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20/12/2017 11h30
Freddy Jeanneteau

Lieu: Amphithéatre BROCA

TITRE: Longitudinal two-photon microscopy of the living brain to tackle cellular plasticity.

Static assembly of multiple cell types in the brain is not sustainable when physiological state deviates from homeostasis. Cellular networks must adapt to changes in the environment, aging and disease conditions. What can be learned from the dynamics of cellular networks assembly/disassembly? My lab uses in vivo 2-photon microscopy of the mouse brain to investigate the structural plasticity of cellular networks in normal living conditions and in various pathological states replicating human diseases. I’ll present 2 on-going projects for: (1) tracking the impact of stress on a cortical synaptic engram of motor learning, and (2) for studying the impact of status epilepticus on the remodeling of the blood brain barrier. The results unravel disease mechanisms and have implications for the design of new treatment strategies.

Lieu: Neurocentre Magendie Seminar room

Giovanni Marsicano from Endocannabinoid and Neuroadaptation Group's lab will give the PhD seminar series December entitled 'Cannabinoid CB1 receptor signaling in the brain: the where matters'.

Invitant : Bordeaux Neurocampus / NBA

Abstract :
Cannabinoid drugs (e.g. the active principle of the plant cannabis, D9-tetrahydrocannabinol, THC) exert several effects on the brain via the activation of the G protein-coupled type-1 cannabinoid receptors (CB1).

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2017/giovanni-marsicano.html

Lieu: PGF

Carmen Sandi will give a presentation entitled "Mitochondria and stress coping strategies" at 6 pm next Sunday 16th of July at the Ecole des Neurosciences / PGF for the Cajal Advanced Neuroscience Training Programme "Advanced Techniques for Synapse Biology".

Pour plus de détails: http://www.fens.org/Training/CAJAL-programme/CAJAL-Courses-2017/ATSB2017/

Lieu: Neurocentre Magendie Seminar room

Jennifer Rodger from School of Biological Sciences, University of Western Australia will give a presentation entitled 'Brain stimulation in animal models: happy mice and active brain cells'

Invitant : Guillaume Lucas, PhD, Neurocentre Magendie

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2017/jennifer-rodger.html

08/06/2017 11h30
Etienne Hebert-Chatelain
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Lieu: Neurocentre Magendie Seminar room

Etienne Hebert-Chatelain, Professor in University of Moncton (Canada), will give a presentation entitled 'Post-translational modifications to regulate mitochondria in physiopathological '

Invitant : Giovanni Marsicano, PhD , Neurocentre Magendie , Team leader: Group "Endocannabinoids and Neuroadaptation"

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2017/etienne-hebert-chatelain.html

24/03/2017 10h30
Dr. Karun Singh : How do Autism spectrum disorder risk genes impact brain development?
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How do Autism spectrum disorder risk genes impact brain development? One of the leading hypotheses is that risk genes disrupt the development of neural circuits. In the first part of my talk, I will go over our use of mouse models to study ASD risk genes and their role in synaptic development and dysfunction. In the final part, I will discuss our latest efforts to study in modeling ASD and synaptic function using gene editing of human neurons, and their potential use for drug discovery.
Selected publications
Kwan, V., Hung, C.L., White, S., Hoszapfel, N.T., Walker, S., Murtaza, N., Unda, B.K., Yuen, R.K.C., Habing, K., Milsom, C., Hope, K., Truant, R., Scherer, S.W. and Singh, K.K*. DIXDC1 phosphorylation and control of dendritic morphology is impaired by rare genetic variants.
Cell Reports 17(7):1892-1904. *corresponding author. PMID: 27829159

Unda, B.K., Kwan, V. and Singh, K.K*. (2016). Neuregulin-1 regulates cortical inhibitory neuron dendrite and synapse growth through DISC1.
Neural Plasticity, Article: 7694385. *corresponding author. PMID: 27847649

Lee, J.H#, Mitchell, R.R#., McNicol, J.D., Shapovalova, Z., Laronde, S., Tanasijevic, B., Milsom, C., Casado, F., Fiebig-Comyn, A., Collins, T.J., Singh, K.K., Bhatia M (2015). Single Transcription Factor Conversion of Human Blood Fate to NPCs with CNS and PNS Developmental Capacity.
Cell Reports. 11(9):1367-76. #equal contributions. PMID: 26004181.

