Les dernières actualités



Afficher par type


Hottopic
12/10/2011 09h00
Daniel Voisin Daniel Voisin from Oliet's lab will present the hottopic. Project: How autonomic responses to noxious stimuli affect the emotional component of pain through the insular cortex

Hottopic
05/10/2011 09h00
Alice AL ABED Alice AL ABED from Marighetto's lab will present the hottopic. Project: Estrogen in age-related decline in memory function

Hottopic
21/09/2011 09h00
Muna HILAL Muna HILAL from Montcouquiol's lab will present "Scribbling spatial memory consolidation"

Hottopic
13/05/2011 12h00
Marion JALABERT Marion JALABERT from Daniel Choquet's IINS lab will present his project entitled 'Neuronal circuits underlying morphine action on dopamine neurons' Description Morphine is a highly potent analgesic with high addictive potential in specific contexts. Although dopamine neurons of the ventral tegmental area (VTA) are widely believed to play an essential role in the development of drug addiction, neuronal circuits underlying morphine action on dopamine neurons have not been fully elucidated. Here, we combined in vivo electrophysiology, tract-tracing experiment and targeted neuronal inactivation to dissect the neural circuit for morphine action on dopamine neurons in rats. First, we found that morphine targets in vivo the GABAergic tail of the ventral tegmental area, also called rostromedial tegmental nucleus, disrupting the balance between inhibition and excitation on dopamine neurons. Second, our data reveal that in the absence of VTA glutamatergic tone, there is no morphine-induced activation of dopamine neurons. We conclude that morphine excites dopamine neurons by simultaneous NMDA/AMPA receptor activation and cessation of GABA receptor activation.

Hottopic
06/05/2011 12h00
Julien COURTIN Julien COURTIN from Piazza's lab will present his project entitled 'A subpopulation of prefrontal putative inhibitory interneurons controls conditioned fear expression'. Accumulating evidence indicate that the medial prefrontal cortex is necessary for conditioned fear expression. It is likely that neuronal changes occurring during fear expression depends on specific interactions between excitatory and inhibitory prefrontal microcircuits. However such microcircuits are still unknown. Recent anatomical and electrophysiological data indicate that cortical inhibitory circuits might regulate pyramidal cell activity at multiple levels. In order to evaluate the role of inhibitory prefrontal microcircuits during expression of conditioned fear responses we used single units recordings in behaving animals submitted to auditory fear conditioning. We found that a subpopulation of prefrontal putative inhibitory interneurons might selectively control conditioned fear expression.

Hottopic
29/04/2011 12h00
Matthias HABERL Matthias HABERL from Frick's lab will present his project entitled 'Neocortical circuitry in a model of mental retardation' The function of cortical circuits emerges from its anatomical wiring diagram and wiring defects are probably involved in a manyfold of neurological diseases. Still the detailed organization of the mammalian neocortex remains largely unknown and exceedingly difficult to investigate. Therefore cutting-edge tools that allow us to dissect the sub-circuits are inevitable. To study connectivity in the neocortex we are using viral tracing techniques, as lentivirus and rabies-based monosynaptic trans-synaptic tracing. We look at changes of connectivity in mental retardation, from fine scale microcircuits up to long ranging projections from the entire brain. We hope not just to learn more about importance of specific circuits in normal and diseased (Fragile X Syndrome) brain but also to understand more about the involvement of wiring defects in neurological diseases in general.

Hottopic
22/04/2011 12h00
Yu ZHANG Yu ZHANG from Frick's lab will present his project entitled 'Pathophysiology of information processing in neocortical dendrites in Fragile X Syndrome' Fragile X Syndrome (FXS) is the most common form of inherited mental retardation syndrome, and it is caused by a silencing mutation of the gene Fmr1 (encoding the protein FMRP). In humans, the consequences of this disorder include hypersensitivity to sensory stimuli, autistic behavior, seizures, and learning and memory deficits. Channelopathies have not been addressed as a prominent feature of FXS, although several ion channel subunits are amongst the genes whose mRNAs are regulated by FMRP. These channels strongly regulate the active properties of dendrites and therefore dendritic information processing. We will probe ion channel dysfunction and its consequences for dendritic function in layer 5B pyramidal neurons of the whisker-related barrel cortex.

Hottopic
15/04/2011 12h00
Isabelle MATIAS Isabelle MATIAS from Marsicano's lab will present his project entitled 'Simultaneous Post-prandial Deregulation of the Orexigenic Endocannabinoid Anandamide and the Anorexigenic Peptide YY in Obesity'

Hottopic
25/02/2011 12h00
Mathilde METNA Mathilde METNA from Marsicano's lab will present her project entitled 'Bimodal control of fear-coping strategies by the endocannabinoid system'.

Hottopic
18/02/2011 12h00
Jerome EZAN Jerome EZAN from Montcouquiol's lab will present his project entitled 'Role of Scribble and Vangl2 in embryonic neuronal migration'