Neurocentre Magendie

Les actualités de l'équipe



Afficher par type



Benjamin Robert reçoit un financement LABEX BRAIN 2016 « PhD extension Grant »





Nathalie Sans (Equipe Montcouquiol-Sans), Lauréate ANR 2016 avec le projet NanoPlanSYN

Projet NanoPlanSYN : Rôle de la voie de signalisation de la polarité planaire dans l’organisation dynamique de la synapse et l’intégration de l’information synaptique: des mécanismes fondamentaux aux conséquences pathophysiologiques





Mireille Montcouquiol reçoit un financement LABEX BRAIN 2016 Recherche pour le projet PCP COMPASS en collaboration avec Vincent Studer





Development and plasticity of the nervous system critically depends on the neuronal cytoskeleton. The organization and dynamic remodeling of the neuronal cytoskeleton contributes to all morphological and functional changes in neurons, including migration, polarization, axon outgrowth, dendrite development and synapse formation. The neuronal cytoskeleton provides tracks for intracellular transport, sets up local cues to position organelles, acts as a signaling device and generates cellular forces that are fundamental to all aspects of neuronal function. Cytoskeleton remodeling and axonal trafficking have emerged as one of the most exciting and rapidly moving fields in cellular neurobiology. This field is experiencing a revolution in molecular, genetic and imaging technologies for analysing the dynamics of these processes during neuronal development and plasticity. The study of the molecular mechanisms of cytoskeletal dynamics and neuronal trafficking are also key to understanding what goes wrong in many neurodevelopmental and neurodegenerative diseases.

With participation of Mireille Montcouquiol




Hottopic
27/04/2016 12h00
Steve DOS SANTOS CARVALHO from Montcouquiol-Sans's lab will give a presentation entitled "Vangl2 affects neuronal outgrowth through regulation of actin dynamics" Seminar at the PGF room!


La Fondation pour la Recherche Médicale reconduit son appel d’offres destiné à apporter un soutien fort et durable à des équipes proposant un programme de recherche innovant en biologie avec des applications potentielles en santé.





Abstract :

La recherche dans le domaine de la synapse est un "axe" fort de Bordeaux Neurocampus. Ce domaine de recherche, avec des approches de biologie moléculaire et cellulaire, d'imagerie et d'électrophysiologie, constitue le thème central d'étude d'une douzaine d'équipes de la FBN.
A cet égard, il faut rappeler que cette journée est ouverte à tous. Elle donne d'autre part la possibilité de faire le point sur les recherches bordelaises et de les replacer dans un cadre plus général par la participation de chercheurs extérieurs à l'Institut.

Invitant : Une organisation Nathalie Sans (Equipe Montcouquiol-Sans) & Maurice Garret

Programme:

9.00-9.45 Antoine Triller (Institut de Biologie de l’Ecole Normale Supérieure) Synapse stability and plasticity beyond super-resolution toward chemistry in cellulo.

9.45-10.15 Nicolas Mallet (IMN) The GABAergic synapse of Globus pallidus neurons: Dogma, Myth and Truth...

10.15-11.00 Tomas Oertner (Center for Molecular Neurobiology, Hamburg) Analyzing vesicular release at individual Schaffer collateral synapses.

11.00-11.20 Coffee break

11.20-11.40 Cyril Déjean (NCM) Prefrontal neuronal assemblies temporally control fear behavior.

11.40-12.10 Francoise Coussen (INNS) AMPAR intracellular transport and synaptic physiology.

12.10-12.55 Marina Mikhaylova (Center for Molecular Neurobiology, Hamburg) Calcium dependent regulation of actin dynamics in spines.

12.55-14.00 lunch

14.00-14.45 Balázs Rosza (Institute of Experimental Medecine, Budapest) Fast 3D imaging of spine, dendritic, and neuronal assemblies in behaving animals.

14:45-15.05 Ingrid Chamma (INNS) Monomeric streptavidin for super-resolution imaging of synaptic adhesion proteins.

15.05-15.25 Valentin Langlais (NCM) EphB3 receptor controls NMDAR functions at the tripartite synapse.

15.25-15:45 Fabien Alcaraz (INCIA) Thalamocortical networks of goal-directed behaviors.

15.45-16.15 Frédéric Gambino (INNS) Synaptic and dendritic coding of associative learning in behaving mice.

16.15-17.00 Graham Knott (Ecole Polytechnique Fédérale de Lausanne) Dendritic spine plasticity.




Hottopic
28/10/2015 12h00
Jerome EZAN from Montcouquiol-Sans's lab will give a presentation entitled "Genetic dissection of Scrib1 functions during forebrain development, impact on animal behaviour"


Bordeaux School of Neurosciences:
The microscopic study of synapses relies on a large array of advanced techniques. Successful research in the field requires technological innovation and the interweaving of a variety of approaches at the molecular, cellular, and functional levels. The advanced course will allow the students to integrate the basic techniques in molecular and cellular neurobiology with advanced state-of-the art molecular, imaging and functional methodologies, through direct hands-on experiments. Taught techniques will range from proteomics and transcriptomics, in vitro and in vivo gene transfer (including viral technology), cellular imaging of proteins by confocal microscopy and by super-resolution microscopy (STED and PALM/STORM), single-particle tracking methodologies, live imaging of protein interactions (FRET, FLIM) at synapses, electron microscopy. The advanced course will also include electrophysiological and optophysiological approaches to address the functional properties of synaptic molecules such as recombinant receptors and to assess the role of various proteins in synaptic function and plasticity.

On-site chair: Nathalie Sans, PhD, University of Bordeaux, FR (Equipe Montcouquiol-Sans)




Séminaire
25/09/2015 11h30
Prof. Juan Burrone

Meeting room: CGFB (Centre de Genomique Fonctionnel) Seminar room

from MRC Centre for Developmental Neurobiology, King's College London's lab will give a presentation entitled 'Neurons, synapses and the axon initial segment: location matters'

Invitant : Mireille Montcouquiol & Laurent Groc