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Zhe ZHAO




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Ph.D. student in Neuroscience at the University of Bordeaux (Oct. 2015 -- Dec. 2019)

Technician in Imaging Facility and Luo Minmin lab at National Institute of Biological Sciences, Beijing, China (Dec. 2011 --Oct. 2015)

Undergraduate in Biological Engineering at Agricultural University of Hebei, China (Sep. 2007-- Jun. 2011)


Expertise: CB1, habenula, fear, anxiety, appetite, neural circuit



The Role of Cannabinoid Receptor type 1 (CB1) in habenular circuits: Habenular nucleus expresses CB1 intensively, and CB1 mRNA especially locates in median hebenular nucleus (MHb). Lots of studies reveal that lateral habenular nucleus (LHb) mediates negative emotions, but we know little about MHb. CB1 is a good entry point to decipher the functions of MHb. We apply stereotaxic injection technology to deliver AAV to MHb with CB1-FLOX mice, AAV can express Cre recombinase, and get the mice of specific CB1 deletion in the MHb. We are studying all kinds of behaviors with the mice, try to discover the role of CB1 in MHb.



2 publication(s) depuis Novembre 2017:


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Les IF indiqués ont été collectés par le Web of Sciences en


18/08/2020 | Cell Rep   IF 8.1
Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory.
Oliveira da Cruz JF, Busquets-Garcia A, Zhao Z, Varilh M, Lavanco G, Bellocchio L, Robin L, Cannich A, Julio-Kalajzic F, Leste-Lasserre T, Maitre M, Drago F, Marsicano G, Soria-Gomez E

Abstract:
A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically affects memory processes is not well understood. We find that a small subclass of type 1 cannabinoid receptor (CB1R)-expressing hippocampal interneurons determines episodic-like memory consolidation by linking dopamine D1 receptor (D1R) signaling to GABAergic transmission. Mice lacking CB1Rs in D1-positive cells (D1-CB1-KO) display impairment in long-term, but not short-term, novel object recognition memory (NOR). Re-expression of CB1Rs in hippocampal D1R-positive cells rescues this NOR deficit. Learning induces an enhancement of in vivo hippocampal long-term potentiation (LTP), which is absent in mutant mice. CB1R-mediated NOR and the associated LTP facilitation involve local control of GABAergic inhibition in a D1-dependent manner. This study reveals that hippocampal CB1R-/D1R-expressing interneurons control NOR memory, identifying a mechanism linking the diversity of hippocampal interneurons to specific behavioral outcomes.




11/2017 | Nat Neurosci   IF 20.1
Synapse-specific astrocyte gating of amygdala-related behavior.
Martin-Fernandez M, Jamison S, Robin LM, Zhao Z, Martin ED, Aguilar J, Benneyworth MA, Marsicano G, Araque A

Abstract:
The amygdala plays key roles in fear and anxiety. Studies of the amygdala have largely focused on neuronal function and connectivity. Astrocytes functionally interact with neurons, but their role in the amygdala remains largely unknown. We show that astrocytes in the medial subdivision of the central amygdala (CeM) determine the synaptic and behavioral outputs of amygdala circuits. To investigate the role of astrocytes in amygdala-related behavior and identify the underlying synaptic mechanisms, we used exogenous or endogenous signaling to selectively activate CeM astrocytes. Astrocytes depressed excitatory synapses from basolateral amygdala via A1 adenosine receptor activation and enhanced inhibitory synapses from the lateral subdivision of the central amygdala via A2A receptor activation. Furthermore, astrocytic activation decreased the firing rate of CeM neurons and reduced fear expression in a fear-conditioning paradigm. Therefore, we conclude that astrocyte activity determines fear responses by selectively regulating specific synapses, which indicates that animal behavior results from the coordinated activity of neurons and astrocytes.