Les dernières actualités

Lieu: Amphi Broca

Principal Investigator, Momentum Laboratory of Molecular Neurobiology,Budapest , Hungary, Hungarian Academy of Sciences - Synaptic junctions are major sites of communication in the brain, where chemical messenger molecules transmit information from presynaptic neurons to their postsynaptic partners.The efficacy of synaptic transmission is not constant in time and space. Instead, its plasticity is a fundamental phenomenon underlying information storage and adaptation to environmental stimuli. Although classical neurotransmitters (such as glutamate and GABA) have well characterized principal roles in mediating basal neurotransmission, emerging evidence has revealed that synapses exploit a plethora of additional messenger molecules integrated into sophisticated signaling pathways to accomplish their complex functions. Thus, the major objective of our laboratory is to identify new signaling systems regulating synaptic transmission and its plasticity. We aspire to delineate the molecular architecture of these novel pathways and to elucidate their physiological roles. Ultimately, this activity is envisaged to help gain a better understanding of synaptic function and reveal new aspects of impaired synaptic activity in brain disorders.

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2019/istvan-katona.html

11/01/2019 11h30
Stefano Palminteri invited by Véronique Deroche-Gamonet
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Lieu: Amphi CGFB

Humans are biased reinforcement learners: evidence from behavioural and neural data

Abstract : The goal of a reinforcement learner is learning what to do so as to maximize future expected reward. A prerequisite to achieve this goal is to learn a action value function, that is an internal estimation of the future expected reward following a given action. In this talk I will present behavioural and neural evidence that humas do not learn this action value function in an objective manner.

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2019/stefano-palminteri.html

19/12/2018 10h00
Ignacio FERNANDEZ MONCADA from Marsicano's lab will give a presentation entitled "A cannabinoid link between astroglial bioenergetics and brain function?"

19/12/2018 10h30
Sebastien DELCASSO from Beyeler's lab will give a presentation entitled "Anatomical and functional organization of valence circuits in the insular cortex."

Offre de poste
Postdoctoral position in Neurobiology of obesity and diabetes

We are searching a highly motivated Postdoctoral researcher to join the research team led by Dr. Daniela Cota at the INSERM Unit 1215, Neurocentre Magendie (http://www.neurocentre-magendie.fr/cota) in Bordeaux, France.
The research focus of the team is the study of the neurobiology of obesity and diabetes. The project that the successful candidate will carry out aims at determining the role of mitochondrial CB1 receptor in the regulation of hypothalamic circuits playing key roles in sensing and integrating information about nutrient availability. This project will be carried out in collaboration with Dr. Giovanni Marsicano’s team (INSERM U1215). Use of specific genetic models, stereotaxic surgery and viral approaches, associated with in vivo behavioral and metabolic assessments, molecular biology and neuroanatomical analysis are the main approaches required.
Candidates should have a doctoral degree in neuroscience/neurobiology/nutrition/metabolism. Previous experience in the study of hypothalamic neuronal circuits involved in the regulation of energy balance and metabolism using rodent models is strongly preferred. Ability to work both independently and cooperatively within a team is essential.
The appointment is for 30 months. The position is available starting May 2019 and is funded by the ANR.
Candidates should send their CV, motivation letter, list of publications and 2 letters of reference to Dr. Daniela Cota (daniela.cota@inserm.fr ).

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Démo PrestoCHILL/FlashFREEZE Microm
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Démo au tour d'un petit-déjeuner du PrestoCHILL/FlashFREEZE de chez Microm.
Ce système permet une congélation rapide et/ou enrobage des échantillons sans isopentane et ni azote.
Cette démo aura lieu le vendredi 14/12 de 9h30 à 11h30 au premier étage en face de la cafétéria.

14/12/2018 14h00
Geoffrey TERRAL - Roles of cannabinoid type-1 receptors in the anterior piriform cortex

- Roles of cannabinoid type-1 receptors in the anterior piriform cortex

Being involved in many behavioral functions, olfaction has powerful influence in guiding our actions. Odors communicate with the central nervous system via specialized receptors in the nose olfactory epithelium that generate neuronal signals, which in turn are eventually distributed and processed in many brain regions. In particular, the anterior piriform cortex (aPC) is an important olfactory area involved in perception and integration of odors. Given the extended role of the main cannabinoid type-1 (CB1) receptor in sensory and memory brain functions, we hypothesized that CB1 receptors could modulate odor processing in the aPC. To this aim, using a combination of anatomical, electrophysiological, and pharmacological approaches, we first characterized the distribution of CB1 receptors and their ability to regulate aPC circuits. We found that CB1 receptors are mainly expressed in GABAergic interneurons where their activation regulates inhibitory transmission and plasticity. Then, we evaluated the role and the impact of CB1 receptor modulation on odor-related aPC processing. In vivo calcium imaging revealed that odor-evoked aPC activity is affected by alteration of CB1 receptor signaling. Additionally, we demonstrated that physiological aPC-CB1 receptors functioning is necessary for retrieve appetitive but not aversive olfactory memory, likely through modulation of local inhibitory circuits. Overall, this work contribute to a better understanding of how CB1 receptors modulate olfactory processes in the aPC.

Date de la soutenance: 14/12/2018 - 14h00
Lieu: Neurocentre Magendie Seminar room

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/formation-doctorale/archives-des-theses/theses-2018/geoffrey-terral.html

13/12/2018 10h00
Olfaction Symposium - organized by Guillaume Ferreira, Lisa Roux & Giovanni Marsicano
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Lieu: Neurocentre Magendie Seminar Room

Si l’olfaction a longtemps été considéré comme une sensorialité « secondaire » de nombreuses découvertes récentes, en particulier sur le fonctionnement cérébral, l’ont remis sur le devant de la scène. Les différents conférenciers illustreront lors d’une première session les bases neurobiologiques qui permettent ces importantes capacités d’apprentissages olfactifs (Busquets-Garcia, Nicole), aussi bien chez l’animal que chez l’homme, et ce dès la naissance (Coureaud, Sullivan). Lors d’une seconde session, les intervenants se focaliseront sur la physiologie des premiers relais cérébraux de traitement de l’information olfactive, à savoir le bulbe olfactif et le cortex piriforme (ou leurs équivalents chez la drosophile) ainsi que leurs étroites interactions (Nissant, Plaçais, Martin et Wilson).

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/symposium-olfaction.html

Info générale
Promotion !

Félicitations à Claire Leger (équipe Oliet) qui obtient sa promotion au grade TS de l'Université de Bordeaux.

07/12/2018 14h00
Vernon Garcia-Rivas from Deroche's lab will defend his PhD thesis entitled "Psychobiological correlates of individual variations in the control of nicotine seeking by nicotine and nicotine-associated cues".

from Deroche's lab will defend his PhD thesis entitled "Psychobiological correlates of individual variations in the control of nicotine seeking by nicotine and nicotine-associated cues".
Date de la soutenance: 07/12/2018 - 14h00
Lieu: Neurocentre Magendie Seminar room