Neurocentre Magendie

Les actualités de l'équipe



Afficher par type


Séminaire
18/07/2016 11h30
Terry Hébert

Meeting room: Neurocentre Magendie Seminar room

from Department of Pharmacology and Therapeutics (McGill University, Canada) will give a presentation entitled 'Nuclear G proteins in cardiac transcriptional regulation'

Invitant : Stéphane Oliet, Team leader: Glia-neuron relations (Neurocentre Magendie)



Info Générale
26/06/2016
Trophées de la Prévention

Le Neurocentre Magendie remporte le 1er trophée de la prévention ! Les Assistants de Prévention (les célèbres AP) ont soumis un dossier dans lequel ils décrivaient l'outil dématérialisé vous permettant de remplir votre Fiche Individuelle d'Exposition. Puis, le jeudi 23 juin, ce projet a été présenté par Aurélie Amado (AP de l'équipe de Stéphane Oliet) devant plus de 100 Assistants de Prévention.
Verdict sans appel puisque Magendie remporte haut la main le trophée du coup de coeur des AP !

« Les Trophées Prévention Santé et Sécurité" étaient organisés pour la première fois par la Délégation Aquitaine du CNRS, l’Université de Bordeaux, l’INRA Bordeaux-Aquitaine, Bordeaux INP, l’Inserm Délégation Aquitaine Poitou-Charentes, l’Université de Pau et des Pays de l’Adour et Sciences Po Bordeaux afin de promouvoir la prévention, la santé et la sécurité dans les unités de recherche.





In mammals, the circulating neurohormone oxytocin (OT) has a role during parturition and lactation.

(Israel et al, Nat Commun, 2014 ; Israel et al, Front Neurosci, 2016). This is illustrated in the last part of the video. Keywords Hypothalamus, Neuroendocrine, Pulsatility, Oxytocin, Magnocellular, Neurones, Burst, Action potentials.

Neonatal testosterone suppresses a neuroendocrine pulse generator required for reproduction.
Israel JM, Cabelguen JM, Le Masson G, Oliet SH, Ciofi P.
Nat Commun. 2014;5:3285. doi: 10.1038/ncomms4285.

Electrophysiology of Hypothalamic Magnocellular Neurons In vitro: A Rhythmic Drive in Organotypic Cultures and Acute Slices.
Israel JM, Oliet SH, Ciofi P. Front Neurosci. 2016 Mar 31;10:109. doi: 10.3389/fnins.2016.00109. eCollection 2016.






Hottopic
13/04/2016 12h00
Silvia CIAPPELLONI from Oliet's lab will give a presentation entitled “Trafficking of water channel AQP4 at glutamatergic synapses”.

Hottopic
18/11/2015 12h00
Mark Sherwood from Oliet's lab will give a presentation entitled "Astrocytic IP3 receptor type-1 regulates hippocampal LTP"

Séminaire
18/09/2015 11h30
Luc Buée

Meeting room: Neurocentre Magendie Seminar room

from DR Inserm 837, Centre de recherche Jean-Pierre Aubert, Faculté de médecine Henri Warembourg's lab will give a presentation entitled "Microtubule-associated tau proteins: from the good guy to the serial killer"

Invitant : Stéphane Oliet, Neurocentre Magendie / Team leader: Glia-neuron relations



Séminaire
04/09/2015 11h30
Arnaud Ruiz

Meeting room: CGFB Univ Bordeaux Carreire

Bi-directional modulation of synaptic integration in small diameter neocortical dendrites

Arnaud Ruiz From University College of London, Senior Lecturer in Cellular Neuroscience and Pharmacology

Invitant : Stéphane Oliet, DR Inserm / Neurocentre Magendie



Soutenance
25/06/2015 14h00
Lucie BLASZCZYK from Oliet's lab will defend her thesis entitled 'Study of thalamic astrocytic and microglial cells in a neuropathic pain model of rat.'

from Oliet's lab will defend her thesis entitled 'Study of thalamic astrocytic and microglial cells in a neuropathic pain model of rat.'

Jury members:
President: Marc Landry, Pf
Rapporteur: Sophie Pezet, MC
Rapporteur: Lénaïc Monconduit, MC
Examiner: Luis Garcia-Larrea, DR1
Thesis supervisor: Valérie Fénelon, Pf

Financing: Financement ministériel allocataire de recherche & Cofi ANR
Date de la soutenance: 25/06/2015 - 14h00
Lieu: CGFB (Centre de Genomique Fonctionnel) Seminar room

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/formation-doctorale/theses-2015/lucie-blaszczyk.html



Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission. Murphy-Royal C, Dupuis JP, Varela JA, Panatier A, Pinson B, Baufreton J, Groc L, Oliet SH. Nat Neurosci. 2015 Feb;18(2):219-26. doi: 10.1038/nn.3901. Epub 2015 Jan 12.



Abstract:
Control of the glutamate time course in the synapse is crucial for excitatory transmission. This process is mainly ensured by astrocytic transporters, high expression of which is essential to compensate for their slow transport cycle. Although molecular mechanisms regulating transporter intracellular trafficking have been identified, the relationship between surface transporter dynamics and synaptic function remains unexplored. We found that GLT-1 transporters were highly mobile on rat astrocytes. Surface diffusion of GLT-1 was sensitive to neuronal and glial activities and was strongly reduced in the vicinity of glutamatergic synapses, favoring transporter retention. Notably, glutamate uncaging at synaptic sites increased GLT-1 diffusion, displacing transporters away from this compartment. Functionally, impairing GLT-1 membrane diffusion through cross-linking in vitro and in vivo slowed the kinetics of excitatory postsynaptic currents, indicative of a prolonged time course of synaptic glutamate. These data provide, to the best of our knowledge, the first evidence for a physiological role of GLT-1 surface diffusion in shaping synaptic transmission.





Stephane Oliet at the Neurocentre Magendie reviews extrasynaptic NMDA receptors organization structure and function in Philosophical Transactions of the Royal Society, another ‘bordelaise’ publication in the oldest scientific journal in the English-speaking world!

Authored by Dr. Thomas Papouin from Tufts University (Boston) and Dr. Stephane Oliet at the Neurocentre Magendie, the review discusses the most recent findings on extrasynaptic NMDA receptors and questions classical views regarding their structure, organization and function.