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Yu ZHANG




Post-Doctorant

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6 publication(s) depuis Janvier 2006:


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10/11/2014 | Nat Neurosci   IF 21.1
Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1 mice.
Zhang Y*, Bonnan A*, Bony G*, Ferezou I, Pietropaolo S, Ginger M, Sans N, Rossier J, Oostra B, Lemasson G, Frick A

Abstract:
Hypersensitivity in response to sensory stimuli and neocortical hyperexcitability are prominent features of Fragile X Syndrome (FXS) and autism spectrum disorders, but little is known about the dendritic mechanisms underlying these phenomena. We found that the primary somatosensory neocortex (S1) was hyperexcited in response to tactile sensory stimulation in Fmr1-/y mice. This correlated with neuronal and dendritic hyperexcitability of S1 pyramidal neurons, which affect all major aspects of neuronal computation, from the integration of synaptic input to the generation of action potential output. Using dendritic electrophysiological recordings, calcium imaging, pharmacology, biochemistry and a computer model, we found that this defect was, at least in part, attributable to the reduction and dysfunction of dendritic h- and BKCa channels. We pharmacologically rescued several core hyperexcitability phenomena by targeting BKCa channels. Our results provide strong evidence pointing to the utility of BKCa channel openers for the treatment of the sensory hypersensitivity aspects of FXS.




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2008 | Nanoscale Res. Lett.   IF 3.2
Subcellular Localization of Thiol-Capped CdTe Quantum Dots in Living Cells
Zhang Y, Mi L, Xiong R, Wang P, Chen J, Yang W, Wang C, Peng Q

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2008 | Small   IF 10.9
Photoluminescence decay dynamics of thiol-capped CdTe quantum dots in living cells under microexcitation
Zhang Y, Mi L, Wang P, Lu S, Chen J, Guo J, Yang W, Wang C

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2006 | J Am Chem Soc   IF 14.7
Time-dependent photoluminescence blue shift of the quantum dots in living cells: Effect of oxidation by singlet oxygen
Zhang Y, He J, Wang P, Chen J, Lu Z, Lu D, Guo J, Wang C, Yang W

Abstract: