PhD/HDR defense
20/06/2019 14h30
Dylan POMMIER from Oliet's lab will give a presentation entitled "L’astrocyte, intégrateur et régulateur de l’activité synaptique excitatrice dans des conditions physiologiques et pathologiques"

from Oliet's lab will give a presentation entitled "L’astrocyte, intégrateur et régulateur de l’activité synaptique excitatrice dans des conditions physiologiques et pathologiques"
Date de la soutenance: 20/06/2019 - 14h30
Lieu: Neurocentre Magendie Seminar room


PhD/HDR defense
17/06/2019 13h30
Stéphanie MAURIAC from Montcouquiol-Sans's lab will give a presentation entitled ...

from Montcouquiol-Sans's lab will give a presentation entitled ...
Date de la soutenance: 17/06/2019 - 13h30
Lieu: Neurocentre Magendie Seminar room


PhD/HDR defense
14/12/2018 14h00
Geoffrey TERRAL - Roles of cannabinoid type-1 receptors in the anterior piriform cortex

- Roles of cannabinoid type-1 receptors in the anterior piriform cortex

Being involved in many behavioral functions, olfaction has powerful influence in guiding our actions. Odors communicate with the central nervous system via specialized receptors in the nose olfactory epithelium that generate neuronal signals, which in turn are eventually distributed and processed in many brain regions. In particular, the anterior piriform cortex (aPC) is an important olfactory area involved in perception and integration of odors. Given the extended role of the main cannabinoid type-1 (CB1) receptor in sensory and memory brain functions, we hypothesized that CB1 receptors could modulate odor processing in the aPC. To this aim, using a combination of anatomical, electrophysiological, and pharmacological approaches, we first characterized the distribution of CB1 receptors and their ability to regulate aPC circuits. We found that CB1 receptors are mainly expressed in GABAergic interneurons where their activation regulates inhibitory transmission and plasticity. Then, we evaluated the role and the impact of CB1 receptor modulation on odor-related aPC processing. In vivo calcium imaging revealed that odor-evoked aPC activity is affected by alteration of CB1 receptor signaling. Additionally, we demonstrated that physiological aPC-CB1 receptors functioning is necessary for retrieve appetitive but not aversive olfactory memory, likely through modulation of local inhibitory circuits. Overall, this work contribute to a better understanding of how CB1 receptors modulate olfactory processes in the aPC.

Date de la soutenance: 14/12/2018 - 14h00
Lieu: Neurocentre Magendie Seminar room

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/formation-doctorale/archives-des-theses/theses-2018/geoffrey-terral.html


PhD/HDR defense
07/12/2018 14h00
Vernon Garcia-Rivas from Deroche's lab will defend his PhD thesis entitled "Psychobiological correlates of individual variations in the control of nicotine seeking by nicotine and nicotine-associated cues".

from Deroche's lab will defend his PhD thesis entitled "Psychobiological correlates of individual variations in the control of nicotine seeking by nicotine and nicotine-associated cues".
Date de la soutenance: 07/12/2018 - 14h00
Lieu: Neurocentre Magendie Seminar room


PhD/HDR defense
06/12/2018 14h00
Marie LODS Role of adult hippocampal neurogenesis in the long-term stabilization of spatial memory

Role of adult hippocampal neurogenesis in the long-term stabilization of spatial memory
Date de la soutenance: 06/12/2018 - 14h00
Lieu: Neurocentre Magendie Seminar room


PhD/HDR defense
30/11/2018 13h30
Laurie ROBIN - Roles of astroglial type 1 cannabinoid receptor (CB1) in memory and synaptic plasticity

- Roles of astroglial type 1 cannabinoid receptor (CB1) in memory and synaptic plasticity

