Neurocentre Magendie

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25/11/2020 10h00
Ana DORREGO-RIVAS from Montcouquiol-Sans's lab will give a presentation entitled 'TBA'
2020-11-25 10:00:00 2020-11-25 10:45:00 Europe/Paris Ana DORREGO-RIVAS 0

26/02/2020 10h30
Jennifer STANIC from Montcouquiol-Sans's lab will give a presentation entitled 'The PSD-95 spatial nano-architecture is altered by Scribble-dependent signaling'

Press review
Carvalho et al in Elife - January 2020

Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth. Steve Dos-Santos Carvalho, Maite M Moreau, Yeri Esther Hien, Michael Garcia, Nathalie Aubailly, Deborah J Henderson, Vincent Studer, Nathalie Sans, Olivier Thoumine, Mireille Montcouquiol. eLife. 2020-01-07. 9.

Here, we show that an early deletion of vangl2 in neuronal progenitors of the forebrain leads to the spatially restricted deficit of only two commissural axon bundles. Mechanistically, we show that the absence of vangl2 leads to an increase in axonal outgrowth due to a reduced turnover of N-cadherin, and a better coupling between the adhesion molecule and the dynamic actin flow in the growth cone. Our results support a model in which Vangl2 acts as a regulator of membrane protein endocytosis and junctional remodeling during growth cone exploration, thereby modulating its outgrowth.

This study benefited from a close collaboration between the groups of Montcouquiol/Sans (Neurocentre Magendie), O. Thoumine (IINS), and V. Studer (IINS), funded by the Labex BRAIN (project PCP Compass).

18/12/2019 10h00
Noémie DEPRET from Montcouquiol-Sans's lab will give a presentation entitled "Planar cell polarity protein Vangl2 : a key player in the morphofonctional development of hippocampal network"

General informations
Bravo Sybille! (Planar Polarity and Plasticity Team )

Congratulations to our M2 student, Sybille Marchese (Team Montcouquiol/Sans), who has won a doctoral contract at the University of Saint Andrews in Scotland with the young team of Dr Juan Alberto Varela, winner of the prestigious ERC programme (

Sybille will use super-resolution imaging techniques to elucidate the extracellular trafficking of protein aggregates (beta-amyloid and alpha-synuclein) in the brain and their direct role in early neurodegeneration.

Good luck Sybille!

Mireille Montcouquiol is the laureate of funding for the highly selective Fondation pour l'Audition created by Franoise Bettencourt Meyers, Jean-Pierre Meyers and the Bettencourt Schueller Foundation. Congrats !!

PhD/HDR defense
17/06/2019 13h30
Stéphanie MAURIAC from Montcouquiol-Sans's lab will give a presentation entitled ...

from Montcouquiol-Sans's lab will give a presentation entitled ...
Date de la soutenance: 17/06/2019 - 13h30
Lieu: Neurocentre Magendie Seminar room