta A, Saunders DM, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schlupp M, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubert K, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sergi A, Serra N, Serrano J, Sestini L, Seyfert P, Shapkin M, Shapoval I, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Sirendi M, Skidmore N, Skwarnicki T, Smith E, Smith IT, Smith J, Smith M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spradlin P, Sridharan S, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stevens H, Stevenson S, Stoica S, Stone S, Storaci B, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Sun L, Sutcliffe W, Swientek K, Syropoulos V, Szczekowski M, Szumlak T, T'Jampens S, Tayduganov A, Tekampe T, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Topp-Joergensen S, Toriello F, Tournefier E, Tourneur S, Trabelsi K, Traill M, Tran MT, Tresch M, Trisovic A, Tsaregorodtsev A, Tsopelas P, Tully A, Tuning N, Ukleja A, Ustyuzhanin A, Uwer U, Vacca C, Vagnoni V, Valassi A, Valat S, Valenti G, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Vernet M, Vesterinen M, Viana Barbosa JV, Viaud B, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitti M, Volkov V, Vollhardt A, Voneki B, Vorobyev A, Vorobyev V, Voss C, de Vries JA, Vazquez Sierra C, Waldi R, Wallace C, Wallace R, Walsh J, Wang J, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams M, Williams MP, Williams M, Williams T, Wilson FF, Wimberley J, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wraight K, Wyllie K, Xie Y, Xing Z, Xu Z, Yang Z, Yao Y, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang L, Zhang Y, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zucchelli S

Abstract:
The production of J/psi mesons in jets is studied in the forward region of proton-proton collisions using data collected with the LHCb detector at a center-of-mass energy of 13 TeV. The fraction of the jet transverse momentum carried by the J/psi meson, z(J/psi) identical withp_{T}(J/psi)/p_{T}(jet), is measured using jets with p_{T}(jet)>20 GeV in the pseudorapidity range 2.5<eta(jet)<4.0. The observed z(J/psi) distribution for J/psi mesons produced in b-hadron decays is consistent with expectations. However, the results for prompt J/psi production do not agree with predictions based on fixed-order nonrelativistic QCD. This is the first measurement of the p_{T} fraction carried by prompt J/psi mesons in jets at any experiment.





09/05/2017 | Mol Psychiatry   IF 12
Inducing a long-term potentiation in the dentate gyrus is sufficient to produce rapid antidepressant-like effects.
Kanzari A, Bourcier-Lucas C, Freyssin A, Abrous DN, Haddjeri N, Lucas G

Abstract:
Recent hypotheses propose that one prerequisite to obtain a rapid antidepressant (AD) effect would reside in processes of synaptic reinforcement occurring within the dentate gyrus (DG) of the hippocampus independently from neurogenesis. However, to date no relationship has been established between an increased DG synaptic plasticity, and rapid AD-like action. To the best of our knowledge, this study shows for the first time that inducing a long-term potentiation (LTP) within the DG by stimulating the perforant pathway (PP) is sufficient to induce such effects. Thus, Sprague-Dawley rats having undergone a successful LTP displayed a significant reduction of immobility when passed acutely 3 days thereafter in the forced swimming test (FST). Further, in a longitudinal paradigm using the pseudo-depressed Wistar-Kyoto rat strain, LTP elicited a decrease of FST immobility after only 2 days, whereas the AD desipramine was not effective before 16 days. In both models, the influence of LTP was transient, as it was no more observed after 8-9 days. No effects were observed on the locomotor activity or on anxiety-related behavior. Theta-burst stimulation of a brain region anatomically adjacent to the PP remained ineffective in the FST. Immunoreactivity of DG cells for phosphorylated histone H3 and doublecortin were not modified three days after LTP, indicating a lack of effect on both cell proliferation and neurogenesis. Finally, depleting brain serotonin contents reduced the success rate of LTP but did not affect its subsequent AD-like effects. These results confirm the 'plastic DG' theory of rapid AD efficacy. Beyond, they point out stimulations of the entorhinal cortex, from which the PP originates, as putative new approaches in AD research.Molecular Psychiatry advance online publication, 9 May 2017; doi:10.1038/mp.2017.94.





05/05/2017 | phys rev lett
Observation of Five New Narrow Omega_{c}^{0} States Decaying to Xi_{c}^{+}K^{-}.
Aaij R, Adeva B, Adinolfi M, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Ali S, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Aslanides E, Auriemma G, Baalouch M, Babuschkin I, Bachmann S, Back JJ, Badalov A, Baesso C, Baker S, Balagura V, Baldini W, Baranov A, Barlow RJ, Barschel C, Barsuk S, Barter W, Baryshnikov F, Baszczyk M, Batozskaya V, Batsukh B, Battista V, Bay A, Beaucourt L, Beddow J, Bedeschi F, Bediaga I, Beiter A, Bel LJ, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Beranek S, Berezhnoy A, Bernet R, Bertolin A, Betancourt C, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bifani S, Billoir P, Birnkraut A, Bitadze A, Bizzeti A, Blake T, Blanc F, Blouw J, Blusk S, Bocci V, Boettcher T, Bondar A, Bondar N, Bonivento W, Bordyuzhin I, Borgheresi A, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJV, Bowen E, Bozzi C, Braun S, Britton T, Brodzicka J, Buchanan E, Burr C, Bursche A, Buytaert J, Cadeddu S, Calabrese R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Castillo Garcia L, Cattaneo M, Cavallero G, Cenci R, Chamont D, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chen S, Cheung SF, Chobanova V, Chrzaszcz M, Chubykin A, Cid Vidal X, Ciezarek G, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Cogan J, Cogneras E, Cogoni V, Cojocariu L, Collins P, Comerma-Montells A, Contu A, Cook A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Cunliffe S, Currie R, D'Ambrosio C, Da Cunha Marinho F, Dall'Occo E, Dalseno J, David PNY, Davis A, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Deckenhoff M, Del Buono L, Dembinski HP, Demmer M, Dendek A, Derkach D, Deschamps O, Dettori F, Dey B, Di Canto A, Di Nezza P, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Dungs K, Durante P, Dzhelyadin R, Dziewiecki M, Dziurda A, Dzyuba A, Deleage N, Easo S, Ebert M, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Esen S, Evans HM, Evans T, Falabella A, Farley N, Farry S, Fay R, Fazzini D, Ferguson D, Fernandez G, Fernandez Prieto A, Ferrari F, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiore M, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fohl K, Fontana M, Fontanelli F, Forshaw DC, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Furfaro E, Farber C, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garra Tico J, Garrido L, Garsed PJ, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Ghez P, Giani S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Greim R, Griffith P, Grillo L, Gruberg Cazon BR, Grunberg O, Gushchin E, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han X, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison J, Hatch M, He J, Head T, Heister A, Hennessy K, Henrard P, Henry L, van Herwijnen E, Hess M, Hicheur A, Hill D, Hombach C, Hopchev PH, Huard ZC, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Idzik M, Ilten P, Jacobsson R, Jalocha J, Jans E, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kecke M, Kelsey M, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kirn T, Klaver S, Klimaszewski K, Klimkovich T, Koliiev S, Kolpin M, Komarov I, Kopecna R, Koppenburg P, Kosmyntseva A, Kotriakhova S, Kozachuk A, Kozeiha M, Kravchuk L, Kreps M, Krokovny P, Kruse F, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kurek K, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, van Leerdam J, Leflat A, Lefrancois J, Lefevre R, Lemaitre F, Lemos Cid E, Leroy O, Lesiak T, Leverington B, Li T, Li Y, Li Z, Likhomanenko T, Lindner R, Lionetto F, Liu X, Loh D, Longstaff I, Lopes JH, Lucchesi D, Lucio Martinez M, Luo H, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Maev O, Maguire K, Malde S, Malinin A, Maltsev T, Manca G, Mancinelli G, Manning P, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Martins Tostes D, Massacrier LM, Massafferri A, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurice E, Maurin B, Mazurov A, McCann M, McNab A, McNulty R, Meadows B, Meier F, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Minard MN, Mitzel DS, Mogini A, Molina Rodriguez J, Monroy IA, Monteil S, Morandin M, Morello MJ, Morgunova O, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Mussini M, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nikodem T, Nogay A, Novoselov A, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJG, Otalora Goicochea JM, Owen P, Oyanguren A, Pais PR, Palano A, Palutan M, Papanestis A, Pappagallo M, Pappalardo LL, Pappenheimer C, Parker W, Parkes C, Passaleva G, Pastore A, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petruzzo M, Picatoste Olloqui E, Pietrzyk B, Pikies M, Pinci D, Pistone A, Piucci A, Placinta V, Playfer S, Plo Casasus M, Poikela T, Polci F, Poli Lener M, Poluektov A, Polyakov I, Polycarpo E, Pomery GJ, Ponce S, Popov A, Popov D, Popovici B, Poslavskii S, Potterat C, Price E, Prisciandaro J, Prouve C, Pugatch V, Puig Navarro A, Punzi G, Qian C, Qian W, Quagliani R, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Raniuk I, Ratnikov F, Raven G, Redi F, Reichert S, Dos Reis AC, Remon Alepuz C, Renaudin V, Ricciardi S, Richards S, Rihl M, Rinnert K, Rives Molina V, Robbe P, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Rodriguez Perez P, Rogozhnikov A, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Ronayne JW, Rotondo M, Rudolph MS, Ruf T, Ruiz Valls P, Saborido Silva JJ, Sadykhov E, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Gonzalo D, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarti A, Satriano C, Satta A, Saunders DM, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schlupp M, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schreiner HF, Schubert K, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sergi A, Serra N, Serrano J, Sestini L, Seyfert P, Shapkin M, Shapoval I, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Sirendi M, Skidmore N, Skwarnicki T, Smith E, Smith IT, Smith J, Smith M, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spradlin P, Sridharan S, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stevens H, Stoica S, Stone S, Storaci B, Stracka S, Stramaglia ME, Straticiuc M, Straumann U, Sun L, Sutcliffe W, Swientek K, Syropoulos V, Szczekowski M, Szumlak T, T'Jampens S, Tayduganov A, Tekampe T, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Topp-Joergensen S, Toriello F, Tourinho Jadallah Aoude R, Tournefier E, Tourneur S, Trabelsi K, Traill M, Tran MT, Tresch M, Trisovic A, Tsaregorodtsev A, Tsopelas P, Tully A, Tuning N, Ukleja A, Ustyuzhanin A, Uwer U, Vacca C, Vagnoni V, Valassi A, Valat S, Valenti G, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Verlage TA, Vernet M, Vesterinen M, Viana Barbosa JV, Viaud B, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitti M, Volkov V, Vollhardt A, Voneki B, Vorobyev A, Vorobyev V, Voss C, de Vries JA, Vazquez Sierra C, Waldi R, Wallace C, Wallace R, Walsh J, Wang J, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams M, Williams MP, Williams M, Williams T, Wilson FF, Wimberley J, Winn MA, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wraight K, Wyllie K, Xie Y, Xing Z, Xu Z, Yang Z, Yang Z, Yao Y, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang L, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zucchelli S

Abstract:
The Xi_{c}^{+}K^{-} mass spectrum is studied with a sample of pp collision data corresponding to an integrated luminosity of 3.3 fb^{-1}, collected by the LHCb experiment. The Xi_{c}^{+} is reconstructed in the decay mode pK^{-}pi^{+}. Five new, narrow excited Omega_{c}^{0} states are observed: the Omega_{c}(3000)^{0}, Omega_{c}(3050)^{0}, Omega_{c}(3066)^{0}, Omega_{c}(3090)^{0}, and Omega_{c}(3119)^{0}. Measurements of their masses and widths are reported.





01/05/2017 |
Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication.
Guedan A, Swieboda D, Charles M, Toussaint M, Johnston SL, Asfor A, Panjwani A, Tuthill TJ, Danahay H, Raynham T, Mousnier A, Solari R

Abstract:
Picornavirus replication is known to cause extensive remodeling of Golgi and endoplasmic reticulum membranes, and a number of the host proteins involved in the viral replication complex have been identified, including oxysterol binding protein (OSBP) and phosphatidylinositol 4-kinase III beta (PI4KB). Since both OSBP and PI4KB are substrates for protein kinase D (PKD) and PKD is known to be involved in the control of Golgi membrane vesicular and lipid transport, we hypothesized that PKD played a role in viral replication. We present multiple lines of evidence in support of this hypothesis. First, infection of HeLa cells with human rhinovirus (HRV) induced the phosphorylation of PKD. Second, PKD inhibitors reduced HRV genome replication, protein expression, and titers in a concentration-dependent fashion and also blocked the replication of poliovirus (PV) and foot-and-mouth disease virus (FMDV) in a variety of cells. Third, HRV replication was significantly reduced in HeLa cells overexpressing wild-type and mutant forms of PKD1. Fourth, HRV genome replication was reduced in HAP1 cells in which the PKD1 gene was knocked out by clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9. Although we have not identified the molecular mechanism through which PKD regulates viral replication, our data suggest that this is not due to enhanced interferon signaling or an inhibition of clathrin-mediated endocytosis, and PKD inhibitors do not need to be present during viral uptake. Our data show for the first time that targeting PKD with small molecules can inhibit the replication of HRV, PV, and FMDV, and therefore, PKD may represent a novel antiviral target for drug discovery.IMPORTANCE Picornaviruses remain an important family of human and animal pathogens for which we have a very limited arsenal of antiviral agents. HRV is the causative agent of the common cold, which in itself is a relatively trivial infection; however, in asthma and chronic obstructive pulmonary disease (COPD) patients, this virus is a major cause of exacerbations resulting in an increased use of medication, worsening symptoms, and, frequently, hospital admission. Thus, HRV represents a substantial health care and economic burden for which there are no approved therapies. We sought to identify a novel host target as a potential anti-HRV therapy. HRV infection induces the phosphorylation of PKD, and inhibitors of this kinase effectively block HRV replication at an early stage of the viral life cycle. Moreover, PKD inhibitors also block PV and FMDV replication. This is the first description that PKD may represent a target for antiviral drug discovery.





05/2017 | Eur J Neurosci   IF 2.8
Species-specific diversity in the anatomical and physiological organisation of the BNST-VTA pathway.
Kaufling J, Girard D, Maitre M, Leste-Lasserre T, Georges F

Abstract:
The anteromedial part of the bed nucleus of the stria terminalis (amBNST) is a limbic structure innervating the ventral tegmental area (VTA) that is remarkably constant across species. The amBNST modulates fear and anxiety, and activation of VTA dopamine (DA) neurons by amBNST afferents seems to be the way by which stress controls motivational states associated with reward or aversion. Because fear learning and anxiety states can be expressed differently between rats and mice, we compared the functional connectivity between amBNST and the VTA-DA neurons in both species using consistent methodological approaches. Using a combination of in vivo electrophysiological, neuroanatomical tracing and laser capture approaches we explored the BNST influences on VTA-DA neuron activity. First, we characterised in rats the molecular phenotype of the amBNST neurons projecting to the VTA. We found that this projection is complex, including both GABAergic and glutamatergic neurons. Then, VTA injections of a conventional retrograde tracer, the beta-sub-unit of the cholera toxin (CTB), revealed a stronger BNST-VTA projection in mice than in rats. Finally, electrical stimulations of the BNST during VTA-DA neuron recording demonstrated a more potent excitatory influence of the amBNST on VTA-DA neuron activity in rats than in mice. These data illustrate anatomically, but also functionally, a significant difference between rats and mice in the amBNST-VTA pathway. More generally, together with previous findings, our research highlights the importance of species differences for the interpretation and the generalisation of research data.





10/04/2017 | Nat Neurosci   IF 21.1
Abnormal wiring of CCK+ basket cells disrupts spatial information coding.
Del Pino I, Brotons-Mas JR, Marques-Smith A, Marighetto A, Frick A, Marin O, Rico B

Abstract:
The function of cortical GABAergic interneurons is largely determined by their integration into specific neural circuits, but the mechanisms controlling the wiring of these cells remain largely unknown. This is particularly true for a major population of basket cells that express the neuropeptide cholecystokinin (CCK). Here we found that the tyrosine kinase receptor ErbB4 was required for the normal integration into cortical circuits of basket cells expressing CCK and vesicular glutamate transporter 3 (VGlut3). The number of inhibitory synapses made by CCK+VGlut3+ basket cells and the inhibitory drive they exerted on pyramidal cells were reduced in conditional mice lacking ErbB4. Developmental disruption of the connectivity of these cells diminished the power of theta oscillations during exploratory behavior, disrupted spatial coding by place cells, and caused selective alterations in spatial learning and memory in adult mice. These results suggest that normal integration of CCK+ basket cells in cortical networks is key to support spatial coding in the hippocampus.





