Neurocentre Magendie

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Seminars
27/05/2016 11h30
Mike Murphy

Meeting room: Neurocentre Magendie Seminar room

from University of Cambridge will give a presentation entitled 'Mitochondrial superoxide production in ischaemia-reperfusion injury'

Invitant : Giovanni Marsicano, Giovanni Marsicano´s Lab / Neurocentre Magendie

Abstract :

Mitochondrial ROS have long been known to contribute to ischaemia-reperfusion (IR) injury in heart attack and stroke, but methods to stop this ROS production were limited. Over the past few years we have developed a mitochondria-targeted S-nitrosating agent, called MitoSNO, that we showed was effective in preventing ROS formation in IR injury with therapeutic implications. In addition, the protection by this compound suggested that ROS production in IR injury was mainly coming from complex I.
This led us to investigate the mechanism of the ROS production and using a metabolomic approach we found that the ROS production in IR injury came from the accumulation of citric acid cycle substrates during ischaemia that then drove mitochondrial ROS production by reverse electron transport at complex I during reperfusion.
This surprising mechanism led up to develop further new therapeutic approaches.



Seminars
13/05/2016 11h30
Alberto Bacci

Meeting room: CGFB Seminar room

from ICM Paris (team leader / Equipe Inhibition synaptique et auto-modulation des microcircuits du cortex cérébral) will give a presentation entitled 'Long-term Plasticity of Neocortical GABAergic Synapses'

Invitant : Giovanni Marsicano, Neurocentre Magendie




Seminars
19/02/2016 11h30
Etienne Hirsch

Meeting room: CGFB Seminar room

from ITMO neurosciences's lab will give a presentation entitled 'Unmet therapeutic needs in Parkinson's disease'

Invitant : Gionanni Marsicano, Neurocentre Magendie




Hottopic
25/11/2015 12h00
Carolina Muguruza from Marsicano's lab will give a presentation entitled "Are you motivated to run? The role of Cannabinoid Type 1 (CB1) Receptors."


Hottopic
03/06/2015 12h00
Roman Serrat from Marsicano's lab will give a presentation entitled "Modulation of synaptic calcium signaling by mitochondrial type 1 cannabinoid receptor"

PhD/HDR defense
13/05/2015 14h00
Tifany DESPREZ from Marsicano's lab will defend her thesis entitled 'Role(s) of mitochondrial type-1 cannabinoid receptors in the brain'

from Marsicano's lab will defend her thesis entitled 'Role(s) of mitochondrial type-1 cannabinoid receptors in the brain'
Date de la soutenance: 13/05/2015 - 14h00
Lieu: CGFB Seminar room

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/formation-doctorale/theses-2015/tifany-desprez.html


Seminars
20/02/2015 11h30
Mario Van der Stellt

Meeting room: Neurocentre Magendie Seminar room

, Principal Investigator Medicinal Chemistry Leiden University, Faculty of Science, will give a presentation entitled 'A Chemical Biology Approach to Control Endocannabinoid Biosynthesis'.

Invitant : Giovanni Marsicano