Les dernières actualités

Lieu: Amphi du Centre Broca

Chef de groupe de l'Université Paris Descartes - Equipe Interactions Glie-Glie et Glie-Neurones dans le laboratoire de Neurophysiopathologie fera une présentation intitulée 'Contributions des astrocytes et de la signalisation satellite au traitement sensoriel'.

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/cendra-agulhon.html

Lieu: Amphi du Centre Broca

from NIH- NIDA (Baltimore/USA)'s lab will give a presentation entitled 'Volitional social interaction prevents drug addiction in rat models'

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/marco-venniro.html

Lieu: Amphi de la CGFB

from Department of Pharmacology & Systems Physiology (University of Cincinnati College of Medicine)'s lab will give a presentation entitled 'Molecular and neurophysiological pathways that promote microglia-mediated neuronal remodeling in response to chronic stress'

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/eric-wohleb.html

Lieu: CGFB Seminar room

from King's College, London / Centre for Developmental Neurobiology's lab will give a presentation entitled 'Mapping Synaptic Contacts: From Dendrites to the Axon Initial Segment'

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/juan-burrone.html

Lieu: Amphi du Centre Broca

from Dean, Graduate College of Biomedical Sciences Western University of Health Sciences (Pomona, CA USA)'s lab will give a presentation entitled 'Opposite functions of calpain-1 and calpain-2 in the brain'

Invitant : Daniel Choquet, Team Leader: Dynamic organization & Function of synapses / Directeur de l'IINS

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/michel-baudry.html

25/09/2018 14h00

Lieu: Neurocentre Magendie Seminar room

Soutenance HDR: Sophie Tronel from Abrous's lab will give a presentation entitled 'Etude de la stabilisation de la mémoire'

21/09/2018 11h30
Jason Shepherd, University of Utah - Host Anna Beyeler
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Lieu: Amphithéâtre du Centre Broca Nouvelle-Aquitaine

Inter-cellular RNA transfer: a novel role of the neuronal gene Arc which encodes a repurposed retrotransposon protein

The neuronal gene Arc is essential for long-lasting information storage in the mammalian brain. We recently found that Arc self-assembles into virus-like capsids that encapsulate RNA. Endogenous Arc protein is released from neurons in extracellular vesicles that mediate the transfer of Arc mRNA into new target cells. These results show that Arc exhibits similar molecular properties to retroviral Gag proteins. Evolutionary analysis indicates that Arc is derived from a vertebrate lineage of Ty3/gypsy retrotransposons, which are also ancestors to retroviruses. These findings suggest that Gag retroelements have been repurposed during evolution to mediate intercellular communication in the nervous system. Our working model posits that Arc protein is locally translated in dendrites, where it forms a capsid that binds local mRNAs that are transported out of the cell.

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/jason-shepherd.html

Lieu: Amphi du Centre Broca

Dr. Marloes Henckens from Department of Cognitive Neuroscience, Donders Institute for Brain (Netherlands)'s lab will give a presentation entitled 'The neural signature of trauma susceptibility'

Invitant : Aline Desmedt, PhD , Maitre de Conférence au Neurocentre Magendie, Team Marighetto 'Pathophysiology of declarative memory'

Posttraumatic stress disorder (PTSD) is a psychiatric disorder which can develop after exposure to a traumatic event. Flashbacks, spontaneous recollection and recurrent nightmares of the trauma are amongst the most devastating symptoms of PTSD, through which patients continuously relive their trauma. Interestingly, only a small fraction (8-10%) of all trauma-exposed individuals eventually develops PTSD, whereas the rest is resilient and remains healthy. But how is the vulnerable brain different from the resilient one and when do these differences arise? Understanding the mechanisms behind these inter-individual differences could contribute to new clinical intervention strategies.
The use of a mouse model for PTSD allows us to study the mechanisms underlying relative resilience or susceptibility to PTSD in a longitudinal fashion, under controlled settings, while allowing for more invasive brain measurements. In this model, mice are first exposed to a traumatic event (i.e., severe unpredictable foot shock), followed by a trigger (i.e., mild predictable foot shock) in a different context one day later. Following a week of recovery, eventual development of PTSD-like symptomatology is assessed using a battery of behavioural tests to identify mice resilient and vulnerable to the trauma. Combining this model with functional MRI obtained both before and after trauma exposure, allowed us to study the development of a potential imbalance in neural network function as a consequence of trauma in the PTSD-vulnerable vs resilient brain, as well as the potential presence of neural abnormalities prior to trauma exposure in these animals. To study brain responses to the trauma itself, we used the so-called targeted recombination in active populations (TRAP) mice, in which the injection of tamoxifen opens up a temporal window in which all neurons expressing certain immediate early genes (reflecting neuronal activity), are permanently fluorescently labelled. We injected these animals with tamoxifen just prior to trauma exposure, and again assessed PTSD-symptoms later on. By re-exposing them to the traumatic context just before sacrifice and analysing trauma retrieval-induced neuronal activity by immunohistochemistry, we were moreover able to analyse the storage of the trauma memory into long-term memory. This allowed us to assess whether aberrant storage of the trauma memory could explain the emotional hypermnesia and contextual hypomnesia of the trauma that seem to characterize PTSD patients.

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/marloes-henckens.html

Lieu: Neurocentre Magendie Seminar room

from Research Center on Animal Cognition's lab will give a presentation entitled 'Searching for the neural bases of non-elemental learning in a miniature brain'

DR CNRS / Centre de Recherches sur la Cognition Animale - UMR 5169 Team leader: Plasticité dépendante de l’expérience chez l’insecte (EXPLAIN) Research Center on Animal Cognition, CNRS - Université de Toulouse

Invitant : Nora Abrous / Team leader : 'Neurogénèse et physiopathologie' , DR Inserm / Neurocentre Magendie

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/martin-giurfa.html

Lieu: Amphi Broca Nouvelle-Aquitaine

from Institut de génomique fonctionnelle de Montpellier, Department of Neuroscience's lab will give a presentation entitled 'RVM GABAergic neurons command enkephalinergic spinal neurons to act as gatekeepers of mechanical pain.'

Invitant : Pascal Fossat , Assistant Professor, Team: Central Mechanisms of Pain Sensitization and Anna Beyeler: Teamleader 'Neural Circuits of Anxiety', IINS et Neurocentre Magendie

Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-2018/amaury-francois.html