Les actualités de l'équipe



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Hottopic
31/03/2021 10h45
Steven CONDAMINE from Montcouquiol-Sans' lab will give a presentation entitled "Deafness in MPDZ mutant: epithelial and/or synaptic origin ?"

Hottopic
25/11/2020 10h00
Ana DORREGO-RIVAS from Montcouquiol-Sans's lab will give a presentation entitled 'A new role for planar cell polarity signaling in neuronal polarity and axonal function'


Hottopic
26/02/2020 10h30
Jennifer STANIC from Montcouquiol-Sans's lab will give a presentation entitled 'The PSD-95 spatial nano-architecture is altered by Scribble-dependent signaling'

Revue de presse
14/01/2020
Carvalho et al in Elife - January 2020

Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth. Steve Dos-Santos Carvalho, Maite M Moreau, Yeri Esther Hien, Michael Garcia, Nathalie Aubailly, Deborah J Henderson, Vincent Studer, Nathalie Sans, Olivier Thoumine, Mireille Montcouquiol. eLife. 2020-01-07. 9.

Here, we show that an early deletion of vangl2 in neuronal progenitors of the forebrain leads to the spatially restricted deficit of only two commissural axon bundles. Mechanistically, we show that the absence of vangl2 leads to an increase in axonal outgrowth due to a reduced turnover of N-cadherin, and a better coupling between the adhesion molecule and the dynamic actin flow in the growth cone. Our results support a model in which Vangl2 acts as a regulator of membrane protein endocytosis and junctional remodeling during growth cone exploration, thereby modulating its outgrowth.

This study benefited from a close collaboration between the groups of Montcouquiol/Sans (Neurocentre Magendie), O. Thoumine (IINS), and V. Studer (IINS), funded by the Labex BRAIN (project PCP Compass).

https://www.bordeaux-neurocampus.fr/steve-dos-santos-carvalho-et-al-in-elife/
https://elifesciences.org/articles/51822




Hottopic
18/12/2019 10h00
Noémie DEPRET from Montcouquiol-Sans's lab will give a presentation entitled "Planar cell polarity protein Vangl2 : a key player in the morphofonctional development of hippocampal network"

Info générale
18/11/2019
Opération DECLICS 2019

L’équipe Montcouquiol - Sans participe ce matin à l’opération DECLICS 2019 au Lycée Sud-Médoc au Taillan Medoc. Rencontres et échanges entre chercheurs, enseignants et lycéens autour des métiers de la Recherche.




Info générale
25/09/2019
Good luck Steph!

Congratulations to our colleague Dr Stephanie Mauriac (Equipe Montcouquiol/Sans), who will join the Holt/Geleoc' lab at the Boston Children's Hospital, Harvard Medical School https://oto.hms.harvard.edu/people/jeffrey-holt

Stephanie will be working on the cochlear system to restore cellular and systems level function in models of human deafness in the US. Good luck Steph!






Info générale
12/09/2019
Bravo Sybille ! (Equipe Polarité Planaire et Plasticité)

Félicitations à notre étudiante de M2 , Sybille Marchese (Equipe Montcouquiol/Sans), qui décroche un contrat doctoral à l'Université de Saint Andrews en Ecosse dans la jeune équipe du Dr Juan Alberto Varela, lauréat du prestigieux programme ERC (https://risweb.st-andrews.ac.uk/portal/en/persons/juan-alberto-varela(bf1154ef-1d43-41e1-b529-7dd9660cea91).html).

Sybille utilisera des techniques d'imagerie à super résolution pour élucider le trafic extracellulaire des agrégats de protéines (bêta-amyloïde et alpha-synucléine) dans le cerveau et leur rôle direct dans la neurodégénération précoce.

Bonne continuation Sybille !






Mireille Montcouquiol est lauréate d'un financement de la très sélective Fondation pour l'Audition créée par Françoise Bettencourt Meyers, Jean-Pierre Meyers et la Fondation Bettencourt Schueller. Bravo !!