Job offers
26/07/2021
Biotech Technician
           Afficher le PDF

Aelis Farma Company:
Aelis Farma's goal is to develop a new pharmacological class: specific CB1 receptor signaling inhibitors (CB1-SSi). CB1-SSi has a unique mechanism of action that has never been tested in humans before. Aelis Farma is currently developing two drug candidates AEF0117 (currently in Phase II) for the treatment of cannabis addiction and cannabis-induced psychosis and, AEF0217 for the treatment of cognitive impairment in Down syndrome. Aelis Farma is extremely committed to the development of these breakthrough treatments and has the ambition to become the leader in SSi drugs.
The company is currently going through a key stage of its development and wishes to reinforce its teams and is looking for a biotechnology technician. This position is based in Bordeaux.

Summary of the position:
Integrated within the Discovery team, you will participate in the screening of new molecules using cellular and/or biochemical tests. As such, you will be in charge of the following tasks:
- Carry out daily cellular and/or biochemical tests in microplates in compliance with established protocols and hygiene and safety rules (L2 level)
- Write protocols, record daily in the laboratory notebook
- Participate in the analysis, synthesis and presentation of results
- Participate in the maintenance of cell cultures (preparation of media, cell passage, etc.)
- Ensure the maintenance of the laboratory environment, the maintenance of the equipment and the follow-up of the stocks of reagents/consumables necessary for the tests

Qualifications required:
- 2 to 3 years of higher education in Biotechnology
- Experience in performing cellular and/or biochemical assays in 96 and/or 384 well formats (use of electronic multichannel pipettes)
- Ability to work in reduced light conditions to perform precision pipetting
- Good command of Excel software, ability to process and analyze a large amount of data
- Experience in cell culture
- Scientific English
- Rigor, meticulousness, dynamism, team spirit
Any experience in one or more of the following fields will be considered as a plus: graphical representation of data with GraphPad Prism software, use of multimode plate readers (luminescence, fluorescence, alpha technology, HTRF), performance of immunoassays, isolation and culture of primary neuronal cells, differentiation and culture of iPS, cell imaging, use of HCS platforms, use of pipetting robots.
Position to be filled quickly

Please send us your documents in English (CV and cover letter) to: e.woodville@aelisfarma.com
Selected candidates will be invited for an interview.





Job offers
26/07/2021
Biotech Assistant Engineer
           Afficher le PDF

Aelis Farma company:
Aelis Farma's goal is to develop a new pharmacological class: specific CB1 receptor signalling inhibitors (CB1-SSi). CB1-SSi has a unique mechanism of action that has never been tested in humans before. Aelis Farma is currently developing two drug candidates AEF0117 (currently in phase II) for the treatment of cannabis addiction and cannabis-induced psychosis and AEF0217 for the treatment of cognitive impairment in Down's syndrome. Aelis Farma is extremely committed to the development of these breakthrough treatments and has the ambition to become the leader in SSi drugs.
The company is currently going through a key stage in its development and is looking to strengthen its teams and is looking for an assistant biotechnology engineer. This position is based in Bordeaux.

Summary of the position:
As part of the Discovery team, you will participate in the screening of new molecules using cellular and biochemical tests. You will be responsible for the following tasks
- Carry out cellular and biochemical tests in microplates in compliance with established protocols and health and safety rules (L2 level)
- Write protocols, record daily in the laboratory notebook
- Participate in the analysis, synthesis and presentation of results
- Participate in the upkeep of the laboratory environment, maintenance of equipment and monitoring of stocks of reagents/consumables required for tests

Qualifications required:
- 5 years of higher education in Biotechnology
- Experience in performing cell-based assays in 96 and/or 384-well formats (use of electronic multichannel pipettes)
- Ability to work in reduced light conditions for precision pipetting
- Proficiency in Excel software for data analysis, ability to process and analyse a large amount of data
- Proficiency in GraphPad Prism for graphing and statistical analysis
- Good level of English (reading, writing, speaking)
- Rigour, meticulousness, dynamism, team spirit
Any experience in one or more of the following fields will be considered a plus: use of multimode plate readers (luminescence, fluorescence, alpha technology, HTRF), performance of immunoassays, study of GPCR signalling pathways, study of the CB1 receptor, knowledge of neurobiology, calcium signalling, isolation and culture of primary neuronal cells, differentiation and culture of iPS, cell imaging, use of HCS platforms, use of pipetting robots.
Position to be filled quickly.

Please send your documents in English (CV and cover letter) to: e.woodville@aelisfarma.com
Selected candidates will be invited for an interview.



