Neurocentre Magendie
Join us

Team News



Sort by


Hottopic
30/11/2011 09h00
Maria SZLAPCZYNSKA Maria SZLAPCZYNSKA from Frick's lab will present the hottopic. Project: Role of Intrinsic Excitability in Learning and Memory in the Prefrontal Cortex Description: The knowledge of how new information is acquired and where it is stored in the brain is critical for our understanding of the normal functioning and the neuropathology of neural circuits underlying memory. It is a generally held belief that long-term memories in the cortex are stored in the strength of synaptic connections between neurons. However, recent studies show that excitability is a plastic property of neurons that can be induced by activity, experience, or disease. We hypothesize that changes in the excitability of prefrontal cortex neurons contribute to learning and the formation of conditioned-fear memory. We investigate this hypothesis by using contextual fear conditioning as well as electrophysiological recordings in pyramidal neurons of the medial prefrontal cortex.

Hottopic
29/04/2011 12h00
Matthias HABERL Matthias HABERL from Frick's lab will present his project entitled 'Neocortical circuitry in a model of mental retardation' The function of cortical circuits emerges from its anatomical wiring diagram and wiring defects are probably involved in a manyfold of neurological diseases. Still the detailed organization of the mammalian neocortex remains largely unknown and exceedingly difficult to investigate. Therefore cutting-edge tools that allow us to dissect the sub-circuits are inevitable. To study connectivity in the neocortex we are using viral tracing techniques, as lentivirus and rabies-based monosynaptic trans-synaptic tracing. We look at changes of connectivity in mental retardation, from fine scale microcircuits up to long ranging projections from the entire brain. We hope not just to learn more about importance of specific circuits in normal and diseased (Fragile X Syndrome) brain but also to understand more about the involvement of wiring defects in neurological diseases in general.

Hottopic
22/04/2011 12h00
Yu ZHANG Yu ZHANG from Frick's lab will present his project entitled 'Pathophysiology of information processing in neocortical dendrites in Fragile X Syndrome' Fragile X Syndrome (FXS) is the most common form of inherited mental retardation syndrome, and it is caused by a silencing mutation of the gene Fmr1 (encoding the protein FMRP). In humans, the consequences of this disorder include hypersensitivity to sensory stimuli, autistic behavior, seizures, and learning and memory deficits. Channelopathies have not been addressed as a prominent feature of FXS, although several ion channel subunits are amongst the genes whose mRNAs are regulated by FMRP. These channels strongly regulate the active properties of dendrites and therefore dendritic information processing. We will probe ion channel dysfunction and its consequences for dendritic function in layer 5B pyramidal neurons of the whisker-related barrel cortex.

Hottopic
28/05/2010 16h00
Mélanie GINGER Hottopics: Mélanie GINGER from Frick's lab will present her project entitled 'Somatosensory cortex defects in Fragile X Syndrome'




inserm
bdx
Bordeaux Neurocampus