Scientists from the Laboratory of Neurodegenerative Diseases (CNRS/CEA/University of Paris-Saclay) and the Neurocentre Magendie (Inserm/University of Bordeaux) have just highlighted the decisive role played by a metabolic pathway in memory impairment in Alzheimer's disease. Their work, to be published on 3 March 2020 in Cell Metabolism, also shows that a particular amino acid intake, in the form of a dietary supplement, restores the spatial memory affected early in mice models of the disease. This is a promising avenue for alleviating Alzheimer's-related memory loss.
Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease. Juliette Le Douce, Marianne Maugard, Julien Veran, Marco Matos, Pierrick Jégo, Pierre-Antoine Vigneron, Emilie Faivre, Xavier Toussay,Michel Vandenberghe, Yaël Balbastre, Juliette Piquet, Elvire Guiot, Nguyet Thuy Tran, Myriam Taverna, Stéphane Marinesco, Ayumi Koyanagi, Shigeki Furuya, Mylène Gaudin-Guerif, Sébastien Goutal, Aurélie Ghettas, Alain Pruvost, Alexis-Pierre Bemelmans, Marie-Claude Gaillard, Karine Cambon, Lev Stimmer, Véronique Sazdovitch, Charles Duyckaerts, Graham Knott, Anne-Sophie Hérard, Thierry Delzescaux, Philippe Hantraye, Emmanuel Brouillet, Bruno Cauli, Stéphane H.R. Oliet, Aude Panatier et Gilles Bonvento. Cell Metabolism, le 3 mars 2020. DOI : 10.1016/j.cmet.2020.02.004
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30063-2