Les dernières actualités






Info générale
08/03/2018
Deroche-Gamonet, Revest et al. in Molecular Psychiatry:
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First causal evidence of a role of neurogenesis in a drug-related behavior.

The hippocampus is the main locus for adult dentate gyrus (DG) neurogenesis. A number of studies have shown that aberrant DG neurogenesis correlates with many neuropsychiatric disorders, including drug addiction. Although clear causal relationships have been established between DG neurogenesis and memory dysfunction or mood-related disorders, evidence of the causal role of DG neurogenesis in drug-seeking behaviors has not been established. Here we assessed the role of new DG neurons in cocaine self-administration using an inducible transgenic approach that selectively depletes adult DG neurogenesis. Our results show that transgenic mice with decreased adult DG neurogenesis exhibit increased motivation to self-administer cocaine and a higher seeking response to cocaine-related cues. These results identify adult hippocampal neurogenesis as a key factor in vulnerability to cocaine addiction.

Deroche-Gamonet V*, Revest JM*, Fiancette JF, Balado E, Koehl M, Grosjean N, Abrous DN*, Piazza PV*. Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior. Mol Psychiatry. 2018 Mar 5. doi: 10.1038/s41380-018-0038-0.




Hottopic
28/02/2018 10h00
Ana DORREGO-RIVAS from Montcouquiol-Sans's lab will give a presentation entitled "The Axonal Initial Segment (AIS): a hub for cell polarity ?"

Hottopic
28/02/2018 10h30
Anastassios KARAGIANNIS from Oliet's lab will give a presentation entitled ""Is stress-induced vulnerability to cocaine an astrocyte-dependent process?""

Hottopic
28/02/2018 11h00
Arnau BUSQUETS-GARCIA from Marsicano's lab will give a presentation entitled "Cannabinoid modulation of higher-order mental processes: From mediated learning to reality testing."


Les travaux de Catherine Benneteau sur les phytoestrogènes réalisés dans l'équipe d'Aline Marighetto ont fait l'objet d'un reportage diffusé dans "le Doc du dimanche" sur France 5. Retrouvez le passage consacré aux travaux magendiens à partie de 14'30".
https://www.france.tv/documentaires/societe/417745-le-doc-du-dimanche-soja-la-grande-invasion.html




Info générale
19/02/2018
A full review on nicotine dependence by Vernon Garcia Rivas & Véronique Deroche-Gamonet in Addiction Biology
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Vernon Garcia-Rivas (3rd year PhD student, Equipe Deroche) signs as first author a review entitled “Not all smokers appear to seek nicotine for the same reasons: implications for preclinical research in nicotine dependence”.
Clinical and preclinical studies have demonstrated consistently that nicotine seeking is a complex behavior involving various psychopharmacological mechanisms. Evidence supports that the population of smokers is heterogeneous, particularly as regards the breadth of motives that determine the urge to smoke. It appears timely that basic neuroscience integrates this heterogeneity to refine our understanding of the neurobiology of nicotine seeking.
Vernon reviews converging psychological, genetic and neurobiological data from clinical and preclinical studies supporting that the mechanisms controlling nicotine seeking may vary from individual to individual. For a better understanding of the mechanisms that drive nicotine seeking, he emphasizes the need for individual-based research strategies in which nicotine seeking, and eventually treatment efficacy, are determined while taking into account individual variations in the mechanisms of nicotine seeking.
http://rdcu.be/HPHl




Info générale
08/02/2018
Vernon Garcia-Rivas et le programme

Le dispositif "Immersion étudiants" est en phase pilote sur l'année universitaire 2017-2018. Il sera un élément du futur Institut d'Etudes Avancés de Bordeaux. Il a pour but de favoriser l'interdisciplinarité. Dans ce cadre, Vernon Garcia-Rivas (Equipe Deroche, PhD 3ème année) a accueilli, les 7 et 8 février 2018, Laure Paindaveine, étudiante en L3 Stratégies, décisions et politiques économiques, et Mathilde Vildy, étudiante L3 Orthophonie.




Info générale
31/01/2018
Disparition de Jean-Marie Cabelguen

Notre collègue et ami Jean-Marie Cabelguen nous a quitté hier après une lutte courageuse contre la maladie.

Jean-Marie a participé à l’aventure du Neurocentre depuis ses débuts, aux côtés de Frédéric Nagy puis de Gwendal Lemasson avant de faire valoir ses droits à la retraite. C’était un chercheur remarquable de part sa culture, son expertise, sa pédagogie et ses qualités humaines. Dans ces moments particulièrement tristes et douloureux, nous pensons à son épouse Marie-Françoise (Montaron), notre collègue et amie, à qui nous présentons nos plus sincères condoléances.




Hottopic
31/01/2018 10h00
Christopher STEVENS from Marighetto's lab will give a presentation entitled "A behavioral mouse model for studying the neuronal underpinnings of confirmation bias"

Hottopic
31/01/2018 10h30
Isabel DEL PINO from Frick's lab will give a presentation entitled "Neural allocation mechanisms of recent and remote memories."