Neurocentre Magendie

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24/06/2020 10h00
Pierre Louis Raux from Revest's lab will give a presentation entitled "Physiological regulation of the cannabinoid type-1 receptor by the neurosteroid pregnenolone: study in mutant CB1-E134G mice"

The competition of the SVS doctoral school of the University of Bordeaux has given its verdict: the Neurocentre gleaned 4 of the 16 doctoral contracts. Congratulations to Mohamed-Lyès KACI (Eq. Abrous, Thesis Director Muriel Koehl) who ranks 5th, Emma MESGUICH (Eq. Marsicano, Thesis Director France Chaouloff) who ranks 7th, Pierre-Louis RAUX (Eq. Revest, Thesis Director Monique Vallée) who ranks 11th and Yifan WU (Eq. Beyeler) who ranks 17th. They will join the centre's teams from next school year.

30/01/2019 10h30
Nadia DI FRANCO from Revest's lab will give a presentation entitled "CB1 in Down Syndrome: a new potential target"

28/03/2018 10h30
Giovanni TOMASELLI from Revest's lab will give a presentation entitled "Role of PREG and its derivates on the regulation of CB1 signalling in mediating THC-induced behavioural effects"

General informations
Deroche-Gamonet, Revest et al. in Molecular Psychiatry:

First causal evidence of a role of neurogenesis in a drug-related behavior.

The hippocampus is the main locus for adult dentate gyrus (DG) neurogenesis. A number of studies have shown that aberrant DG neurogenesis correlates with many neuropsychiatric disorders, including drug addiction. Although clear causal relationships have been established between DG neurogenesis and memory dysfunction or mood-related disorders, evidence of the causal role of DG neurogenesis in drug-seeking behaviors has not been established. Here we assessed the role of new DG neurons in cocaine self-administration using an inducible transgenic approach that selectively depletes adult DG neurogenesis. Our results show that transgenic mice with decreased adult DG neurogenesis exhibit increased motivation to self-administer cocaine and a higher seeking response to cocaine-related cues. These results identify adult hippocampal neurogenesis as a key factor in vulnerability to cocaine addiction.

Deroche-Gamonet V*, Revest JM*, Fiancette JF, Balado E, Koehl M, Grosjean N, Abrous DN*, Piazza PV*. Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior. Mol Psychiatry. 2018 Mar 5. doi: 10.1038/s41380-018-0038-0.

Pregnenolone can protect the brain from cannabis intoxication.
Vallée M, Vitiello S, Bellocchio L, Hébert-Chatelain E, Monlezun S, Martin-Garcia E, Kasanetz F, Baillie GL, Panin F, Cathala A, Roullot-Lacarrière V, Fabre S, Hurst DP, Lynch DL, Shore DM, Deroche-Gamonet V, Spampinato U, Revest JM, Maldonado R, Reggio PH, Ross RA, Marsicano G, Piazza PV.
Science. 2014 Jan 3;343(6166):94-8. doi: 10.1126/science.1243985

Jean Michel Revest and P-V Piazza's team

BDNF-TrkB signaling through Erk1/2MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids. - See more at:

Kasanetz F, Lafourcade M, Deroche-Gamonet V, Revest JM, Berson N, Balado E, Fiancette JF, Renault P, Piazza PV, Manzoni OJ.
Prefrontal synaptic markers of cocaine addiction-like behavior in rats.
Mol Psychiatry. 2012 May 15. 2012

Yves Deris had interviewed Marlène Maître and Jean-Michel Revest to talk about their publication in the Journal of Neuroscience Methods.