The endocannabinoid system is an important modulator of physiological functions. It is composed of cannabinoid receptors, their endogenous lipid ligands (the endocannabinoids) and the enzymatic machinery for endocannabinoid synthesis and degradation. The type-1 cannabinoid receptors (CB1) are expressed in different cell types of the brain and are known to be involved in memory processes. Endocannabinoids are mobilized in an activity-dependent manner in brain areas involved in the modulation of memory such as the hippocampus. In this brain region, CB1 receptors are mainly expressed at neuronal pre-synaptic terminals where their stimulation inhibits the release of neurotransmitters, thereby modulating several forms of synaptic activity.
Besides their expression in neurons, CB1 receptors are also expressed in astrocytes. Along with the pre- and post-synaptic neurons, astrocytes are part of the “tripartite synapse”, where they participate in synaptic plasticity and associated memory processes. Interestingly, modulation of astroglial CB1 receptors has been proposed to facilitate glutamatergic transmission in the hippocampus. In this brain area, astrocytes regulate the activity of N-methyl-D-aspartate receptors (NMDARs) through the control of the synaptic levels of their co-agonist D-serine, thereby mediating long-term synaptic plasticity. However, the mechanisms inducing D-serine release by astrocytes are still not identified. Interestingly, our laboratory showed that the negative effect of exogenous cannabinoids on spatial working memory is mediated by astroglial CB1 receptors through a NMDAR-dependent mechanism in the hippocampus, but the physiological role of astroglial CB1 remains unknown.
One of the forms of memory involving CB1 receptors is novel object recognition memory (NOR). The exogenous stimulation of hippocampal CB1 receptors inhibits the consolidation of long-term NOR formation. Constitutive global deletion of CB1 receptors in mice leaves NOR intact, suggesting that endogenous CB1 receptor signaling is not necessary for long-term NOR. However, recent studies pointed-out that, likely due to compensatory mechanisms, the global deletion of the CB1 gene might mask cell typespecific roles of CB1 receptors, indicating that more sophisticated tools are required to fully understand the physiological roles of the endocannabinoid system in complex
behavioral functions.
In this work, we investigated the physiological role of the astroglial CB1 receptors on NOR formation and synaptic plasticity. By using a combination of genetic, behavioral, electrophysiological, imaging and biochemical techniques, we showed that endogenous activation of astroglial CB1 receptors is necessary for the consolidation of long-term NOR memory, through a mechanism involving the supply of D-serine to enhance synaptic NMDARs-dependent plasticity in the dorsal hippocampus. This study uncovers an unforeseen mechanism underlying D-serine release, triggering NMDARs activity and long-term memory formation.

Date de la soutenance: 30/11/2018 - 13h30
Lieu: module 2.1 (au dessus du RU)

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/formation-doctorale/archives-des-theses/theses-2018/laurie-robin.html


PhD/HDR defense
26/11/2018 14h00
Thomas KERLOCH A study on the development of granular neurons of the dentate gyrus: morphogenesis and regulation by Rnd2.

A study on the development of granular neurons of the dentate gyrus: morphogenesis and regulation by Rnd2.
Date de la soutenance: 26/11/2018 - 14h00
Lieu: Neurocentre Magendie Seminar room


PhD/HDR defense
22/11/2018 14h30
Arjun A-BHASKARAN Cellular and circuit mechanisms of neocortical dysfunction in Fragile X Syndrome

Cellular and circuit mechanisms of neocortical dysfunction in Fragile X Syndrome
Date de la soutenance: 22/11/2018 - 14h30
Lieu: Magendie Salle de conference


PhD/HDR defense
08/11/2018 14h00
Muriel KOEHL will support her HDR entitled: 'The Brain in the Making: The Place of Adult Neurognosis'

will support her HDR entitled: 'The Brain in the Making: The Place of Adult Neurognosis'
Date de la soutenance: 08/11/2018 - 14h00
Lieu: Neurocentre Magendie Seminar room


PhD/HDR defense
18/12/2017 14h30
Eva-Gunnel DUCOURNEAU from Marighetto's lab will defend her Ph.D. thesis entitled 'Rôle de la plasticité cellulaire au sein du circuit hippocampo-amygdalien dans la formation d'une mémoire de peur normale ou traumatique'

from Marighetto's lab will defend her Ph.D. thesis entitled 'Rôle de la plasticité cellulaire au sein du circuit hippocampo-amygdalien dans la formation d'une mémoire de peur normale ou traumatique'
Date de la soutenance: 18/12/2017 - 14h30
Lieu: Neurocentre Magendie Seminar room

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/formation-doctorale/these-2017/eva-gunnel-ducourneau.html