News & Events






General informations
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The plasticity of synaptic transmission efficacy plays a central role during neuronal development for the refinement of neuronal circuits and at all ages for the short and long term storage of memories and their erasure. Defects in synapse function and their altered plasticity is thought to be the primary cause of several brain disorders. Despite its recognized importance and decades of investigations by hundreds of laboratories, the molecular and cellular basis of the various forms of synaptic plasticity still remain largely mysterious.

This conference proposes to bring together among the most famous international and French experts on the molecular and cellular basis of synaptic plasticity, with a focus on its relation to memory. We will gather experts from neurotransmitter receptor structure, synapse nanoscale organization, synapse physiology to signaling and molecular mechanisms as well as the latest advances in our understanding of the tri-partite synapse mechanisms involved in synaptic plasticity and thus memory. Our speaker list is a harmonious balance between young and more established investigators, respecting diversity and gender balance.

Scientific comitee :

- Daniel Choquet (IINS)
- Laurent Groc (IINS)
- Aude Panatier (NCM - Oliet Team)




General informations
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Neurodevelopmental disorders: from molecular mechanisms to social inclusion.
18-22 May 2022.

Neurodevelopmental disorders are a group of different conditions in which the development of the central nervous system is disrupted and which often have lifelong consequences. This brain dysfunction can manifest itself in neuropsychiatric problems (autism spectrum disorders, schizophrenia, Fragile X syndrome, Down's syndrome...) or in impaired motor function, learning, language or non-verbal communication. Many developmental processes can go awry, sometimes simultaneously, affecting the generation of an appropriate diversity of neuronal cell types, their migration to the correct sites in the brain and the establishment of accurate connectivity with target cells, leading to complex brain and sensory dysfunctions and neurological diseases.
During this three-day symposium, experts from different fields of developmental neuroscience, human neuropsychology, epidemiology, brain imaging, and genetics and epigenetics, as well as clinicians, will discuss the current state of research on neurodevelopmental disorders and its challenges for human health. By integrating neurodevelopmental perspectives with basic, translational and clinical approaches, this meeting will foster discussion and exchange, as well as a new understanding of the complexity of these disorders.


Scientific Committee
Anouck AMESTOY ; Charles Perrens Hospital
Jean-René CAZALETS; INCIA
Sophie LAYÉ ; Nutrineuro
Mireille MONTCOUQUIOL ; Neurocentre Magendie
Nathalie SANS ; Neurocentre Magendie





General informations
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Hello everyone,

We would like to inform you of the opening of the registration for the Workshop 260 "CRISPR-Cas9: new advances and future challenges" which will take place in Bordeaux from 20 to 22 October 2021.

Registration deadline: 9 July 2021

Programme and registration details on the website https://evenium-site.com/site/atelier-de-l-inserm-260-2021






Seminars
11/10/2021 09h00
Symposium : « Cellular and molecular actors of memory formation and stabilisation »
2021-10-11 09:00:00 2021-10-11 18:00:00 Europe/Paris Symposium : « Cellular and molecular actors of memory formation and stabilisation » 0    Show the web article Link

Lieu: Centre Broca Nouvelle-Aquitaine

Organizers: Guillaume Ferreira (NutriNeuro), Bruno Bontempi (IMN) and Sophie Tronel (NeuroCentre Magendie)

Program:

9:00–9:30
Tomàs Ryan (Trinity College of Dublin, Ireland)
Information Storage in Memory Engrams.

9:30–10:00
Johannes Gräff (Ecole Polytechnique Fédérale de Lausanne, Switzerland)
Recent insights into remote fear memory attenuation.

10:00 –10:30 – pause

10:30 –11:00
Amy Milton (University of Cambridge, United Kingdom)
Great (mismatched) expectations: retrieval–extinction of fear and drug memories.

11:00–11:30.
Sophie Tronel: Role of adult hippocampal neurogenesis in long–term memory reconsolidation. (NeuroCentre Magendie, Equipe Marighetto, Bordeaux, France)

11:30 –12:00.
Bruno Bontempi (IMN, Bordeaux, France)
The long and winding road to remote memory formation: is itconsolidationor transformation?

12:00 –14:00 Lunch

14:00 –14:30.
Gabrielle Girardeau (Institut du Fer-à-Moulin, Paris, France)
Neural mechanisms for memory and emotional processing during sleep.

