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Seminars
25/09/2018 14h00
Sophie TRONEL
2018-09-25 14:00:00 2018-09-25 16:00:00 Europe/Paris Sophie TRONEL 0

Lieu: Neurocentre Magendie Seminar room

Soutenance HDR: Sophie Tronel from Abrous's lab will give a presentation entitled "Etude de la stabilisation de la mémoire"



Seminars
21/09/2018 11h30
Jason Shepherd, University of Utah - Host Anna Beyeler
   Show the web article Link

Lieu: Amphithéâtre du Centre Broca Nouvelle-Aquitaine

Inter-cellular RNA transfer: a novel role of the neuronal gene Arc which encodes a repurposed retrotransposon protein

The neuronal gene Arc is essential for long-lasting information storage in the mammalian brain. We recently found that Arc self-assembles into virus-like capsids that encapsulate RNA. Endogenous Arc protein is released from neurons in extracellular vesicles that mediate the transfer of Arc mRNA into new target cells. These results show that Arc exhibits similar molecular properties to retroviral Gag proteins. Evolutionary analysis indicates that Arc is derived from a vertebrate lineage of Ty3/gypsy retrotransposons, which are also ancestors to retroviruses. These findings suggest that Gag retroelements have been repurposed during evolution to mediate intercellular communication in the nervous system. Our working model posits that Arc protein is locally translated in dendrites, where it forms a capsid that binds local mRNAs that are transported out of the cell.



Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/jason-shepherd.html



Lieu: Amphi du Centre Broca

Dr. Marloes Henckens from Department of Cognitive Neuroscience, Donders Institute for Brain (Netherlands)'s lab will give a presentation entitled 'The neural signature of trauma susceptibility'

Invitant : Aline Desmedt, PhD , Maitre de Conférence au Neurocentre Magendie, Team Marighetto 'Pathophysiology of declarative memory'

Posttraumatic stress disorder (PTSD) is a psychiatric disorder which can develop after exposure to a traumatic event. Flashbacks, spontaneous recollection and recurrent nightmares of the trauma are amongst the most devastating symptoms of PTSD, through which patients continuously relive their trauma. Interestingly, only a small fraction (8-10%) of all trauma-exposed individuals eventually develops PTSD, whereas the rest is resilient and remains healthy. But how is the vulnerable brain different from the resilient one and when do these differences arise? Understanding the mechanisms behind these inter-individual differences could contribute to new clinical intervention strategies.
The use of a mouse model for PTSD allows us to study the mechanisms underlying relative resilience or susceptibility to PTSD in a longitudinal fashion, under controlled settings, while allowing for more invasive brain measurements. In this model, mice are first exposed to a traumatic event (i.e., severe unpredictable foot shock), followed by a trigger (i.e., mild predictable foot shock) in a different context one day later. Following a week of recovery, eventual development of PTSD-like symptomatology is assessed using a battery of behavioural tests to identify mice resilient and vulnerable to the trauma. Combining this model with functional MRI obtained both before and after trauma exposure, allowed us to study the development of a potential imbalance in neural network function as a consequence of trauma in the PTSD-vulnerable vs resilient brain, as well as the potential presence of neural abnormalities prior to trauma exposure in these animals. To study brain responses to the trauma itself, we used the so-called targeted recombination in active populations (TRAP) mice, in which the injection of tamoxifen opens up a temporal window in which all neurons expressing certain immediate early genes (reflecting neuronal activity), are permanently fluorescently labelled. We injected these animals with tamoxifen just prior to trauma exposure, and again assessed PTSD-symptoms later on. By re-exposing them to the traumatic context just before sacrifice and analysing trauma retrieval-induced neuronal activity by immunohistochemistry, we were moreover able to analyse the storage of the trauma memory into long-term memory. This allowed us to assess whether aberrant storage of the trauma memory could explain the emotional hypermnesia and contextual hypomnesia of the trauma that seem to characterize PTSD patients.


Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/marloes-henckens.html



Lieu: Neurocentre Magendie Seminar room

from Research Center on Animal Cognition's lab will give a presentation entitled 'Searching for the neural bases of non-elemental learning in a miniature brain'

DR CNRS / Centre de Recherches sur la Cognition Animale - UMR 5169 Team leader: Plasticité dépendante de l’expérience chez l’insecte (EXPLAIN) Research Center on Animal Cognition, CNRS - Université de Toulouse

Invitant : Nora Abrous / Team leader : 'Neurogénèse et physiopathologie' , DR Inserm / Neurocentre Magendie


Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/martin-giurfa.html



Lieu: Amphi Broca Nouvelle-Aquitaine

from Institut de génomique fonctionnelle de Montpellier, Department of Neuroscience's lab will give a presentation entitled 'RVM GABAergic neurons command enkephalinergic spinal neurons to act as gatekeepers of mechanical pain.'

Invitant : Pascal Fossat , Assistant Professor, Team: Central Mechanisms of Pain Sensitization and Anna Beyeler: Teamleader 'Neural Circuits of Anxiety', IINS et Neurocentre Magendie






Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/amaury-francois.html



Lieu: Université, Agora du Haut Carré, Talenc

Point fort de l’année ! le « Neurocampus Day » avec ses 6 instituts de recherche, ses rencontres, ses échanges prometteurs , une journée riche en sciences du cerveau... Domaine du Haut Carré , Talence le Jeudi 17 Mai 2018

Du Neurocentre Magendie:
14h40-15h05 Anna Beyeler / Anatomical and functional organization of neural populations in the amygdala and insula

17h15-17h40 Luigi Bellochio (Equipe Marsicano) / Striatonigral mitochondrial CB1 receptors mediate cannabinoid-induced catalepsy


Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/neurocampus-day.html



Lieu: Neurocentre Magendie Seminar room

Davide Amato will present his latest work on the role of D1 and D2 neurons of the nucleus accumbens in cocaine sensitization and cross-sensitization with antipsychotics. The study he will share was performed with single-cell calcium imaging in freely moving mice.

Invited by Anna Beyeler.


Pour plus de détails: https://www.fau.eu/alumni/research-alumni/research-alumni-interviews/interview-with-dr-davide-amato/


Seminars
30/03/2018 08h30
16th SYNAPSE DAY MEETING, March 2018
   Show the web article Link

Lieu: Amphi Broca-Nouvelle Aquitaine

16th SYNAPSE DAY MEETING, March 2018


Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/journee-synapse.html


Seminars
20/12/2017 11h30
Freddy Jeanneteau

Lieu: Amphithéatre BROCA

TITRE: Longitudinal two-photon microscopy of the living brain to tackle cellular plasticity.

Static assembly of multiple cell types in the brain is not sustainable when physiological state deviates from homeostasis. Cellular networks must adapt to changes in the environment, aging and disease conditions. What can be learned from the dynamics of cellular networks assembly/disassembly? My lab uses in vivo 2-photon microscopy of the mouse brain to investigate the structural plasticity of cellular networks in normal living conditions and in various pathological states replicating human diseases. I’ll present 2 on-going projects for: (1) tracking the impact of stress on a cortical synaptic engram of motor learning, and (2) for studying the impact of status epilepticus on the remodeling of the blood brain barrier. The results unravel disease mechanisms and have implications for the design of new treatment strategies.





Lieu: Neurocentre Magendie Seminar room

Giovanni Marsicano from Endocannabinoid and Neuroadaptation Group's lab will give the PhD seminar series December entitled 'Cannabinoid CB1 receptor signaling in the brain: the where matters'.

Invitant : Bordeaux Neurocampus / NBA

Abstract :
Cannabinoid drugs (e.g. the active principle of the plant cannabis, D9-tetrahydrocannabinol, THC) exert several effects on the brain via the activation of the G protein-coupled type-1 cannabinoid receptors (CB1).




Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2017/giovanni-marsicano.html