La date de naissance d'un neurone détermine sa fonction dans la mémoire

Influence of ontogenetic age on the role of dentate granule neurons. Tronel S, Lemaire V, Charrier V, Montaron MF, Abrous DN. Brain Struct Funct. 2014 Feb 9. ;

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A collaboration between experts of neurosecretion and experts of neuronal rhythms shows the importance of tempo in the reproduction. February 2014




Press review
10/02/2014
Hippocampal neurogenesis
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Neuroscientist Dr Nora Abrous is leading a team of researchers in
the quest to further knowledge of the neuronal basis of memory. The
group has already uncovered novel findings surrounding the role and
importance of generating new adult neurons in the hippocampus

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Experiments are conducted on the impact in the brain tetrahydrocannabinol, one of the cabannis active derivatives, by researchers at the laboratory Inserm in Bordeaux (Gironde)





Pregnenolone can protect the brain from cannabis intoxication.
Vallée M, Vitiello S, Bellocchio L, Hébert-Chatelain E, Monlezun S, Martin-Garcia E, Kasanetz F, Baillie GL, Panin F, Cathala A, Roullot-Lacarrière V, Fabre S, Hurst DP, Lynch DL, Shore DM, Deroche-Gamonet V, Spampinato U, Revest JM, Maldonado R, Reggio PH, Ross RA, Marsicano G, Piazza PV.
Science. 2014 Jan 3;343(6166):94-8. doi: 10.1126/science.1243985





Two teams of researchers from Inserm " have discovered that a molecule [ pregnenolone ] produced by the brain was a natural defense mechanism against the harmful effects of cannabis ," reported AFP and France Info . With high doses of cannabis administered to rats and mice , the researchers were able to " increase the cerebral concentration of pregnenolone in the brain and block the harmful effects of the active ingredient of cannabis ( THC ), which acts on receptors cannabinoid (CB1 ) on neurons , "said the news agency . Pier Vincenzo Piazza, who led the study , said that the intakes were " on the order of 3 to 10 times more " than those which are exposed to regular cannabis users . The researcher explains that he developed derivatives of pregnenolone "modified so that it can be absorbed by the body and does not evolve into steroid hormones ." Hope and add " to begin clinical trials on humans in a year to a year and a half at least ." According to him, if the effectiveness of derivatives was confirmed, it would be the "first pharmacological therapy of cannabis dependence ."

AFP , France Info, 02/01




Press review
06/01/2014
The brain at the base of addictions







Deux équipes de chercheurs de l’Inserm dirigées par Pier Vincenzo Piazza et Giovanni Marsicano (Unité Inserm 862 “Neurocentre Magendie” à Bordeaux) viennent de découvrir qu’une molécule produite par le cerveau, la prégnénolone, constitue un mécanisme naturel de défense contre les effets néfastes du cannabis chez l’animal. Comment ? En empêchant le THC, le principe actif du cannabis, d’activer pleinement ses récepteurs cérébraux, notamment le récepteur CB1 dont la sur-activation par le THC est responsable des effets intoxicants du cannabis. Grâce à l’identification de ce mécanisme, les chercheurs développent déjà des approches pour le traitement de l’addiction au cannabis.





Molecule produced by the brain would fight against memory impairment and the general loss of motivation according to a study by researchers at Inserm





Cyril Herry's team of Neurocentre Magendie has identified 2 populations of nervous cells involved in emotional regulation.A discovery that could revolutionize the treatment of anxiety.