14:30 –15:00.
Laure Verret (Centre de Recherche sur la Cognition Animal, Université de Toulouse, France)
Interneuronal dysfunction and memory impairment in Alzheimer’s disease

15:00 –15:30.
Aline Desmedt (NeuroCentre Magendie, Equipe Marighetto, Bordeaux, France)
Multilevel hippocampal alterations can cause PTSD-like memory.

15:30–16:00 – Break

16:00–16:30.
Gisella Vetere (ESPCI, Paris)
Long–term memory consolidation in the neuronal network: a role for the thalamus.

16:30–17:15.
Keynote lecture: Paul Frankland (University of Toronto, Canada)
The organization of recent and remote memory

Registration here



Pour plus de détails: https://www.bordeaux-neurocampus.fr/en/event/symposium-cellular-and-molecular-actors-of-memory-formation-and-stabilisation/


Seminars
22/09/2021 09h00
4th joint franco-british Meeting of neuroendocrinology
2021-09-22 09:00:00 2021-09-22 17:00:00 Europe/Paris 4th joint franco-british Meeting of neuroendocrinology 0    Show the web article Link

Lieu: Neurocentre Magendie Seminar room

The neuroendocrinologists in Bordeaux have the honor to organize in 2021 the 4th joint meeting between the SNE (French Society for Neuroendocrinology) and the BSN (British Society for Neuroendocrinology).

The congress will last 3 full days, from the 22nd to the 24th of September 2021, and will be entirely online. The scientific program elaborated by both the SNE’s and BSN’s scientific committees includes 4 plenary lectures and 4 symposia. The objective of the meeting is to highlight the recent advances in Neuroendocrinology with the best specialists in the field.

Registration here: https://bsn-sne2020.sciencesconf.org/

Plenary lectures:

Joëlle Cohen-Tannoudji, Waljit Dhillo, Sakina Mhaouty-Kodja, Steve A. Brown

Organizing team:

Marie-Pierre Moisan, Nutrineuro
Daniela Cota, Neurocentre Magendie
Xavier Fioramonti, Nutrineuro
Philippe Ciofi (Oliet team), Neurocentre Magendie
Muriel Darnaudery, Nutrineuro



Pour plus de détails: https://bsn-sne2020.sciencesconf.org/


Seminars
21/09/2021 09h00
Synapse Day
2021-09-21 09:00:00 2021-09-21 17:00:00 Europe/Paris Synapse Day 0    Show the web article Link

Lieu: Centre Broca Nouvelle-Aquitaine

Registration here: https://www.bordeaux-neurocampus.fr/event/synapse-day/

Program
9:00 Christoph Schmidt-Hieber (Institut Pasteur, Paris)
SynapticA and circuit basis of distinct memory formation in the hippocampus

9:45 Noémie Depret (Neurocentre Magendie, Montcouquiol-Sans team, Bordeaux)
Vangl2 regulates hippocampal mossy fiber-CA3 synapse formation and morphofonctional plasticity

10:05 Nicolas Chenouard (IINS, Bordeaux)
Imaging the activity of subcortical-cortical axonal projections during associative learning

10:25-10.55 Coffee break

10:55 Morgane Lebon-Jego (IMN, Bordeaux)
Dopaminergic control of the primary motor cortex microcircuits during motor skill learning

11:25 Camille Quilgars (INCIA, Bordeaux)
Transient motor training in newborn mice reshapes transcriptome and synaptic plasticity in motoneurons

11:45 Konstantina Liouta (IINS, Bordeaux)
TBA

12:05 Harold Gillavry (Utrecht University, Netherlands)
CRISPR/Cas9-mediated genome editing tools to resolve the dynamic nanoscale organization of endogenous proteins at excitatory synapses

12:50-14:30 Lunch

14:30 Stéphane Bancelin (IINS, Bordeaux)
in vivo 3D-STED microscopy in the hippocampus

15:00 Angela Getz (IINS, Bordeaux)
Development of an experimental model for high-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic and behavioral plasticity

15:20 Mathieu DiMiceli (Nutrineuro, Bordeaux)
Dietary polyunsaturated fatty acids modulate endocannabinoid-mediated synaptic plasticity in the nucleus accumbens

15:40 Daniel Jercog (Neurocentre Magendie, Herry team, Bordeaux)
Prefrontal population coding of defensive behaviors

16:00 Maria-Cecilia Angulo (Institut de Psychiatrie et Neurosciences, Paris)
Myelination of parvalbumin interneurons shapes cortical inhibition



Pour plus de détails: https://www.bordeaux-neurocampus.fr/event/synapse-day/


General informations
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Venue: Bordeaux School of Neuroscience

The normal aging process is associated with reduced performance on cognitive tasks that require one to quickly process or transform information to make a decision, including measures of speed of processing, executive cognitive function, working and relational memories. Structural and functional alterations in the brain correlate with these age-related cognitive changes, such as loss of synapses, and dysfunction of neuronal networks. It is crucial to develop new approaches that consider the whole neuroanatomical, endocrine, immunological, vascular and cellular changes impacting on cognition.

