Equipe Oliet - Relations glie-neurone

Glia-neuron interactions

Principal investigator: Stéphane Oliet, PhD.


Our group is investigating neuron-glia interactions with a particular interest for the tripartite synapse that considers astrocytes as active partners of chemical synapses.

The ability of astrocytes to ensure neurotransmitter uptake and to release gliotransmitters and their impact on synaptic transmission and synaptic plasticity has raised a lot of attention, identifying astroglial cells as possible targets to generate new and effective therapeutic strategies for brain diseases.

The general objective of our current research projects is to enhance our understanding of glial functions in healthy and diseased nervous system. We aim at characterize the impact of astrocytes on synaptic functions in physiological conditions as well as in the context of different pathologies like Alzheimer disease, multiple sclerosis, amyotrophic lateral sclerosis and addiction. To investigate glia-neurons interactions, we are using different physiological and pathological models in combination with the multidisciplinary approach available in our team like in vitro electrophysiology, morphological analysis, biochemical assays, state-of-the-art cell imaging and MRI.

More specifically, we are interested in deciphering the cellular mechanisms underlying gliotrasmission from detecting synaptic activity, identifying intracellular 2nd messenger pathways and defining independent domains of activity within individual astrocytes. We are also interested in analyzing fine anatomical morphological changes as well as monitoring membrane trafficking of key proteins. All these different glial-dependent process are investigated in regards of their impact onto synaptic transmission, synaptic plasticity, neuronal excitability, network activity and behaviour.



Team members



Stéphane OLIET
Team leader

Stephanie CHEVALLIER
Senior Teacher/Researcher

Delphine LAMARGUE HAMEL
Senior Teacher/Researcher

Aurélie RUET
Senior Teacher/Researcher

Thomas TOURDIAS
Senior Teacher/Researcher

Daniel VOISIN
Senior Teacher/Researcher

Bruno BROCHET
Principal Investigator

Philippe CIOFI
Principal Investigator

Vincent DOUSSET
Principal Investigator

Gwendal LEMASSON
Principal Investigator

Aude PANATIER
Principal Investigator

Aurélie AMADIO
ITA

Nadège DUBOURDIEU
ITA

Claire LEGER
ITA

Aymeric OLIVEIRA
ITA

Misa ARIZONO
Post Doc

Ismail KOUBIYR
Post Doc

Marco MATOS
Post Doc

Dorian ARNOUIL
PhD

Julien BOUREL
PhD