Singh, K.K., Ge, X., Mao, Y., Drane, L., Meletis, K., Samuels, B.A. and Tsai, L.H. (2010). Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. Neuron 67, 33-48. PMID: 20624590.

Scientific focus :
Dr. Karun Singh is an Investigator at the Stem Cell and Cancer Research Institute (SCCRI) and an Assistant Professor with the Department of Biochemistry and Biomedical Sciences at McMaster University, Canada since 2012. He holds the David Braley Chair in Human Stem Cell Research. He obtained his PhD from the University of Toronto and his postdoctoral training at the Massachusetts Institute of Technology (MIT) in USA. Currently, Dr. Singh's independent program employs a combination of mouse and patient-derived neural cellular models to study how genes associated with Autism spectrum disorders impact brain development. Currently his lab is focusing on 3 questions:

1. What is the normal role of ASD linked genes during mammalian brain development, with a particular emphasis on synaptic development?
2. How do ASD-linked genetic mutations impair brain (synaptic) development, from a biochemical to the functional perspective?
3. Is it possible to model neurodevelopmental disorders using human neuronal models, and use them for drug discovery?

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2017/karun-singh.html

Lieu: Neurocentre Magendie Seminar room

Journée ARSEP portes ouvertes 2016

Rencontre avec les chercheurs dans les laboratoires dédiés à la Sclérose en plaques

14h : Accueil et présentation du Neurocentre Magendie (Franck Burglen, secrétaire général)
14h30 : Etude des troubles de la mémoire dans la Sclérose en plaques, approche expérimentale chez l’animal (Pr Thomas Tourdias, PU-PH )
15h : Programme rééducation fonctionnelle (Dr Delphine Larmargue Hamel, orthophoniste réseau AQUISEP)
15h30 : Recherche clinique : Troubles cognitifs, mécanisme et détection de la Sclérose en plaques (Pr Bruno Brochet, PU-PH / Dr Mathilde Deloire, coordinatrice étude clinique CHU)

Pour plus de détails: https://www.arsep.org/fr/188-journees-porte-ouverte.html

29/09/2016 09h00
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Lieu: Neurocentre Magendie Seminar room

Comment optimiser ma technique de pipetage?
Quelle balance choisir pour réaliser mes pesées?
Comment calibrer mon électrode de pH et comment bien l'entretenir?
Ce sont peut-être des questions que vous vous posez...
Pour répondre à toutes ces questions, en partenariat avec Melter Toledo, une journée scientifique est organisée le 29 septembre 2016 au Neurocentre Magendie sur la thématique des BPL.
Accès libre avec cours théoriques et workshops.

Pour plus de détails: neurocentre-magendie.fr/NCM_Downloads/Programme_BPL_Bordeaux.pdf

Lieu: Neurocentre Magendie Seminar room

from University of Trieste's lab will give a presentation entitled 'An in vitro model to study neuronal atrophy and rescue in neurodevelopmental disorders: the case of Rett Syndrome'

Invitant : Daniel Voisin, Neurocentre Magendie / Professor - PhD, University of Bordeaux / Team : Glia-neuron relations

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2016/enrico-tongiorgi.html

Lieu: Neurocentre Magendie Seminar room

from Department of Pharmacology and Therapeutics (McGill University, Canada) will give a presentation entitled 'Nuclear G proteins in cardiac transcriptional regulation'

Invitant : Stéphane Oliet, Team leader: Glia-neuron relations (Neurocentre Magendie)

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2016/terry-hebert.html