Maria SZLAPCZYNSKA Maria SZLAPCZYNSKA from Frick's lab will present the hottopic.
Project: Role of Intrinsic Excitability in Learning and Memory in the Prefrontal Cortex
Description: The knowledge of how new information is acquired and where it is stored in the brain is critical for our understanding of the normal functioning and the neuropathology of neural circuits underlying memory. It is a generally held belief that long-term memories in the cortex are stored in the strength of synaptic connections between neurons. However, recent studies show that excitability is a plastic property of neurons that can be induced by activity, experience, or disease. We hypothesize that changes in the excitability of prefrontal cortex neurons contribute to learning and the formation of conditioned-fear memory. We investigate this hypothesis by using contextual fear conditioning as well as electrophysiological recordings in pyramidal neurons of the medial prefrontal cortex.