07/04/2017 | Nat Commun   IF 11.9
Defective Gpsm2/Galphai3 signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome.
Mauriac SA, Hien YE, Bird JE, Carvalho SD, Peyroutou R, Lee SC, Moreau MM, Blanc JM, Geyser A, Medina C, Thoumine O, Beer-Hammer S, Friedman TB, Ruttiger L, Forge A, Nurnberg B*, Sans N*, Montcouquiol M*

Abstract:
Mutations in GPSM2 cause Chudley-McCullough syndrome (CMCS), an autosomal recessive neurological disorder characterized by early-onset sensorineural deafness and brain anomalies. Here, we show that mutation of the mouse orthologue of GPSM2 affects actin-rich stereocilia elongation in auditory and vestibular hair cells, causing deafness and balance defects. The G-protein subunit Galphai3, a well-documented partner of Gpsm2, participates in the elongation process, and its absence also causes hearing deficits. We show that Gpsm2 defines an approximately 200 nm nanodomain at the tips of stereocilia and this localization requires the presence of Galphai3, myosin 15 and whirlin. Using single-molecule tracking, we report that loss of Gpsm2 leads to decreased outgrowth and a disruption of actin dynamics in neuronal growth cones. Our results elucidate the aetiology of CMCS and highlight a new molecular role for Gpsm2/Galphai3 in the regulation of actin dynamics in epithelial and neuronal tissues.





01/04/2017 | Biol Psychiatry   IF 11.5
CB1 Cannabinoid Receptors Mediate Cognitive Deficits and Structural Plasticity Changes During Nicotine Withdrawal.
Saravia R, Flores A, Plaza-Zabala A, Busquets-Garcia A, Pastor A, de la Torre R, Di Marzo V, Marsicano G, Ozaita A, Maldonado R, Berrendero F

Abstract:
BACKGROUND: Tobacco withdrawal is associated with deficits in cognitive function, including attention, working memory, and episodic memory. Understanding the neurobiological mechanisms involved in these effects is crucial because cognitive deficits during nicotine withdrawal may predict relapse in humans. METHODS: We investigated in mice the role of CB1 cannabinoid receptors (CB1Rs) in memory impairment and spine density changes induced by nicotine withdrawal precipitated by the nicotinic antagonist mecamylamine. Drugs acting on the endocannabinoid system and genetically modified mice were used. RESULTS: Memory impairment during nicotine withdrawal was blocked by the CB1R antagonist rimonabant or the genetic deletion of CB1R in forebrain gamma-aminobutyric acidergic (GABAergic) neurons (GABA-CB1R). An increase of 2-arachidonoylglycerol (2-AG), but not anandamide, was observed during nicotine withdrawal. The selective inhibitor of 2-AG biosynthesis O7460 abolished cognitive deficits of nicotine abstinence, whereas the inhibitor of 2-AG enzymatic degradation JZL184 did not produce any effect in cognitive impairment. Moreover, memory impairment was prevented by the selective mammalian target of rapamycin inhibitor temsirolimus and the protein synthesis inhibitor anisomycin. Mature dendritic spines on CA1 pyramidal hippocampal neurons decreased 4 days after the precipitation of nicotine withdrawal, when the cognitive deficits were still present. Indeed, a correlation between memory performance and mature spine density was found. Interestingly, these structural plasticity alterations were normalized in GABA-CB1R conditional knockout mice and after subchronic treatment with rimonabant. CONCLUSIONS: These findings underline the interest of CB1R as a target to improve cognitive performance during early nicotine withdrawal. Cognitive deficits in early abstinence are associated with increased relapse risk.





27/03/2017 | Development   IF 5.8
Wnts contribute to neuromuscular junction formation through distinct signaling pathways.
Messeant J, Ezan J, Delers P, Glebov K, Marchiol C, Lager F, Renault G, Tissir F, Montcouquiol M, Sans N, Legay C, Strochlic L

Abstract:
Understanding the developmental steps shaping the formation of the neuromuscular junction (NMJ) connecting motoneurons to skeletal muscle fibers, is critical. Wnt morphogens are key players in the formation of this specialized peripheral synapse. Yet, the individual and collaborative functions of Wnts as well as their downstream pathways remain poorly understood at the NMJ. Here, we demonstrate through Wnt4 and Wnt11 gain of function studies in culture or in mice that Wnts enhance acetylcholine receptor (AChR) clustering and motor axon outgrowth. In contrast, loss of Wnt11 or Wnt-dependent signaling in vivo decreases AChR clustering and motor nerve terminal branching. Both Wnt4 and Wnt11 stimulate AChR clustering and mRNA downstream activation of the beta-catenin pathway. Strikingly, Wnt4 and Wnt11 co-immunoprecipitate with Vangl2, a core component of the Planar Cell Polarity (PCP) pathway, which accumulates at embryonic NMJ. Moreover, mice bearing a Vangl2 loss of function mutation (looptail) exhibit a decreased number of AChR clusters and overgrowth of motor axons bypassing AChR clusters. Taken together, our results provide genetic and biochemical evidences that Wnt4 and Wnt11 cooperatively contribute to mammalian NMJ formation through activation of both the canonical and Vangl2-dependent core PCP pathways.





22/03/2017 | Neuron   IF 14.4
The CB1 Receptor as the Cornerstone of Exostasis.
Piazza PV, Cota D, Marsicano G

Abstract:
The type-1 cannabinoid receptor (CB1) is the main effector of the endocannabinoid system (ECS), which is involved in most brain and body functions. In this Perspective, we provide evidence indicating that CB1 receptor functions are key determinants of bodily coordinated exostatic processes. First, we will introduce the concepts of endostasis and exostasis as compensation or accumulation for immediate or future energy needs and discuss how exostasis has been necessary for the survival of species during evolution. Then, we will argue how different specific biological functions of the CB1 receptor in the body converge to provide physiological exostatic processes. Finally, we will introduce the concept of proactive evolution-induced diseases (PEIDs), which helps explain the seeming paradox that an evolutionary-selected physiological function can become the cause of epidemic pathological conditions, such as obesity. We propose here a possible unifying theory of CB1 receptor functions that can be tested by future experimental studies.





21/03/2017 | Sci Rep   IF 4
Sweet taste in apple: the role of sorbitol, individual sugars, organic acids and volatile compounds.
Aprea E, Charles M, Endrizzi I, Laura Corollaro M, Betta E, Biasioli F, Gasperi F

Abstract:
Sweetness is one of the main drivers of consumer preference, and thus is given high priority in apple breeding programmes. Due to the complexity of sweetness evaluation, soluble solid content (SSC) is commonly used as an estimation of this trait. Nevertheless, it has been demonstrated that SSC and sweet taste are poorly correlated. Though individual sugar content may vary greatly between and within apple cultivars, no previous study has tried to investigate the relationship between the amount of individual sugars, or ratios of these, and apple sweetness. In this work, we quantified the major sugars (sucrose, glucose, fructose, xylose) and sorbitol and explored their influence on perceived sweetness in apple; we also related this to malic acid content, SSC and volatile compounds. Our data confirmed that the correlation between sweetness and SSC is weak. We found that sorbitol content correlates (similarly to SSC) with perceived sweetness better than any other single sugar or total sugar content. The single sugars show no differentiable importance in determining apple sweetness. Our predictive model based on partial least squares regression shows that after sorbitol and SSC, the most important contribution to apple sweetness is provided by several volatile compounds, mainly esters and farnesene.





17/03/2017 | acs chem biol   IF 4.4
Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases.
Baggelaar MP, van Esbroeck AC, van Rooden EJ, Florea BI, Overkleeft HS, Marsicano G, Chaouloff F, van der Stelt M

Abstract:
The biosynthetic and catabolic enzymes of the endocannabinoids tightly regulate endocannabinoid-mediated activation of the cannabinoid CB1 receptor. Monitoring the activities of these endocannabinoid hydrolases in different brain regions is, therefore, key to gaining insight into spatiotemporal control of CB1 receptor-mediated physiology. We have employed a comparative chemical proteomics approach to quantitatively map the activity profile of endocannabinoid hydrolases in various mouse brain regions at the same time. To this end, we used two different activity-based probes: fluorophosphonate-biotin (FP-biotin), which quantifies FAAH, ABHD6, and MAG-lipase activity, and MB108, which detects DAGL-alpha, ABHD4, ABHD6, and ABHD12. In total, 32 serine hydrolases were evaluated in the frontal cortex, hippocampus, striatum, and cerebellum. Comparison of endocannabinoid hydrolase activity in the four brain regions revealed that FAAH activity was highest in the hippocampus, and MAGL activity was most pronounced in the frontal cortex, whereas DAGL-alpha was most active in the cerebellum. Comparison of the activity profiles with a global proteomics data set revealed pronounced differences. This could indicate that post-translational modification of the endocannabinoid hydrolases is important to regulate their activity. Next, the effect of genetic deletion of the CB1 receptor was studied. No difference in the enzymatic activity was found in the cerebellum, striatum, frontal cortex, and hippocampus of CB1 receptor knockout animals compared to wild type mice. Our results are in line with previous reports and indicate that the CB1 receptor exerts no regulatory control over the basal production and degradation of endocannabinoids and that genetic deletion of the CB1 receptor does not induce compensatory mechanisms in endocannabinoid hydrolase activity.





17/03/2017 | phys rev lett
Observation of B_{c}^{+}-->D^{0}K^{+} Decays.
Aaij R, Adeva B, Adinolfi M, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Ali S, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Aslanides E, Auriemma G, Baalouch M, Babuschkin I, Bachmann S, Back JJ, Badalov A, Baesso C, Baker S, Balagura V, Baldini W, Barlow RJ, Barschel C, Barsuk S, Barter W, Baryshnikov F, Baszczyk M, Batozskaya V, Batsukh B, Battista V, Bay A, Beaucourt L, Beddow J, Bedeschi F, Bediaga I, Bel LJ, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Berezhnoy A, Bernet R, Bertolin A, Betancourt C, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bifani S, Billoir P, Bird T, Birnkraut A, Bitadze A, Bizzeti A, Blake T, Blanc F, Blouw J, Blusk S, Bocci V, Boettcher T, Bondar A, Bondar N, Bonivento W, Bordyuzhin I, Borgheresi A, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJ, Bowen E, Bozzi C, Braun S, Britsch M, Britton T, Brodzicka J, Buchanan E, Burr C, Bursche A, Buytaert J, Cadeddu S, Calabrese R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Castillo Garcia L, Cattaneo M, Cavallero G, Cenci R, Chamont D, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chen S, Cheung SF, Chobanova V, Chrzaszcz M, Cid Vidal X, Ciezarek G, Clarke PE, Clemencic M, Cliff HV, Closier J, Coco V, Cogan J, Cogneras E, Cogoni V, Cojocariu L, Collazuol G, Collins P, Comerma-Montells A, Contu A, Cook A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Cunliffe S, Currie R, D'Ambrosio C, Da Cunha Marinho F, Dall'Occo E, Dalseno J, David PN, Davis A, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Deckenhoff M, Del Buono L, Demmer M, Dendek A, Derkach D, Deschamps O, Dettori F, Dey B, Di Canto A, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Dungs K, Durante P, Dzhelyadin R, Dziurda A, Dzyuba A, Deleage N, Easo S, Ebert M, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Esen S, Evans HM, Evans T, Falabella A, Farley N, Farry S, Fay R, Fazzini D, Ferguson D, Fernandez Prieto A, Ferrari F, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiore M, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fohl K, Fontana M, Fontanelli F, Forshaw DC, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Furfaro E, Farber C, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garra Tico J, Garrido L, Garsed PJ, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Ghez P, Giani S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Griffith P, Grillo L, Gruberg Cazon BR, Grunberg O, Gushchin E, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hamilton B, Han X, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison J, Hatch M, He J, Head T, Heister A, Hennessy K, Henrard P, Henry L, van Herwijnen E, Hess M, Hicheur A, Hill D, Hombach C, Hopchev H, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Idzik M, Ilten P, Jacobsson R, Jaeger A, Jalocha J, Jans E, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kecke M, Kelsey M, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kirn T, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Komarov I, Koopman RF, Koppenburg P, Kosmyntseva A, Kozachuk A, Kozeiha M, Kravchuk L, Kreplin K, Kreps M, Krokovny P, Kruse F, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kurek K, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, van Leerdam J, Leflat A, Lefrancois J, Lefevre R, Lemaitre F, Lemos Cid E, Leroy O, Lesiak T, Leverington B, Li T, Li Y, Likhomanenko T, Lindner R, Linn C, Lionetto F, Liu X, Loh D, Longstaff I, Lopes JH, Lucchesi D, Lucio Martinez M, Luo H, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Maev O, Maguire K, Malde S, Malinin A, Maltsev T, Manca G, Mancinelli G, Manning P, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Martins Tostes D, Massacrier LM, Massafferri A, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurice E, Maurin B, Mazurov A, McCann M, McNab A, McNulty R, Meadows B, Meier F, Meissner M, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Minard MN, Mitzel DS, Mogini A, Molina Rodriguez J, Monroy IA, Monteil S, Morandin M, Morawski P, Morda A, Morello MJ, Morgunova O, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Mussini M, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nikodem T, Nogay A, Novoselov A, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJ, Otalora Goicochea JM, Otto A, Owen P, Oyanguren A, Pais PR, Palano A, Palutan M, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel GD, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petruzzo M, Picatoste Olloqui E, Pietrzyk B, Pikies M, Pinci D, Pistone A, Piucci A, Placinta V, Playfer S, Plo Casasus M, Poikela T, Polci F, Poluektov A, Polyakov I, Polycarpo E, Pomery GJ, Popov A, Popov D, Popovici B, Poslavskii S, Potterat C, Price E, Price JD, Prisciandaro J, Pritchard A, Prouve C, Pugatch V, Puig Navarro A, Punzi G, Qian W, Quagliani R, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Raniuk I, Ratnikov F, Raven G, Redi F, Reichert S, Dos Reis AC, Remon Alepuz C, Renaudin V, Ricciardi S, Richards S, Rihl M, Rinnert K, Rives Molina V, Robbe P, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Rodriguez Perez P, Rogozhnikov A, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Ronayne JW, Rotondo M, Rudolph MS, Ruf T, Ruiz Valls P, Saborido Silva JJ, Sadykhov E, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarti A, Satriano C, Satta A, Saunders DM, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schlupp M, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schubert K, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sergi A, Serra N, Serrano J, Sestini L, Seyfert P, Shapkin M, Shapoval I, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Sirendi M, Skidmore N, Skwarnicki T, Smith E, Smith IT, Smith J, Smith M, Snoek H, Soares Lavra L, Sokoloff MD, Soler FJ, Souza De Paula B, Spaan B, Spradlin P, Sridharan S, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stevens H, Stevenson S, Stoica S, Stone S, Storaci B, Stracka S, Straticiuc M, Straumann U, Sun L, Sutcliffe W, Swientek K, Syropoulos V, Szczekowski M, Szumlak T, T'Jampens S, Tayduganov A, Tekampe T, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Topp-Joergensen S, Toriello F, Tournefier E, Tourneur S, Trabelsi K, Traill M, Tran MT, Tresch M, Trisovic A, Tsaregorodtsev A, Tsopelas P, Tully A, Tuning N, Ukleja A, Ustyuzhanin A, Uwer U, Vacca C, Vagnoni V, Valassi A, Valat S, Valenti G, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Vernet M, Vesterinen M, Viana Barbosa JV, Viaud B, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitti M, Volkov V, Vollhardt A, Voneki B, Vorobyev A, Vorobyev V, Voss C, de Vries JA, Vazquez Sierra C, Waldi R, Wallace C, Wallace R, Walsh J, Wang J, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams M, Williams MP, Williams M, Williams T, Wilson FF, Wimberley J, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wraight K, Wyllie K, Xie Y, Xing Z, Xu Z, Yang Z, Yao Y, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang L, Zhang Y, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zucchelli S

Abstract:
Using proton-proton collision data corresponding to an integrated luminosity of 3.0 fb^{-1}, recorded by the LHCb detector at center-of-mass energies of 7 and 8 TeV, the B_{c}^{+}-->D^{0}K^{+} decay is observed with a statistical significance of 5.1 standard deviations. By normalizing to B^{+}-->D[over ]^{0}pi^{+} decays, a measurement of the branching fraction multiplied by the production rates for B_{c}^{+} relative to B^{+} mesons in the LHCb acceptance is obtained, R_{D^{0}K}=(f_{c}/f_{u})xB(B_{c}^{+}-->D^{0}K^{+})=(9.3_{-2.5}^{+2.8}+/-0.6)x10^{ -7}, where the first uncertainty is statistical and the second is systematic. This decay is expected to proceed predominantly through weak annihilation and penguin amplitudes, and is the first B_{c}^{+} decay of this nature to be observed.