This 3-week course will cover the fundamentals of cognitive aging -including inter-individual differences, cognitive and brain reserve and risk factors- and highlight the newest functional imaging methods to study human brain function. The Faculty will share the state-of-the-art molecular, optical, computational, electrophysiological, behavioural and epidemiological approaches available for studying the aging brain in diverse model systems. The Students will learn the potential and limitations of these methods, through practical experience in a combination of lectures addressing aging in both humans and animal models and hands-on-projects. They will acquire sufficient practical experience to model, design and interpret experiments and brainstorm on novel technologies and hypotheses to explore the aging of the brain using more integrative and creative approaches.

Keynote speakers:
Hélène Amieva - University of Bordeaux
Adam Antebi - MPI for Biology of Ageing
Carol Barnes - University of Arizona
LucBuée-Centrede Recherche Jean-Pierre Aubert
Gwenaëlle Catheline - University of Bordeaux
Maria Llorens-Martin - Centro de Biologia
Molecular Severo Ochoa
Aline Marighetto - University of Bordeaux
Lars Nyberg - Umeå University
Laure Rondi-Reig - Sorbonne University
Yaakov Stern - Columbia University
Tony Wyss-Coray - Stanford University

Course director: Luísa Lopes
Co-directors: Cheryl Grady and Nora Abrous

Application deadline: 25 May 2020
Stipends are available

Registration
Fee : 3.500 € (includes tuition fee, accommodation and meals)

The CAJAL programme offers 4 stipends per course (waived registration fee, not including travel expenses). Please apply through the course online application form. In order to identify candidates in real need of a stipend, any grant applicant is encouraged to first request funds from their lab, institution or government.

Kindly note that if you benefited from a Cajal stipend in the past, you are no longer eligible to receive this kind of funding. However other types of funding (such as partial travel grants from sponsors) might be made available after the participants selection process, depending on the course.

For enquiries, please contact: info@cajal-training.org




Seminars
17/09/2021 11h30
Lee Hogarth
2021-09-17 11:30:00 2021-09-17 12:30:00 Europe/Paris Lee Hogarth 0    Show the web article Link

Lieu: Neurocentre Magendie Seminar room

from University of Exeter (UK - https://psychology.exeter.ac.uk/) will give a presentation entitled "The persistence of addiction is better explained by socioeconomic deprivation related factors powerfully motivating goal-directed drug choice than by automaticity, habit or compulsion theories favoured by the brain disease model"

Abstract

Since its inception, the brain disease model of addiction (BDMA) has iteratively explained the puzzle of addiction (why drug use persists despite harms) by appealing to various automaticity accounts, including (but not limited to) automatic cue reactivity, habit and compulsion theories. The current talk will evaluate this claim of the BDMA by reviewing studies which have experimentally tested whether individual variation in addiction (dependence) severity can plausibly be explained by propensity to automatic cue-elicited, habitual or compulsive control over drug choice. The evidence clearly indicates that drug choice, even in dependent individuals, is not automatic, habitual or compulsive in nature. Rather, the puzzle of addiction is better explained by factors related to socioeconomic deprivation powerfully augmenting the expected value of the drug relative to alternative rewards, promoting persistent goal-directed drug choice by outweighing expected harms. The implication is that there should be a reorientation of research funding priorities to focus on interventions that address social structural, environmental and psychosocial factors that motivate goal-directed drug choice, rather than pursuing (thus far) fruitless (in terms of therapeutic impact) investigations into proposed biomedical mechanisms underpinning automatic, habitual or compulsive drug seeking.

