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Lieu: CGFB

, Schild Professor of Pharmacology and HoD, will give a presentation entitled 'Axe Synapse'.

Invitant : Nathalie Sans, Maurice Garret

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-fbn-2015/tina-bashford.html

Lieu: Neurocentre Magendie Seminar room

will give a presentation entitled 'Adolescent cannabinoid exposure and psychosis: further insight into the molecular underpinnings'.

Invitant : Stéphanie Callé-Garnier, INCIA

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-fbn-2015/tiziana-rubino.html

25/02/2015 13h30
Isabel del Pino

Lieu: Neurocentre Magendie Seminar room

"Implications of gabaergic miswiring on brain function: role of Nrg/Erbb4 signaling in interneuron development".

Invited by Andreas Frick

Abstract: Inhibitory cells are essential to fine-tuning the activity of neural circuits. Different classes of interneurons target distinct subcellular compartments of the pyramidal cell. This suggests that there is a differential contribution of each subtype of interneuron in the regulation of the network. In particular, cholecystokinin (CCK) expressing interneurons differ in chemical features and their postsynaptic targets, yet the role of each of these subtypes in the regulation of neuronal network activity is poorly understood. In this study, we describe a subpopulation of CCK interneurons co-expressing the vesicular glutamate transporter 3 (VGlut3) that also shows tyrosine kinase ErbB4 receptor expression. These interneurons are mainly basket cells targeting both, pyramidal cells and Parvalbumin-expressing interneurons in the hippocampus. To address the role of CCK-VGlut3 interneurons in network activity regulation, we combined mouse genetics with a set of different experimental approaches. Our results suggest that specific conditional deletion of ErbB4 receptor from CCK-expressing cells, results in deficient VGlut3 innervation. In addition, abnormal wiring of CCK-VGlut3 expressing interneurons perturbs cortical oscillatory activity as well as spatial representation in vivo and leads to specific behavioural deficits.

Lieu: Neurocentre Magendie Seminar room

, Principal Investigator Medicinal Chemistry Leiden University, Faculty of Science, will give a presentation entitled 'A Chemical Biology Approach to Control Endocannabinoid Biosynthesis'.

Invitant : Giovanni Marsicano

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-fbn-2015/mario-van-der-stellt.html

Lieu: Neurocentre Magendie Seminar room

Leonie Pothmann from the group of Prof. Heinz Beck (University of Bonn Medical Center) is giving a talk entitled 'Changes of inhibitory micronetworks in the epileptic hippocampus and their response to anticonvulsant drugs' on Wednesday, 15:00 in the Salle de conference of the Neurocentre.

CA1 microcircuits show profound reorganization in human and experimental temporal lobe epilepsy due to synaptic sprouting, loss of certain neuron types, and functional synaptic changes. The divers tasks of interneurons suggest, however, that morphological and behavioral alterations of surviving interneurons will also strongly influence network activity. The temporal activity pattern of a given interneuron is shaped by its synaptic inputs as well as its intrinsic properties. The spatial component of inhibition is determined by the axon morphology of different interneuron classes. Within CA1, a major source of excitatory input of interneurons is provided by local CA1 pyramidal cells, thereby creating a feedback inhibitory loop. We investigated whether the spatio-temporal profile of feedback inhibition in CA1 is changed in experimental epilepsy.

In the second part of my talk I will present data describing the effects of anticonvulsant drugs on the functioning of inhibitory microcircuits. The mechanisms of action of many CNS drugs have been studied extensively at the level of their target proteins, but the effects of these compounds at the level of complex CNS networks composed of different types of excitatory and inhibitory neurons are not well understood. Many currently used anticonvulsant drugs are known to exert potent use-dependent blocking effects on voltage-gated Na+ channels, thereby inhibiting pathological high-frequency firing. However, some GABAergic inhibitory neurons are capable of firing at very high rates, suggesting that these anticonvulsants should cause impaired GABAergic inhibition. We therefore studied the effects of different sodium channel blocking anticonvulsants on GABAergic inhibitory micro-networks in the rodent hippocampus of control and epileptic animals.

Pour plus de détails: http://www.neuroscience.univ-bordeauxsegalen.fr/fr/manifestations-scientifiques/seminaires-fbn-2015/leonie-pothmann.html

Lieu: Neurocentre Magendie Seminar room

Une invitation de Xavier Leinekugel de l'IMN:
Molecular, cellular and activity-dependent mechanisms controlling arealization and cell-type specification in the developing mouse neocortex

Pour plus de détails: http://www.neuroscience.univ-bordeauxsegalen.fr/fr/manifestations-scientifiques/seminaires-fbn/michelle-studer.html

29/03/2013 09h00
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Lieu: Journée Synapse - 11th Synapse Day Meeting / Salle de conférences Institut François Magendie

organisation Maurice Garret & Nathalie Sans
La recherche dans le domaine de la synapse est un 'axe' fort de Bordeaux Neurosciences. Ce domaine de recherche, avec des approches de biologie moléculaire et cellulaire, d'imagerie et d'électrophysiologie, constitue le thème central d'étude d'une douzaine d'équipes de la FBN . A cet égard, il faut rappeler que cette journée est ouverte à tous. Elle donne d'autre part la possibilité de faire le point sur les recherches bordelaises et de les replacer dans un cadre plus général par la participation de chercheurs extérieurs à l'Institut.

Pour plus de détails: http://www.neuroscience.univ-bordeauxsegalen.fr/fr/manifestations-scientifiques/congres/journee-synapse.html

27/03/2013 12h00
Matthias Haberl

Lieu: Seminar room

MAtthias Haberl from Frick's lab will present "Revealing brain anatomy using recombinant rabies virus"

20/03/2013 12h00
Sophie Tronel

Lieu: Seminar room

Sophie Tronel from Abrous's lab will present "Role of hippocampal neurogenesis in memory reconsolidation"

20/12/2012 14h00
PhD Defence Audrey Bonnan (Frick team)
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Lieu: Salle de conférences PGF

PhD Defence Audrey Bonnan 'Pathophysiology of information processing in neocortical dendrites in Fragile X Syndrome'

Pour plus de détails: http://www.cgfb.u-bordeaux2.fr/detail-reservation?rid=1662