03/2017 | Glia   IF 5.8
Astrocytic IP3 Rs: Contribution to Ca2+ signalling and hippocampal LTP.
Sherwood MW, Arizono M, Hisatsune C, Bannai H, Ebisui E, Sherwood JL, Panatier A, Oliet SH, Mikoshiba K

Abstract:
Astrocytes regulate hippocampal synaptic plasticity by the Ca2+ dependent release of the N-methyl d-aspartate receptor (NMDAR) co-agonist d-serine. Previous evidence indicated that d-serine release would be regulated by the intracellular Ca2+ release channel IP3 receptor (IP3 R), however, genetic deletion of IP3 R2, the putative astrocytic IP3 R subtype, had no impact on synaptic plasticity or transmission. Although IP3 R2 is widely believed to be the only functional IP3 R in astrocytes, three IP3 R subtypes (1, 2, and 3) have been identified in vertebrates. Therefore, to better understand gliotransmission, we investigated the functionality of IP3 R and the contribution of the three IP3 R subtypes to Ca2+ signalling. As a proxy for gliotransmission, we found that long-term potentiation (LTP) was impaired by dialyzing astrocytes with the broad IP3 R blocker heparin, and rescued by exogenous d-serine, indicating that astrocytic IP3 Rs regulate d-serine release. To explore which IP3 R subtypes are functional in astrocytes, we used pharmacology and two-photon Ca2+ imaging of hippocampal slices from transgenic mice (IP3 R2-/- and IP3 R2-/- ;3-/- ). This approach revealed that underneath IP3 R2-mediated global Ca2+ events are an overlooked class of IP3 R-mediated local events, occurring in astroglial processes. Notably, multiple IP3 Rs were recruited by high frequency stimulation of the Schaffer collaterals, a classical LTP induction protocol. Together, these findings show the dependence of LTP and gliotransmission on Ca2+ release by astrocytic IP3 Rs. GLIA 2017;65:502-513.





03/2017 | J Clin Microbiol   IF 5
Evaluation of the Parasight Platform for Malaria Diagnosis.
Eshel Y, Houri-Yafin A, Benkuzari H, Lezmy N, Soni M, Charles M, Swaminathan J, Solomon H, Sampathkumar P, Premji Z, Mbithi C, Nneka Z, Onsongo S, Maina D, Levy-Schreier S, Cohen CL, Gluck D, Pollak JJ, Salpeter SJ

Abstract:
The World Health Organization estimates that nearly 500 million malaria tests are performed annually. While microscopy and rapid diagnostic tests (RDTs) are the main diagnostic approaches, no single method is inexpensive, rapid, and highly accurate. Two recent studies from our group have demonstrated a prototype computer vision platform that meets those needs. Here we present the results from two clinical studies on the commercially available version of this technology, the Sight Diagnostics Parasight platform, which provides malaria diagnosis, species identification, and parasite quantification. We conducted a multisite trial in Chennai, India (Apollo Hospital [n = 205]), and Nairobi, Kenya (Aga Khan University Hospital [n = 263]), in which we compared the device to microscopy, RDTs, and PCR. For identification of malaria, the device performed similarly well in both contexts (sensitivity of 99% and specificity of 100% at the Indian site and sensitivity of 99.3% and specificity of 98.9% at the Kenyan site, compared to PCR). For species identification, the device correctly identified 100% of samples with Plasmodium vivax and 100% of samples with Plasmodium falciparum in India and 100% of samples with P. vivax and 96.1% of samples with P. falciparum in Kenya, compared to PCR. Lastly, comparisons of the device parasite counts with those of trained microscopists produced average Pearson correlation coefficients of 0.84 at the Indian site and 0.85 at the Kenyan site.





Abstract:
The endocannabinoid system (ECS), including cannabinoid type 1 and type 2 receptors (CB1R and CB2R), endogenous ligands called endocannabinoids and their related enzymatic machinery, is known to have a role in the regulation of energy balance. Past information generated on the ECS, mainly focused on the involvement of this system in the central nervous system regulation of food intake, while at the same time clinical studies pointed out the therapeutic efficacy of brain-penetrant CB1R antagonists like rimonabant for obesity and metabolic disorders. Rimonabant was removed from the market in 2009 and its obituary written due to its psychiatric side effects. However, in the meanwhile a number of investigations had started to highlight the roles of the peripheral ECS in the regulation of metabolism, bringing up new hope that the ECS might still represent target for treatment. Accordingly, peripherally-restricted CB1R antagonists or inverse agonists have shown to effectively reduce body weight, adiposity, insulin resistance and dyslipidemia in obese animal models. Very recent investigations have further expanded the possible toolbox for the modulation of the ECS, by demonstrating the existence of endogenous allosteric inhibitors of CB1R, the characterization of the structure of the human CB1R, and the likely involvement of CB2R in metabolic disorders. Here we give an overview of these findings, discussing what the future may hold in the context of strategies targeting the ECS in metabolic disease.





Abstract:
KEY POINTS: Vagal sensory inputs transmit information from the viscera to brainstem neurones located in the nucleus tractus solitarii to set physiological parameters. These excitatory synapses exhibit a CB1 endocannabinoid-induced long-term depression (LTD) triggered by vagal fibre stimulation. We investigated the impact of nutritional status on long-term changes in this long-term synaptic plasticity. Food deprivation prevents LTD induction by disrupting CB1 receptor signalling. Short-term refeeding restores the capacity of vagal synapses to express LTD. Ghrelin and cholecystokinin, respectively released during fasting and refeeding, play a key role in the control of LTD via the activation of energy sensing pathways such as AMPK and the mTOR and ERK pathways. ABSTRACT: Communication form the viscera to the brain is essential to set physiological homoeostatic parameters but also to drive more complex behaviours such as mood, memory and emotional states. Here we investigated the impact of the nutritional status on long-term changes in excitatory synaptic transmission in the nucleus tractus solitarii, a neural hub integrating visceral signals. These excitatory synapses exhibit a CB1 endocannabinoid (eCB)-induced long-term depression (LTD) triggered by vagal fibre stimulation. Since eCB signalling is known to be an important component of homoeostatic regulation of the body and is regulated during various stressful conditions, we tested the hypothesis that food deprivation alters eCB signalling in central visceral afferent fibres. Food deprivation prevents eCB-LTD induction due to the absence of eCB signalling. This loss was reversed by blockade of ghrelin receptors. Activation of the cellular fuel sensor AMP-activated protein kinase or inhibition of the mechanistic target of rapamycin pathway abolished eCB-LTD in free-fed rats. Signals associated with energy surfeit, such as short-term refeeding, restore eCB-LTD induction, which in turn requires activation of cholecystokinin receptors and the extracellular signal-regulated kinase pathway. These data suggest a tight link between eCB-LTD in the NTS and nutritional status and shed light on the key role of eCB in the integration of visceral information.





24/02/2017 | phys rev lett
Observation of the Annihilation Decay Mode B^{0}-->K^{+}K^{-}.
Aaij R, Adeva B, Adinolfi M, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Ali S, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Aslanides E, Auriemma G, Baalouch M, Babuschkin I, Bachmann S, Back JJ, Badalov A, Baesso C, Baker S, Baldini W, Barlow RJ, Barschel C, Barsuk S, Barter W, Baszczyk M, Batozskaya V, Batsukh B, Battista V, Bay A, Beaucourt L, Beddow J, Bedeschi F, Bediaga I, Bel LJ, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Benton J, Berezhnoy A, Bernet R, Bertolin A, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bifani S, Billoir P, Bird T, Birnkraut A, Bitadze A, Bizzeti A, Blake T, Blanc F, Blouw J, Blusk S, Bocci V, Boettcher T, Bondar A, Bondar N, Bonivento W, Borgheresi A, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJ, Bowen E, Bozzi C, Braun S, Britsch M, Britton T, Brodzicka J, Buchanan E, Burr C, Bursche A, Buytaert J, Cadeddu S, Calabrese R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez D, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Castillo Garcia L, Cattaneo M, Cauet C, Cavallero G, Cenci R, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chen S, Cheung SF, Chobanova V, Chrzaszcz M, Cid Vidal X, Ciezarek G, Clarke PE, Clemencic M, Cliff HV, Closier J, Coco V, Cogan J, Cogneras E, Cogoni V, Cojocariu L, Collazuol G, Collins P, Comerma-Montells A, Contu A, Cook A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Cunliffe S, Currie R, D'Ambrosio C, Da Cunha Marinho F, Dall'Occo E, Dalseno J, David PN, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Deckenhoff M, Del Buono L, Demmer M, Derkach D, Deschamps O, Dettori F, Dey B, Di Canto A, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Dungs K, Durante P, Dzhelyadin R, Dziurda A, Dzyuba A, Deleage N, Easo S, Ebert M, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Elsasser C, Ely S, Esen S, Evans HM, Evans T, Falabella A, Farley N, Farry S, Fay R, Fazzini D, Ferguson D, Fernandez Albor V, Fernandez Prieto A, Ferrari F, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiore M, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fohl K, Fontana M, Fontanelli F, Forshaw DC, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Furfaro E, Farber C, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garra Tico J, Garrido L, Garsed PJ, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Ghez P, Giani S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Grabalosa Gandara M, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Griffith P, Grillo L, Gruberg Cazon BR, Grunberg O, Gushchin E, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hall S, Hamilton B, Han X, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison J, Hatch M, He J, Head T, Heister A, Hennessy K, Henrard P, Henry L, Hernando Morata JA, van Herwijnen E, Hess M, Hicheur A, Hill D, Hombach C, Hopchev H, Hulsbergen W, Humair T, Hushchyn M, Hussain N, Hutchcroft D, Idzik M, Ilten P, Jacobsson R, Jaeger A, Jalocha J, Jans E, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Kanso W, Karacson M, Kariuki JM, Karodia S, Kecke M, Kelsey M, Kenyon IR, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kirn T, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Komarov I, Koopman RF, Koppenburg P, Kosmyntseva A, Kozachuk A, Kozeiha M, Kravchuk L, Kreplin K, Kreps M, Krokovny P, Kruse F, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kurek K, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lambert D, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, van Leerdam J, Lees JP, Leflat A, Lefrancois J, Lefevre R, Lemaitre F, Lemos Cid E, Leroy O, Lesiak T, Leverington B, Li Y, Likhomanenko T, Lindner R, Linn C, Lionetto F, Liu B, Liu X, Loh D, Longstaff I, Lopes JH, Lucchesi D, Lucio Martinez M, Luo H, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Maev O, Maguire K, Malde S, Malinin A, Maltsev T, Manca G, Mancinelli G, Manning P, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marino P, Marks J, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Martins Tostes D, Massacrier LM, Massafferri A, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurin B, Mazurov A, McCann M, McCarthy J, McNab A, McNulty R, Meadows B, Meier F, Meissner M, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Minard MN, Mitzel DS, Mogini A, Molina Rodriguez J, Monroy IA, Monteil S, Morandin M, Morawski P, Morda A, Morello MJ, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Mussini M, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen AD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nikodem T, Novoselov A, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJ, Otalora Goicochea JM, Otto A, Owen P, Oyanguren A, Pais PR, Palano A, Palombo F, Palutan M, Panman J, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel GD, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petruzzo M, Picatoste Olloqui E, Pietrzyk B, Pikies M, Pinci D, Pistone A, Piucci A, Playfer S, Plo Casasus M, Poikela T, Polci F, Poluektov A, Polyakov I, Polycarpo E, Pomery GJ, Popov A, Popov D, Popovici B, Poslavskii S, Potterat C, Price E, Price JD, Prisciandaro J, Pritchard A, Prouve C, Pugatch V, Puig Navarro A, Punzi G, Qian W, Quagliani R, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Raniuk I, Raven G, Redi F, Reichert S, Dos Reis AC, Remon Alepuz C, Renaudin V, Ricciardi S, Richards S, Rihl M, Rinnert K, Rives Molina V, Robbe P, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Rodriguez Perez P, Rogozhnikov A, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Ronayne JW, Rotondo M, Rudolph MS, Ruf T, Ruiz Valls P, Saborido Silva JJ, Sadykhov E, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarti A, Satriano C, Satta A, Saunders DM, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schlupp M, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schubert K, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sergi A, Serra N, Serrano J, Sestini L, Seyfert P, Shapkin M, Shapoval I, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Shires A, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Sirendi M, Skidmore N, Skwarnicki T, Smith E, Smith IT, Smith J, Smith M, Snoek H, Sokoloff MD, Soler FJ, Souza De Paula B, Spaan B, Spradlin P, Sridharan S, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stevenson S, Stoica S, Stone S, Storaci B, Stracka S, Straticiuc M, Straumann U, Sun L, Sutcliffe W, Swientek K, Syropoulos V, Szczekowski M, Szumlak T, T'Jampens S, Tayduganov A, Tekampe T, Teklishyn M, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Topp-Joergensen S, Toriello F, Tournefier E, Tourneur S, Trabelsi K, Traill M, Tran MT, Tresch M, Trisovic A, Tsaregorodtsev A, Tsopelas P, Tully A, Tuning N, Ukleja A, Ustyuzhanin A, Uwer U, Vacca C, Vagnoni V, Valassi A, Valat S, Valenti G, Vallier A, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Vernet M, Vesterinen M, Viaud B, Vieira D, Vieites Diaz M, Vilasis-Cardona X, Volkov V, Vollhardt A, Voneki B, Vorobyev A, Vorobyev V, Voss C, de Vries JA, Vazquez Sierra C, Waldi R, Wallace C, Wallace R, Walsh J, Wang J, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams M, Williams MP, Williams M, Williams T, Wilson FF, Wimberley J, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wraight K, Wright S, Wyllie K, Xie Y, Xing Z, Xu Z, Yang Z, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang L, Zhang Y, Zhelezov A, Zheng Y, Zhokhov A, Zhu X, Zhukov V, Zucchelli S

Abstract:
A search for the B^{0}-->K^{+}K^{-} decay is performed using pp-collision data collected by LHCb. The data set corresponds to integrated luminosities of 1.0 and 2.0 fb^{-1} at center-of-mass energies of 7 and 8 TeV, respectively. This decay is observed for the first time, with a significance of more than 5 standard deviations. The analysis also results in an improved measurement of the branching fraction for the B_{s}^{0}-->pi^{+}pi^{-} decay. The measured branching fractions are B(B^{0}-->K^{+}K^{-})=(7.80+/-1.27+/-0.81+/-0.21)x10^{-8} and B(B_{s}^{0}-->pi^{+}pi^{-})=(6.91+/-0.54+/-0.63+/-0.19+/-0.40)x10^{-7}. The first uncertainty is statistical, the second is systematic, the third is due to the uncertainty on the B^{0}-->K^{+}pi^{-} branching fraction used as a normalization. For the B_{s}^{0} mode, the fourth accounts for the uncertainty on the ratio of the probabilities for b quarks to hadronize into B_{s}^{0} and B^{0} mesons.





21/02/2017 | Mol Psychiatry   IF 12
Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice.
Busquets-Garcia A, Soria-Gomez E, Redon B, Mackenbach Y, Vallee M, Chaouloff F, Varilh M, Ferreira G, Piazza PV, Marsicano G

Abstract:
Cannabis-induced acute psychotic-like states (CIAPS) represent a growing health issue, but their underlying neurobiological mechanisms are poorly understood. The use of antipsychotics and benzodiazepines against CIAPS is limited by side effects and/or by their ability to tackle only certain aspects of psychosis. Thus, safer wide-spectrum treatments are currently needed. Although the blockade of cannabinoid type-1 receptor (CB1) had been suggested as a therapeutical means against CIAPS, the use of orthosteric CB1 receptor full antagonists is strongly limited by undesired side effects and low efficacy. The neurosteroid pregnenolone has been recently shown to act as a potent endogenous allosteric signal-specific inhibitor of CB1 receptors. Thus, we tested in mice the potential therapeutic use of pregnenolone against acute psychotic-like effects of Delta9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis. We found that pregnenolone blocks a wide spectrum of THC-induced endophenotypes typically associated with psychotic-like states, including impairments in cognitive functions, somatosensory gating and social interaction. In order to capture THC-induced positive psychotic-like symptoms (e.g. perceptual delusions), we adapted a behavioral paradigm based on associations between different sensory modalities and selective devaluation, allowing the measurement of mental sensory representations in mice. Acting at hippocampal CB1 receptors, THC impaired the correct processing of mental sensory representations (reality testing) in an antipsychotic- and pregnenolone-sensitive manner. Overall, this work reveals that signal-specific inhibitors mimicking pregnenolone effects can be considered as promising new therapeutic tools to treat CIAPS.Molecular Psychiatry advance online publication, 21 February 2017; doi:10.1038/mp.2017.4.





