Les dernières actualités






Soutenance
14/12/2018 14h00
Geoffrey TERRAL - Roles of cannabinoid type-1 receptors in the anterior piriform cortex

- Roles of cannabinoid type-1 receptors in the anterior piriform cortex

Being involved in many behavioral functions, olfaction has powerful influence in guiding our actions. Odors communicate with the central nervous system via specialized receptors in the nose olfactory epithelium that generate neuronal signals, which in turn are eventually distributed and processed in many brain regions. In particular, the anterior piriform cortex (aPC) is an important olfactory area involved in perception and integration of odors. Given the extended role of the main cannabinoid type-1 (CB1) receptor in sensory and memory brain functions, we hypothesized that CB1 receptors could modulate odor processing in the aPC. To this aim, using a combination of anatomical, electrophysiological, and pharmacological approaches, we first characterized the distribution of CB1 receptors and their ability to regulate aPC circuits. We found that CB1 receptors are mainly expressed in GABAergic interneurons where their activation regulates inhibitory transmission and plasticity. Then, we evaluated the role and the impact of CB1 receptor modulation on odor-related aPC processing. In vivo calcium imaging revealed that odor-evoked aPC activity is affected by alteration of CB1 receptor signaling. Additionally, we demonstrated that physiological aPC-CB1 receptors functioning is necessary for retrieve appetitive but not aversive olfactory memory, likely through modulation of local inhibitory circuits. Overall, this work contribute to a better understanding of how CB1 receptors modulate olfactory processes in the aPC.

Date de la soutenance: 14/12/2018 - 14h00
Lieu: Neurocentre Magendie Seminar room

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/formation-doctorale/archives-des-theses/theses-2018/geoffrey-terral.html


Séminaire
13/12/2018 10h00
Olfaction Symposium - organized by Guillaume Ferreira, Lisa Roux & Giovanni Marsicano
   Afficher l'article web Link

Lieu: Neurocentre Magendie Seminar Room

Si l’olfaction a longtemps été considéré comme une sensorialité « secondaire » de nombreuses découvertes récentes, en particulier sur le fonctionnement cérébral, l’ont remis sur le devant de la scène. Les différents conférenciers illustreront lors d’une première session les bases neurobiologiques qui permettent ces importantes capacités d’apprentissages olfactifs (Busquets-Garcia, Nicole), aussi bien chez l’animal que chez l’homme, et ce dès la naissance (Coureaud, Sullivan). Lors d’une seconde session, les intervenants se focaliseront sur la physiologie des premiers relais cérébraux de traitement de l’information olfactive, à savoir le bulbe olfactif et le cortex piriforme (ou leurs équivalents chez la drosophile) ainsi que leurs étroites interactions (Nissant, Plaçais, Martin et Wilson).


Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/symposium-olfaction.html


Info générale
10/12/2018
Promotion !

Félicitations à Claire Leger (équipe Oliet) qui obtient sa promotion au grade TS de l'Université de Bordeaux.




Soutenance
07/12/2018 14h00
Vernon Garcia-Rivas from Deroche's lab will defend his PhD thesis entitled "Psychobiological correlates of individual variations in the control of nicotine seeking by nicotine and nicotine-associated cues".

from Deroche's lab will defend his PhD thesis entitled "Psychobiological correlates of individual variations in the control of nicotine seeking by nicotine and nicotine-associated cues".
Date de la soutenance: 07/12/2018 - 14h00
Lieu: Neurocentre Magendie Seminar room


Soutenance
06/12/2018 14h00
Marie LODS Rôle de la neurogenèse hippocampique adulte dans la stabilisation à long terme de la mémoire spatiale

Rôle de la neurogenèse hippocampique adulte dans la stabilisation à long terme de la mémoire spatiale
Date de la soutenance: 06/12/2018 - 14h00
Lieu: Neurocentre Magendie Seminar room


Séminaire
05/12/2018 10h00
Vladimir Ivosev, invited by Anna Beyeler
   Afficher l'article web Link

