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Carvalho et al in Elife - January 2020

Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth. Steve Dos-Santos Carvalho, Maite M Moreau, Yeri Esther Hien, Michael Garcia, Nathalie Aubailly, Deborah J Henderson, Vincent Studer, Nathalie Sans, Olivier Thoumine, Mireille Montcouquiol. eLife. 2020-01-07. 9.

Here, we show that an early deletion of vangl2 in neuronal progenitors of the forebrain leads to the spatially restricted deficit of only two commissural axon bundles. Mechanistically, we show that the absence of vangl2 leads to an increase in axonal outgrowth due to a reduced turnover of N-cadherin, and a better coupling between the adhesion molecule and the dynamic actin flow in the growth cone. Our results support a model in which Vangl2 acts as a regulator of membrane protein endocytosis and junctional remodeling during growth cone exploration, thereby modulating its outgrowth.

This study benefited from a close collaboration between the groups of Montcouquiol/Sans (Neurocentre Magendie), O. Thoumine (IINS), and V. Studer (IINS), funded by the Labex BRAIN (project PCP Compass).

Job offers
Postdoc Position in sensory information processing and perception

The Cortical Plasticity group at the Neurocentre Magendie (Bordeaux, France) is seeking to recruit a postdoctoral researcher to join their group in 2020.

We are interested in the function of neocortical circuits and their pathophysiological modification in neurodevelopmental disorders. In particular, we study sensory information processing and perception. To address this, we will use in vivo calcium imaging (two-photon/miniscope) and electrophysiological approaches (multi-electrode/whole-cell) in behaving mice.
We are looking for a highly motivated and proactive candidate with experience in in vivo electrophysiology and/or calcium imaging and analysis of this data. The successful candidate is expected to make significant contributions to the direction and conceptualization of the project. The appointee must have a PhD or equivalent qualification in either neuroscience, life sciences, medicine, or physics. The candidate should also have a good level of proficiency in English.

The team is based at the Neurocentre Magendie, an INSERM research institute, and a member of the Bordeaux Neurocampus — a center of excellence for neuroscience research in France. The day-to-day language is English, but support would be provided for learning French if the candidate so wishes.

The project is funded for three years.

Interested applicants should send a cv, brief statement of research experience and interests, and names of 2-3 references to Dr. Andreas Frick:

On 3 December 2019, Andreas Frick received the Marcel Dassault Award for his work on the processing of sensory information in the ASD.

A post-doc position in electrophysiology, optogenetics and functional imaging is available in the group of Dr. Nathalie Sans (Neurocentre Magendie).

We are looking for highly motivated researchers to analyse and manipulate hippocampal circuits involved in specific behavioural paradigms. The successful candidate is expected to have a strong interest in neuroscience with an expertise in whole-cell patch clamp, optogenetics and/or viral manipulation (preferably in the DG-CA3 network). The offered position is part of ongoing projects regarding the plasticity of the hippocampal network organization under pathophysiological conditions.

The ideal candidate should have a Ph.D. degree in neuroscience, physiology, or a related field (within the past five years and ideally is less than 35 years old). Candidates should be highly self-motivated, energetic, able to work independently and in collaboration.
There is some flexibility in the starting date, with preference within the first semester of 2020.

Applications should include a detailed CV with publication list, a brief statement of research experience and interests and at least two references to Dr. Nathalie Sans.

Contract length: 2 years


Nathalie Sans

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Cyril Herry, an influential researcher!

Thanks to the 5200 citations of his work, Cyril Herry appears in the ranking Clarivate Analytics of the most influential researchers in the last 10 years. This ranking is based on data and analysis through ralises bibliomtriques experts from the Institute for Scientific Information Web of Science Group. The Web of Science Group recognizes 6 216 scientists who have demonstrated significant influence your product using their peers by publishing numerous articles that rank among the 1% most cits per domain per year. The analysis covers the period 2008-2018. Only 10 other researchers from Inserm and 4 others from the University of Bordeaux are included in this ranking. Congratulations Cyril!

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