Equipe Abrous

Neurogenesis and pathophysiology, Group leader: Nora Abrous, PhD.


Research Objectives


The discovery that new neurons (neurogenesis) are generated in the adult mammalian brain, including humans, has generated a very strong interest in the scientific community. Indeed, adult neurogenesis takes place in the serrated gyrus of the hippocampal formation. This vast region, which allows the constitution of temporo-spatial memories and is involved in mood regulation, is affected by aging and exposure to stress. Our team is interested in the role of neurogenesis in different hippocampal functions (memory and mood) and in the physiopathology of the hippocampus that can be induced during development or during aging. We conduct longitudinal studies, from embryonic to senescent stages, taking into account individual differences to understand the role of these new neurons in hippocampal functions. We are also studying the effects of etiological factors such as prenatal stress that can induce pathological memories. In order to accomplish our projects we use multidisciplinary approaches ranging from cellular and molecular biology (viral production and development of transgenic models) to imaging and electrophysiological and behavioural studies.

 

 

Our research is divided into several projects: 

  • Implication of neurogenesis in hippocampal pathophysiology - Muriel Koehl
  • Role of adult hippocampal neurogenesis in memory stabilization (consolidation and reconsolidation) - Sophie Tronel
  • Role of Rnds proteins in the regulation of neurogenesis and hippocampal functions - Emilie Pacary
  • Role of adult hippocampal neurogenesis in mood - Guillaume Lucas

 

 

Team members



Nora ABROUS
Team leader
Michel LE-MOAL
Teacher-Researcher
Muriel KOEHL
Researcher
Guillaume LUCAS
Researcher
Emilie PACARY
Researcher
Sophie TRONEL
Researcher
Mylene BLANCHARD
ITA
Vanessa CHARRIER
ITA
Fanny FARRUGIA
ITA
Joelle HOANG-CHAUHONG
ITA (33%)
Thomas KERLOCH
ITA (50%)
Marie LODS
ITA (50%)