Agenda






Hottopic
29/05/2019 10h30
Anes JU from Beyeler's lab will give a presentation entitled "Serotonin receptor expression of the insular cortex involved in anxiety"

Séminaire
03/05/2019 14h00
Dr. Julia Lemos, Dissecting the actions of CRF in the NAc
   Afficher l'article web Link

Lieu: Amphi Centre Broca

Dr. Julia Lemos is an Assistant Professor at the Department of Neuroscience of the University of Minnesota (USA) and will present the work of her lab dissecting the actions of corticotropin releasing factor (CRF) in the nucleus accumbens.
Host: Anna Beyeler

Outside of its well-characterized actions in the HPA axis, the stress-associated peptide corticotropin-releasing factor (CRF) regulates neuronal excitability and synaptic transmission in several extrahypothalamic brain regions. Previous research has shown that CRF in the nucleus accumbens (NAc) promotes appetitive behavior through mechanisms that remain poorly understood. We have recently showed that CRF potentiates both dopaminergic and cholinergic transmission in the NAc. However, it is unknown how CRF regulates the activity of medium spiny neurons (MSNs), the principle projection neurons of the NAc, to modulate behavioral output. MSNs are classified by their peptide expression and projection targets within the basal ganglia: dMSNs form the direct projection pathway and express dynorphin, whereas iMSNs form the indirect pathway and express enkephalin. RNAscope in situ hybridization was used to assess Crh1 mRNA expression in MSN subpopulations, identifying dMSNs and iMSNs with expression of dynorphin (pdyn) or enkephalin (pEnk), respectively. 20% of all cells were positive for Crh1 mRNA, with approximately 30% co-expressing pEnk mRNA (iMSNs), 30% co-expressing pDyn mRNA (dMSNs) and 30% co-expressing neither marker. Using whole-cell patch clamp electrophysiology recordings in brain slices, we examined the function of exogenously-applied CRF on the excitability of MSNs in the NAc core. Application of 100 nM CRF produced a leftward shift in the current-voltage relationship, demonstrating that CRF can enhance the firing rate of both dMSNs and iMSNs. Next steps will focus on identifying the role of CRF receptor subtypes in enhancing the spiking activity in MSNs and elucidate whether this effect is through direct actions on MSNs or through dopaminergic and cholinergic modulation of MSNs.


Pour plus de détails: https://www.lemoslaboratory.org/


Hottopic
24/04/2019 10h00
Julien BOUREL from Oliet's lab will give a presentation entitled " "Role of the complement component C3 in memory deficits at the early stage of experimental multiple sclerosis"

Hottopic
24/04/2019 10h30
Bastien REDON from Marsicano's lab will give a presentation entitled ""Role of the endocannabinoid system in motivation for wheel running and palatable food"

Autre évènement
02/04/2019 11h30
Marché de Pâques du Clas Inserm Le marché CLAS Inserm se déroulera dans le hall du Neurocentre Magendie de 11h30 à 14h.

Le marché CLAS Inserm se déroulera dans le hall du Neurocentre Magendie de 11h30 à 14h.

Exposants :
- Miel et produits de la ruche ;
- So Soap ;
- Arts et déco Dany Denaud ;
- Chocolats Antton ;
- Ansome Thé Bio ;
- Association Lagmitaba Artisanat Sahélien
- Alexandre Brochard Photographies

Date de l'évènement: 02/04/2019 - 11h30
Lieu: Hall Magendie

Pour plus de détails: https://neurocentre-magendie.fr/NCM_Pictures/PDFActus/2019-04-02_ressource_fichier_marcha.pdf


Hottopic
27/03/2019 10h00
Camille ALLARD from Cota's lab will give a presentation entitled "Role of mitochondrial cannabinoid receptor 1 in pancreatic islets".

Hottopic
27/03/2019 10h30
Arjun A-BHASKARAN from Frick's lab will give a presentation entitled ''Cellular and circuit level dysfunctions contributing to atypical sensory information processing in fragile x syndrome.''

Hottopic
27/02/2019 10h00
Kamila CASTRO from Frick's lab will give a presentation entitled 'Brain network and Autism Spectrum Disorder'

Hottopic
27/02/2019 10h30
Zoe HUSSON from Cota's lab will give a presentation entitled "Role of the POMC-ventral striatal neurocircuit in the development of diet- induced obesity"

Hottopic
27/02/2019 11h00
Zhe ZHAO from Marsicano's lab will give a presentation entitled “Role of the cannabinoid receptor type 1 in the control of water intake”.