mTORC1 and CB1 receptor signaling regulate excitatory glutamatergic inputs onto the hypothalamic paraventricular nucleus in response to energy availability

Wilfrid Mazier, Nicolas Saucisse, Vincent Simon, Astrid Cannich, Giovanni Marsicano, Federico Massa & Daniela Cota

Program available here: https://dopaminesociety.org/program/

In parallel with the scientific and industrial career that we know, Piervi is also the author of Homo biologicus, published by Albin Michel and presented to the public in Mollat ​​Bookstore September 18. Come and talk with our former director.

For the university, the development of this label is a means of attesting to the quality of a platform and guaranteeing its expertise.

A research platform is the grouping on the same site of scientific equipment and/or expertise intended to offer a large community of users high-level research services.

The university has invited its partners: CNRS, Inserm and INRA to be part of the labelling committee in order to award the label to candidate platforms.

27 labelled platforms

Recent work has shown that these receptors are also present in the mitochondrial membranes of the brain where they regulate the bioenergetic processes and amnesic effects of cannabinoids. Thus, the pharmacological effects of cannabinoids derived from cannabis are partially dependent on the regulation of cerebral mitochondrial activity.

Congratulations to our M2 student, Sybille Marchese (Team Montcouquiol/Sans), who has won a doctoral contract at the University of Saint Andrews in Scotland with the young team of Dr Juan Alberto Varela, winner of the prestigious ERC programme (https://risweb.st-andrews.ac.uk/portal/en/persons/juan-alberto-varela(bf1154ef-1d43-41e1-b529-7dd9660cea91).html).

Sybille will use super-resolution imaging techniques to elucidate the extracellular trafficking of protein aggregates (beta-amyloid and alpha-synuclein) in the brain and their direct role in early neurodegeneration.

Good luck Sybille!