17/02/2017 | phys rev lett
Observation of the Decay Xi_{b}^{-}-->pK^{-}K^{-}.
Aaij R, Adeva B, Adinolfi M, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Ali S, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Aslanides E, Auriemma G, Baalouch M, Babuschkin I, Bachmann S, Back JJ, Badalov A, Baesso C, Baker S, Balagura V, Baldini W, Barlow RJ, Barschel C, Barsuk S, Barter W, Baszczyk M, Batozskaya V, Batsukh B, Battista V, Bay A, Beaucourt L, Beddow J, Bedeschi F, Bediaga I, Bel LJ, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Berezhnoy A, Bernet R, Bertolin A, Betancourt C, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bifani S, Billoir P, Bird T, Birnkraut A, Bitadze A, Bizzeti A, Blake T, Blanc F, Blouw J, Blusk S, Bocci V, Boettcher T, Bondar A, Bondar N, Bonivento W, Bordyuzhin I, Borgheresi A, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJ, Bowen E, Bozzi C, Braun S, Britsch M, Britton T, Brodzicka J, Buchanan E, Burr C, Bursche A, Buytaert J, Cadeddu S, Calabrese R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Castillo Garcia L, Cattaneo M, Cavallero G, Cenci R, Chamont D, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chen S, Cheung SF, Chobanova V, Chrzaszcz M, Cid Vidal X, Ciezarek G, Clarke PE, Clemencic M, Cliff HV, Closier J, Coco V, Cogan J, Cogneras E, Cogoni V, Cojocariu L, Collazuol G, Collins P, Comerma-Montells A, Contu A, Cook A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Cunliffe S, Currie R, D'Ambrosio C, Da Cunha Marinho F, Dall'Occo E, Dalseno J, David PN, Davis A, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Deckenhoff M, Del Buono L, Demmer M, Dendek A, Derkach D, Deschamps O, Dettori F, Dey B, Di Canto A, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Dungs K, Durante P, Dzhelyadin R, Dziurda A, Dzyuba A, Deleage N, Easo S, Ebert M, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Esen S, Evans HM, Evans T, Falabella A, Farley N, Farry S, Fay R, Fazzini D, Ferguson D, Fernandez Prieto A, Ferrari F, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiore M, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fohl K, Fontana M, Fontanelli F, Forshaw DC, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Furfaro E, Farber C, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garra Tico J, Garrido L, Garsed PJ, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Ghez P, Giani S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Griffith P, Grillo L, Gruberg Cazon BR, Grunberg O, Gushchin E, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hall S, Hamilton B, Han X, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison J, Hatch M, He J, Head T, Heister A, Hennessy K, Henrard P, Henry L, van Herwijnen E, Hess M, Hicheur A, Hill D, Hombach C, Hopchev H, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Idzik M, Ilten P, Jacobsson R, Jaeger A, Jalocha J, Jans E, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kecke M, Kelsey M, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kirn T, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Komarov I, Koopman RF, Koppenburg P, Kosmyntseva A, Kozachuk A, Kozeiha M, Kravchuk L, Kreplin K, Kreps M, Krokovny P, Kruse F, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kurek K, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, van Leerdam J, Leflat A, Lefrancois J, Lefevre R, Lemaitre F, Lemos Cid E, Leroy O, Lesiak T, Leverington B, Li T, Li Y, Likhomanenko T, Lindner R, Linn C, Lionetto F, Liu X, Loh D, Longstaff I, Lopes JH, Lucchesi D, Lucio Martinez M, Luo H, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Maev O, Maguire K, Malde S, Malinin A, Maltsev T, Manca G, Mancinelli G, Manning P, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Martins Tostes D, Massacrier LM, Massafferri A, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurice E, Maurin B, Mazurov A, McCann M, McNab A, McNulty R, Meadows B, Meier F, Meissner M, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Minard MN, Mitzel DS, Mogini A, Molina Rodriguez J, Monroy IA, Monteil S, Morandin M, Morawski P, Morda A, Morello MJ, Morgunova O, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Mussini M, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nikodem T, Nogay A, Novoselov A, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJ, Otalora Goicochea JM, Otto A, Owen P, Oyanguren A, Pais PR, Palano A, Palombo F, Palutan M, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel GD, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petruzzo M, Picatoste Olloqui E, Pietrzyk B, Pikies M, Pinci D, Pistone A, Piucci A, Placinta V, Playfer S, Plo Casasus M, Poikela T, Polci F, Poluektov A, Polyakov I, Polycarpo E, Pomery GJ, Popov A, Popov D, Popovici B, Poslavskii S, Potterat C, Price E, Price JD, Prisciandaro J, Pritchard A, Prouve C, Pugatch V, Puig Navarro A, Punzi G, Qian W, Quagliani R, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Raniuk I, Ratnikov F, Raven G, Redi F, Reichert S, Dos Reis AC, Remon Alepuz C, Renaudin V, Ricciardi S, Richards S, Rihl M, Rinnert K, Rives Molina V, Robbe P, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Rodriguez Perez P, Rogozhnikov A, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Ronayne JW, Rotondo M, Rudolph MS, Ruf T, Ruiz Valls P, Saborido Silva JJ, Sadykhov E, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarti A, Satriano C, Satta A, Saunders DM, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schlupp M, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schubert K, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sergi A, Serra N, Serrano J, Sestini L, Seyfert P, Shapkin M, Shapoval I, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Sirendi M, Skidmore N, Skwarnicki T, Smith E, Smith IT, Smith J, Smith M, Snoek H, Soares Lavra L, Sokoloff MD, Soler FJ, Souza De Paula B, Spaan B, Spradlin P, Sridharan S, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stevens H, Stevenson S, Stoica S, Stone S, Storaci B, Stracka S, Straticiuc M, Straumann U, Sun L, Sutcliffe W, Swientek K, Syropoulos V, Szczekowski M, Szumlak T, T'Jampens S, Tayduganov A, Tekampe T, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Topp-Joergensen S, Toriello F, Tournefier E, Tourneur S, Trabelsi K, Traill M, Tran MT, Tresch M, Trisovic A, Tsaregorodtsev A, Tsopelas P, Tully A, Tuning N, Ukleja A, Ustyuzhanin A, Uwer U, Vacca C, Vagnoni V, Valassi A, Valat S, Valenti G, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Vernet M, Vesterinen M, Viana Barbosa JV, Viaud B, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitti M, Volkov V, Vollhardt A, Voneki B, Vorobyev A, Vorobyev V, Voss C, de Vries JA, Vazquez Sierra C, Waldi R, Wallace C, Wallace R, Walsh J, Wang J, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams M, Williams MP, Williams M, Williams T, Wilson FF, Wimberley J, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wraight K, Wyllie K, Xie Y, Xing Z, Xu Z, Yang Z, Yao Y, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang L, Zhang Y, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zucchelli S

Abstract:
Decays of the Xi_{b}^{-} and Omega_{b}^{-} baryons to the charmless final states ph^{-}h^{'-}, where h^{(')} denotes a kaon or pion, are searched for with the LHCb detector. The analysis is based on a sample of proton-proton collision data collected at center-of-mass energies sqrt[s]=7 and 8 TeV, corresponding to an integrated luminosity of 3 fb^{-1}. The decay Xi_{b}^{-}-->pK^{-}K^{-} is observed with a significance of 8.7 standard deviations, and evidence at the level of 3.4 standard deviations is found for the Xi_{b}^{-}-->pK^{-}pi^{-} decay. Results are reported, relative to the B^{-}-->K^{+}K^{-}K^{-} normalization channel, for the products of branching fractions and b-hadron production fractions. The branching fractions of Xi_{b}^{-}-->pK^{-}pi^{-} and Xi_{b}^{-}-->ppi^{-}pi^{-} relative to Xi_{b}^{-}-->pK^{-}K^{-} decays are also measured.





17/02/2017 | mmwr morb mortal wkly rep
Transmission of Zika Virus - Haiti, October 12, 2015-September 10, 2016.
Journel I, Andrecy LL, Metellus D, Pierre JS, Faublas RM, Juin S, Dismer AM, Fitter DL, Neptune D, Laraque MJ, Corvil S, Pierre M, Buteau J, Lafontant D, Patel R, Lemoine JF, Lowrance DW, Charles M, Boncy J, Adrien P

Abstract:
Zika virus disease is caused by infection with a flavivirus with broad geographic distribution and is most frequently transmitted by the bite of an infected mosquito. The disease was first identified in the World Health Organization's Region of the Americas in 2015 and was followed by a surge in reported cases of congenital microcephaly in Brazil; Zika virus disease rapidly spread to the rest of the region and the Caribbean (1), including Haiti. Infection with the virus is associated with adverse fetal outcomes (1) and rare neurologic complications in adults. The magnitude of public health issues associated with Zika virus led the World Health Organization to declare the Zika virus outbreak a Public Health Emergency of International Concern on February 1, 2016 (2). Because many persons with mild Zika virus disease are asymptomatic and might not seek care, it is difficult to estimate the actual incidence of Zika virus infection. During October 12, 2015-September 10, 2016, the Haitian Ministry of Public Health and Population (Ministere de la Sante Publique et de la Population [MSPP]) detected 3,036 suspected cases of Zika virus infection in the general population, 22 suspected cases of Zika virus disease among pregnant women, 13 suspected cases of Guillain-Barre syndrome (GBS), and 29 suspected cases of Zika-associated congenital microcephaly. Nineteen (0.6%) patients with suspected Zika virus disease, residing in Ouest (10 patients), Artibonite (six), and Centre (three) administrative departments,* have been confirmed by laboratory testing, including two among pregnant women and 17 in the general population. Ongoing laboratory-enhanced surveillance to monitor Zika virus disease in Haiti is important to understanding the outbreak and ensuring effective response activities.





Abstract:
A systematic comparison was performed between batch bottle and continuous-flow column microcosms (BMs and CMs, respectively) commonly used for in situ groundwater remedial design. Review of recent literature (2000-2014) showed a preference for reporting batch kinetics, even when corresponding column data were available. Additionally, CMs produced higher observed rate constants, exceeding those of BMs by a factor of 6.1+/-1.1 standard error. In a subsequent laboratory investigation, 12 equivalent microcosm pairs were constructed from fractured bedrock and perchloroethylene (PCE) impacted groundwater. First-order PCE transformation kinetics of CMs were 8.0+/-4.8 times faster than BMs (rates: 1.23+/-0.87 vs. 0.16+/-0.05d(-1), respectively). Additionally, CMs transformed 16.1+/-8.0-times more mass than BMs owing to continuous-feed operation. CMs are concluded to yield more reliable kinetic estimates because of much higher data density stemming from long-term, steady-state conditions. Since information from BMs and CMs is valuable and complementary, treatability studies should report kinetic data from both when available. This first systematic investigation of BMs and CMs highlights the need for a more unified framework for data use and reporting in treatability studies informing decision-making for field-scale groundwater remediation.





03/02/2017 | phys rev lett
Measurement of the b-Quark Production Cross Section in 7 and 13 TeV pp Collisions.
Aaij R, Adeva B, Adinolfi M, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Ali S, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Aslanides E, Auriemma G, Baalouch M, Babuschkin I, Bachmann S, Back JJ, Badalov A, Baesso C, Baker S, Baldini W, Barlow RJ, Barschel C, Barsuk S, Barter W, Baszczyk M, Batozskaya V, Batsukh B, Battista V, Bay A, Beaucourt L, Beddow J, Bedeschi F, Bediaga I, Bel LJ, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Benton J, Berezhnoy A, Bernet R, Bertolin A, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bifani S, Billoir P, Bird T, Birnkraut A, Bitadze A, Bizzeti A, Blake T, Blanc F, Blouw J, Blusk S, Bocci V, Boettcher T, Bondar A, Bondar N, Bonivento W, Borgheresi A, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJ, Bowen E, Bozzi C, Braun S, Britsch M, Britton T, Brodzicka J, Buchanan E, Burr C, Bursche A, Buytaert J, Cadeddu S, Calabrese R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez D, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Castillo Garcia L, Cattaneo M, Cauet C, Cavallero G, Cenci R, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chen S, Cheung SF, Chobanova V, Chrzaszcz M, Cid Vidal X, Ciezarek G, Clarke PE, Clemencic M, Cliff HV, Closier J, Coco V, Cogan J, Cogneras E, Cogoni V, Cojocariu L, Collazuol G, Collins P, Comerma-Montells A, Contu A, Cook A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Cunliffe S, Currie R, D'Ambrosio C, Da Cunha Marinho F, Dall'Occo E, Dalseno J, David PN, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Deckenhoff M, Del Buono L, Demmer M, Derkach D, Deschamps O, Dettori F, Dey B, Di Canto A, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Dungs K, Durante P, Dzhelyadin R, Dziurda A, Dzyuba A, Deleage N, Easo S, Ebert M, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Elsasser C, Ely S, Esen S, Evans HM, Evans T, Falabella A, Farley N, Farry S, Fay R, Fazzini D, Ferguson D, Fernandez Albor V, Fernandez Prieto A, Ferrari F, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiore M, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fohl K, Fontana M, Fontanelli F, Forshaw DC, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Furfaro E, Farber C, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garra Tico J, Garrido L, Garsed PJ, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Ghez P, Giani S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Grabalosa Gandara M, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Griffith P, Grillo L, Gruberg Cazon BR, Grunberg O, Gushchin E, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hall S, Hamilton B, Han X, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison J, Hatch M, He J, Head T, Heister A, Hennessy K, Henrard P, Henry L, Hernando Morata JA, van Herwijnen E, Hess M, Hicheur A, Hill D, Hombach C, Hopchev H, Hulsbergen W, Humair T, Hushchyn M, Hussain N, Hutchcroft D, Idzik M, Ilten P, Jacobsson R, Jaeger A, Jalocha J, Jans E, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Kanso W, Karacson M, Kariuki JM, Karodia S, Kecke M, Kelsey M, Kenyon IR, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kirn T, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Komarov I, Koopman RF, Koppenburg P, Kosmyntseva A, Kozachuk A, Kozeiha M, Kravchuk L, Kreplin K, Kreps M, Krokovny P, Kruse F, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kurek K, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lambert D, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, van Leerdam J, Lees JP, Leflat A, Lefrancois J, Lefevre R, Lemaitre F, Lemos Cid E, Leroy O, Lesiak T, Leverington B, Li Y, Likhomanenko T, Lindner R, Linn C, Lionetto F, Liu B, Liu X, Loh D, Longstaff I, Lopes JH, Lucchesi D, Lucio Martinez M, Luo H, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Maev O, Maguire K, Malde S, Malinin A, Maltsev T, Manca G, Mancinelli G, Manning P, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marino P, Marks J, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Martins Tostes D, Massacrier LM, Massafferri A, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurin B, Mazurov A, McCann M, McCarthy J, McNab A, McNulty R, Meadows B, Meier F, Meissner M, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Minard MN, Mitzel DS, Mogini A, Molina Rodriguez J, Monroy IA, Monteil S, Morandin M, Morawski P, Morda A, Morello MJ, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Mussini M, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen AD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nikodem T, Novoselov A, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJ, Otalora Goicochea JM, Otto A, Owen P, Oyanguren A, Pais PR, Palano A, Palombo F, Palutan M, Panman J, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel GD, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petruzzo M, Picatoste Olloqui E, Pietrzyk B, Pikies M, Pinci D, Pistone A, Piucci A, Playfer S, Plo Casasus M, Poikela T, Polci F, Poluektov A, Polyakov I, Polycarpo E, Pomery GJ, Popov A, Popov D, Popovici B, Poslavskii S, Potterat C, Price E, Price JD, Prisciandaro J, Pritchard A, Prouve C, Pugatch V, Puig Navarro A, Punzi G, Qian W, Quagliani R, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Raniuk I, Raven G, Redi F, Reichert S, Dos Reis AC, Remon Alepuz C, Renaudin V, Ricciardi S, Richards S, Rihl M, Rinnert K, Rives Molina V, Robbe P, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Rodriguez Perez P, Rogozhnikov A, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Ronayne JW, Rotondo M, Rudolph MS, Ruf T, Ruiz Valls P, Saborido Silva JJ, Sadykhov E, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarti A, Satriano C, Satta A, Saunders DM, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schlupp M, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schubert K, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sergi A, Serra N, Serrano J, Sestini L, Seyfert P, Shapkin M, Shapoval I, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Shires A, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Sirendi M, Skidmore N, Skwarnicki T, Smith E, Smith IT, Smith J, Smith M, Snoek H, Sokoloff MD, Soler FJ, Souza De Paula B, Spaan B, Spradlin P, Sridharan S, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stevenson S, Stoica S, Stone S, Storaci B, Stracka S, Straticiuc M, Straumann U, Sun L, Sutcliffe W, Swientek K, Syropoulos V, Szczekowski M, Szumlak T, T'Jampens S, Tayduganov A, Tekampe T, Teklishyn M, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Topp-Joergensen S, Toriello F, Tournefier E, Tourneur S, Trabelsi K, Traill M, Tran MT, Tresch M, Trisovic A, Tsaregorodtsev A, Tsopelas P, Tully A, Tuning N, Ukleja A, Ustyuzhanin A, Uwer U, Vacca C, Vagnoni V, Valassi A, Valat S, Valenti G, Vallier A, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Vernet M, Vesterinen M, Viaud B, Vieira D, Vieites Diaz M, Vilasis-Cardona X, Volkov V, Vollhardt A, Voneki B, Vorobyev A, Vorobyev V, Voss C, de Vries JA, Vazquez Sierra C, Waldi R, Wallace C, Wallace R, Walsh J, Wang J, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams M, Williams MP, Williams M, Williams T, Wilson FF, Wimberley J, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wraight K, Wright S, Wyllie K, Xie Y, Xing Z, Xu Z, Yang Z, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang L, Zhang Y, Zhang Y, Zhelezov A, Zheng Y, Zhokhov A, Zhu X, Zhukov V, Zucchelli S

Abstract:
Measurements of the cross section for producing b quarks in the reaction pp-->bb[over ]X are reported in 7 and 13 TeV collisions at the LHC as a function of the pseudorapidity eta in the range 2<eta<5 covered by the acceptance of the LHCb experiment. The measurements are done using semileptonic decays of b-flavored hadrons decaying into a ground-state charmed hadron in association with a muon. The cross sections in the covered eta range are 72.0+/-0.3+/-6.8 and 154.3+/-1.5+/-14.3 mub for 7 and 13 TeV. The ratio is 2.14+/-0.02+/-0.13, where the quoted uncertainties are statistical and systematic, respectively. The agreement with theoretical expectation is good at 7 TeV, but differs somewhat at 13 TeV. The measured ratio of cross sections is larger at lower eta than the model prediction.