Invited by Véronique Deroche-Gamonet (Neurocentre Magendie)



Pour plus de détails: https://www.bordeaux-neurocampus.fr/event/seminaire-lee-hogarth/


General informations
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The ANR has published :

- Its 2022 action plan, which notably describes the calls for projects that will be proposed for the 2022 edition:

https://anr.fr/fr/actualites-de-lanr/details/news/plan-daction-2022-de-lagence-nationale-de-la-recherche-evolutions-et-nouvelle-feuille-de-route-p/

- Its generic call for projects in version 1.0 - of 20 July 2021 (note that an update will be available in September 2021):

https://anr.fr/fr/detail/call/appel-a-projets-generique-aapg-2022/

Stage 1 closes on 28 October 2021

In addition, a cycle of thematic webinars is proposed from 1 to 30 September 2021. These webinars will focus on the evolutions of the action plan, the axes of the AAPG 2022 by scientific department, the calls dedicated to public-private partnerships, the calls turned towards Europe and international, the calls "Science with and for society", the financial regulation, the consortium agreements, the tools for monitoring projects.

To register: https://evenement.anr.fr/anrtour2022/registration/register



A few developments relating to the APPG are worth noting including:

- Eligibility for the "young researcher" instrument is limited to 5 years after taking up a post in a research and knowledge dissemination organisation or institution.
- Reintroduction of the "single-team research project" instrument (PRME), which targets projects carried out by a team or a laboratory.





General informations
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Summary
Coping with threatening situations is at the core of mammal’s defensive systems. Defensive behavior
is supported by a large network of neuronal structures including the basolateral amygdala (BLA) and
dorso-medial prefrontal cortex (dmPFC). One of the main defensive responses when facing a danger
is avoidance behavior, which are learned responses that allow an animal to prevent the occurrence of
an aversive event. Excessive avoidance in the absence of a real threat is a hallmark of pathological
conditions such as anxiety-related disorders. This is why it is important to understand avoidance
behavior underlying neuronal mechanisms.
The main concept developed in our study is about how sensory information and avoidance behavior
are dynamically encoded in the dmPFC, a structure involved in both goal-directed behavior and
emotional regulation. To address these questions, we use a combination of behavioural approaches,
in vivo electrophysiology, pharmacology and optogenetics, together with advance video tracking and
machine learning techniques.
We use an active avoidance task, where mice are placed in a maze with 2 symmetric compartments
and challenged with 2 auditory stimuli. One, that we call CS+, it is associated with an unpleasant shock
after 7 seconds. Another sound, that we called CS-, it is neutral. In addition, shuttling from the current
compartment cancels any ongoing sound and contingent shock, and this defines an avoidance
response. Mice learn to discriminate the 2 sounds by selectively avoiding to CS+.
We performed single-unit recordings in the dmPFC and analyzed the data by using artificial
intelligence tools. We first observe that, despite the discrete structure of the sound used (sound-pips),
neuronal populations in the dmPFC maintain information about the presence of CS+, even during the
absence of auditory inputs (in between sound-pips). In contrast, this is not occurring during CSpresentations.
When we inactivate the amygdala while recording the dmPFC, we observe that
avoidance to CS+ is dramatically impaired. Moreover, although dmPFC neuronal decoders still show
information about the presence of the sound-pips, the information about CS+ in between sound-pips is
missing, showing that the dmPFC relies on the BLA to construct sustained representations of threats
from associated sensory inputs.
While dmPFC strongly represents CS+ at the onset, it does not predict avoidance behaviour. However,
right before starting the avoidance running response, dmPFC contains information about the
upcoming avoidance action. This, in contrast, is not observed when we consider analogous
spontaneous run movements, indicating that the dmPFC neuronal signature we observe before the
avoidance run is specific to the impending avoidance action. Finally, to study the causal role of the
dmPFC activity in avoidance behaviour we performed time-specific inactivations using optogenetics.
When we briefly inactivate the dmPFC at the onset of the CS, we induce a delay in the time in which
avoidance responses are performed. Also, when we inactivate the dmPFC after CS onset, we reduce
the avoidance response probability. This later result confirms that there is a dynamic process taking
place in the dmPFC linking threats with the initiation of defensive actions.
Over the past decades, it has been clear that the BLA plays a key role in threat-related behavior.
However, in recent years it has also become evident that the prefrontal cortex regulates threat
responses. In this study we show that the BLA is necessary to link the representations of a CS with
threat. Moreover, the dmPFC is also necessary to dynamically link this threat representation with
defensive actions. Finally, this dynamic process is critical to define the temporal evolution of
avoidance behavior.