Translated with www.DeepL.com/Translator (free version)





▪▪▪ Post-doctoral position for 2 years, starting in April 2021
▪▪▪ 35-42 k€ + benefits / year, depending on the experience of the applicant
▪▪▪ We are using state of the art circuit dissection in mice to pin point the functional role of neural populations of the insular cortex in emotional valence and anxiety, and to identify cellular and synaptic dysfunctions of those populations in stress-induced models of psychiatric pathologies
▪▪▪ We are looking for an expert of SLICE ELECTROPHYSIOLOGY and SYNAPTIC PLASTICITY in mice
▪▪▪ The lab is part of the Bordeaux Neurocampus encompassing more than 50 labs dedicated to Neuroscience, providing an exceptionally rich environment.
▪▪▪ Send a CV including three references, and a cover letter describing experience, goals and reasons for the interest in this position (anna.beyeler@inserm.fr).
▪▪▪ Google scholar: https://scholar.google.fr/citations?user=bTLNLBEAAAAJ&hl=en




Job offers
03/11/2020
Postdoctoral position in Neurobiology of obesity and diabetes

We are searching for a highly motivated Postdoctoral researcher to join the research team Energy Balance and Obesity at the INSERM Unit 1215, Neurocentre Magendie (http://www.neurocentre-magendie.fr/cota) in Bordeaux, France.

The research focus of the team is the study of the neurobiology of obesity and diabetes. The project that the successful candidate will carry out aims at studying the molecular and functional heterogeneity of hypothalamic neurons implicated in food intake and body weight regulation.

This project is fully funded by an ANR (French National Research Agency) grant. The candidate will use specific genetic murine models, stereotaxic surgery, and viral approaches, associated with in vivo behavioral and metabolic assessments, molecular biology, and neuroanatomical analysis. The project will also involve the use of in vivo calcium imaging.

Candidates should have a doctoral degree in neuroscience/neurobiology/nutrition/or metabolism. Previous experience in the study of hypothalamic neuronal circuits in rodent models is preferred. The ability to work both independently and cooperatively within a team is essential.

The appointment is for 2 years, but candidates will be encouraged and guided to apply for additional funding opportunities. The position is available starting from April 2021.

Candidates should send their CV, motivation letter, list of publications, and 2 letters of reference to Dr. Carmelo Quarta (carmelo.quarta@inserm.fr) and Dr. Daniela Cota (daniela.cota@inserm.fr).





Job offers
19/12/2019
Postdoc Position in sensory information processing and perception

The Cortical Plasticity group at the Neurocentre Magendie (Bordeaux, France) is seeking to recruit a postdoctoral researcher to join their group in 2020.

We are interested in the function of neocortical circuits and their pathophysiological modification in neurodevelopmental disorders. In particular, we study sensory information processing and perception. To address this, we will use in vivo calcium imaging (two-photon/miniscope) and electrophysiological approaches (multi-electrode/whole-cell) in behaving mice.
We are looking for a highly motivated and proactive candidate with experience in in vivo electrophysiology and/or calcium imaging and analysis of this data. The successful candidate is expected to make significant contributions to the direction and conceptualization of the project. The appointee must have a PhD or equivalent qualification in either neuroscience, life sciences, medicine, or physics. The candidate should also have a good level of proficiency in English.

The team is based at the Neurocentre Magendie, an INSERM research institute, and a member of the Bordeaux Neurocampus — a center of excellence for neuroscience research in France. The day-to-day language is English, but support would be provided for learning French if the candidate so wishes.

The project is funded for three years.

Interested applicants should send a cv, brief statement of research experience and interests, and names of 2-3 references to Dr. Andreas Frick: andreas.frick@inserm.fr






A post-doc position in electrophysiology, optogenetics and functional imaging is available in the group of Dr. Nathalie Sans (Neurocentre Magendie).

We are looking for highly motivated researchers to analyse and manipulate hippocampal circuits involved in specific behavioural paradigms. The successful candidate is expected to have a strong interest in neuroscience with an expertise in whole-cell patch clamp, optogenetics and/or viral manipulation (preferably in the DG-CA3 network). The offered position is part of ongoing projects regarding the plasticity of the hippocampal network organization under pathophysiological conditions.

The ideal candidate should have a Ph.D. degree in neuroscience, physiology, or a related field (within the past five years and ideally is less than 35 years old). Candidates should be highly self-motivated, energetic, able to work independently and in collaboration.
There is some flexibility in the starting date, with preference within the first semester of 2020.

Applications should include a detailed CV with publication list, a brief statement of research experience and interests and at least two references to Dr. Nathalie Sans.

Contract length: 2 years

Contact

Nathalie Sans
nathalie.sans@inserm.fr