02/02/2017 | J Neurosci Res   IF 4.1
Astroglial glutamate transporters in the brain: Regulating neurotransmitter homeostasis and synaptic transmission.
Murphy-Royal C, Dupuis J, Groc L, Oliet SH

Abstract:
Astrocytes, the major glial cell type in the central nervous system (CNS), are critical for brain function and have been implicated in various disorders of the central nervous system. These cells are involved in a wide range of cerebral processes including brain metabolism, control of central blood flow, ionic homeostasis, fine-tuning synaptic transmission, and neurotransmitter clearance. Such varied roles can be efficiently carried out due to the intimate interactions astrocytes maintain with neurons, the vasculature, as well as with other glial cells. Arguably, one of the most important functions of astrocytes in the brain is their control of neurotransmitter clearance. This is particularly true for glutamate whose timecourse in the synaptic cleft needs to be controlled tightly under physiological conditions to maintain point-to-point excitatory transmission, thereby limiting spillover and activation of more receptors. Most importantly, accumulation of glutamate in the extracellular space can trigger excessive activation of glutamatergic receptors and lead to excitotoxicity, a trademark of many neurodegenerative diseases. It is thus of utmost importance for both physiological and pathophysiological reasons to understand the processes that control glutamate time course within the synaptic cleft and regulate its concentrations in the extracellular space. (c) 2017 Wiley Periodicals, Inc.





01/02/2017 | Endocrinology   IF 3.8
Islet Endothelial Cell: Friend and Foe.
Mazier W, Cota D



02/2017 | Neuropsychopharmacology   IF 7.2
Individual Variations in the Mechanisms of Nicotine Seeking: A Key for Research on Nicotine Dependence.
Garcia-Rivas V, Cannella N, Deroche-Gamonet V



02/2017 | funct ecol
How did the domestication of Fertile Crescent grain crops increase their yields?
Preece C, Livarda A, Christin PA, Wallace M, Martin G, Charles M, Jones G, Rees M, Osborne CP

Abstract:
The origins of agriculture, 10 000 years ago, led to profound changes in the biology of plants exploited as grain crops, through the process of domestication. This special case of evolution under cultivation led to domesticated cereals and pulses requiring humans for their dispersal, but the accompanying mechanisms causing higher productivity in these plants remain unknown. The classical view of crop domestication is narrow, focusing on reproductive and seed traits including the dispersal, dormancy and size of seeds, without considering whole-plant characteristics. However, the effects of initial domestication events can be inferred from consistent differences between traditional landraces and their wild progenitors.We studied how domestication increased the yields of Fertile Crescent cereals and pulses using a greenhouse experiment to compare landraces with wild progenitors. We grew eight crops: barley, einkorn and emmer wheat, oat, rye, chickpea, lentil and pea. In each case, comparison of multiple landraces with their wild progenitors enabled us to quantify the effects of domestication rather than subsequent crop diversification. To reveal the mechanisms underpinning domestication-linked yield increases, we measured traits beyond those classically associated with domestication, including the rate and duration of growth, reproductive allocation, plant size and also seed mass and number.Cereal and pulse crops had on average 50% higher yields than their wild progenitors, resulting from a 40% greater final plant size, 90% greater individual seed mass and 38% less chaff or pod material, although this varied between species. Cereal crops also had a higher seed number per spike compared with their wild ancestors. However, there were no differences in growth rate, total seed number, proportion of reproductive biomass or the duration of growth.The domestication of Fertile Crescent crops resulted in larger seed size leading to a larger plant size, and also a reduction in chaff, with no decrease in seed number per individual, which proved a powerful package of traits for increasing yield. We propose that the important steps in the domestication process should be reconsidered, and the domestication syndrome broadened to include a wider range of traits.





13/01/2017 | phys rev lett
First Experimental Study of Photon Polarization in Radiative B_{s}^{0} Decays.
Aaij R, Adeva B, Adinolfi M, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Ali S, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Aslanides E, Auriemma G, Baalouch M, Babuschkin I, Bachmann S, Back JJ, Badalov A, Baesso C, Baker S, Baldini W, Barlow RJ, Barschel C, Barsuk S, Barter W, Baszczyk M, Batozskaya V, Batsukh B, Battista V, Bay A, Beaucourt L, Beddow J, Bedeschi F, Bediaga I, Bel LJ, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Benton J, Berezhnoy A, Bernet R, Bertolin A, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bifani S, Billoir P, Bird T, Birnkraut A, Bitadze A, Bizzeti A, Blake T, Blanc F, Blouw J, Blusk S, Bocci V, Boettcher T, Bondar A, Bondar N, Bonivento W, Borgheresi A, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJ, Bowen E, Bozzi C, Braun S, Britsch M, Britton T, Brodzicka J, Buchanan E, Burr C, Bursche A, Buytaert J, Cadeddu S, Calabrese R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez D, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Castillo Garcia L, Cattaneo M, Cauet C, Cavallero G, Cenci R, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chen S, Cheung SF, Chobanova V, Chrzaszcz M, Cid Vidal X, Ciezarek G, Clarke PE, Clemencic M, Cliff HV, Closier J, Coco V, Cogan J, Cogneras E, Cogoni V, Cojocariu L, Collazuol G, Collins P, Comerma-Montells A, Contu A, Cook A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Cunliffe S, Currie R, D'Ambrosio C, Da Cunha Marinho F, Dall'Occo E, Dalseno J, David PN, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Deckenhoff M, Del Buono L, Demmer M, Derkach D, Deschamps O, Dettori F, Dey B, Di Canto A, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Dungs K, Durante P, Dzhelyadin R, Dziurda A, Dzyuba A, Deleage N, Easo S, Ebert M, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Elsasser C, Ely S, Esen S, Evans HM, Evans T, Falabella A, Farley N, Farry S, Fay R, Fazzini D, Ferguson D, Fernandez Albor V, Fernandez Prieto A, Ferrari F, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiore M, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fohl K, Fontana M, Fontanelli F, Forshaw DC, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Furfaro E, Farber C, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garra Tico J, Garrido L, Garsed PJ, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Ghez P, Giani S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Grabalosa Gandara M, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Griffith P, Grillo L, Gruberg Cazon BR, Grunberg O, Gushchin E, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hall S, Hamilton B, Han X, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison J, Hatch M, He J, Head T, Heister A, Hennessy K, Henrard P, Henry L, Hernando Morata JA, van Herwijnen E, Hess M, Hicheur A, Hill D, Hombach C, Hopchev H, Hulsbergen W, Humair T, Hushchyn M, Hussain N, Hutchcroft D, Idzik M, Ilten P, Jacobsson R, Jaeger A, Jalocha J, Jans E, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Kanso W, Karacson M, Kariuki JM, Karodia S, Kecke M, Kelsey M, Kenyon IR, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kirn T, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Komarov I, Koopman RF, Koppenburg P, Kosmyntseva A, Kozachuk A, Kozeiha M, Kravchuk L, Kreplin K, Kreps M, Krokovny P, Kruse F, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kurek K, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lambert D, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, van Leerdam J, Lees JP, Leflat A, Lefrancois J, Lefevre R, Lemaitre F, Lemos Cid E, Leroy O, Lesiak T, Leverington B, Li Y, Likhomanenko T, Lindner R, Linn C, Lionetto F, Liu B, Liu X, Loh D, Longstaff I, Lopes JH, Lucchesi D, Lucio Martinez M, Luo H, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Maev O, Maguire K, Malde S, Malinin A, Maltsev T, Manca G, Mancinelli G, Manning P, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marino P, Marks J, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Martins Tostes D, Massacrier LM, Massafferri A, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurin B, Mazurov A, McCann M, McCarthy J, McNab A, McNulty R, Meadows B, Meier F, Meissner M, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Minard MN, Mitzel DS, Mogini A, Molina Rodriguez J, Monroy IA, Monteil S, Morandin M, Morawski P, Morda A, Morello MJ, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Mussini M, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen AD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nikodem T, Novoselov A, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJ, Otalora Goicochea JM, Otto A, Owen P, Oyanguren A, Pais PR, Palano A, Palombo F, Palutan M, Panman J, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel GD, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petruzzo M, Picatoste Olloqui E, Pietrzyk B, Pikies M, Pinci D, Pistone A, Piucci A, Playfer S, Plo Casasus M, Poikela T, Polci F, Poluektov A, Polyakov I, Polycarpo E, Pomery GJ, Popov A, Popov D, Popovici B, Poslavskii S, Potterat C, Price E, Price JD, Prisciandaro J, Pritchard A, Prouve C, Pugatch V, Puig Navarro A, Punzi G, Qian W, Quagliani R, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Raniuk I, Raven G, Redi F, Reichert S, Dos Reis AC, Remon Alepuz C, Renaudin V, Ricciardi S, Richards S, Rihl M, Rinnert K, Rives Molina V, Robbe P, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Rodriguez Perez P, Rogozhnikov A, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Ronayne JW, Rotondo M, Rudolph MS, Ruf T, Ruiz Valls P, Saborido Silva JJ, Sadykhov E, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarti A, Satriano C, Satta A, Saunders DM, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schlupp M, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schubert K, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sergi A, Serra N, Serrano J, Sestini L, Seyfert P, Shapkin M, Shapoval I, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Shires A, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Sirendi M, Skidmore N, Skwarnicki T, Smith E, Smith IT, Smith J, Smith M, Snoek H, Sokoloff MD, Soler FJ, Souza De Paula B, Spaan B, Spradlin P, Sridharan S, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stevenson S, Stoica S, Stone S, Storaci B, Stracka S, Straticiuc M, Straumann U, Sun L, Sutcliffe W, Swientek K, Syropoulos V, Szczekowski M, Szumlak T, T'Jampens S, Tayduganov A, Tekampe T, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Topp-Joergensen S, Toriello F, Tournefier E, Tourneur S, Trabelsi K, Traill M, Tran MT, Tresch M, Trisovic A, Tsaregorodtsev A, Tsopelas P, Tully A, Tuning N, Ukleja A, Ustyuzhanin A, Uwer U, Vacca C, Vagnoni V, Valassi A, Valat S, Valenti G, Vallier A, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Vernet M, Vesterinen M, Viaud B, Vieira D, Vieites Diaz M, Vilasis-Cardona X, Volkov V, Vollhardt A, Voneki B, Vorobyev A, Vorobyev V, Voss C, de Vries JA, Vazquez Sierra C, Waldi R, Wallace C, Wallace R, Walsh J, Wang J, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams M, Williams MP, Williams M, Williams T, Wilson FF, Wimberley J, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wraight K, Wright S, Wyllie K, Xie Y, Xing Z, Xu Z, Yang Z, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang L, Zhang Y, Zhang Y, Zhelezov A, Zheng Y, Zhokhov A, Zhu X, Zhukov V, Zucchelli S

Abstract:
The polarization of photons produced in radiative B_{s}^{0} decays is studied for the first time. The data are recorded by the LHCb experiment in pp collisions corresponding to an integrated luminosity of 3 fb^{-1} at center-of-mass energies of 7 and 8 TeV. A time-dependent analysis of the B_{s}^{0}-->varphigamma decay rate is conducted to determine the parameter A^{Delta}, which is related to the ratio of right- over left-handed photon polarization amplitudes in b-->sgamma transitions. A value of A^{Delta}=-0.98_{-0.52}^{+0.46}_{-0.20}^{+0.23} is measured. This result is consistent with the standard model prediction within 2 standard deviations.





