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Andreas FRICK

Principal Investigator

Phone : 33(0)5 57 57 37 04
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« Dr. rer nat » (PhD): summa cum laude. Institut Max-Planck pour Psychiatrie, Université Technique de Munich, Munich, Allemagne. Superviseur Pr. H. U. Dodt et Pr. H. Zieglgaensberger
Chercheur postdoctorant, boursier d'excellence Feodor Lynen (Alexander von Humboldt foundation). Baylor College of Medicine, Division de Neuroscience, Houston, Texas, Etats-Unis. Superviseur : Pr Daniel Johnston
Chargé de Recherche. Institut Max-Planck pour la Recherche Médicale, Département de Biologie Cellulaire, Heidelberg, Allemagne. Directeur : Pr. Bert Sakmann
Chargé de recherche INSERM «AVENIR », Neurocentre Magendie (2008-2010)
Chercheur INSERM statutaire CR1, Neurocentre Magendie (depuis 2009)

34 publication(s) since Novembre 1998:

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The indicated IF have been collected by the Web of Sciences in

15/04/2003 | J Neurosci   IF 6.1
Normalization of Ca2+ signals by small oblique dendrites of CA1 pyramidal neurons.
Frick A, Magee J, Koester HJ, Migliore M, Johnston D

Oblique dendrites of CA1 pyramidal neurons predominate in stratum radiatum and receive approximately 80% of the synaptic input from Schaffer collaterals. Despite this fact, most of our understanding of dendritic signal processing in these neurons comes from studies of the main apical dendrite. Using a combination of Ca2+ imaging and whole-cell recording techniques in rat hippocampal slices, we found that the properties of the oblique dendrites differ markedly from those of the main dendrites. These different properties tend to equalize the Ca2+ rise from single action potentials as they backpropagate into the oblique dendrites from the main trunk. Evidence suggests that this normalization of Ca2+ signals results from a higher density of a transient, A-type K+ current [I(K(A))] in the oblique versus the main dendrites. The higher density of I(K(A)) may have important implications for our understanding of synaptic integration and plasticity in these structures.

09/2001 | J Neurophysiol   IF 2.6
Glutamate receptors form hot spots on apical dendrites of neocortical pyramidal neurons.
Frick A, Zieglgansberger W, Dodt HU

Apical dendrites of layer V cortical pyramidal neurons are a major target for glutamatergic synaptic inputs from cortical and subcortical brain regions. Because innervation from these regions is somewhat laminar along the dendrites, knowing the distribution of glutamate receptors on the apical dendrites is of prime importance for understanding the function of neural circuits in the neocortex. To examine this issue, we used infrared-guided laser stimulation combined with whole cell recordings to quantify the spatial distribution of glutamate receptors along the apical dendrites of layer V pyramidal neurons. Focally applied (<10 microm) flash photolysis of caged glutamate on the soma and along the apical dendrite revealed a highly nonuniform distribution of glutamate responsivity. Up to four membrane areas (extent 22 microm) of enhanced glutamate responsivity (hot spots) were detected on the dendrites with the amplitude and integral of glutamate-evoked responses at hot spots being three times larger than responses evoked at neighboring sites. We found no association of these physiological hot spots with dendritic branch points. It appeared that the larger responses evoked at hot spots resulted from an increase in activation of both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptors and not a recruitment of voltage-activated sodium or calcium conductances. Stimulation of hot spots did, however, facilitate the triggering of both Na+ spikes and Ca(2+) spikes, suggesting that hot spots may serve as dendritic initiation zones for regenerative spikes.

01/10/1999 | Science   IF 41
Precisely localized LTD in the neocortex revealed by infrared-guided laser stimulation.
Dodt H, Eder M, Frick A, Zieglgansberger W

In a direct approach to elucidate the origin of long-term depression (LTD), glutamate was applied onto dendrites of neurons in rat neocortical slices. An infrared-guided laser stimulation was used to release glutamate from caged glutamate in the focal spot of an ultraviolet laser. A burst of light flashes caused an LTD-like depression of glutamate receptor responses, which was highly confined to the region of 'tetanic' stimulation (<10 micrometers). A similar depression of glutamate receptor responses was observed during LTD of synaptic transmission. A spatially highly specific postsynaptic mechanism can account for the LTD induced by glutamate release.

11/1998 | Eur J Neurosci   IF 2.8
NMDA and AMPA receptors on neocortical neurons are differentially distributed.
Dodt HU, Frick A, Kampe K, Zieglgansberger W

The distribution of glutamate receptor subtypes on the surface of neurons is highly relevant for synaptic activation and signal processing in the neocortex. As a novel approach we have used infra-red videomicroscopy in combination with photostimulation or microiontophoresis in brain slices of rat neocortex to map the distribution of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors on pyramidal neurons of layer V. Both modes of application revealed a spatially distinct distribution of glutamate receptor subtypes: the soma and the proximal dendrite of neurons are highly sensitive to NMDA, whereas the more distal parts of the dendrite are more sensitive to AMPA. An implication is that NMDA receptors near the soma might regulate the amplification of synaptic signals resulting from AMPA receptor activation on remote dendritic sites.