Lieu: Neurocentre Magendie Seminar room

VectorBuilder - a revolutionary platform for vector design, custom cloning, virus packaging and library construction
VectorBuilder aims at providing researchers with one-stop solutions to all their vector design, custom cloning and virus packaging needs. Besides cloning and virus packaging, VectorBuilder offers many other molecular biology services such as BAC modification (recombineering), library construction, DNA/RNA preparation, mutagenesis, and many more. Our web-based design tool provides a highly intuitive workflow for you to design your desired vector with just a few mouse clicks, all for free. You can then use our online ordering system to purchase the custom cloning of your vector – along with related services such as virus packaging – as easily as shopping on Amazon. The cost and turnaround time are just a fraction of DIY. So, stop the headaches of DIY your own vectors and viruses, and outsource to VectorBuilder today.


Pour plus de détails: https://en.vectorbuilder.com/


Soutenance
30/11/2018 13h30
Laurie ROBIN - Rôles du récepteur astroglial des cannabinoïdes de type 1 (CB1) dans la mémoire et la plasticité synaptique Le système endocannabinoïde est un modulateur important des fonctions physiologiques ; il est composé de récepteurs cannabinoïdes, de leurs ligands lipidiques endogènes (les endocannabinoïdes) et de la machine enzymatique de synthèse et dégradation endocannabinoïdes ; Les récepteurs cannabinoïdes de type 1 (CB1) sont exprimés dans différents types de cellules du cerveau et participent aux processus mémoire.

- Rôles du récepteur astroglial des cannabinoïdes de type 1 (CB1) dans la mémoire et la plasticité synaptique Le système endocannabinoïde est un modulateur important des fonctions physiologiques ; il est composé de récepteurs cannabinoïdes, de leurs ligands lipidiques endogènes (les endocannabinoïdes) et de la machine enzymatique de synthèse et dégradation endocannabinoïdes ; Les récepteurs cannabinoïdes de type 1 (CB1) sont exprimés dans différents types de cellules du cerveau et participent aux processus mémoire.
Date de la soutenance: 30/11/2018 - 13h30
Lieu: module 2.1 (au dessus du RU)

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/formation-doctorale/archives-des-theses/theses-2018/laurie-robin.html


Hottopic
28/11/2018 10h00
Mehdi BHOURI from Montcouquiol-Sans's lab will give a presentation entitled 'Role of the planar cell polarity protein Vangl2 in hippocampal circuits involved in memory.'

Hottopic
28/11/2018 10h30
Marco MATOS from Oliet's lab will give a presentation entitled "Apolipoprotein E -ε4 in the development of synaptic impairment in Alzheimer's disease."

Séminaire
27/11/2018 11h00
Abel Eraso Pichot (Autonomous University of Barcelona)

Lieu: Neurocentre Magendie Seminar room

- Adaptive regulation of calcium excitability and energy metabolism by CREB-dependent transcription in astrocytes: study of the mechanisms governing astrocyte plasticity

An increasing body of evidence suggests that astrocytes participate in higher-brain functions, controlling from synaptic transmission to global brain waves and learning and memory processes. Different mechanisms have been proposed to mediate these astrocyte-dependent processes, astrocytic lactate release and calcium-dependent gliotransmission being the main known effectors. The existence of control of brain functions by astrocytes suggests that astrocytes may shape brain functions in response to experience as much as neurons, thus constituting the phenomenon of astrocyte plasticity. In neurons, the transcription factor CREB is the best known coordinator of synaptic and intrinsic plasticity. The fact that, in astrocytes, CREB activation is also activity-dependent, positions CREB as an ideal target to promote plasticity-related changes in astrocytes, too. In this study, we have analyzed the effect of the activation of CREB-dependent transcription in astrocytes, specifically regarding calcium signals and metabolism. We have demonstrated that activation of CREB-dependent transcription reduces cytosolic calcium events via mitochondria and increases lactate release, which may have impact on synaptic transmission. An important contribution of the study is the molecular analysis of astrocytic mitochondria, which has revealed that astrocytes may use fuels other than glucose such as fatty acids to meet basic energy metabolic demands. Taken together, our results establish astrocytic CREB as a hub in astrocyte-plasticity and shed light on the interplay between plasticity and energy metabolism in astrocytes.