13/01/2017 | phys rev lett
Observation of J/psivarphi Structures Consistent with Exotic States from Amplitude Analysis of B^{+}-->J/psivarphiK^{+} Decays.
Aaij R, Adeva B, Adinolfi M, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Ali S, Alkhazov G, Alvarez Cartelle P, Alves AA, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Aquines Gutierrez O, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Aslanides E, Auriemma G, Baalouch M, Babuschkin I, Bachmann S, Back JJ, Badalov A, Baesso C, Baldini W, Barlow RJ, Barschel C, Barsuk S, Barter W, Batozskaya V, Batsukh B, Battista V, Bay A, Beaucourt L, Beddow J, Bedeschi F, Bediaga I, Bel LJ, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Benton J, Berezhnoy A, Bernet R, Bertolin A, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bifani S, Billoir P, Bird T, Birnkraut A, Bitadze A, Bizzeti A, Blake T, Blanc F, Blouw J, Blusk S, Bocci V, Boettcher T, Bondar A, Bondar N, Bonivento W, Borgheresi A, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJ, Bowen E, Bozzi C, Braun S, Britsch M, Britton T, Brodzicka J, Buchanan E, Burr C, Bursche A, Buytaert J, Cadeddu S, Calabrese R, Calvi M, Calvo Gomez M, Campana P, Campora Perez D, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Castillo Garcia L, Cattaneo M, Cauet C, Cavallero G, Cenci R, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chen S, Cheung SF, Chobanova V, Chrzaszcz M, Cid Vidal X, Ciezarek G, Clarke PE, Clemencic M, Cliff HV, Closier J, Coco V, Cogan J, Cogneras E, Cogoni V, Cojocariu L, Collazuol G, Collins P, Comerma-Montells A, Contu A, Cook A, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Cunliffe S, Currie R, D'Ambrosio C, Dall'Occo E, Dalseno J, David PN, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Deckenhoff M, Del Buono L, Demmer M, Derkach D, Deschamps O, Dettori F, Dey B, Di Canto A, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Dungs K, Durante P, Dzhelyadin R, Dziurda A, Dzyuba A, Deleage N, Easo S, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Elsasser C, Ely S, Esen S, Evans HM, Evans T, Falabella A, Farley N, Farry S, Fay R, Fazzini D, Ferguson D, Fernandez Albor V, Ferrari F, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiore M, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fohl K, Fontana M, Fontanelli F, Forshaw DC, Forty R, Frank M, Frei C, Fu J, Furfaro E, Farber C, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gandelman M, Gandini P, Gao Y, Garcia Pardinas J, Garra Tico J, Garrido L, Garsed PJ, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Ghez P, Giani S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Grabalosa Gandara M, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Griffith P, Grillo L, Gruberg Cazon BR, Grunberg O, Gushchin E, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hall S, Hamilton B, Han X, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison J, Hatch M, He J, Head T, Heister A, Hennessy K, Henrard P, Henry L, Hernando Morata JA, van Herwijnen E, Hess M, Hicheur A, Hill D, Hombach C, Hulsbergen W, Humair T, Hushchyn M, Hussain N, Hutchcroft D, Idzik M, Ilten P, Jacobsson R, Jaeger A, Jalocha J, Jans E, Jawahery A, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Kanso W, Karacson M, Kariuki JM, Karodia S, Kecke M, Kelsey M, Kenyon IR, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kirn T, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Komarov I, Koopman RF, Koppenburg P, Kozachuk A, Kozeiha M, Kravchuk L, Kreplin K, Kreps M, Krokovny P, Kruse F, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kurek K, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lambert D, Lanfranchi G, Langenbruch C, Langhans B, Latham T, Lazzeroni C, Le Gac R, van Leerdam J, Lees JP, Leflat A, Lefrancois J, Lefevre R, Lemaitre F, Lemos Cid E, Leroy O, Lesiak T, Leverington B, Li Y, Likhomanenko T, Lindner R, Linn C, Lionetto F, Liu B, Liu X, Loh D, Longstaff I, Lopes JH, Lucchesi D, Lucio Martinez M, Luo H, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Maev O, Maguire K, Malde S, Malinin A, Maltsev T, Manca G, Mancinelli G, Manning P, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marino P, Marks J, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Martins Tostes D, Massacrier LM, Massafferri A, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurin B, Mazurov A, McCann M, McCarthy J, McNab A, McNulty R, Meadows B, Meier F, Meissner M, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Minard MN, Mitzel DS, Molina Rodriguez J, Monroy IA, Monteil S, Morandin M, Morawski P, Morda A, Morello MJ, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Mussini M, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen AD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nikodem T, Novoselov A, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJ, Otalora Goicochea JM, Otto A, Owen P, Oyanguren A, Pais PR, Palano A, Palombo F, Palutan M, Panman J, Papanestis A, Pappagallo M, Pappalardo LL, Pappenheimer C, Parker W, Parkes C, Passaleva G, Pastore A, Patel GD, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petruzzo M, Picatoste Olloqui E, Pietrzyk B, Pikies M, Pinci D, Pistone A, Piucci A, Playfer S, Plo Casasus M, Poikela T, Polci F, Poluektov A, Polyakov I, Polycarpo E, Pomery GJ, Popov A, Popov D, Popovici B, Potterat C, Price E, Price JD, Prisciandaro J, Pritchard A, Prouve C, Pugatch V, Puig Navarro A, Punzi G, Qian W, Quagliani R, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Raniuk I, Raven G, Redi F, Reichert S, Dos Reis AC, Remon Alepuz C, Renaudin V, Ricciardi S, Richards S, Rihl M, Rinnert K, Rives Molina V, Robbe P, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Rodriguez Perez P, Rogozhnikov A, Roiser S, Romanovskiy V, Romero Vidal A, Ronayne JW, Rotondo M, Ruf T, Ruiz Valls P, Saborido Silva JJ, Sadykhov E, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarti A, Satriano C, Satta A, Saunders DM, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schlupp M, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schubert K, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sergi A, Serra N, Serrano J, Sestini L, Seyfert P, Shapkin M, Shapoval I, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Shires A, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Sirendi M, Skidmore N, Skwarnicki T, Smith E, Smith IT, Smith J, Smith M, Snoek H, Sokoloff MD, Soler FJ, Souza D, Souza De Paula B, Spaan B, Spradlin P, Sridharan S, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stenyakin O, Stevenson S, Stoica S, Stone S, Storaci B, Stracka S, Straticiuc M, Straumann U, Sun L, Sutcliffe W, Swientek K, Syropoulos V, Szczekowski M, Szumlak T, T'Jampens S, Tayduganov A, Tekampe T, Tellarini G, Teubert F, Thomas C, Thomas E, van Tilburg J, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Topp-Joergensen S, Toriello F, Tournefier E, Tourneur S, Trabelsi K, Traill M, Tran MT, Tresch M, Trisovic A, Tsaregorodtsev A, Tsopelas P, Tully A, Tuning N, Ukleja A, Ustyuzhanin A, Uwer U, Vacca C, Vagnoni V, Valat S, Valenti G, Vallier A, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Vernet M, Vesterinen M, Viaud B, Vieira D, Vieites Diaz M, Vilasis-Cardona X, Volkov V, Vollhardt A, Voneki B, Voong D, Vorobyev A, Vorobyev V, Voss C, de Vries JA, Vazquez Sierra C, Waldi R, Wallace C, Wallace R, Walsh J, Wang J, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams M, Williams MP, Williams M, Williams T, Wilson FF, Wimberley J, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wraight K, Wright S, Wyllie K, Xie Y, Xing Z, Xu Z, Yang Z, Yin H, Yu J, Yuan X, Yushchenko O, Zangoli M, Zarebski KA, Zavertyaev M, Zhang L, Zhang Y, Zhang Y, Zhelezov A, Zheng Y, Zhokhov A, Zhukov V, Zucchelli S

Abstract:
The first full amplitude analysis of B^{+}-->J/psivarphiK^{+} with J/psi-->mu^{+}mu^{-}, varphi-->K^{+}K^{-} decays is performed with a data sample of 3 fb^{-1} of pp collision data collected at sqrt[s]=7 and 8 TeV with the LHCb detector. The data cannot be described by a model that contains only excited kaon states decaying into varphiK^{+}, and four J/psivarphi structures are observed, each with significance over 5 standard deviations. The quantum numbers of these structures are determined with significance of at least 4 standard deviations. The lightest has mass consistent with, but width much larger than, previous measurements of the claimed X(4140) state.





12/01/2017 | Cell   IF 36.2
Blood on the Tracks: Two Pathways for Predation.
Rozeske RR, Herry C

Abstract:
Accurate predatory behavior requires coordination between pursuit activity and prey consumption, yet the underlying neuronal circuits are unknown. A novel study published in this issue of Cell identifies two coordinated circuits emanating from the central amygdala that control the efficiency of prey capture and the ability to deliver fatal bites to prey.





Abstract:
Limitation of plant productivity by the low partial pressure of atmospheric CO2 (Ca ) experienced during the last glacial period is hypothesized to have been an important constraint on the origins of agriculture. In support of this hypothesis, previous work has shown that glacial Ca limits vegetative growth in the wild progenitors of both C3 and C4 founder crops. Here, we present data showing that glacial Ca also reduces grain yield in both crop types. We grew four wild progenitors of C3 (einkorn wheat and barley) and C4 crops (foxtail and broomcorn millets) at glacial and postglacial Ca , measuring grain yield and the morphological and physiological components contributing to these yield changes. The C3 species showed a significant increase in unthreshed grain yield of ~50% with the glacial to postglacial increase in Ca , which matched the stimulation of photosynthesis, suggesting that increases in photosynthesis are directly translated into yield at subambient levels of Ca . Increased yield was controlled by a higher rate of tillering, leading to a larger number of tillers bearing fertile spikes, and increases in seed number and size. The C4 species showed smaller, but significant, increases in grain yield of 10-15%, arising from larger seed numbers and sizes. Photosynthesis was enhanced by Ca in only one C4 species and the effect diminished during development, suggesting that an indirect mechanism mediated by plant water relations could also be playing a role in the yield increase. Interestingly, the C4 species at glacial Ca showed some evidence that photosynthetic capacity was upregulated to enhance carbon capture. Development under glacial Ca also impacted negatively on the subsequent germination and viability of seeds. These results suggest that the grain production of both C3 and C4 crop progenitors was limited by the atmospheric conditions of the last glacial period, with important implications for the origins of agriculture.





2017 | Methods Mol Biol   IF 0.8
Dual Anterograde and Retrograde Viral Tracing of Reciprocal Connectivity.
Haberl MG, Ginger M, Frick A

Abstract:
Current large-scale approaches in neuroscience aim to unravel the complete connectivity map of specific neuronal circuits, or even the entire brain. This emerging research discipline has been termed connectomics. Recombinant glycoprotein-deleted rabies virus (RABV G) has become an important tool for the investigation of neuronal connectivity in the brains of a variety of species. Neuronal infection with even a single RABV G particle results in high-level transgene expression, revealing the fine-detailed morphology of all neuronal features-including dendritic spines, axonal processes, and boutons-on a brain-wide scale. This labeling is eminently suitable for subsequent post-hoc morphological analysis, such as semiautomated reconstruction in 3D. Here we describe the use of a recently developed anterograde RABV G variant together with a retrograde RABV G for the investigation of projections both to, and from, a particular brain region. In addition to the automated reconstruction of a dendritic tree, we also give as an example the volume measurements of axonal boutons following RABV G-mediated fluorescent marker expression. In conclusion RABV G variants expressing a combination of markers and/or tools for stimulating/monitoring neuronal activity, used together with genetic or behavioral animal models, promise important insights in the structure-function relationship of neural circuits.





2017 | front mol neurosci   IF 3.7
Differential Alteration in Expression of Striatal GABAAR Subunits in Mouse Models of Huntington's Disease.
Du Z, Tertrais M, Courtand G, Leste-Lasserre T, Cardoit L, Masmejean F, Halgand C, Cho YH, Garret M

Abstract:
Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive motor symptoms that are preceded by cognitive deficits and is considered as a disorder that primarily affects forebrain striatal neurons. To gain a better understanding of the molecular and cellular mechanisms associated with disease progression, we analyzed the expression of proteins involved in GABAergic neurotransmission in the striatum of the R6/1 transgenic mouse model. Western blot, quantitative PCR and immunohistochemical analyses were conducted on male R6/1 mice and age-matched wild type littermates. Analyses were performed on 2 and 6 month-old animals, respectively, before and after the onset of motor symptoms. Expression of GAD 67, GAD 65, NL2, or gephyrin proteins, involved in GABA synthesis or synapse formation did not display major changes. In contrast, expression of alpha1, alpha3 and alpha5 GABAAR subunits was increased while the expression of delta was decreased, suggesting a change in tonic- and phasic inhibitory transmission. Western blot analysis of the striatum from 8 month-old Hdh Q111, a knock-in mouse model of HD with mild deficits, confirmed the alpha1 subunit increased expression. From immunohistochemical analyses, we also found that alpha1 subunit expression is increased in medium-sized spiny projection neurons (MSN) and decreased in parvalbumin (PV)-expressing interneurons at 2 and 6 months in R6/1 mice. Moreover, alpha2 subunit labeling on the PV and MSN cell membranes was increased at 2 months and decreased at 6 months. Alteration of gene expression in the striatum and modification of GABAA receptor subtypes in both interneurons and projection neurons suggested that HD mutation has a profound effect on synaptic plasticity at an early stage, before the onset of motor symptoms. These results also indicate that cognitive and other behavioral deficits may be associated with changes in GABAergic neurotransmission that consequently could be a relevant target for early therapeutic treatment.





Abstract:
Layer 5 (L5) is a major neocortical output layer containing L5A slender-tufted (L5A-st) and L5B thick-tufted (L5B-tt) pyramidal neurons. These neuron types differ in their in vivo firing patterns, connectivity and dendritic morphology amongst other features, reflecting their specific functional role within the neocortical circuits. Here, we asked whether the active properties of the basal dendrites that receive the great majority of synaptic inputs within L5 differ between these two pyramidal neuron classes. To quantify their active properties, we measured the efficacy with which action potential (AP) firing patterns backpropagate along the basal dendrites by measuring the accompanying calcium transients using two-photon laser scanning microscopy in rat somatosensory cortex slices. For these measurements we used both 'artificial' three-AP patterns and more complex physiological AP patterns that were previously recorded in anesthetized rats in L5A-st and L5B-tt neurons in response to whisker stimulation. We show that AP patterns with relatively few APs (3APs) evoke a calcium response in L5B-tt, but not L5A-st, that is dependent on the temporal pattern of the three APs. With more complex in vivo recorded AP patterns, the average calcium response was similar in the proximal dendrites but with a decay along dendrites (measured up to 100 mum) of L5B-tt but not L5A-st neurons. Interestingly however, the whisker evoked AP patterns-although very different for the two cell types-evoke similar calcium responses. In conclusion, although the effectiveness with which different AP patterns evoke calcium transients vary between L5A-st and L5B-tt cell, the calcium influx appears to be tuned such that whisker-evoked calcium transients are within the same dynamic range for both cell types.





2017 | PLoS ONE   IF 2.8
Long-term effects of interference on short-term memory performance in the rat.
Missaire M, Fraize N, Joseph MA, Hamieh AM, Parmentier R, Marighetto A, Salin PA, Malleret G

Abstract:
A distinction has always been made between long-term and short-term memory (also now called working memory, WM). The obvious difference between these two kinds of memory concerns the duration of information storage: information is supposedly transiently stored in WM while it is considered durably consolidated into long-term memory. It is well acknowledged that the content of WM is erased and reset after a short time, to prevent irrelevant information from proactively interfering with newly stored information. In the present study, we used typical WM radial maze tasks to question the brief lifespan of spatial WM content in rodents. Groups of rats were submitted to one of two different WM tasks in a radial maze: a WM task involving the repetitive presentation of a same pair of arms expected to induce a high level of proactive interference (PI) (HIWM task), or a task using a different pair in each trial expected to induce a low level of PI (LIWM task). Performance was effectively lower in the HIWM group than in LIWM in the final trial of each training session, indicative of a 'within-session/short-term' PI effect. However, we also observed a different 'between-session/long-term' PI effect between the two groups: while performance of LIWM trained rats remained stable over days, the performance of HIWM rats dropped after 10 days of training, and this impairment was visible from the very first trial of the day, hence not attributable to within-session PI. We also showed that a 24 hour-gap across training sessions known to allow consolidation processes to unfold, was a necessary and sufficient condition for the long-term PI effect to occur. These findings suggest that in the HIWM task, WM content was not entirely reset between training sessions and that, in specific conditions, WM content can outlast its purpose by being stored more permanently, generating a long-term deleterious effect of PI. The alternative explanation is that WM content could be transferred and stored more permanently in an intermediary form or memory between WM and long-term memory.





