News & Events







Lieu: Agora du Domaine du Haut-Carré (Talence)

MetaboDay aims at promoting interactions between researchers of the Bordeaux area interested in the various aspects of metabolism. This scientific event is open to researchers, post-docs and PhD students from all fields.

Registration is free but mandatory.


Pour plus de détails: www.tbmcore.u-bordeaux.fr/metabo-day/


Hottopic
29/01/2020 10h00
Imane HUREL from Marsicano's lab will give a presentation entitled 'Choosing between exercise and food in a closed economy setting: role of CB1 receptors'

Hottopic
29/01/2020 10h30
Vincent SIMON from Cota's lab will give a presentation entitled ' "Uniting FISH and IHC techniques: a tale of wonder and despair"'

Seminars
24/01/2020 11h30
Francisco Papaleo

Lieu: Centre Broca Nouvelle-Aquitaine

from IIT Central Research Labs Genova's lab will give a presentation entitled 'Bottom-Up and Top-Down Control of Emotion Recognition'

Francisco Papaleo
Senior Researcher Tenure Track – Principal Investigator
IIT Central Research Labs Genova
https://www.iit.it/people/francesco-papaleo

Invited by Giovanni Marsicano (Neurocentre Magendie)

Summary:

The prefrontal cortex (PFC) has been implicated in processing of the emotional state of others through nonverbal communication. This social cognitive function is altered in psychiatric disorders such as autism and schizophrenia and is hypothesized to rely on an intact cortical neuronal excitatory and inhibitory balance. Here, by combining in vivo electrophysiology with a behavioral task for emotion recognition in mice, we show that neurons in the medial prefrontal cortex (mPFC) are differentially activated during exploration of conspecifics depending on their affective state. Optogenetic manipulations revealed a double dissociation of interneuron roles in emotion recognition; specifically, inhibition of mPFC somatostatin (SOM+) but not of parvalbumin (PV+) interneurons abolishes emotion discrimination. Conversely, activation of mPFC SOM+ interneurons induces social discrimination in this task. Our findings provide new insights into the neurobiological mechanisms of emotion recognition.



Seminars
23/01/2020 18h30
Conférence : « Déséquilibre alimentaire : quelles conséquences »

Lieu: Médiathèque Jacques Ellul de Pessac


Par Véronique Pallet (NutriNeuro) et Blandine Cherifi (Neurocentre Magendie)

Animé par Thierry Amédée (IINS)




Press review
14/01/2020
Carvalho et al in Elife - January 2020

Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth. Steve Dos-Santos Carvalho, Maite M Moreau, Yeri Esther Hien, Michael Garcia, Nathalie Aubailly, Deborah J Henderson, Vincent Studer, Nathalie Sans, Olivier Thoumine, Mireille Montcouquiol. eLife. 2020-01-07. 9.

Here, we show that an early deletion of vangl2 in neuronal progenitors of the forebrain leads to the spatially restricted deficit of only two commissural axon bundles. Mechanistically, we show that the absence of vangl2 leads to an increase in axonal outgrowth due to a reduced turnover of N-cadherin, and a better coupling between the adhesion molecule and the dynamic actin flow in the growth cone. Our results support a model in which Vangl2 acts as a regulator of membrane protein endocytosis and junctional remodeling during growth cone exploration, thereby modulating its outgrowth.

This study benefited from a close collaboration between the groups of Montcouquiol/Sans (Neurocentre Magendie), O. Thoumine (IINS), and V. Studer (IINS), funded by the Labex BRAIN (project PCP Compass).

https://www.bordeaux-neurocampus.fr/steve-dos-santos-carvalho-et-al-in-elife/
https://elifesciences.org/articles/51822





Job offers
19/12/2019
Postdoc Position in sensory information processing and perception

The Cortical Plasticity group at the Neurocentre Magendie (Bordeaux, France) is seeking to recruit a postdoctoral researcher to join their group in 2020.

We are interested in the function of neocortical circuits and their pathophysiological modification in neurodevelopmental disorders. In particular, we study sensory information processing and perception. To address this, we will use in vivo calcium imaging (two-photon/miniscope) and electrophysiological approaches (multi-electrode/whole-cell) in behaving mice.
We are looking for a highly motivated and proactive candidate with experience in in vivo electrophysiology and/or calcium imaging and analysis of this data. The successful candidate is expected to make significant contributions to the direction and conceptualization of the project. The appointee must have a PhD or equivalent qualification in either neuroscience, life sciences, medicine, or physics. The candidate should also have a good level of proficiency in English.

The team is based at the Neurocentre Magendie, an INSERM research institute, and a member of the Bordeaux Neurocampus — a center of excellence for neuroscience research in France. The day-to-day language is English, but support would be provided for learning French if the candidate so wishes.

The project is funded for three years.

Interested applicants should send a cv, brief statement of research experience and interests, and names of 2-3 references to Dr. Andreas Frick: andreas.frick@inserm.fr





Hottopic
18/12/2019 10h00
Noémie DEPRET from Montcouquiol-Sans's lab will give a presentation entitled "Planar cell polarity protein Vangl2 : a key player in the morphofonctional development of hippocampal network"

Hottopic
18/12/2019 10h45
Sourav GHOSH from Frick's lab will give a presentation entitled 'A common excitability phenotype of neocortical neurons in genetic forms of autism'