Agenda & Actualités







Habenular CB1 Receptors Control the Expression of Aversive Memories.

Memory is not a simple box of souvenirs. Memories are also, and most importantly, a safety system for organisms. With the help of negative memories, known as “aversive” memories, we can avoid a threat that we have already confronted. We have just discovered that the cannabinoid receptors of the brain control these memories that are crucial for survival. This study is published in Neuron.

http://cell.altmetric.com/details/4549728





Bordeaux School of Neurosciences:
The microscopic study of synapses relies on a large array of advanced techniques. Successful research in the field requires technological innovation and the interweaving of a variety of approaches at the molecular, cellular, and functional levels. The advanced course will allow the students to integrate the basic techniques in molecular and cellular neurobiology with advanced state-of-the art molecular, imaging and functional methodologies, through direct hands-on experiments. Taught techniques will range from proteomics and transcriptomics, in vitro and in vivo gene transfer (including viral technology), cellular imaging of proteins by confocal microscopy and by super-resolution microscopy (STED and PALM/STORM), single-particle tracking methodologies, live imaging of protein interactions (FRET, FLIM) at synapses, electron microscopy. The advanced course will also include electrophysiological and optophysiological approaches to address the functional properties of synaptic molecules such as recombinant receptors and to assess the role of various proteins in synaptic function and plasticity.

On-site chair: Nathalie Sans, PhD, University of Bordeaux, FR (Equipe Montcouquiol-Sans)





The endocannabinoid system (ECS) adjusts behavior and metabolism by responding to environmental changes in food availability. ECS activity is benefi cial when access to food is scarce or unpredictable but in times of plenty, the ECS favors obesity and metabolic disease. In pages 524–537 of this issue, Mazier et al present emerging evidence that suggest new physiological roles of the ECS in the context of energy balance, and point to novel mechanisms of action, that again renders the ECS as an attractive target for therapy. Cover image created by Charlie Padgett.





La deuxième édition des International Bordeaux Neurocampus - Brain Conferences aura lieu du 30 septembre au 2 octobre 2015. Elle se déroulera à l'Institut d'optique d'Aquitaine à Talence





Lieu: CGFB (Centre de Genomique Fonctionnel) Seminar room

from MRC Centre for Developmental Neurobiology, King's College London's lab will give a presentation entitled 'Neurons, synapses and the axon initial segment: location matters'

Invitant : Mireille Montcouquiol & Laurent Groc


Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-fbn-2015/juan-burrone.html



Lieu: Neurocentre Magendie Seminar room

from DR Inserm 837, Centre de recherche Jean-Pierre Aubert, Faculté de médecine Henri Warembourg's lab will give a presentation entitled "Microtubule-associated tau proteins: from the good guy to the serial killer"

Invitant : Stéphane Oliet, Neurocentre Magendie / Team leader: Glia-neuron relations


Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-fbn-2015/luc-bue.html



Lieu: CGFB Univ Bordeaux Carreire

Bi-directional modulation of synaptic integration in small diameter neocortical dendrites

Arnaud Ruiz From University College of London, Senior Lecturer in Cellular Neuroscience and Pharmacology

Invitant : Stéphane Oliet, DR Inserm / Neurocentre Magendie


Pour plus de détails: http://www.bordeaux-neurocampus.fr/fr/manifestations-scientifiques/seminaires-fbn-2015/arnaud-ruiz.html



Une mémoire de peur anormale comme modèle de mémoire traumatique
Aline Desmedt, Aline Marighetto, and Pier-Vincenzo Piazza
Biological Psychiatry September 1, 2015; 78:290–297

Aline Desmedt: Alors que la plupart des modèles animaux actuels de mémoire traumatique se focalisent sur l’hypermnésie liée au trauma, cette revue soutient la thèse selon laquelle l’amnésie vis-à-vis du contexte environnemental du trauma est au cœur de l’état de stress post-traumatique (ESPT). Un modèle de mémoire de type ESPT récemment mis au point chez la souris y est décrit : il fournit le moyen de distinguer une mémoire normale et adaptative d’un épisode de stress d’une mémoire traumatique pathologique, incluant, elle, une telle amnésie. Cette distinction est mise en exergue dans la mesure où elle s’avère cruciale pour l’identification de biomarqueurs de l’ESPT, lesquels diffèrent nécessairement des altérations biologiques adaptatives induites par un stress."






Focus sur la modulation du comportement par les récepteurs CB1 : l’importance de son profil d’expression

Dissecting the cannabinergic control of behavior: The where matters.
Arnau Busquets-Garcia, Tifany Desprez, Mathilde Metna-Laurent, Luigi Bellocchio, Giovanni Marsicano and Edgar Soria-Gomez
Bioessays. 2015 Aug 11. doi: 10.1002/bies.201500046. [Epub ahead of print]

Group "Endocannabinoids and Neuroadaptation," NeuroCentre Magendie, INSERM U862, Bordeaux Neurocampus, University of Bordeaux, Bordeaux, France.





Circuits neuronaux impliqués dans l'expression et la récupération des réponses de peur: avancées récentes et potentielles stratégies thérapeutiques.