2017 | eur phys j c part fields
New algorithms for identifying the flavour of [Formula: see text] mesons using pions and protons.
Aaij R, Adeva B, Adinolfi M, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Ali S, Alkhazov G, Alvarez Cartelle P, Alves AA Jr, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Aslanides E, Auriemma G, Baalouch M, Babuschkin I, Bachmann S, Back JJ, Badalov A, Baesso C, Baker S, Baldini W, Barlow RJ, Barschel C, Barsuk S, Barter W, Baszczyk M, Batozskaya V, Batsukh B, Battista V, Bay A, Beaucourt L, Beddow J, Bedeschi F, Bediaga I, Bel LJ, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Benton J, Berezhnoy A, Bernet R, Bertolin A, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bifani S, Billoir P, Bird T, Birnkraut A, Bitadze A, Bizzeti A, Blake T, Blanc F, Blouw J, Blusk S, Bocci V, Boettcher T, Bondar A, Bondar N, Bonivento W, Bordyuzhin I, Borgheresi A, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJV, Bowen E, Bozzi C, Braun S, Britsch M, Britton T, Brodzicka J, Buchanan E, Burr C, Bursche A, Buytaert J, Cadeddu S, Calabrese R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez D, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Castillo Garcia L, Cattaneo M, Cauet C, Cavallero G, Cenci R, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chen S, Cheung SF, Chobanova V, Chrzaszcz M, Cid Vidal X, Ciezarek G, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Cogan J, Cogneras E, Cogoni V, Cojocariu L, Collins P, Comerma-Montells A, Contu A, Cook A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Cunliffe S, Currie R, D'Ambrosio C, Da Cunha Marinho F, Dall'Occo E, Dalseno J, David PNY, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Deckenhoff M, Del Buono L, Demmer M, Dendek A, Derkach D, Deschamps O, Dettori F, Dey B, Di Canto A, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Dungs K, Durante P, Dzhelyadin R, Dziurda A, Dzyuba A, Deleage N, Easo S, Ebert M, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Elsasser C, Ely S, Esen S, Evans HM, Evans T, Falabella A, Farley N, Farry S, Fay R, Fazzini D, Ferguson D, Fernandez Prieto A, Ferrari F, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiore M, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fohl K, Fontana M, Fontanelli F, Forshaw DC, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Furfaro E, Farber C, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garra Tico J, Garrido L, Garsed PJ, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Ghez P, Giani S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Grabalosa Gandara M, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Griffith P, Grillo L, Gruberg Cazon BR, Grunberg O, Gushchin E, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hall S, Hamilton B, Han X, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison J, Hatch M, He J, Head T, Heister A, Hennessy K, Henrard P, Henry L, Hernando Morata JA, van Herwijnen E, Hess M, Hicheur A, Hill D, Hombach C, Hopchev PH, Hulsbergen W, Humair T, Hushchyn M, Hussain N, Hutchcroft D, Idzik M, Ilten P, Jacobsson R, Jaeger A, Jalocha J, Jans E, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Kanso W, Karacson M, Kariuki JM, Karodia S, Kecke M, Kelsey M, Kenyon IR, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kirn T, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Komarov I, Koopman RF, Koppenburg P, Kosmyntseva A, Kozeiha M, Kravchuk L, Kreplin K, Kreps M, Krokovny P, Kruse F, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kurek K, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lambert D, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, van Leerdam J, Lees JP, Leflat A, Lefrancois J, Lefevre R, Lemaitre F, Lemos Cid E, Leroy O, Lesiak T, Leverington B, Li Y, Likhomanenko T, Lindner R, Linn C, Lionetto F, Liu B, Liu X, Loh D, Longstaff I, Lopes JH, Lucchesi D, Lucio Martinez M, Luo H, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Maev O, Maguire K, Malde S, Malinin A, Maltsev T, Manca G, Mancinelli G, Manning P, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marino P, Marks J, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Martins Tostes D, Massacrier LM, Massafferri A, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurin B, Mazurov A, McCann M, McCarthy J, McNab A, McNulty R, Meadows B, Meier F, Meissner M, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Minard MN, Mitzel DS, Mogini A, Molina Rodriguez J, Monroy IA, Monteil S, Morandin M, Morawski P, Morda A, Morello MJ, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Mussini M, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen AD, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nikodem T, Novoselov A, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJG, Otalora Goicochea JM, Otto A, Owen P, Oyanguren A, Pais PR, Palano A, Palombo F, Palutan M, Panman J, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel GD, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petruzzo M, Picatoste Olloqui E, Pietrzyk B, Pikies M, Pinci D, Pistone A, Piucci A, Playfer S, Plo Casasus M, Poikela T, Polci F, Poluektov A, Polyakov I, Polycarpo E, Pomery GJ, Popov A, Popov D, Popovici B, Poslavskii S, Potterat C, Price E, Price JD, Prisciandaro J, Pritchard A, Prouve C, Pugatch V, Puig Navarro A, Punzi G, Qian W, Quagliani R, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Raniuk I, Ratnikov F, Raven G, Redi F, Reichert S, Dos Reis AC, Remon Alepuz C, Renaudin V, Ricciardi S, Richards S, Rihl M, Rinnert K, Rives Molina V, Robbe P, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Rodriguez Perez P, Rogozhnikov A, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Ronayne JW, Rotondo M, Rudolph MS, Ruf T, Ruiz Valls P, Saborido Silva JJ, Sadykhov E, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarti A, Satriano C, Satta A, Saunders DM, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schlupp M, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schubert K, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sergi A, Serra N, Serrano J, Sestini L, Seyfert P, Shapkin M, Shapoval I, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Shires A, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Sirendi M, Skidmore N, Skwarnicki T, Smith E, Smith IT, Smith J, Smith M, Snoek H, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spradlin P, Sridharan S, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stevenson S, Stoica S, Stone S, Storaci B, Stracka S, Straticiuc M, Straumann U, Sun L, Sutcliffe W, Swientek K, Syropoulos V, Szczekowski M, Szumlak T, T'Jampens S, Tayduganov A, Tekampe T, Teklishyn M, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Topp-Joergensen S, Toriello F, Tournefier E, Tourneur S, Trabelsi K, Traill M, Tran MT, Tresch M, Trisovic A, Tsaregorodtsev A, Tsopelas P, Tully A, Tuning N, Ukleja A, Ustyuzhanin A, Uwer U, Vacca C, Vagnoni V, Valassi A, Valat S, Valenti G, Vallier A, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Vernet M, Vesterinen M, Viaud B, Vieira D, Vieites Diaz M, Vilasis-Cardona X, Volkov V, Vollhardt A, Voneki B, Vorobyev A, Vorobyev V, Voss C, de Vries JA, Vazquez Sierra C, Waldi R, Wallace C, Wallace R, Walsh J, Wang J, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams M, Williams MP, Williams M, Williams T, Wilson FF, Wimberley J, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wraight K, Wyllie K, Xie Y, Xu Z, Yang Z, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang L, Zhang Y, Zhelezov A, Zheng Y, Zhokhov A, Zhu X, Zhukov V, Zucchelli S

Abstract:
Two new algorithms for use in the analysis of [Formula: see text] collision are developed to identify the flavour of [Formula: see text] mesons at production using pions and protons from the hadronization process. The algorithms are optimized and calibrated on data, using [Formula: see text] decays from [Formula: see text] collision data collected by LHCb at centre-of-mass energies of 7 and 8 TeV . The tagging power of the new pion algorithm is 60% greater than the previously available one; the algorithm using protons to identify the flavour of a [Formula: see text] meson is the first of its kind.





2017 | eur phys j c part fields
Search for massive long-lived particles decaying semileptonically in the LHCb detector.
Aaij R, Adeva B, Adinolfi M, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Ali S, Alkhazov G, Alvarez Cartelle P, Alves AA Jr, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Aslanides E, Auriemma G, Baalouch M, Babuschkin I, Bachmann S, Back JJ, Badalov A, Baesso C, Baker S, Baldini W, Barlow RJ, Barschel C, Barsuk S, Barter W, Baszczyk M, Batozskaya V, Batsukh B, Battista V, Bay A, Beaucourt L, Beddow J, Bedeschi F, Bediaga I, Bel LJ, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Benton J, Berezhnoy A, Bernet R, Bertolin A, Betancourt C, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bifani S, Billoir P, Bird T, Birnkraut A, Bitadze A, Bizzeti A, Blake T, Blanc F, Blouw J, Blusk S, Bocci V, Boettcher T, Bondar A, Bondar N, Bonivento W, Bordyuzhin I, Borgheresi A, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJV, Bowen E, Bozzi C, Braun S, Britsch M, Britton T, Brodzicka J, Buchanan E, Burr C, Bursche A, Buytaert J, Cadeddu S, Calabrese R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Castillo Garcia L, Cattaneo M, Cauet C, Cavallero G, Cenci R, Chamont D, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chen S, Cheung SF, Chobanova V, Chrzaszcz M, Cid Vidal X, Ciezarek G, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Cogan J, Cogneras E, Cogoni V, Cojocariu L, Collazuol G, Collins P, Comerma-Montells A, Contu A, Cook A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Cunliffe S, Currie R, D'Ambrosio C, Da Cunha Marinho F, Dall'Occo E, Dalseno J, David PNY, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Deckenhoff M, Del Buono L, Demmer M, Dendek A, Derkach D, Deschamps O, Dettori F, Dey B, Di Canto A, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Dungs K, Durante P, Dzhelyadin R, Dziurda A, Dzyuba A, Deleage N, Easo S, Ebert M, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Esen S, Evans HM, Evans T, Falabella A, Farley N, Farry S, Fay R, Fazzini D, Ferguson D, Fernandez Prieto A, Ferrari F, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiore M, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fohl K, Fontana M, Fontanelli F, Forshaw DC, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Furfaro E, Farber C, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garra Tico J, Garrido L, Garsed PJ, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Ghez P, Giani S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Gandara MG, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Griffith P, Grillo L, Gruberg Cazon BR, Grunberg O, Gushchin E, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hall S, Hamilton B, Han X, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison J, Hatch M, He J, Head T, Heister A, Hennessy K, Henrard P, Henry L, van Herwijnen E, Hess M, Hicheur A, Hill D, Hombach C, Hopchev H, Hulsbergen W, Humair T, Hushchyn M, Hussain N, Hutchcroft D, Idzik M, Ilten P, Jacobsson R, Jaeger A, Jalocha J, Jans E, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Kanso W, Karacson M, Kariuki JM, Karodia S, Kecke M, Kelsey M, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kirn T, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Komarov I, Koopman RF, Koppenburg P, Kosmyntseva A, Kozachuk A, Kozeiha M, Kravchuk L, Kreplin K, Kreps M, Krokovny P, Kruse F, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kurek K, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, van Leerdam J, Leflat A, Lefrancois J, Lefevre R, Lemaitre F, Lemos Cid E, Leroy O, Lesiak T, Leverington B, Li T, Li Y, Likhomanenko T, Lindner R, Linn C, Lionetto F, Liu X, Loh D, Longstaff I, Lopes JH, Lucchesi D, Lucio Martinez M, Luo H, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Maev O, Maguire K, Malde S, Malinin A, Maltsev T, Manca G, Mancinelli G, Manning P, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marino P, Marks J, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Martins Tostes D, Massacrier LM, Massafferri A, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurin B, Mazurov A, McCann M, McCarthy J, McNab A, McNulty R, Meadows B, Meier F, Meissner M, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Minard MN, Mitzel DS, Mogini A, Molina Rodriguez J, Monroy IA, Monteil S, Morandin M, Morawski P, Morda A, Morello MJ, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Mussini M, Muster B, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nikodem T, Novoselov A, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJG, Otalora Goicochea JM, Otto A, Owen P, Oyanguren A, Pais PR, Palano A, Palombo F, Palutan M, Panman J, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel GD, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petruzzo M, Picatoste Olloqui E, Pietrzyk B, Pikies M, Pinci D, Pistone A, Piucci A, Playfer S, Plo Casasus M, Poikela T, Polci F, Poluektov A, Polyakov I, Polycarpo E, Pomery GJ, Popov A, Popov D, Popovici B, Poslavskii S, Potterat C, Price E, Price JD, Prisciandaro J, Pritchard A, Prouve C, Pugatch V, Puig Navarro A, Punzi G, Qian W, Quagliani R, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Raniuk I, Ratnikov F, Raven G, Redi F, Reichert S, Dos Reis AC, Remon Alepuz C, Renaudin V, Ricciardi S, Richards S, Rihl M, Rinnert K, Rives Molina V, Robbe P, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Rodriguez Perez P, Rogozhnikov A, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Ronayne JW, Rotondo M, Rudolph MS, Ruf T, Ruiz Valls P, Saborido Silva JJ, Sadykhov E, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarti A, Satriano C, Satta A, Saunders DM, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schlupp M, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schubert K, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sergi A, Serra N, Serrano J, Sestini L, Seyfert P, Shapkin M, Shapoval I, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Sirendi M, Skidmore N, Skwarnicki T, Smith E, Smith IT, Smith J, Smith M, Snoek H, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spradlin P, Sridharan S, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stevenson S, Stoica S, Stone S, Storaci B, Stracka S, Straticiuc M, Straumann U, Sun L, Sutcliffe W, Swientek K, Syropoulos V, Szczekowski M, Szumlak T, T'Jampens S, Tayduganov A, Tekampe T, Teklishyn M, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Topp-Joergensen S, Toriello F, Tournefier E, Tourneur S, Trabelsi K, Traill M, Tran MT, Tresch M, Trisovic A, Tsaregorodtsev A, Tsopelas P, Tully A, Tuning N, Ukleja A, Ustyuzhanin A, Uwer U, Vacca C, Vagnoni V, Valassi A, Valat S, Valenti G, Vallier A, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Vernet M, Vesterinen M, Viaud B, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitti M, Volkov V, Vollhardt A, Voneki B, Vorobyev A, Vorobyev V, Voss C, de Vries JA, Vazquez Sierra C, Waldi R, Wallace C, Wallace R, Walsh J, Wang J, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams M, Williams MP, Williams M, Williams T, Wilson FF, Wimberley J, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wraight K, Wyllie K, Xie Y, Xing Z, Xu Z, Yang Z, Yao Y, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang L, Zhang Y, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zucchelli S

Abstract:
A search is presented for massive long-lived particles decaying into a muon and two quarks. The dataset consists of proton-proton interactions at centre-of-mass energies of 7 and 8 TeV, corresponding to integrated luminosities of 1 and 2[Formula: see text], respectively. The analysis is performed assuming a set of production mechanisms with simple topologies, including the production of a Higgs-like particle decaying into two long-lived particles. The mass range from 20 to 80 [Formula: see text] and lifetimes from 5 to 100[Formula: see text] are explored. Results are also interpreted in terms of neutralino production in different R-Parity violating supersymmetric models, with masses in the 23-198 GeV/[Formula: see text] range. No excess above the background expectation is observed and upper limits are set on the production cross-section for various points in the parameter space of theoretical models.





2017 | eur phys j c part fields
Measurement of the phase difference between short- and long-distance amplitudes in the [Formula: see text] decay.
Aaij R, Adeva B, Adinolfi M, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Ali S, Alkhazov G, Alvarez Cartelle P, Alves AA Jr, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Aslanides E, Auriemma G, Baalouch M, Babuschkin I, Bachmann S, Back JJ, Badalov A, Baesso C, Baker S, Balagura V, Baldini W, Barlow RJ, Barschel C, Barsuk S, Barter W, Baszczyk M, Batozskaya V, Batsukh B, Battista V, Bay A, Beaucourt L, Beddow J, Bedeschi F, Bediaga I, Bel LJ, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Berezhnoy A, Bernet R, Bertolin A, Betancourt C, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bifani S, Billoir P, Bird T, Birnkraut A, Bitadze A, Bizzeti A, Blake T, Blanc F, Blouw J, Blusk S, Bocci V, Boettcher T, Bondar A, Bondar N, Bonivento W, Bordyuzhin I, Borgheresi A, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJV, Bowen E, Bozzi C, Braun S, Britsch M, Britton T, Brodzicka J, Buchanan E, Burr C, Bursche A, Buytaert J, Cadeddu S, Calabrese R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Castillo Garcia L, Cattaneo M, Cavallero G, Cenci R, Chamont D, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chen S, Cheung SF, Chobanova V, Chrzaszcz M, Cid Vidal X, Ciezarek G, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Cogan J, Cogneras E, Cogoni V, Cojocariu L, Collazuol G, Collins P, Comerma-Montells A, Contu A, Cook A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Cunliffe S, Currie R, D'Ambrosio C, Da Cunha Marinho F, Dall'Occo E, Dalseno J, David PNY, Davis A, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Deckenhoff M, Del Buono L, Demmer M, Dendek A, Derkach D, Deschamps O, Dettori F, Dey B, Di Canto A, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Dungs K, Durante P, Dzhelyadin R, Dziurda A, Dzyuba A, Deleage N, Easo S, Ebert M, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Esen S, Evans HM, Evans T, Falabella A, Farley N, Farry S, Fay R, Fazzini D, Ferguson D, Fernandez Prieto A, Ferrari F, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiore M, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fohl K, Fontana M, Fontanelli F, Forshaw DC, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Funk W, Furfaro E, Farber C, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garra Tico J, Garrido L, Garsed PJ, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Ghez P, Giani S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Griffith P, Grillo L, Gruberg Cazon BR, Grunberg O, Gushchin E, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hall S, Hamilton B, Han X, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison J, Hatch M, He J, Head T, Heister A, Hennessy K, Henrard P, Henry L, van Herwijnen E, Hess M, Hicheur A, Hill D, Hombach C, Hopchev H, Hulsbergen W, Humair T, Hushchyn M, Hutchcroft D, Idzik M, Ilten P, Jacobsson R, Jaeger A, Jalocha J, Jans E, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Karacson M, Kariuki JM, Karodia S, Kecke M, Kelsey M, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kirn T, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Komarov I, Koopman RF, Koppenburg P, Kosmyntseva A, Kozachuk A, Kozeiha M, Kravchuk L, Kreplin K, Kreps M, Krokovny P, Kruse F, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kurek K, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, van Leerdam J, Leflat A, Lefrancois J, Lefevre R, Lemaitre F, Lemos Cid E, Leroy O, Lesiak T, Leverington B, Li T, Li Y, Likhomanenko T, Lindner R, Linn C, Lionetto F, Liu X, Loh D, Longstaff I, Lopes JH, Lucchesi D, Lucio Martinez M, Luo H, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Maev O, Maguire K, Malde S, Malinin A, Maltsev T, Manca G, Mancinelli G, Manning P, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marinangeli M, Marino P, Marks J, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Martins Tostes D, Massacrier LM, Massafferri A, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurice E, Maurin B, Mazurov A, McCann M, McNab A, McNulty R, Meadows B, Meier F, Meissner M, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Minard MN, Mitzel DS, Mogini A, Molina Rodriguez J, Monroy IA, Monteil S, Morandin M, Morawski P, Morda A, Morello MJ, Morgunova O, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Mussini M, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nikodem T, Nogay A, Novoselov A, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJG, Otalora Goicochea JM, Otto A, Owen P, Oyanguren A, Pais PR, Palano A, Palombo F, Palutan M, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel GD, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petruzzo M, Picatoste Olloqui E, Pietrzyk B, Pikies M, Pinci D, Pistone A, Piucci A, Placinta V, Playfer S, Plo Casasus M, Poikela T, Polci F, Poluektov A, Polyakov I, Polycarpo E, Pomery GJ, Popov A, Popov D, Popovici B, Poslavskii S, Potterat C, Price E, Price JD, Prisciandaro J, Pritchard A, Prouve C, Pugatch V, Puig Navarro A, Punzi G, Qian W, Quagliani R, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Raniuk I, Ratnikov F, Raven G, Redi F, Reichert S, Dos Reis AC, Remon Alepuz C, Renaudin V, Ricciardi S, Richards S, Rihl M, Rinnert K, Rives Molina V, Robbe P, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Rodriguez Perez P, Rogozhnikov A, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Ronayne JW, Rotondo M, Rudolph MS, Ruf T, Ruiz Valls P, Saborido Silva JJ, Sadykhov E, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarti A, Satriano C, Satta A, Saunders DM, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schlupp M, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schubert K, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sergi A, Serra N, Serrano J, Sestini L, Seyfert P, Shapkin M, Shapoval I, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Sirendi M, Skidmore N, Skwarnicki T, Smith E, Smith IT, Smith J, Smith M, Snoek H, Soares Lavra L, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spradlin P, Sridharan S, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stevens H, Stevenson S, Stoica S, Stone S, Storaci B, Stracka S, Straticiuc M, Straumann U, Sun L, Sutcliffe W, Swientek K, Syropoulos V, Szczekowski M, Szumlak T, T'Jampens S, Tayduganov A, Tekampe T, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Topp-Joergensen S, Toriello F, Tournefier E, Tourneur S, Trabelsi K, Traill M, Tran MT, Tresch M, Trisovic A, Tsaregorodtsev A, Tsopelas P, Tully A, Tuning N, Ukleja A, Ustyuzhanin A, Uwer U, Vacca C, Vagnoni V, Valassi A, Valat S, Valenti G, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Vernet M, Vesterinen M, Viana Barbosa JV, Viaud B, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitti M, Volkov V, Vollhardt A, Voneki B, Vorobyev A, Vorobyev V, Voss C, de Vries JA, Vazquez Sierra C, Waldi R, Wallace C, Wallace R, Walsh J, Wang J, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams M, Williams MP, Williams M, Williams T, Wilson FF, Wimberley J, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wraight K, Wyllie K, Xie Y, Xing Z, Xu Z, Yang Z, Yao Y, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang L, Zhang Y, Zhang Y, Zhelezov A, Zheng Y, Zhu X, Zhukov V, Zucchelli S

