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Philippe CIOFI




Principal Investigator

Phone : 33(0)5 57 57 37 38 / 33(0)5 57 57 36 00
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Cursus:
1984-87: PhD Univ. Lille (France), Neuroanatomy - Neuroendocrinology
1987-90: Post-Doc, Univ. Calif. Irvine, Neuroanatomy - Neuroendocrinology
1991- :Inserm Investigator, Neuroanatomy - Neuroendocrinology






72 publication(s) since Décembre 1985:


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Abstract:
The distributions of perikarya exhibiting human somatocrinin (hGHRF) and neuropeptide Y (NPY) like immunoreactivities (IR) were compared in the arcuate nucleus of colchicine-treated rats. The majority of hGHRF perikarya was found to exhibit simultaneously NPY IR, while virtually no NPY IR was detected in the external layer of the median eminence. It is suggested that the majority of the hGHRF neurons of the rat arcuate nucleus constitutes a tubero-extra-infundibularly projecting system.




Abstract:
In the brains of colchicine-treated guinea pigs, antibodies directed against the C-terminal sequence of cholecystokinin octapeptide (CCK-8) and cross-reacting with gastrin, visualized a dense population of cell bodies in the arcuate nucleus, periportal nerve endings in the external layer of the median eminence and a few fibers in the neurohypophysis. In the adenohypophysis, at least the major part of corticomelanotrophs were labelled. Immunostainings are compared to those reported in the rat.