News & Events







Seminars
14/02/2020 11h30
Chantal Mathis

Lieu: Neurocentre Magendie Seminar room

from DR2 CNRS, LNCA, Strasbourg's lab will give a presentation entitled 'Early memory deficits appearing during preclinical stages in mouse models of Alzheimer disease'

Invited by Nora Abrous (Neurocentre Magendie)

Abstract

Over the last decade, the main finding about Alzheimer’s disease (AD) is that initial signs have been detected 15 to 20 years before diagnosis (e.g., see Bateman et al, 2012 and Jack et al, 2009). Since then, a great deal of efforts concentrated on the identification of early events and biomarkers that might help us to understand AD pathogenesis. The nature and severity of recognition deficits evolve as AD pathology spreads through medial temporal lobe networks and connected brain structures playing a key role in recognition memories. Therefore, object recognition paradigms have been useful to determine early memory deficits in animal models of AD. The pertinence of behavioral data provided by these paradigms will be analyzed in regard to the neuropathological phenotype of genetically modified rodent models of AD. Our aim is to outline clear advantages and possible limitations in their translational value. We propose that future progress depends on understanding neural networks supporting each form of recognition memory in parallel with the improvement of animal models of AD.






Lieu: Agora du Domaine du Haut-Carré (Talence)

MetaboDay aims at promoting interactions between researchers of the Bordeaux area interested in the various aspects of metabolism. This scientific event is open to researchers, post-docs and PhD students from all fields.

Registration is free but mandatory.


Pour plus de détails: www.tbmcore.u-bordeaux.fr/metabo-day/


Hottopic
29/01/2020 10h00
Imane HUREL from Marsicano's lab will give a presentation entitled 'Choosing between exercise and food in a closed economy setting: role of CB1 receptors'

Hottopic
29/01/2020 10h30
Vincent SIMON from Cota's lab will give a presentation entitled ' "Uniting FISH and IHC techniques: a tale of wonder and despair"'

Seminars
24/01/2020 11h30
Francisco Papaleo

Lieu: Centre Broca Nouvelle-Aquitaine

from IIT Central Research Labs Genova's lab will give a presentation entitled 'Bottom-Up and Top-Down Control of Emotion Recognition'

Francisco Papaleo
Senior Researcher Tenure Track – Principal Investigator
IIT Central Research Labs Genova
https://www.iit.it/people/francesco-papaleo

Invited by Giovanni Marsicano (Neurocentre Magendie)

Summary:

The prefrontal cortex (PFC) has been implicated in processing of the emotional state of others through nonverbal communication. This social cognitive function is altered in psychiatric disorders such as autism and schizophrenia and is hypothesized to rely on an intact cortical neuronal excitatory and inhibitory balance. Here, by combining in vivo electrophysiology with a behavioral task for emotion recognition in mice, we show that neurons in the medial prefrontal cortex (mPFC) are differentially activated during exploration of conspecifics depending on their affective state. Optogenetic manipulations revealed a double dissociation of interneuron roles in emotion recognition; specifically, inhibition of mPFC somatostatin (SOM+) but not of parvalbumin (PV+) interneurons abolishes emotion discrimination. Conversely, activation of mPFC SOM+ interneurons induces social discrimination in this task. Our findings provide new insights into the neurobiological mechanisms of emotion recognition.



Seminars
23/01/2020 18h30
Conférence : « Déséquilibre alimentaire : quelles conséquences »

Lieu: Médiathèque Jacques Ellul de Pessac


Par Véronique Pallet (NutriNeuro) et Blandine Cherifi (Neurocentre Magendie)

Animé par Thierry Amédée (IINS)




Press review
14/01/2020
Carvalho et al in Elife - January 2020

Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth. Steve Dos-Santos Carvalho, Maite M Moreau, Yeri Esther Hien, Michael Garcia, Nathalie Aubailly, Deborah J Henderson, Vincent Studer, Nathalie Sans, Olivier Thoumine, Mireille Montcouquiol. eLife. 2020-01-07. 9.

Here, we show that an early deletion of vangl2 in neuronal progenitors of the forebrain leads to the spatially restricted deficit of only two commissural axon bundles. Mechanistically, we show that the absence of vangl2 leads to an increase in axonal outgrowth due to a reduced turnover of N-cadherin, and a better coupling between the adhesion molecule and the dynamic actin flow in the growth cone. Our results support a model in which Vangl2 acts as a regulator of membrane protein endocytosis and junctional remodeling during growth cone exploration, thereby modulating its outgrowth.

This study benefited from a close collaboration between the groups of Montcouquiol/Sans (Neurocentre Magendie), O. Thoumine (IINS), and V. Studer (IINS), funded by the Labex BRAIN (project PCP Compass).

https://www.bordeaux-neurocampus.fr/steve-dos-santos-carvalho-et-al-in-elife/
https://elifesciences.org/articles/51822