Abstract:
A measurement of the phase difference between the short- and long-distance contributions to the [Formula: see text] decay is performed by analysing the dimuon mass distribution. The analysis is based on pp collision data corresponding to an integrated luminosity of 3[Formula: see text] collected by the LHCb experiment in 2011 and 2012. The long-distance contribution to the [Formula: see text] decay is modelled as a sum of relativistic Breit-Wigner amplitudes representing different vector meson resonances decaying to muon pairs, each with their own magnitude and phase. The measured phases of the [Formula: see text] and [Formula: see text] resonances are such that the interference with the short-distance component in dimuon mass regions far from their pole masses is small. In addition, constraints are placed on the Wilson coefficients, [Formula: see text] and [Formula: see text], and the branching fraction of the short-distance component is measured.





2017 | eur phys j c part fields
Observation of [Formula: see text] and [Formula: see text] decays.
Aaij R, Adeva B, Adinolfi M, Ajaltouni Z, Akar S, Albrecht J, Alessio F, Alexander M, Ali S, Alkhazov G, Alvarez Cartelle P, Alves AA Jr, Amato S, Amerio S, Amhis Y, An L, Anderlini L, Andreassi G, Andreotti M, Andrews JE, Appleby RB, Archilli F, d'Argent P, Arnau Romeu J, Artamonov A, Artuso M, Aslanides E, Auriemma G, Baalouch M, Babuschkin I, Bachmann S, Back JJ, Badalov A, Baesso C, Baker S, Baldini W, Barlow RJ, Barschel C, Barsuk S, Barter W, Baszczyk M, Batozskaya V, Batsukh B, Battista V, Bay A, Beaucourt L, Beddow J, Bedeschi F, Bediaga I, Bel LJ, Bellee V, Belloli N, Belous K, Belyaev I, Ben-Haim E, Bencivenni G, Benson S, Benton J, Berezhnoy A, Bernet R, Bertolin A, Betancourt C, Betti F, Bettler MO, van Beuzekom M, Bezshyiko I, Bifani S, Billoir P, Bird T, Birnkraut A, Bitadze A, Bizzeti A, Blake T, Blanc F, Blouw J, Blusk S, Bocci V, Boettcher T, Bondar A, Bondar N, Bonivento W, Bordyuzhin I, Borgheresi A, Borghi S, Borisyak M, Borsato M, Bossu F, Boubdir M, Bowcock TJV, Bowen E, Bozzi C, Braun S, Britsch M, Britton T, Brodzicka J, Buchanan E, Burr C, Bursche A, Buytaert J, Cadeddu S, Calabrese R, Calvi M, Calvo Gomez M, Camboni A, Campana P, Campora Perez DH, Capriotti L, Carbone A, Carboni G, Cardinale R, Cardini A, Carniti P, Carson L, Carvalho Akiba K, Casse G, Cassina L, Castillo Garcia L, Cattaneo M, Cauet C, Cavallero G, Cenci R, Charles M, Charpentier P, Chatzikonstantinidis G, Chefdeville M, Chen S, Cheung SF, Chobanova V, Chrzaszcz M, Cid Vidal X, Ciezarek G, Clarke PEL, Clemencic M, Cliff HV, Closier J, Coco V, Cogan J, Cogneras E, Cogoni V, Cojocariu L, Collazuol G, Collins P, Comerma-Montells A, Contu A, Cook A, Coombs G, Coquereau S, Corti G, Corvo M, Costa Sobral CM, Couturier B, Cowan GA, Craik DC, Crocombe A, Cruz Torres M, Cunliffe S, Currie R, D'Ambrosio C, Da Cunha Marinho F, Dall'Occo E, Dalseno J, David PNY, Davis A, De Aguiar Francisco O, De Bruyn K, De Capua S, De Cian M, De Miranda JM, De Paula L, De Serio M, De Simone P, Dean CT, Decamp D, Deckenhoff M, Del Buono L, Demmer M, Dendek A, Derkach D, Deschamps O, Dettori F, Dey B, Di Canto A, Dijkstra H, Dordei F, Dorigo M, Dosil Suarez A, Dovbnya A, Dreimanis K, Dufour L, Dujany G, Dungs K, Durante P, Dzhelyadin R, Dziurda A, Dzyuba A, Deleage N, Easo S, Ebert M, Egede U, Egorychev V, Eidelman S, Eisenhardt S, Eitschberger U, Ekelhof R, Eklund L, Ely S, Esen S, Evans HM, Evans T, Falabella A, Farley N, Farry S, Fay R, Fazzini D, Ferguson D, Fernandez Prieto A, Ferrari F, Ferreira Rodrigues F, Ferro-Luzzi M, Filippov S, Fini RA, Fiore M, Fiorini M, Firlej M, Fitzpatrick C, Fiutowski T, Fleuret F, Fohl K, Fontana M, Fontanelli F, Forshaw DC, Forty R, Franco Lima V, Frank M, Frei C, Fu J, Furfaro E, Farber C, Gallas Torreira A, Galli D, Gallorini S, Gambetta S, Gandelman M, Gandini P, Gao Y, Garcia Martin LM, Garcia Pardinas J, Garra Tico J, Garrido L, Garsed PJ, Gascon D, Gaspar C, Gavardi L, Gazzoni G, Gerick D, Gersabeck E, Gersabeck M, Gershon T, Ghez P, Giani S, Gibson V, Girard OG, Giubega L, Gizdov K, Gligorov VV, Golubkov D, Golutvin A, Gomes A, Gorelov IV, Gotti C, Govorkova E, Grabalosa Gandara M, Graciani Diaz R, Granado Cardoso LA, Grauges E, Graverini E, Graziani G, Grecu A, Griffith P, Grillo L, Gruberg Cazon BR, Grunberg O, Gushchin E, Guz Y, Gys T, Gobel C, Hadavizadeh T, Hadjivasiliou C, Haefeli G, Haen C, Haines SC, Hall S, Hamilton B, Han X, Hansmann-Menzemer S, Harnew N, Harnew ST, Harrison J, Hatch M, He J, Head T, Heister A, Hennessy K, Henrard P, Henry L, Hernando Morata JA, van Herwijnen E, Hess M, Hicheur A, Hill D, Hombach C, Hopchev H, Hulsbergen W, Humair T, Hushchyn M, Hussain N, Hutchcroft D, Idzik M, Ilten P, Jacobsson R, Jaeger A, Jalocha J, Jans E, Jawahery A, Jiang F, John M, Johnson D, Jones CR, Joram C, Jost B, Jurik N, Kandybei S, Kanso W, Karacson M, Kariuki JM, Karodia S, Kecke M, Kelsey M, Kenyon IR, Kenzie M, Ketel T, Khairullin E, Khanji B, Khurewathanakul C, Kirn T, Klaver S, Klimaszewski K, Koliiev S, Kolpin M, Komarov I, Koopman RF, Koppenburg P, Kosmyntseva A, Kozachuk A, Kozeiha M, Kravchuk L, Kreplin K, Kreps M, Krokovny P, Kruse F, Krzemien W, Kucewicz W, Kucharczyk M, Kudryavtsev V, Kuonen AK, Kurek K, Kvaratskheliya T, Lacarrere D, Lafferty G, Lai A, Lanfranchi G, Langenbruch C, Latham T, Lazzeroni C, Le Gac R, van Leerdam J, Lees JP, Leflat A, Lefrancois J, Lefevre R, Lemaitre F, Lemos Cid E, Leroy O, Lesiak T, Leverington B, Li Y, Likhomanenko T, Lindner R, Linn C, Lionetto F, Liu B, Liu X, Loh D, Longstaff I, Lopes JH, Lucchesi D, Lucio Martinez M, Luo H, Lupato A, Luppi E, Lupton O, Lusiani A, Lyu X, Machefert F, Maciuc F, Maev O, Maguire K, Malde S, Malinin A, Maltsev T, Manca G, Mancinelli G, Manning P, Maratas J, Marchand JF, Marconi U, Marin Benito C, Marino P, Marks J, Martellotti G, Martin M, Martinelli M, Martinez Santos D, Martinez Vidal F, Martins Tostes D, Massacrier LM, Massafferri A, Matev R, Mathad A, Mathe Z, Matteuzzi C, Mauri A, Maurin B, Mazurov A, McCann M, McCarthy J, McNab A, McNulty R, Meadows B, Meier F, Meissner M, Melnychuk D, Merk M, Merli A, Michielin E, Milanes DA, Minard MN, Mitzel DS, Mogini A, Molina Rodriguez J, Monroy IA, Monteil S, Morandin M, Morawski P, Morda A, Morello MJ, Moron J, Morris AB, Mountain R, Muheim F, Mulder M, Mussini M, Muller D, Muller J, Muller K, Muller V, Naik P, Nakada T, Nandakumar R, Nandi A, Nasteva I, Needham M, Neri N, Neubert S, Neufeld N, Neuner M, Nguyen AD, Nguyen TD, Nguyen-Mau C, Nieswand S, Niet R, Nikitin N, Nikodem T, Novoselov A, O'Hanlon DP, Oblakowska-Mucha A, Obraztsov V, Ogilvy S, Oldeman R, Onderwater CJG, Otalora Goicochea JM, Otto A, Owen P, Oyanguren A, Pais PR, Palano A, Palombo F, Palutan M, Panman J, Papanestis A, Pappagallo M, Pappalardo LL, Parker W, Parkes C, Passaleva G, Pastore A, Patel GD, Patel M, Patrignani C, Pearce A, Pellegrino A, Penso G, Pepe Altarelli M, Perazzini S, Perret P, Pescatore L, Petridis K, Petrolini A, Petrov A, Petruzzo M, Picatoste Olloqui E, Pietrzyk B, Pikies M, Pinci D, Pistone A, Piucci A, Playfer S, Plo Casasus M, Poikela T, Polci F, Poluektov A, Polyakov I, Polycarpo E, Pomery GJ, Popov A, Popov D, Popovici B, Poslavskii S, Potterat C, Price E, Price JD, Prisciandaro J, Pritchard A, Prouve C, Pugatch V, Puig Navarro A, Punzi G, Qian W, Quagliani R, Rachwal B, Rademacker JH, Rama M, Ramos Pernas M, Rangel MS, Raniuk I, Ratnikov F, Raven G, Redi F, Reichert S, Dos Reis AC, Remon Alepuz C, Renaudin V, Ricciardi S, Richards S, Rihl M, Rinnert K, Rives Molina V, Robbe P, Rodrigues AB, Rodrigues E, Rodriguez Lopez JA, Rodriguez Perez P, Rogozhnikov A, Roiser S, Rollings A, Romanovskiy V, Romero Vidal A, Ronayne JW, Rotondo M, Rudolph MS, Ruf T, Ruiz Valls P, Saborido Silva JJ, Sadykhov E, Sagidova N, Saitta B, Salustino Guimaraes V, Sanchez Mayordomo C, Sanmartin Sedes B, Santacesaria R, Santamarina Rios C, Santimaria M, Santovetti E, Sarti A, Satriano C, Satta A, Saunders DM, Savrina D, Schael S, Schellenberg M, Schiller M, Schindler H, Schlupp M, Schmelling M, Schmelzer T, Schmidt B, Schneider O, Schopper A, Schubert K, Schubiger M, Schune MH, Schwemmer R, Sciascia B, Sciubba A, Semennikov A, Sergi A, Serra N, Serrano J, Sestini L, Seyfert P, Shapkin M, Shapoval I, Shcheglov Y, Shears T, Shekhtman L, Shevchenko V, Siddi BG, Silva Coutinho R, Silva de Oliveira L, Simi G, Simone S, Sirendi M, Skidmore N, Skwarnicki T, Smith E, Smith IT, Smith J, Smith M, Snoek H, Sokoloff MD, Soler FJP, Souza De Paula B, Spaan B, Spradlin P, Sridharan S, Stagni F, Stahl M, Stahl S, Stefko P, Stefkova S, Steinkamp O, Stemmle S, Stenyakin O, Stevenson S, Stoica S, Stone S, Storaci B, Stracka S, Straticiuc M, Straumann U, Sun L, Sutcliffe W, Swientek K, Syropoulos V, Szczekowski M, Szumlak T, T'Jampens S, Tayduganov A, Tekampe T, Tellarini G, Teubert F, Thomas E, van Tilburg J, Tilley MJ, Tisserand V, Tobin M, Tolk S, Tomassetti L, Tonelli D, Topp-Joergensen S, Toriello F, Tournefier E, Tourneur S, Trabelsi K, Traill M, Tran MT, Tresch M, Trisovic A, Tsaregorodtsev A, Tsopelas P, Tully A, Tuning N, Ukleja A, Ustyuzhanin A, Uwer U, Vacca C, Vagnoni V, Valassi A, Valat S, Valenti G, Vallier A, Vazquez Gomez R, Vazquez Regueiro P, Vecchi S, van Veghel M, Velthuis JJ, Veltri M, Veneziano G, Venkateswaran A, Vernet M, Vesterinen M, Viaud B, Vieira D, Vieites Diaz M, Viemann H, Vilasis-Cardona X, Vitti M, Volkov V, Vollhardt A, Voneki B, Vorobyev A, Vorobyev V, Voss C, de Vries JA, Vazquez Sierra C, Waldi R, Wallace C, Wallace R, Walsh J, Wang J, Ward DR, Wark HM, Watson NK, Websdale D, Weiden A, Whitehead M, Wicht J, Wilkinson G, Wilkinson M, Williams M, Williams MP, Williams M, Williams T, Wilson FF, Wimberley J, Wishahi J, Wislicki W, Witek M, Wormser G, Wotton SA, Wraight K, Wyllie K, Xie Y, Xing Z, Xu Z, Yang Z, Yin H, Yu J, Yuan X, Yushchenko O, Zarebski KA, Zavertyaev M, Zhang L, Zhang Y, Zhang Y, Zhelezov A, Zheng Y, Zhokhov A, Zhu X, Zhukov V, Zucchelli S

Abstract:
The decays [Formula: see text] and [Formula: see text] are observed for the first time using a data sample corresponding to an integrated luminosity of 3.0 fb[Formula: see text], collected by the LHCb experiment in proton-proton collisions at the centre-of-mass energies of 7 and 8[Formula: see text]. The branching fractions relative to that of [Formula: see text] are measured to be [Formula: see text]where the first uncertainties are statistical and the second are systematic.